Institution: I2SYSBIO
Research Groups: Systems Biology Modeling
Position: PI, Tenured Researcher
Contact email: arnau.montagud@csic.es
BCB Committee: Expertise mapping
BCB Community: Bioinformatics tools, benchmarks and data visualization, Mathematical modeling in computational biology
BCB Services: No services assigned.
Research topics: Model organisms, Personal medicine, Biosystems Modeling, Gene regulatory networks, Metabolic modelling, Pathway analysis, Pathway analysis, Regulatory biology, Benchmarking, Analysis packages (R, Python, etc.), Desktop application, High-performance Computing, Parallel Computing
Publications
Ponce-de-Leon, M., Montagud, A., Noel, V., Pradas, G., Meert, A., Barillot, E., Calzone, L., & Valencia, A. (2022). PhysiBoSS 2.0: a sustainable integration of stochastic Boolean and agent-based modelling frameworks. https://doi.org/10.1101/2022.01.06.468363
Montagud, A., Béal, J., Tobalina, L., Traynard, P., Subramanian, V., Szalai, B., Alföldi, R., Puskás, L., Valencia, A., Barillot, E., Saez-Rodriguez, J., & Calzone, L. (2022). Patient-specific Boolean models of signalling networks guide personalised treatments. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.72626
Akasiadis, C., Ponce‐de‐Leon, M., Montagud, A., Michelioudakis, E., Atsidakou, A., Alevizos, E., Artikis, A., Valencia, A., & Paliouras, G. (2022). Parallel model exploration for tumor treatment simulations. Computational Intelligence, 38(4), 1379–1401. Portico. https://doi.org/10.1111/coin.12515
Ruscone, M., Montagud, A., Chavrier, P., Destaing, O., Bonnet, I., Zinovyev, A., Barillot, E., Noël, V., & Calzone, L. (2022). Multiscale model of the different modes of cancer cell invasion. https://doi.org/10.1101/2022.10.07.511296
Santus, E., Marino, N., Cirillo, D., Chersoni, E., Montagud, A., Santuccione Chadha, A., Valencia, A., Hughes, K., & Lindvall, C. (2021). Artificial Intelligence–Aided Precision Medicine for COVID-19: Strategic Areas of Research and Development. Journal of Medical Internet Research, 23(3), e22453. https://doi.org/10.2196/22453
Saxena, G., Ponce-de-Leon, M., Montagud, A., Vicente Dorca, D., & Valencia, A. (2021). BioFVM-X: An MPI+OpenMP 3-D Simulator for Biological Systems. Computational Methods in Systems Biology, 266–279. https://doi.org/10.1007/978-3-030-85633-5_18
Montagud, A., Ponce-de-Leon, M., & Valencia, A. (2021). Systems biology at the giga-scale: Large multiscale models of complex, heterogeneous multicellular systems. Current Opinion in Systems Biology, 28, 100385. https://doi.org/10.1016/j.coisb.2021.100385
Ponce-de-Leon, M., Montagud, A., Akasiadis, C., Schreiber, J., Ntiniakou, T., & Valencia, A. (2021). Optimizing Dosage-Specific Treatments in a Multi-Scale Model of a Tumor Growth. https://doi.org/10.1101/2021.12.17.473136
Giatrakos, N., Arnu, D., Bitsakis, T., Deligiannakis, A., Garofalakis, M., Klinkenberg, R., Konidaris, A., Kontaxakis, A., Kotidis, Y., Samoladas, V., Simitsis, A., Stamatakis, G., Temme, F., Torok, M., Yaqub, E., Montagud, A., Ponce de León, M., Arndt, H., & Burkard, S. (2020). INforE. Proceedings of the 29th ACM International Conference on Information & Knowledge Management, 3389–3392. https://doi.org/10.1145/3340531.3417435
Béal, J., Montagud, A., Traynard, P., Barillot, E., & Calzone, L. (2019). Personalization of Logical Models With Multi-Omics Data Allows Clinical Stratification of Patients. Frontiers in Physiology, 9. https://doi.org/10.3389/fphys.2018.01965
Gamermann, D., Montagud, A., Conejero, J. A., Fernández de Córdoba, P., & Urchueguía, J. F. (2019). Large scale evaluation of differences between network-based and pairwise sequence-alignment-based methods of dendrogram reconstruction. PLOS ONE, 14(9), e0221631. https://doi.org/10.1371/journal.pone.0221631
Forget, A., Martignetti, L., Puget, S., Calzone, L., Brabetz, S., Picard, D., Montagud, A., Liva, S., Sta, A., Dingli, F., Arras, G., Rivera, J., Loew, D., Besnard, A., Lacombe, J., Pagès, M., Varlet, P., Dufour, C., Yu, H., … Ayrault, O. (2018). Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell, 34(3), 379-395.e7. https://doi.org/10.1016/j.ccell.2018.08.002
Letort, G., Montagud, A., Stoll, G., Heiland, R., Barillot, E., Macklin, P., Zinovyev, A., & Calzone, L. (2018). PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling. Bioinformatics, 35(7), 1188–1196. https://doi.org/10.1093/bioinformatics/bty766
Montagud, A., Traynard, P., Martignetti, L., Bonnet, E., Barillot, E., Zinovyev, A., & Calzone, L. (2017). Conceptual and computational framework for logical modelling of biological networks deregulated in diseases. Briefings in Bioinformatics, 20(4), 1238–1249. https://doi.org/10.1093/bib/bbx163
