Institution: CRAG
Research Groups: Animal genomics
Position: Researcher
Contact email: alex.clop@cragenomica.es
BCB Committee: No committees assigned.
BCB Community: No communities assigned.
BCB Tools:
BCB Services:
Research topics: Animal genomics, Single-cell omics, RNA Sequencing (RNA-seq), Single-cell (scRNA-seq)
Biography: Veterinarian by training with experience on genomics analysis of livestock species and human biomedical research. PhD at Universitat Autònoma de Barcelona. Two postdocs in animal and human genomics at the University of Liege and Kings' College London. 2.5 year experience in technology translation in the frame of animal genomics. Currently working at the Centre for Research in Agricultural Genomics CRAG, on Animal Genomics.
Publications
Sa, P., Gòdia, M., Lewis, N., Lian, Y., & Clop, A. (2024). Genomic, transcriptomic and epigenomic analysis towards the understanding of porcine semen quality traits. Past, current and future trends. Animal Reproduction Science, 269, 107543. https://doi.org/10.1016/j.anireprosci.2024.107543
Ureña, I., González, C., Ramón, M., Gòdia, M., Clop, A., Calvo, J. H., Carabaño, M. J., & Serrano, M. (2022). Exploring the ovine sperm transcriptome by RNAseq techniques. I Effect of seasonal conditions on transcripts abundance. PLOS ONE, 17(3), e0264978. https://doi.org/10.1371/journal.pone.0264978
Lian, Y., Gòdia, M., Castello, A., Rodriguez-Gil, J. E., Balasch, S., Sanchez, A., & Clop, A. (2021). Characterization of the Impact of Density Gradient Centrifugation on the Profile of the Pig Sperm Transcriptome by RNA-Seq. Frontiers in Veterinary Science, 8. https://doi.org/10.3389/fvets.2021.668158
Cardoso, T. F., Luigi‐Sierra, M. G., Castelló, A., Cabrera, B., Noce, A., Mármol‐Sánchez, E., García‐González, R., Fernández‐Arias, A., Alabart, J. L., López‐Olvera, J. R., Mentaberre, G., Granados‐Torres, J. E., Cardells‐Peris, J., Molina, A., Sànchez, A., Clop, A., & Amills, M. (2021). Assessing the levels of intraspecific admixture and interspecific hybridization in Iberian wild goats (Capra pyrenaica). Evolutionary Applications, 14(11), 2618–2634. Portico. https://doi.org/10.1111/eva.13299
Ablondi, M., Gòdia, M., Rodriguez-Gil, J. E., Sánchez, A., & Clop, A. (2020). Characterisation of sperm piRNAs and their correlation with semen quality traits in swine. https://doi.org/10.1101/2020.03.16.994178
Godia, M., Reverter, A., Gonzalez-Prendes, R., Ramayo-Caldas, Y., Castello, A., Rodriguez-Gil, J. E., Sanchez, A., & Clop, A. (2020). An integrative systems biology approach to identify the molecular basis of sperm quality in swine. https://doi.org/10.21203/rs.3.rs-19366/v1
Gòdia, M., Castelló, A., Rocco, M., Cabrera, B., Rodríguez-Gil, J. E., Balasch, S., Lewis, C., Sánchez, A., & Clop, A. (2020). Identification of circular RNAs in porcine sperm and evaluation of their relation to sperm motility. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-64711-z
Gòdia, M., Ramayo-Caldas, Y., Zingaretti, L. M., Darwich, L., López, S., Rodríguez-Gil, J. E., Yeste, M., Sánchez, A., & Clop, A. (2020). A pilot RNA-seq study in 40 pietrain ejaculates to characterize the porcine sperm microbiome. Theriogenology, 157, 525–533. https://doi.org/10.1016/j.theriogenology.2020.08.001
Gòdia, M., Casellas, J., Ruiz-Herrera, A., Rodríguez-Gil, J. E., Castelló, A., Sánchez, A., & Clop, A. (2020). Whole genome sequencing identifies allelic ratio distortion in sperm involving genes related to spermatogenesis in a swine model. DNA Research, 27(5). https://doi.org/10.1093/dnares/dsaa019
Gòdia, M., Reverter, A., González-Prendes, R., Ramayo-Caldas, Y., Castelló, A., Rodríguez-Gil, J.-E., Sánchez, A., & Clop, A. (2020). A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine. Genetics Selection Evolution, 52(1). https://doi.org/10.1186/s12711-020-00592-0
Gòdia, M., Estill, M., Castelló, A., Balasch, S., Rodríguez-Gil, J. E., Krawetz, S. A., Sánchez, A., & Clop, A. (2019). A RNA-Seq Analysis to Describe the Boar Sperm Transcriptome and Its Seasonal Changes. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.00299
