Fish pathology

Institution: Instituto de Acuicultura Torre de la Sal (IATS)

Members (researchers): Alberto Falcó Graciá, Marta Narváez Asensio

Home page: https://iats.csic.es/fish-pathology-group/?lang=en
Contact email: ariadna.sitja@csic.es

Currently there are no tools associated with this research group.

There are no service units associated with this research group.

Research topics:

Animal genomics, Gene regulatory networks, Microbial Communities, Phylogenetic Analysis

Publications

Díaz-Puertas, R., Álvarez-Martínez, F. J., Rodríguez-Cañas, E., Borrás, F., Valente, A. J. M., Paixao, J. A., Falcó, A., & Mallavia, R. (2025). An Innovative Approach Based on the Green Synthesis of Silver Nanoparticles Using Pomegranate Peel Extract for Antibacterial Purposes. Bioinorganic Chemistry and Applications, 2025(1). Portico. https://doi.org/10.1155/bca/2009069

Adamek, M., Matras, M., Surachetpong, W., Rakus, K., Stachnik, M., Bauer, J., Falco, A., Jung-Schroers, V., Piewbang, C., Techangamsuwan, S., El Rahman, S. A., Paley, R., Reichert, M., & Steinhagen, D. (2023). How susceptible are rainbow trout and brown trout to infection with tilapia lake virus at increased water temperature – Is there any potential for climate change driven host jump? Aquaculture, 571, 739469. https://doi.org/10.1016/j.aquaculture.2023.739469

Díaz-Puertas, R., Álvarez-Martínez, F. J., Falco, A., Barrajón-Catalán, E., & Mallavia, R. (2023). Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review. Polymers, 15(6), 1392. https://doi.org/10.3390/polym15061392

Díaz-Puertas, R., Rodríguez-Cañas, E., Bello-Perez, M., Fernández-Oliver, M., Mallavia, R., & Falco, A. (2023). Viricidal Activity of Thermoplastic Polyurethane Materials with Silver Nanoparticles. Nanomaterials, 13(9), 1467. https://doi.org/10.3390/nano13091467

Díaz-Puertas, R., Adamek, M., Mallavia, R., & Falco, A. (2023). Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents. Marine Drugs, 21(6), 350. https://doi.org/10.3390/md21060350

Adamek, M., Rebl, A., Matras, M., Lodder, C., Abd El Rahman, S., Stachnik, M., Rakus, K., Bauer, J., Falco, A., Jung-Schroers, V., Piewbang, C., Techangamsuwan, S., Surachetpong, W., Reichert, M., Tetens, J., & Steinhagen, D. (2022). Immunological insights into the resistance of Nile tilapia strains to an infection with tilapia lake virus. Fish & Shellfish Immunology, 124, 118–133. https://doi.org/10.1016/j.fsi.2022.03.027

Adamek, M., Matras, M., Rebl, A., Stachnik, M., Falco, A., Bauer, J., Miebach, A.-C., Teitge, F., Jung-Schroers, V., Abdullah, M., Krebs, T., Schröder, L., Fuchs, W., Reichert, M., & Steinhagen, D. (2022). Don’t Let It Get Under Your Skin! – Vaccination Protects the Skin Barrier of Common Carp From Disruption Caused by Cyprinid Herpesvirus 3. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.787021

Falco, A., Adamek, M., Pereiro, P., Hoole, D., Encinar, J., Novoa, B., & Mallavia, R. (2022). The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases. Marine Drugs, 20(6), 363. https://doi.org/10.3390/md20060363

Bello-Perez, M., Esparza, I., De la Encina, A., Bartolome, T., Molina, T., Sanjuan, E., Falco, A., Enjuanes, L., Sola, I., & Usera, F. (2022). Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2. International Journal of Environmental Research and Public Health, 19(21), 13780. https://doi.org/10.3390/ijerph192113780

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., Adamopoulos, I. E., Adeli, K., Adolph, T. E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B. B., Agnello, M., … Tong, C.-K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy, 17(1), 1–382. https://doi.org/10.1080/15548627.2020.1797280

