Institution: CABIMER
Research Groups: Epigenetics and Gene Expression
Position: Postdoc
Contact email: alvaro.gallego@cabimer.es
BCB Committee: Junior Hub
BCB Community: Omics data analysis and function, Bioinformatics tools, benchmarks and data visualization
BCB Tools: No tools assigned.
BCB Services: No services assigned.
Research topics: Functional genomics, Function prediction, Functional annotation, Pathway analysis, Phylogenetic Analysis, Sequence analysis, Mapping, Sequence Alignment, Sequence error correction, Molecular flexibility, Molecular Interactions/Docking, Mutation Analysis and design, Protein/Nucleic Acid design, Structure prediction, Structure-function relationship, Systems Biology, Integrative Analysis, Network Biology, Pathway analysis, Regulatory biology, Artificial Intelligence, Deep Learning in Biology, Knowledge graphs, Large language models, Machine Learning in Biology, Data Visualization, Statistical Methods for Biology, Bayesian statistics, Experimental design, Frequentist analysis, Multivariate statistics, Non-parametric statistics, Omics, Epigenomics, 3D chromatin structure, Chromatin accessibility, DNA methylation, Histone structure and regulation, Genomics, Genome Assembly, Genome Sequencing, Genomic Annotation, Single-cell omics, Variant calling, Transcriptomics, Expression Profiling, RNA Sequencing (RNA-seq), Single-cell (scRNA-seq), Spatial transcriptomics
Publications
Parra-Perez, A. M., Gallego-Martinez, A., Escalera-Balsera, A., Robles-Bolivar, P., Perez-Carpena, P., & Lopez-Escamez, J. A. (2025). Different contribution of missense and loss-of-function variants to the genetic structure of familial and sporadic Meniere disease. https://doi.org/10.1101/2025.04.22.25326157
Lamolda, M., Frejo, L., Martin-Lagos, J., Cara, F. E., Gallego-Martinez, A., & Lopez-Escamez, J. A. (2025). A Neuron-Like Cellular Model for Severe Tinnitus Associated with Rare Variations in the ANK2 Gene. Molecular Neurobiology, 62(5), 6467–6477. https://doi.org/10.1007/s12035-024-04674-8
Flook, M., Rojano, E., Gallego-Martinez, A., Escalera-Balsera, A., Perez-Carpena, P., Moleon, M. del C., Gonzalez-Aguado, R., Rivero de Jesus, V., Domínguez-Durán, E., Frejo, L., G. Ranea, J. A., & Lopez-Escamez, J. A. (2024). Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease. Genes & Immunity, 25(2), 124–131. https://doi.org/10.1038/s41435-024-00260-z
Serrano-Herrera, A., Lopez-Escamez, J. A., Gallego-Martinez, A., & Perez-Carpena, P. (2024). Trends in the diagnosis of paediatric sensorineural hearing loss: a scoping review of gene panels, exome and genome sequencing. International Journal of Audiology, 1–7. https://doi.org/10.1080/14992027.2024.2435564
Lamolda, M., Frejo, L., Gallego-Martinez, A., & Lopez-Escamez, J. A. (2023). Application of Human Stem Cells to Model Genetic Sensorineural Hearing Loss and Meniere Disease. https://doi.org/10.20944/preprints202302.0321.v1
Lopez-Escamez, J. A., Parra-Perez, A. M., & Gallego-Martinez, A. (2023). An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European descendant population. https://doi.org/10.21203/rs.3.rs-3327290/v1
Escalera-Balsera, A., Parra-Perez, A. M., Gallego-Martinez, A., Frejo, L., Martin-Lagos, J., Rivero de Jesus, V., Pérez-Vázquez, P., Perez-Carpena, P., & Lopez-Escamez, J. A. (2023). Rare Deletions or Large Duplications Contribute to Genetic Variation in Patients with Severe Tinnitus and Meniere Disease. Genes, 15(1), 22. https://doi.org/10.3390/genes15010022