Cirera, S., Clop, A., Jacobsen, M. J., Guerin, M., Lesnik, P., Jørgensen, C. B., Fredholm, M., & Karlskov‐Mortensen, P. (2018). A targeted genotyping approach enhances identification of variants in taste receptor and appetite/reward genes of potential functional importance for obesity‐related porcine traits. Animal Genetics, 49(2), 110–118. Portico. https://doi.org/10.1111/age.12641
Gòdia, M., Mayer, F. Q., Nafissi, J., Castelló, A., Rodríguez-Gil, J. E., Sánchez, A., & Clop, A. (2018). A technical assessment of the porcine ejaculated spermatozoa for a sperm-specific RNA-seq analysis. Systems Biology in Reproductive Medicine, 64(4), 291–303. https://doi.org/10.1080/19396368.2018.1464610
Eusebi, P. G., González‐Prendes, R., Quintanilla, R., Tibau, J., Cardoso, T. F., Clop, A., & Amills, M. (2017). A genome‐wide association analysis for carcass traits in a commercial Duroc pig population. Animal Genetics, 48(4), 466–469. Portico. https://doi.org/10.1111/age.12545
Rodriguez-Cortes, A., Martori, C., Martinez-Florez, A., Clop, A., Amills, M., Kubejko, J., Llull, J., Nadal, J. M., & Alberola, J. (2017). Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-03662-4
Clop, A., Huisman, A., van As, P., Sharaf, A., Derdak, S., & Sanchez, A. (2016). Identification of genetic variation in the swine toll-like receptors and development of a porcine TLR genotyping array. Genetics Selection Evolution, 48(1). https://doi.org/10.1186/s12711-016-0206-0
Clop, A., Bertoni, A., Spain, S. L., Simpson, M. A., Pullabhatla, V., Tonda, R., Hundhausen, C., Di Meglio, P., De Jong, P., Hayday, A. C., Nestle, F. O., Barker, J. N., Bell, R. J. A., Capon, F., & Trembath, R. C. (2013). An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element. PLoS ONE, 8(8), e71690. https://doi.org/10.1371/journal.pone.0071690
Clop, A., Vidal, O., & Amills, M. (2012). Copy number variation in the genomes of domestic animals. Animal Genetics, 43(5), 503–517. Portico. https://doi.org/10.1111/j.1365-2052.2012.02317.x
Knight, J., Spain, S. L., Capon, F., Hayday, A., Nestle, F. O., Clop, A., Barker, J. N., Weale, M. E., & Trembath, R. C. (2012). Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis. Human Molecular Genetics, 21(23), 5185–5192. https://doi.org/10.1093/hmg/dds344
Hundhausen, C., Bertoni, A., Mak, R. K., Botti, E., Di Meglio, P., Clop, A., Laggner, U., Chimenti, S., Hayday, A. C., Barker, J. N., Trembath, R. C., Capon, F., & Nestle, F. O. (2012). Allele-Specific Cytokine Responses at the HLA-C Locus: Implications for Psoriasis. Journal of Investigative Dermatology, 132(3), 635–641. https://doi.org/10.1038/jid.2011.378
Burri, A., Hysi, P., Clop, A., Rahman, Q., & Spector, T. D. (2012). A Genome-Wide Association Study of Female Sexual Dysfunction. PLoS ONE, 7(4), e35041. https://doi.org/10.1371/journal.pone.0035041
Zidi, A., Amills, M., Tomás, A., Vidal, O., Ramírez, O., Carrizosa, J., Urrutia, B., Serradilla, J. M., & Clop, A. (2010). Short communication: Genetic variability in the predicted microRNA target sites of caprine casein genes. Journal of Dairy Science, 93(4), 1749–1753. https://doi.org/10.3168/jds.2009-2741
Clop, A., Zidi, A., & Amills, M. (2010). Identification of positively selected sites in the goat kappa casein (CSN3) gene. Animal Genetics, 41(3), 332–332. Portico. https://doi.org/10.1111/j.1365-2052.2009.02001.x
Valeyev, N. V., Hundhausen, C., Umezawa, Y., Kotov, N. V., Williams, G., Clop, A., Ainali, C., Ouzounis, C., Tsoka, S., & Nestle, F. O. (2010). A Systems Model for Immune Cell Interactions Unravels the Mechanism of Inflammation in Human Skin. PLoS Computational Biology, 6(12), e1001024. https://doi.org/10.1371/journal.pcbi.1001024
Matika, O., Sechi, S., Pong-Wong, R., Houston, R. D., Clop, A., Woolliams, J. A., & Bishop, S. C. (2010). Characterization of OAR1 and OAR18 QTL associated with muscle depth in British commercial terminal sire sheep. Animal Genetics, 42(2), 172–180. https://doi.org/10.1111/j.1365-2052.2010.02121.x