Pinto, F., Pacheco, C. C., Oliveira, P., Montagud, A., Landels, A., Couto, N., Wright, P. C., Urchueguía, J. F., & Tamagnini, P. (2015). Improving aSynechocystis-based photoautotrophic chassis through systematic genome mapping and validation of neutral sites. DNA Research, 22(6), 425–437. https://doi.org/10.1093/dnares/dsv024
Gamermann, D., Montagud, A., Conejero, J. A., Urchueguía, J. F., & de Córdoba, P. F. (2014). New Approach for Phylogenetic Tree Recovery Based on Genome-Scale Metabolic Networks. Journal of Computational Biology, 21(7), 508–519. https://doi.org/10.1089/cmb.2013.0150
Triana, J., Montagud, A., Siurana, M., Fuente, D., Urchueguía, A., Gamermann, D., Torres, J., Tena, J., De Córdoba, P., & Urchueguía, J. (2014). Generation and Evaluation of a Genome-Scale Metabolic Network Model of Synechococcus elongatus PCC7942. Metabolites, 4(3), 680–698. https://doi.org/10.3390/metabo4030680
Montagud, A., Gamermann, D., Fernández de Córdoba, P., & Urchueguía, J. F. (2013). Synechocystissp. PCC6803 metabolic models for the enhanced production of hydrogen. Critical Reviews in Biotechnology, 35(2), 184–198. https://doi.org/10.3109/07388551.2013.829799
GAMERMANN, D., MONTAGUD, A., APARICIO, P., NAVARRO, E., TRIANA, J., VILLATORO, F. R., URCHUEGUÍA, J. F., & DE CÓRDOBA, P. F. (2012). A MODULAR SYNTHETIC DEVICE TO CALIBRATE PROMOTERS. Journal of Biological Systems, 20(01), 37–55. https://doi.org/10.1142/s0218339012500015
Lopo, M., Montagud, A., Navarro, E., Cunha, I., Zille, A., de Córdoba, P. F., Moradas-Ferreira, P., Tamagnini, P., & Urchueguía, J. F. (2012). Experimental and Modeling Analysis of <i> Synechocystis </i>sp. PCC 6803 Growth. Microbial Physiology, 22(2), 71–82. Portico. https://doi.org/10.1159/000336850
Pinto, F., van Elburg, K. A., Pacheco, C. C., Lopo, M., Noirel, J., Montagud, A., Urchueguía, J. F., Wright, P. C., & Tamagnini, P. (2012). Construction of a chassis for hydrogen production: physiological and molecular characterization of a Synechocystis sp. PCC 6803 mutant lacking a functional bidirectional hydrogenase. Microbiology, 158(2), 448–464. https://doi.org/10.1099/mic.0.052282-0
Reyes, R., Gamermann, D., Montagud, A., Fuente, D., Triana, J., Urchueguía, J. F., & de Córdoba, P. F. (2012). Automation on the Generation of Genome-Scale Metabolic Models. Journal of Computational Biology, 19(12), 1295–1306. https://doi.org/10.1089/cmb.2012.0183
Belda, E., Pedrola, L., Peretó, J., Martínez-Blanch, J. F., Montagud, A., Navarro, E., Urchueguía, J., Ramón, D., Moya, A., & Porcar, M. (2011). Microbial Diversity in the Midguts of Field and Lab-Reared Populations of the European Corn Borer Ostrinia nubilalis. PLoS ONE, 6(6), e21751. https://doi.org/10.1371/journal.pone.0021751
Montagud, A., Zelezniak, A., Navarro, E., de Córdoba, P. F., Urchueguía, J. F., & Patil, K. R. (2011). Flux coupling and transcriptional regulation within the metabolic network of the photosynthetic bacterium Synechocystis sp. PCC6803. Biotechnology Journal, 6(3), 330–342. Portico. https://doi.org/10.1002/biot.201000109
Vilanova, C., Hueso, Á., Palanca, C., Marco, G., Pitarch, M., Otero, E., Crespo, J., Szablowski, J., Rivera, S., Domínguez-Escribà, L., Navarro, E., Montagud, A., de Córdoba, P. F., González, A., Ariño, J., Moya, A., Urchueguía, J., & Porcar, M. (2011). Aequorin-expressing yeast emits light under electric control. Journal of Biotechnology, 152(3), 93–95. https://doi.org/10.1016/j.jbiotec.2011.01.005
Montagud, A., Navarro, E., Fernández de Córdoba, P., Urchueguía, J. F., & Patil, K. R. (2010). Reconstruction and analysis of genome-scale metabolic model of a photosynthetic bacterium. BMC Systems Biology, 4(1). https://doi.org/10.1186/1752-0509-4-156
Delás, J., Notari, M., Forés, J., Pechuan, J., Porcar, M., Navarro, E., Montagud, A., Baguena, M., Peretó, J., Córdoba, P. F. de, González-Barroso, M. M., Rial, E., Moya, A., & Urchueguía, J. (2009). Yeast cultures with UCP1 uncoupling activity as a heating device. New Biotechnology, 26(6), 300–306. https://doi.org/10.1016/j.nbt.2009.09.005
Navarro, E., Montagud, A., Fernández de Córdoba, P., & Urchueguía, J. F. (2009). Metabolic flux analysis of the hydrogen production potential in Synechocystis sp. PCC6803. International Journal of Hydrogen Energy, 34(21), 8828–8838. https://doi.org/10.1016/j.ijhydene.2009.08.036
Research lines:
There are no lines of investigation associated with this user.
Funding:
- SysBioHPC. Scaling-up System Biology modelling tools to High-Performance Computing: Programa CIDE GenT. Regional (GVA). 01/01/2024 - 31/12/2027.
