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Institution: IATA
Research Groups: Systems biology in yeast of biotechnological interest
Position: Científico Titular
Home page: https://fungialab.iata.csic.es/
Contact email: david.perisnavarro@iata.csic.es
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Research topics: Genome Assembly, Genome Sequencing, Genomic Annotation, Population genomics, Variant calling
Biography: Scientific contributions
Dr. Peris has a Ph.D. in Biotechnology (University of Valencia, 2012). Since 2021, he is Principal Investigator with a Research Council of Norway (RCN) grant at University of Oslo (Norway) and in 2024 Tenured Researcher (Científico Titular) at Institute of Agrochemistry and Food Technology (IATA)-CSIC. He has developed his research in four different countries: Spain, UK, US and Norway. David Peris has expertise in comparative genomics, fungal evolution, highthroughput microbial phenotyping, bioinformatics and biotechnological applications. Dr. Peris is studying mechanisms of speciation and adaptation in fungi (mushroom-like and yeasts). His international UiO/IATA FunGIA lab (Fungal Genomics & Industrial Applications Lab) implements bioinformatic tools to study evolution and adaptation of fungi; and develops new molecular methods for generating new strains with applications in the production of healthy, safe and sustainable food products.
Contribution to society
Peris’ research has been transferred to the society by 3 intellectual disclosure reports and 2 patents. He developed molecular methods to generate yeast diversity that can offer new traits of industrial interest. Heineken® has used their strains to generate a new line of beers, the “Wild Lager”.
Other contributions
Dr. Peris has been involved in 24 research projects, 10 as a Principal Investigator. He was also president of Spanish Scientist in US-Midwest (2015-2017), developing mentoring and outreach programs, and he participated actively in outreach events organized by SFNO(Spanske Forskere i Norge).IENO (2021). He is member of 2 journal editorial boards, he has been project reviewer (1 country) and reviewer for 18 international journals.
Important prizes and fellowships
In 2017, he received the postdoctoral Marie Sklodowska-Curie fellowship; in 2018, he was recipient of the DeLill Nasser Award of Genetics Society of Americ; and in 2024, he received the 1st Maria Blasco Award by the Spanish Embassy in Norway and SFNO.IENO. Other prizes: 1 oral talk prize (ISSY33) and 1 poster prize (ECFG15).
Publications
Lu, D., Methlie, I.-S., Sønstebø, J. H., Andersen, A., Peris, D., Maurice, S., Kauserud, H., & Skrede, I. (2025). Postglacial history of a widespread wood-decaying fungus in Europe suggests migration out of multiple refugia followed by admixture. https://doi.org/10.22541/au.174974758.83731521/v1
Peris, D., Lu, D. S., Kinneberg, V. B., Methlie, I.-S., Dahl, M. S., James, T. Y., Kauserud, H., & Skrede, I. (2022). Large-scale fungal strain sequencing unravels the molecular diversity in mating loci maintained by long-term balancing selection. PLOS Genetics, 18(3), e1010097. https://doi.org/10.1371/journal.pgen.1010097
Kinneberg, V. B., Lü, D. S., Peris, D., Ravinet, M., & Skrede, I. (2022). Introgression between highly divergent fungal sister species. https://doi.org/10.1101/2022.08.26.505392
Sorribes-Dauden, R., Jordá, T., Peris, D., Martínez-Pastor, M. T., & Puig, S. (2022). Adaptation of Saccharomyces Species to High-Iron Conditions. International Journal of Molecular Sciences, 23(22), 13965. https://doi.org/10.3390/ijms232213965
Libkind, D., Peris, D., Cubillos, F. A., Steenwyk, J. L., Opulente, D. A., Langdon, Q. K., Rokas, A., & Hittinger, C. T. (2020). Into the wild: new yeast genomes from natural environments and new tools for their analysis. FEMS Yeast Research, 20(2). https://doi.org/10.1093/femsyr/foaa008
Langdon, Q. K., Peris, D., Eizaguirre, J. I., Opulente, D. A., Buh, K. V., Sylvester, K., Jarzyna, M., Rodríguez, M. E., Lopes, C. A., Libkind, D., & Hittinger, C. T. (2020). Postglacial migration shaped the genomic diversity and global distribution of the wild ancestor of lager-brewing hybrids. PLOS Genetics, 16(4), e1008680. https://doi.org/10.1371/journal.pgen.1008680
