Our laboratory is dedicated to studying the molecular and cellular mechanisms underlying cancer development. The genome of cells can experience errors, but our bodies possess sophisticated DNA repair mechanisms that are essential for preventing genomic instability. This instability is a key factor in the onset of various diseases, including cancer. Gaining a deeper understanding of these mechanisms is not only crucial for better comprehending the disease, but also for developing new therapies specifically aimed at eliminating tumor cells by correcting or blocking genomic instability. In addition, our team investigates how the synergy between radiotherapy and immunotherapy can enhance cancer treatments—particularly in lung cancer—by optimizing therapeutic responses and boosting the effectiveness in eliminating malignant cells.
Publications
Gómez Cabello, D., Aguilar Morante, D., Bernal Bayard, J., & López Igual, M. R. (2025). Pregunta a un científic@. Estrés nucleolar en cáncer. Portal de Vídeo Didáctico de La Universidad de Sevilla. Internet Archive. https://doi.org/10.35466/vid2025n8446
López Igual, M. del R., Gómez Cabello, D., Aguilar Morante, D., & Bernal Bayard, J. (2024). Domesticando bacterias fotosintéticas. Portal de Vídeo Didáctico de La Universidad de Sevilla. Internet Archive. https://doi.org/10.35466/vid2024n8441
Pappas, G., Munk, S. H. N., Watanabe, K., Thomas, Q., Gál, Z., Gram, H. H., Lee, M., Gómez-Cabello, D., Kanellis, D. C., Olivares-Chauvet, P., Larsen, D. H., Gregersen, L. H., Maya-Mendoza, A., Galanos, P., & Bartek, J. (2023). MDC1 maintains active elongation complexes of RNA polymerase II. Cell Reports, 42(1), 111979. https://doi.org/10.1016/j.celrep.2022.111979
Checa-Rodriguez, C., Suarez-Quintero, B., Contreras, L., Korsholm, L., Payne-Larsen, D. H., de la Cruz Diaz, J., Bartek, J., & Gomez-Cabello, D. (2023). RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instability. https://doi.org/10.1101/2023.10.20.563274
Aguilar-Morante, D., Gómez-Cabello, D., Quek, H., Liu, T., Hamerlik, P., & Lim, Y. C. (2022). Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma. Biomedicines, 10(2), 332. https://doi.org/10.3390/biomedicines10020332
Gómez-Cabello, D., Pappas, G., Aguilar-Morante, D., Dinant, C., & Bartek, J. (2022). CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33027-z
Jimeno, S., Fernández-Ávila, M. J., Cruz-García, A., Cepeda-García, C., Gómez-Cabello, D., & Huertas, P. (2015). Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice. Nucleic Acids Research, 43(2), 987–999. https://doi.org/10.1093/nar/gku1384
Gomez-Cabello, D., Jimeno, S., Fernández-Ávila, M. J., & Huertas, P. (2013). New Tools to Study DNA Double-Strand Break Repair Pathway Choice. PLoS ONE, 8(10), e77206. https://doi.org/10.1371/journal.pone.0077206
Gómez-Cabello, D., Adrados, I., Gamarra, D., Kobayashi, H., Takatsu, Y., Takatsu, K., Gil, J., & Palmero, I. (2013). DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts. Aging Cell, 12(5), 923–931. https://doi.org/10.1111/acel.12117
Gómez-Cabello, D., Callejas, S., Benguría, A., Moreno, A., Alonso, J., & Palmero, I. (2010). Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1. Cancer Research, 70(5), 1866–1874. https://doi.org/10.1158/0008-5472.can-09-2088
Oliveras, G., Blancafort, A., Urruticoechea, A., Campuzano, O., Gómez‐Cabello, D., Brugada, R., López‐Rodríguez, M. L., Colomer, R., & Puig, T. (2010). Novel anti‐fatty acid synthase compounds with anti‐cancer activity in HER2+ breast cancer. Annals of the New York Academy of Sciences, 1210(1), 86–92. Portico. https://doi.org/10.1111/j.1749-6632.2010.05777.x
Jin, Q., Yuan, L. X., Boulbes, D., Baek, J. M., Wang, Y. N., Gomez-Cabello, D., Hawke, D. H., Yeung, S. C., Lee, M. H., Hortobagyi, G. N., Hung, M. C., & Esteva, F. J. (2010). Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Research, 12(6). https://doi.org/10.1186/bcr2777
Menendez, C., Abad, M., Gomez-Cabello, D., Moreno, A., & Palmero, I. (2009). ING Proteins in Cellular Senescence. Current Drug Targets, 10(5), 406–417. https://doi.org/10.2174/138945009788185077