Neira, J. L., Palomino-Schätzlein, M., Hurtado-Gómez, E., Ortore, M. G., & Falcó, A. (2021). An N-terminal half fragment of the histidine phosphocarrier protein, HPr, is disordered but binds to HPr partners and shows antibacterial properties. Biochimica et Biophysica Acta (BBA) - General Subjects, 1865(12), 130015. https://doi.org/10.1016/j.bbagen.2021.130015

Bello-Perez, M., Adamek, M., Coll, J., Figueras, A., Novoa, B., & Falco, A. (2021). Modulation of the Tissue Expression Pattern of Zebrafish CRP-Like Molecules Suggests a Relevant Antiviral Role in Fish Skin. Biology, 10(2), 78. https://doi.org/10.3390/biology10020078

Neira, J. L., Ortega-Alarcón, D., Rizzuti, B., Palomino-Schätzlein, M., Velázquez-Campoy, A., & Falcó, A. (2021). Residual Helicity at the Active Site of the Histidine Phosphocarrier, HPr, Modulates Binding Affinity to Its Natural Partners. International Journal of Molecular Sciences, 22(19), 10805. https://doi.org/10.3390/ijms221910805

Mira, A., Rubio-Camacho, M., Alarcón, D., Rodríguez-Cañas, E., Fernández-Carvajal, A., Falco, A., & Mallavia, R. (2021). L-Menthol-Loadable Electrospun Fibers of PMVEMA Anhydride for Topical Administration. Pharmaceutics, 13(11), 1845. https://doi.org/10.3390/pharmaceutics13111845

Falco, A., Bello-Perez, M., Díaz-Puertas, R., Mold, M., & Adamek, M. (2021). Update on the Inactivation Procedures for the Vaccine Development Prospects of a New Highly Virulent RGNNV Isolate. Vaccines, 9(12), 1441. https://doi.org/10.3390/vaccines9121441

Bello-Perez, M., Pereiro, P., Coll, J., Novoa, B., Perez, L., & Falco, A. (2020). Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-57501-0

Mira, A., Sainz-Urruela, C., Codina, H., Jenkins, S. I., Rodriguez-Diaz, J. C., Mallavia, R., & Falco, A. (2020). Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics. Nanomaterials, 10(3), 486. https://doi.org/10.3390/nano10030486

Bello-Perez, M., Sola, I., Novoa, B., Klionsky, D. J., & Falco, A. (2020). Canonical and Noncanonical Autophagy as Potential Targets for COVID-19. Cells, 9(7), 1619. https://doi.org/10.3390/cells9071619

Falco, A., & Mallavia, R. (2020). Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering. Nanomaterials, 10(9), 1714. https://doi.org/10.3390/nano10091714

Bello-Perez, M., Falco, A., Novoa, B., Perez, L., & Coll, J. (2019). Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms. PLOS ONE, 14(1), e0201509. https://doi.org/10.1371/journal.pone.0201509

Martínez-Ortega, L., Mira, A., Fernandez-Carvajal, A., Mateo, C. R., Mallavia, R., & Falco, A. (2019). Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment. Pharmaceutics, 11(1), 14. https://doi.org/10.3390/pharmaceutics11010014

Falco, A., Medina-Gali, R. M., Poveda, J. A., Bello-Perez, M., Novoa, B., & Encinar, J. A. (2019). Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion. Marine Drugs, 17(2), 87. https://doi.org/10.3390/md17020087

Medina-Gali, R., Belló-Pérez, M., Martínez-López, A., Falcó, A., Ortega-Villaizan, M. M., Encinar, J. A., Novoa, B., Coll, J., & Perez, L. (2018). Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish & Shellfish Immunology, 82, 514–521. https://doi.org/10.1016/j.fsi.2018.08.056

Bello-Perez, M., Falco, A., Encinar, J. A., Novoa, B., Perez, L., & Coll, J. (2018). 25-Hydroxyl-cholesterol Binds and Enhance Anti-viral Effects of Zebrafish Monomeric C-reactive Proteins. https://doi.org/10.1101/371856