Robles-Bolivar, P., Bächinger, D., Parra-Perez, A. M., Román-Naranjo, P., Escalera-Balsera, A., Gallego-Martinez, A., Eckhard, A. H., & Lopez-Escamez, J. A. (2022). A novel nonsense variant in the CENPP gene segregates in a Swiss family with autosomal dominant low-frequency sensorineural hearing loss. European Journal of Human Genetics, 30(11), 1301–1305. https://doi.org/10.1038/s41431-022-01184-w
Gallego-Martinez, A., Escalera-Balsera, A., Trpchevska, N., Robles-Bolivar, P., Roman-Naranjo, P., Frejo, L., Perez-Carpena, P., Bulla, J., Gallus, S., Canlon, B., Cederroth, C. R., & Lopez-Escamez, J. A. (2022). Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus. Npj Genomic Medicine, 7(1). https://doi.org/10.1038/s41525-022-00341-w
Schoisswohl, S., Langguth, B., Schecklmann, M., Bernal-Robledano, A., Boecking, B., Cederroth, C. R., Chalanouli, D., Cima, R., Denys, S., Dettling-Papargyris, J., Escalera-Balsera, A., Espinosa-Sanchez, J. M., Gallego-Martinez, A., Giannopoulou, E., Hidalgo-Lopez, L., Hummel, M., Kikidis, D., Koller, M., Lopez-Escamez, J. A., … Schlee, W. (2021). Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial. Trials, 22(1). https://doi.org/10.1186/s13063-021-05835-z
Schlee, W., Schoisswohl, S., Staudinger, S., Schiller, A., Lehner, A., Langguth, B., Schecklmann, M., Simoes, J., Neff, P., Marcrum, S. C., Spiliopoulou, M., Niemann, U., Schleicher, M., Unnikrishnan, V., Puga, C., Mulansky, L., Pryss, R., Vogel, C., Allgaier, J., … Kikidis, D. (2021). Towards a unification of treatments and interventions for tinnitus patients: The EU research and innovation action UNITI. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine, 441–451. https://doi.org/10.1016/bs.pbr.2020.12.005
Gu, S., Olszewski, R., Nelson, L., Gallego-Martinez, A., Lopez-Escamez, J. A., & Hoa, M. (2021). Identification of Potential Meniere’s Disease Targets in the Adult Stria Vascularis. Frontiers in Neurology, 12. https://doi.org/10.3389/fneur.2021.630561
Flook, M., Escalera-Balsera, A., Gallego-Martinez, A., Espinosa-Sanchez, J. M., Aran, I., Soto-Varela, A., & Lopez-Escamez, J. A. (2021). DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease. Biomedicines, 9(11), 1530. https://doi.org/10.3390/biomedicines9111530
Gallego-Martinez, A., & Lopez-Escamez, J. A. (2020). Genetic architecture of Meniere’s disease. Hearing Research, 397, 107872. https://doi.org/10.1016/j.heares.2019.107872
Amanat, S., Gallego-Martinez, A., & Lopez-Escamez, J. A. (2020). Genetic Inheritance and Its Contribution to Tinnitus. The Behavioral Neuroscience of Tinnitus, 29–47. https://doi.org/10.1007/7854_2020_155
Martinez-Gomez, E., Gallego-Martinez, A., Roman-Naranjo, P., & Lopez-Escamez, J. A. (2020). Clinical and molecular genetics of Meniere disease. Medizinische Genetik, 32(2), 141–148. https://doi.org/10.1515/medgen-2020-2019
Roman-Naranjo, P., Gallego-Martinez, A., Soto-Varela, A., Aran, I., Moleon, M. del C., Espinosa-Sanchez, J. M., Amor-Dorado, J. C., Batuecas-Caletrio, A., Perez-Vazquez, P., & Lopez-Escamez, J. A. (2020). Burden of Rare Variants in the OTOG Gene in Familial Meniere’s Disease. Ear & Hearing, 41(6), 1598–1605. https://doi.org/10.1097/aud.0000000000000878
Peña-Chilet, M., Roldán, G., Perez-Florido, J., Ortuño, F. M., Carmona, R., Aquino, V., Lopez-Lopez, D., Loucera, C., Fernandez-Rueda, J. L., Gallego, A., García-Garcia, F., González-Neira, A., Pita, G., Núñez-Torres, R., Santoyo-López, J., Ayuso, C., Minguez, P., Avila-Fernandez, A., Corton, M., … Dopazo, J. (2020). CSVS, a crowdsourcing database of the Spanish population genetic variability. Nucleic Acids Research, 49(D1), D1130–D1137. https://doi.org/10.1093/nar/gkaa794
Gallego-Martinez, A., Requena, T., Roman-Naranjo, P., & Lopez-Escamez, J. A. (2019). Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.00076