Peris, D., Alexander, W. G., Fisher, K. J., Moriarty, R. V., Basuino, M. G., Ubbelohde, E. J., Wrobel, R. L., & Hittinger, C. T. (2020). Synthetic hybrids of six yeast species. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-15559-4
Perea-Sanz, L., Peris, D., Belloch, C., & Flores, M. (2019). Debaryomyces hansenii Metabolism of Sulfur Amino Acids As Precursors of Volatile Sulfur Compounds of Interest in Meat Products. Journal of Agricultural and Food Chemistry, 67(33), 9335–9343. https://doi.org/10.1021/acs.jafc.9b03361
Baker, E. P., Peris, D., Moriarty, R. V., Li, X. C., Fay, J. C., & Hittinger, C. T. (2019). Mitochondrial DNA and temperature tolerance in lager yeasts. Science Advances, 5(1). https://doi.org/10.1126/sciadv.aav1869
Li, X. C., Peris, D., Hittinger, C. T., Sia, E. A., & Fay, J. C. (2019). Mitochondria-encoded genes contribute to evolution of heat and cold tolerance in yeast. Science Advances, 5(1). https://doi.org/10.1126/sciadv.aav1848
Langdon, Q. K., Peris, D., Baker, E. P., Opulente, D. A., Nguyen, H.-V., Bond, U., Gonçalves, P., Sampaio, J. P., Libkind, D., & Hittinger, C. T. (2019). Fermentation innovation through complex hybridization of wild and domesticated yeasts. Nature Ecology & Evolution, 3(11), 1576–1586. https://doi.org/10.1038/s41559-019-0998-8
Eizaguirre, J. I., Peris, D., Rodríguez, M. E., Lopes, C. A., De Los Ríos, P., Hittinger, C. T., & Libkind, D. (2018). Phylogeography of the wild Lager‐brewing ancestor (Saccharomyces eubayanus) in Patagonia. Environmental Microbiology, 20(10), 3732–3743. Portico. https://doi.org/10.1111/1462-2920.14375
Gonçalves, C., Wisecaver, J. H., Kominek, J., Oom, M. S., Leandro, M. J., Shen, X.-X., Opulente, D. A., Zhou, X., Peris, D., Kurtzman, C. P., Hittinger, C. T., Rokas, A., & Gonçalves, P. (2018). Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage. ELife, 7. CLOCKSS. https://doi.org/10.7554/elife.33034
Higgins, D. A., Young, M. K. M., Tremaine, M., Sardi, M., Fletcher, J. M., Agnew, M., Liu, L., Dickinson, Q., Peris, D., Wrobel, R. L., Hittinger, C. T., Gasch, A. P., Singer, S. W., Simmons, B. A., Landick, R., Thelen, M. P., & Sato, T. K. (2018). Natural Variation in the Multidrug Efflux Pump SGE1 Underlies Ionic Liquid Tolerance in Yeast. Genetics, 210(1), 219–234. https://doi.org/10.1534/genetics.118.301161
Peris, D., Moriarty, R. V., Alexander, W. G., Baker, E., Sylvester, K., Sardi, M., Langdon, Q. K., Libkind, D., Wang, Q.-M., Bai, F.-Y., Leducq, J.-B., Charron, G., Landry, C. R., Sampaio, J. P., Gonçalves, P., Hyma, K. E., Fay, J. C., Sato, T. K., & Hittinger, C. T. (2017). Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production. Biotechnology for Biofuels, 10(1). https://doi.org/10.1186/s13068-017-0763-7
Peris, D., Pérez‐Torrado, R., Hittinger, C. T., Barrio, E., & Querol, A. (2017). On the origins and industrial applications of Saccharomyces cerevisiae × Saccharomyces kudriavzevii hybrids. Yeast, 35(1), 51–69. Portico. https://doi.org/10.1002/yea.3283
McIlwain, S. J., Peris, D., Sardi, M., Moskvin, O. V., Zhan, F., Myers, K. S., Riley, N. M., Buzzell, A., Parreiras, L. S., Ong, I. M., Landick, R., Coon, J. J., Gasch, A. P., Sato, T. K., & Hittinger, C. T. (2016). Genome Sequence and Analysis of a Stress-Tolerant, Wild-Derived Strain ofSaccharomyces cerevisiaeUsed in Biofuels Research. G3 Genes|Genomes|Genetics, 6(6), 1757–1766. https://doi.org/10.1534/g3.116.029389
Peris, D., Pérez-Través, L., Belloch, C., & Querol, A. (2016). Enological characterization of Spanish Saccharomyces kudriavzevii strains, one of the closest relatives to parental strains of winemaking and brewing Saccharomyces cerevisiae × S. kudriavzevii hybrids. Food Microbiology, 53, 31–40. https://doi.org/10.1016/j.fm.2015.07.010
Alexander, W. G., Peris, D., Pfannenstiel, B. T., Opulente, D. A., Kuang, M., & Hittinger, C. T. (2016). Efficient engineering of marker-free synthetic allotetraploids of Saccharomyces. Fungal Genetics and Biology, 89, 10–17. https://doi.org/10.1016/j.fgb.2015.11.002
Peris, D., Langdon, Q. K., Moriarty, R. V., Sylvester, K., Bontrager, M., Charron, G., Leducq, J.-B., Landry, C. R., Libkind, D., & Hittinger, C. T. (2016). Complex Ancestries of Lager-Brewing Hybrids Were Shaped by Standing Variation in the Wild Yeast Saccharomyces eubayanus. PLOS Genetics, 12(7), e1006155. https://doi.org/10.1371/journal.pgen.1006155