Vázquez-Guilló, R., Falco, A., Martínez-Tomé, M. J., Mateo, C. R., Herrero, M. A., Vázquez, E., & Mallavia, R. (2018). Advantageous Microwave-Assisted Suzuki Polycondensation for the Synthesis of Aniline-Fluorene Alternate Copolymers as Molecular Model with Solvent Sensing Properties. Polymers, 10(2), 215. https://doi.org/10.3390/polym10020215

Bello-Pérez, M., Falco, A., Galiano, V., Coll, J., Perez, L., & Encinar, J. A. (2018). Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV). Drug Design, Development and Therapy, Volume 12, 2337–2359. https://doi.org/10.2147/dddt.s171087

Vázquez-Guilló, R., Martínez-Tomé, M. J., Kahveci, Z., Torres, I., Falco, A., Mallavia, R., & Mateo, C. R. (2018). Synthesis and Characterization of a Novel Green Cationic Polyfluorene and Its Potential Use as a Fluorescent Membrane Probe. Polymers, 10(9), 938. https://doi.org/10.3390/polym10090938

Bello-Perez, M., Falco, A., Medina, R., Encinar, J. A., Novoa, B., Perez, L., Estepa, A., & Coll, J. (2017). Structure and functionalities of the human c-reactive protein compared to the zebrafish multigene family of c-reactive-like proteins. Developmental & Comparative Immunology, 69, 33–40. https://doi.org/10.1016/j.dci.2016.12.001

Bello-Perez, M., Falco, A., Medina-Gali, R., Pereiro, P., Encinar, J. A., Novoa, B., Perez, L., & Coll, J. (2017). Neutralization of viral infectivity by zebrafish c-reactive protein isoforms. Molecular Immunology, 91, 145–155. https://doi.org/10.1016/j.molimm.2017.09.005

Mira, A., Mateo, C. R., Mallavia, R., & Falco, A. (2017). Poly(methyl vinyl ether-alt-maleic acid) and ethyl monoester as building polymers for drug-loadable electrospun nanofibers. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-17542-4

Espín-Palazón, R., Martínez-López, A., Roca, F. J., López-Muñoz, A., Tyrkalska, S. D., Candel, S., García-Moreno, D., Falco, A., Meseguer, J., Estepa, A., & Mulero, V. (2016). TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLOS Pathogens, 12(6), e1005699. https://doi.org/10.1371/journal.ppat.1005699

Kahveci, Z., Vázquez-Guilló, R., Mira, A., Martinez, L., Falcó, A., Mallavia, R., & Mateo, C. R. (2016). Selective recognition and imaging of bacterial model membranes over mammalian ones by using cationic conjugated polyelectrolytes. The Analyst, 141(22), 6287–6296. https://doi.org/10.1039/c6an01427e

Falco, A., Miest, J. J., Pionnier, N., Pietretti, D., Forlenza, M., Wiegertjes, G. F., & Hoole, D. (2014). β-Glucan-supplemented diets increase poly(I:C)-induced gene expression of Mx, possibly via Tlr3-mediated recognition mechanism in common carp (Cyprinus carpio). Fish & Shellfish Immunology, 36(2), 494–502. https://doi.org/10.1016/j.fsi.2013.12.005

Pionnier, N., Falco, A., Miest, J. J., Shrive, A. K., & Hoole, D. (2014). Feeding common carp Cyprinus carpio with β-glucan supplemented diet stimulates C-reactive protein and complement immune acute phase responses following PAMPs injection. Fish & Shellfish Immunology, 39(2), 285–295. https://doi.org/10.1016/j.fsi.2014.05.008

Falco, A., Barrajón-Catalán, E., Menéndez-Gutiérrez, M. P., Coll, J., Micol, V., & Estepa, A. (2013). Melittin-loaded immunoliposomes against viral surface proteins, a new approach to antiviral therapy. Antiviral Research, 97(2), 218–221. https://doi.org/10.1016/j.antiviral.2012.12.004