Ramirez, O., Ojeda, A., Tomas, A., Gallardo, D., Huang, L. S., Folch, J. M., Clop, A., Sanchez, A., Badaoui, B., Hanotte, O., Galman-Omitogun, O., Makuza, S. M., Soto, H., Cadillo, J., Kelly, L., Cho, I. C., Yeghoyan, S., Perez-Enciso, M., & Amills, M. (2009). Integrating Y-Chromosome, Mitochondrial, and Autosomal Data to Analyze the Origin of Pig Breeds. Molecular Biology and Evolution, 26(9), 2061–2072. https://doi.org/10.1093/molbev/msp118
Hadjipavlou, G., Matika, O., Clop, A., & Bishop, S. C. (2008). Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep. Animal Genetics, 39(4), 346–353. Portico. https://doi.org/10.1111/j.1365-2052.2008.01734.x
Hamelin, M., Sayd, T., Chambon, C., Bouix, J., Bibé, B., Milenkovic, D., Leveziel, H., Georges, M., Clop, A., Marinova, P., & Laville, E. (2007). Differential expression of sarcoplasmic proteins in four heterogeneous ovine skeletal muscles. PROTEOMICS, 7(2), 271–280. Portico. https://doi.org/10.1002/pmic.200600309
Hamelin, M., Sayd, T., Chambon, C., Bouix, J., Bibé, B., Milenkovic, D., Leveziel, H., Georges, M., Clop, A., Marinova, P., & Laville, E. (2006). Proteomic analysis of ovine muscle hypertrophy1. Journal of Animal Science, 84(12), 3266–3276. https://doi.org/10.2527/jas.2006-162
Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, C., & Georges, M. (2006). A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nature Genetics, 38(7), 813–818. https://doi.org/10.1038/ng1810
Clop, A., Amills, M., Noguera, J. L., Fernández, A., Capote, J., Ramón, M. M., Kelly, L., Kijas, J. M. H., Andersson, L., & Sànchez, A. (2004). Estimating the frequency of Asian cytochrome B haplotypes in standard European and local Spanish pig breeds. Genetics Selection Evolution, 36(1). https://doi.org/10.1186/1297-9686-36-1-97
Clop, A., Ovilo, C., Perez-Enciso, M., Cercos, A., Tomas, A., Fernandez, A., Coll, A., Folch, J. M., Barragan, C., Diaz, I., Oliver, M. A., Varona, L., Silio, L., Sanchez, A., & Noguera, J. L. (2003). Detection of QTL affecting fatty acid composition in the pig. Mammalian Genome, 14(9), 650–656. https://doi.org/10.1007/s00335-002-2210-7
Cristina, Ó., Oliver, A., Noguera, J. L., Clop, A., Barragán, C., Varona, L., Rodríguez, C., Toro, M., Sánchez, A., Pérez-Enciso, M., & Silió, L. (2002). Test for positional candidate genes for body composition on pig chromosome 6. Genetics Selection Evolution, 34(4). https://doi.org/10.1186/1297-9686-34-4-465
VARONA, L., OVILO, C., CLOP, A., NOGUERA, J. L., PÉREZ-ENCISO, M., COLL, A., FOLCH, J. M., BARRAGÁN, C., TORO, M. A., BABOT, D., & SÁNCHEZ, A. (2002). QTL mapping for growth and carcass traits in an Iberian by Landrace pig intercross: additive, dominant and epistatic effects. Genetical Research, 80(2), 145–154. https://doi.org/10.1017/s0016672302005803
Research lines:
Funding:
- PigQSem: Genomic approaches for the assessment of boar semen quality (AGL2013-44978-R): MINECO - AEI. Spanish. 01/01/2014 - 31/10/2017.
- Genomics applied to the development of DNA markers for boar reproduction traits: Ministerio de Economía, Industria y Competitividad. Spanish. 01/01/2017 - 30/09/2021.
- Molecular analysis of semen quality at the cell level in swine (MoSeC;PID2021-123725OB-I00): Ministerio de Ciencia e Innovación Type of entity: Government's ministry. 01/09/2022 - 01/09/2026.
- BoarTeSC (PID21115): Europeam Comission 4th Call for Transnational Access to the EASI-Genomics facilities. European. 30/09/2022 - 31/07/2023.
More info
Collaborating Companies: Pig Improvement Company PIC
Gepork
Semen Cardona
Participation in:
Doctoral Programs: Program on Animal Production from Universitat Autonoma de Barcelona
International Research Networks: Member of the International Society of Animal Genomics ISAG Member of the Functional Annotation of Animal Genomes Consortium FAANG Member of the Societat Catalana de Biologia