Zhou, X., Peris, D., Kominek, J., Kurtzman, C. P., Hittinger, C. T., & Rokas, A. (2016). In SilicoWhole Genome Sequencer and Analyzer (iWGS): a Computational Pipeline to Guide the Design and Analysis ofde novoGenome Sequencing Studies. G3 Genes|Genomes|Genetics, 6(11), 3655–3662. https://doi.org/10.1534/g3.116.034249
Baker, E., Wang, B., Bellora, N., Peris, D., Hulfachor, A. B., Koshalek, J. A., Adams, M., Libkind, D., & Hittinger, C. T. (2015). The Genome Sequence ofSaccharomyces eubayanusand the Domestication of Lager-Brewing Yeasts. Molecular Biology and Evolution, 32(11), 2818–2831. https://doi.org/10.1093/molbev/msv168
Peris, D., Arias, A., Orlić, S., Belloch, C., Pérez-Través, L., Querol, A., & Barrio, E. (2015). Mitochondrial introgression suggests extensive ancestral hybridization events amongSaccharomycesspecies. https://doi.org/10.1101/028324
Peris, D., Sylvester, K., Libkind, D., Gonçalves, P., Sampaio, J. P., Alexander, W. G., & Hittinger, C. T. (2014). Population structure and reticulate evolution of Saccharomyces eubayanus and its lager‐brewing hybrids. Molecular Ecology, 23(8), 2031–2045. Portico. https://doi.org/10.1111/mec.12702
Peris, D., Lopes, C. A., Arias, A., & Barrio, E. (2012). Reconstruction of the Evolutionary History of Saccharomyces cerevisiae x S. kudriavzevii Hybrids Based on Multilocus Sequence Analysis. PLoS ONE, 7(9), e45527. https://doi.org/10.1371/journal.pone.0045527
Peris, D., Lopes, C. A., Belloch, C., Querol, A., & Barrio, E. (2012). Comparative genomics among Saccharomyces cerevisiae × Saccharomyces kudriavzevii natural hybrid strains isolated from wine and beer reveals different origins. BMC Genomics, 13(1). https://doi.org/10.1186/1471-2164-13-407
Peris, D., Belloch, C., Lopandić, K., Álvarez‐Pérez, J. M., Querol, A., & Barrio, E. (2012). The molecular characterization of new types of Saccharomyces cerevisiae × S. kudriavzevii hybrid yeasts unveils a high genetic diversity. Yeast, 29(2), 81–91. Portico. https://doi.org/10.1002/yea.2891
El‐Sharoud, W. M., Belloch, C., Peris, D., & Querol, A. (2009). Molecular Identification of Yeasts Associated with Traditional Egyptian Dairy Products. Journal of Food Science, 74(7). Portico. https://doi.org/10.1111/j.1750-3841.2009.01258.x
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Patents: I3. P170039US01 – Marker-free synthetic Saccharomyces allotetraploids and the constructs to create them. 19th AUG 2016. Inventors: William Gerald Alexander, David Peris Navarro, Christopher Todd Hittinger.
I2. P160162US01 - New wild strains of Saccharomyces eubayanus, the non-S. cerevisiae parent of hybrid lager-brewing yeasts. WARF UW-Madison, 3rd DEC 2015. Inventors: Chris T. Hittinger, Kayla Sylvester, Kelly V. Buh, Ryan V. Moriarty, Quinn K. Langdon, David Peris Navarro.
I1. P140088US01 - Wisconsin strains of Saccharomyces eubayanus, the cold-adapted parent of the lager-brewing yeast S. pastorianus (S. cerevisiae x S. eubayanus). WARF UW-Madison, 17th OCT 2013. Inventors: Chris Hittinger, David Peris Navarro, Kayla Sylvester. http://bit.ly/30BdjeY
P2. US20200048645A1 – Yeast strains with selected or altered mitotypes and methods of making and using the same. WARF UW-Madison, 18/06/2024 – 07/08/2039. Inventors: Chris T. Hittinger, EmilyClare Baker, David Peris Navarro. https://bit.ly/3EC3VM2
P1. US20180127784A1 – Synthetic Yeast Cells and Methods of Making and Using the Same. WARF UW-Madison, 27/02/2024 – 07/11/2037. Inventors: William Gerald Alexander, David Peris Navarro, Christopher Todd Hittinger. https://bit.ly/3Aux7SI
HPC Resources: SAGA
Garnatxa
DRAGO
CESGA
Participation in:
Master Programs: Bioinformatics - UV Calidad y seguridad Alimentaria - UV Molecular Biology, Cellular and Genetics - UV
Doctoral Programs: Biomedicine and Biotechnology - UV Biodiversity and Evolutionary Biology - UV
National Research Networks: AdaptNET: adaptation genomics. Red Española de Investigación en Levaduras (REDiL) CONEXIONES CSIC@GENOMA Catalan initiative for the Earth Biogenome Project (CBP)
International Research Networks: European Reference Genome Atlas (ERGA) Society for the Protection of Underground Network (SPUN) Digital Life Norway (DLN)
Other Participation: csicconexion