Chinchilla, B., Gomez-Casado, E., Encinas, P., Falco, A., Estepa, A., & Coll, J. (2013). In VitroNeutralization of Viral Hemorrhagic Septicemia Virus by Plasma from Immunized Zebrafish. Zebrafish, 10(1), 43–51. https://doi.org/10.1089/zeb.2012.0805

Pionnier, N., Falco, A., Miest, J., Frost, P., Irnazarow, I., Shrive, A., & Hoole, D. (2013). Dietary β-glucan stimulate complement and C-reactive protein acute phase responses in common carp (Cyprinus carpio) during an Aeromonas salmonicida infection. Fish & Shellfish Immunology, 34(3), 819–831. https://doi.org/10.1016/j.fsi.2012.12.017

Pietretti, D., Spaink, H. P., Falco, A., Forlenza, M., & Wiegertjes, G. F. (2013). Accessory molecules for Toll-like receptors in Teleost fish. Identification of TLR4 interactor with leucine-rich repeats (TRIL). Molecular Immunology, 56(4), 745–756. https://doi.org/10.1016/j.molimm.2013.07.012

Miest, J. J., Falco, A., Pionnier, N. P. M., Frost, P., Irnazarow, I., Williams, G. T., & Hoole, D. (2012). The influence of dietary β-glucan, PAMP exposure and Aeromonas salmonicida on apoptosis modulation in common carp (Cyprinus carpio). Fish & Shellfish Immunology, 33(4), 846–856. https://doi.org/10.1016/j.fsi.2012.07.014

Falco, A., Frost, P., Miest, J., Pionnier, N., Irnazarow, I., & Hoole, D. (2012). Reduced inflammatory response to Aeromonas salmonicida infection in common carp (Cyprinus carpio L.) fed with β-glucan supplements. Fish & Shellfish Immunology, 32(6), 1051–1057. https://doi.org/10.1016/j.fsi.2012.02.028

Pereiro, P., Martinez-Lopez, A., Falco, A., Dios, S., Figueras, A., Coll, J. M., Novoa, B., & Estepa, A. (2012). Protection and antibody response induced by intramuscular DNA vaccine encoding for viral haemorrhagic septicaemia virus (VHSV) G glycoprotein in turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 32(6), 1088–1094. https://doi.org/10.1016/j.fsi.2012.03.004

Falco, A., Cartwright, J. R., Wiegertjes, G. F., & Hoole, D. (2012). Molecular characterization and expression analysis of two new C-reactive protein genes from common carp (Cyprinus carpio). Developmental & Comparative Immunology, 37(1), 127–138. https://doi.org/10.1016/j.dci.2011.10.005

Balseiro, P., Falcó, A., Romero, A., Dios, S., Martínez-López, A., Figueras, A., Estepa, A., & Novoa, B. (2011). Mytilus galloprovincialis Myticin C: A Chemotactic Molecule with Antiviral Activity and Immunoregulatory Properties. PLoS ONE, 6(8), e23140. https://doi.org/10.1371/journal.pone.0023140

Ortega-Villaizan, M., Chico, V., Martinez-Lopez, A., Falco, A., Perez, L., Coll, J. M., & Estepa, A. (2011). In vitro analysis of the factors contributing to the antiviral state induced by a plasmid encoding the viral haemorrhagic septicaemia virus glycoprotein G in transfected trout cells. Vaccine, 29(4), 737–743. https://doi.org/10.1016/j.vaccine.2010.11.021

García, I., Galiana, A., Falcó, A., Estepa, A., & Perez, L. (2011). Characterization of an infectious pancreatic necrosis (IPN) virus carrier cell culture with resistance to superinfection with heterologous viruses. Veterinary Microbiology, 149(1–2), 48–55. https://doi.org/10.1016/j.vetmic.2010.10.017

Barrajón-Catalán, E., Menéndez-Gutiérrez, M. P., Falco, A., Carrato, A., Saceda, M., & Micol, V. (2010). Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level. Cancer Letters, 290(2), 192–203. https://doi.org/10.1016/j.canlet.2009.09.010