Flook, M., Frejo, L., Gallego-Martinez, A., Martin-Sanz, E., Rossi-Izquierdo, M., Amor-Dorado, J. C., Soto-Varela, A., Santos-Perez, S., Batuecas-Caletrio, A., Espinosa-Sanchez, J. M., Pérez-Carpena, P., Martinez-Martinez, M., Aran, I., & Lopez-Escamez, J. A. (2019). Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.01229
Roman-Naranjo, P., Gallego-Martinez, A., Soto-Varela, A., Aran, I., Moleon, M. del C., Espinosa-Sanchez, J. M., Amor-Dorado, J. C., Batuecas-Caletrio, A., Perez-Vazquez, P., & Lopez-Escamez, J. A. (2019). Rare Variants in theOTOGGene Are a Frequent Cause of Familial Meniere’s Disease. https://doi.org/10.1101/771527
Gallego-Martinez, A., Requena, T., Roman-Naranjo, P., May, P., & Lopez-Escamez, J. A. (2019). Enrichment of damaging missense variants in genes related with axonal guidance signalling in sporadic Meniere’s disease. Journal of Medical Genetics, 57(2), 82–88. https://doi.org/10.1136/jmedgenet-2019-106159
Ahmad, H., Requena, T., Frejo, L., Cobo, M., Gallego-Martinez, A., Martin, F., Lopez-Escamez, J. A., & Bronstein, A. M. (2018). Clinical and Functional Characterization of a Missense ELF2 Variant in a CANVAS Family. Frontiers in Genetics, 9. https://doi.org/10.3389/fgene.2018.00085
Gallego-Martinez, A., Espinosa-Sanchez, J. M., & Lopez-Escamez, J. A. (2018). Genetic contribution to vestibular diseases. Journal of Neurology, 265(S1), 29–34. https://doi.org/10.1007/s00415-018-8842-7
Frejo, L., Gallego-Martinez, A., Requena, T., Martin-Sanz, E., Amor-Dorado, J. C., Soto-Varela, A., Santos-Perez, S., Espinosa-Sanchez, J. M., Batuecas-Caletrio, A., Aran, I., Fraile, J., Rossi-Izquierdo, M., & Lopez-Escamez, J. A. (2018). Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-23911-4
Requena, T., Gallego-Martinez, A., & Lopez-Escamez, J. A. (2018). Bioinformatic Integration of Molecular Networks and Major Pathways Involved in Mice Cochlear and Vestibular Supporting Cells. Frontiers in Molecular Neuroscience, 11. https://doi.org/10.3389/fnmol.2018.00108
Gallego-Martinez, A., Requena, T., Roman-Naranjo, P., & Lopez-Escamez, J. A. (2018). Excess of rare missense variants in hearing loss genes in sporadic Meniere disease. https://doi.org/10.1101/393322
Frejo, L., Requena, T., Okawa, S., Gallego-Martinez, A., Martinez-Bueno, M., Aran, I., Batuecas-Caletrio, A., Benitez-Rosario, J., Espinosa-Sanchez, J. M., Fraile-Rodrigo, J. J., García-Arumi, A. M., González-Aguado, R., Marques, P., Martin-Sanz, E., Perez-Fernandez, N., Pérez-Vázquez, P., Perez-Garrigues, H., Santos-Perez, S., Soto-Varela, A., … Lopez-Escamez, J. A. (2017). Regulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere’s Disease. Frontiers in Immunology, 8. https://doi.org/10.3389/fimmu.2017.01739
Requena, T., Gallego-Martinez, A., & Lopez-Escamez, J. A. (2017). A pipeline combining multiple strategies for prioritizing heterozygous variants for the identification of candidate genes in exome datasets. Human Genomics, 11(1). https://doi.org/10.1186/s40246-017-0107-5
Martín-Sierra, C., Requena, T., Frejo, L., Price, S. D., Gallego-Martinez, A., Batuecas-Caletrio, A., Santos-Pérez, S., Soto-Varela, A., Lysakowski, A., & Lopez-Escamez, J. A. (2016). A novel missense variant inPRKCBsegregates low-frequency hearing loss in an autosomal dominant family with Meniere’s disease. Human Molecular Genetics, 25(16), 3407–3415. https://doi.org/10.1093/hmg/ddw183
Martín-Sierra, C., Gallego-Martinez, A., Requena, T., Frejo, L., Batuecas-Caletrío, A., & Lopez-Escamez, J. A. (2016). Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere’s disease. European Journal of Human Genetics, 25(2), 200–207. https://doi.org/10.1038/ejhg.2016.154
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