Chico, V., Martinez-Lopez, A., Ortega-Villaizan, M., Falco, A., Perez, L., Coll, J. M., & Estepa, A. (2010). Pepscan Mapping of Viral Hemorrhagic Septicemia Virus Glycoprotein G Major Lineal Determinants Implicated in Triggering Host Cell Antiviral Responses Mediated by Type I Interferon. Journal of Virology, 84(14), 7140–7150. https://doi.org/10.1128/jvi.00023-10

Falco, A., Encinas, P., Carbajosa, S., Cuesta, A., Chaves-Pozo, E., Tafalla, C., Estepa, A., & Coll, J. M. (2009). Transfection improvements of fish cell lines by using deacylated polyethylenimine of selected molecular weights. Fish & Shellfish Immunology, 26(3), 559–566. https://doi.org/10.1016/j.fsi.2009.02.013

Ortega-Villaizan, M., Chico, V., Falco, A., Perez, L., Coll, J. M., & Estepa, A. (2009). The rainbow trout TLR9 gene and its role in the immune responses elicited by a plasmid encoding the glycoprotein G of the viral haemorrhagic septicaemia rhabdovirus (VHSV). Molecular Immunology, 46(8–9), 1710–1717. https://doi.org/10.1016/j.molimm.2009.02.006

Chico, V., Ortega-Villaizan, M., Falco, A., Tafalla, C., Perez, L., Coll, J. M., & Estepa, A. (2009). The immunogenicity of viral haemorragic septicaemia rhabdovirus (VHSV) DNA vaccines can depend on plasmid regulatory sequences. Vaccine, 27(13), 1938–1948. https://doi.org/10.1016/j.vaccine.2009.01.103

Falco, A., Ortega-Villaizan, M., Chico, V., Brocal, I., Perez, L., Coll, J., & Estepa, A. (2009). Antimicrobial Peptides as Model Molecules for the Development of Novel Antiviral Agents in Aquaculture. Mini-Reviews in Medicinal Chemistry, 9(10), 1159–1164. https://doi.org/10.2174/138955709789055171

Falco, A., Brocal, I., Pérez, L., Coll, J. M., Estepa, A., & Tafalla, C. (2008). In vivo modulation of the rainbow trout (Oncorhynchus mykiss) immune response by the human alpha defensin 1, HNP1. Fish & Shellfish Immunology, 24(1), 102–112. https://doi.org/10.1016/j.fsi.2007.09.007

Falco, A., Chico, V., Marroquí, L., Perez, L., Coll, J. M., & Estepa, A. (2008). Expression and antiviral activity of a β-defensin-like peptide identified in the rainbow trout (Oncorhynchus mykiss) EST sequences. Molecular Immunology, 45(3), 757–765. https://doi.org/10.1016/j.molimm.2007.06.358

Falco, A., Mas, V., Tafalla, C., Perez, L., Coll, J. M., & Estepa, A. (2007). Dual antiviral activity of human alpha-defensin-1 against viral haemorrhagic septicaemia rhabdovirus (VHSV): Inactivation of virus particles and induction of a type I interferon-related response. Antiviral Research, 76(2), 111–123. https://doi.org/10.1016/j.antiviral.2007.06.006

Brocal, I., Falco, A., Mas, V., Rocha, A., Perez, L., Coll, J. M., & Estepa, A. (2006). Stable expression of bioactive recombinant pleurocidin in a fish cell line. Applied Microbiology and Biotechnology, 72(6), 1217–1228. https://doi.org/10.1007/s00253-006-0393-7

Mas, V., Falco, A., Brocal, I., Perez, L., Coll, J. M., & Estepa, A. (2006). Identification of selective inhibitors of VHSV from biased combinatorial libraries of N,N′-disubstituted 2,5-piperazinediones. Antiviral Research, 72(2), 107–115. https://doi.org/10.1016/j.antiviral.2006.04.005

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