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Institution: IC
Research Groups: Bioinformatics unit at IC
Position: Unit responsible
Home page: https://cajal.csic.es/en/omic-technologies/
Contact email: jpigna@cajal.csic.es
BCB Committee: No committees assigned.
BCB Community: No communities assigned.
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BCB Services: Bioinformatics unit at IC
Research topics: Computational Methods, Applications of Computational Biology, Animal genomics, Development, Model organisms, Gene regulatory networks, Functional genomics, Pathway analysis, Data Analysis, Artificial Intelligence, Deep Learning in Biology, Machine Learning in Biology, Data Visualization, Statistical Methods for Biology, Bayesian statistics, Experimental design, Multivariate statistics, Non-parametric statistics, Omics, Chromatin accessibility, DNA methylation, Genomics, Genome Sequencing, Single-cell omics, Variant calling, Transcriptomics, Expression Profiling, RNA Sequencing (RNA-seq), Single-cell (scRNA-seq), Spatial transcriptomics, Resources, Bioinformatics enabling techniques, Benchmarking, Bioinformatics education, Standards in Computational Biology, Bioinformatics Software and Tools, Analysis packages (R, Python, etc.)
Biography: Dr. Pignatelli got a PhD in Molecular Biology from the Madrid Autonoma de Madrid. He is the person in charge of the Omics and Bioinformatics Unit and the Neuroendrocrinology laboratory at the Cajal Center for Neuroscience CSIC. He also participates on the CSIC PTI Neuroaging+. He has published more than 30 articles in peer reviewed scientific journals, and has supervised 1 doctoral thesis, as well as, TFM and TFG works.
Publications
Le Meur, M., Pignatelli, J., Blasi, P., & Palomo, V. (2025). Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders. Advanced Drug Delivery Reviews, 220, 115561. https://doi.org/10.1016/j.addr.2025.115561
Cintado, E., Tezanos, P., De las Casas, M., Muela, P., McGreevy, K. R., Fontn-Lozano, ngela, Sacristn-Horcajada, E., Pignatelli, J., de Ceballos, M. L., del Hierro, M. J., Fernndez-Punzano, J., Montoliu, L., & Trejo, J. L. (2024). Grandfathers-to-Grandsons Transgenerational Transmission of Exercise Positive Effects on Cognitive Performance. The Journal of Neuroscience, 44(23), e2061232024. https://doi.org/10.1523/jneurosci.2061-23.2024
Nuñez, A., Zegarra-Valdivia, J., Fernandez de Sevilla, D., Pignatelli, J., & Torres Aleman, I. (2023). The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states. Molecular Psychiatry, 28(8), 3220–3230. https://doi.org/10.1038/s41380-023-02136-6
Zegarra-Valdivia, J. A., Pignatelli, J., Nuñez, A., & Torres Aleman, I. (2023). The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences, 24(22), 16440. https://doi.org/10.3390/ijms242216440
Suda, K., Pignatelli, J., Genis, L., Fernandez, A. M., Fernandez de Sevilla, E., Fernandez de la Cruz, I., Pozo-Rodrigalvarez, A., de Ceballos, M. L., Díaz-Pacheco, S., Herrero-Labrador, R., & Torres Aleman, I. (2023). A Role for Astrocytic Insulin-Like Growth Factor I Receptors in the Response to Ischemic Insult. https://doi.org/10.1101/2023.01.13.523904
Cintado, E., Tezanos, P., De las Casas, M., Muela, P., McGreevy, K. R., Fontán-Lozano, Á., Sacristán-Horcajada, E., Pignatelli, J., de Ceballos, M. L., del Hierro, M. J., Fernández-Punzano, J., Montoliu, L., & Trejo, J. L. (2023). Transgenerational effects of exercise on mouse brain and cognition. https://doi.org/10.1101/2023.03.08.531840
Crespo, I., Pignatelli, J., Kinare, V., Méndez-Gómez, H. R., Esgleas, M., Román, M. J., Canals, J. M., Tole, S., & Vicario, C. (2022). Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex. Molecular Neurobiology, 59(9), 5750–5765. https://doi.org/10.1007/s12035-022-02936-x
Fernández Acosta, F. J., Luque-Molina, I., Vecino, R., Díaz-Guerra, E., Defterali, Ç., Pignatelli, J., & Vicario, C. (2022). Morphological Diversity of Calretinin Interneurons Generated From Adult Mouse Olfactory Bulb Core Neural Stem Cells. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.932297
Fernandez, A. M., Martinez-Rachadell, L., Navarrete, M., Pose-Utrilla, J., Davila, J. C., Pignatelli, J., Diaz-Pacheco, S., Guerra-Cantera, S., Viedma-Moreno, E., Palenzuela, R., Ruiz de Martin Esteban, S., Mostany, R., Garcia-Caceres, C., Tschöp, M., Iglesias, T., de Ceballos, M. L., Gutierrez, A., & Torres Aleman, I. (2022). Insulin regulates neurovascular coupling through astrocytes. Proceedings of the National Academy of Sciences, 119(29). https://doi.org/10.1073/pnas.2204527119
Fernández de Sevilla, M. E., Pignatelli, J., Zegarra-Valdivia, J. A., Mendez, P., Nuñez, A., & Torres Alemán, I. (2022). Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons. Molecular Psychiatry, 27(4), 2182–2196. https://doi.org/10.1038/s41380-022-01442-9
Zegarra-Valdivia, J. A., Fernandes, J., Trueba-Saiz, A., de Sevilla, M. E. F., Pignatelli, J., Suda, K., Martinez-Rachadell, L., Fernandez, A. M., Esparza, J., Vega, M., Nuñez, A., & Aleman, I. T. (2021). INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE. https://doi.org/10.1101/2021.02.23.432494
Noriega-Prieto, J. A., Maglio, L. E., Zegarra-Valdivia, J. A., Pignatelli, J., Fernandez, A. M., Martinez-Rachadell, L., Fernandes, J., Núñez, Á., Araque, A., Torres-Alemán, I., & Fernández de Sevilla, D. (2021). Astrocytic IGF-IRs Induce Adenosine-Mediated Inhibitory Downregulation and Improve Sensory Discrimination. The Journal of Neuroscience, 41(22), 4768–4781. https://doi.org/10.1523/jneurosci.0005-21.2021
Pignatelli, J., de Sevilla, E. F., Sperber, J., Horrillo, J. D., Medina-Gomez, G., & Aleman, I. T. (2021). Insulin-Like Growth Factor I Couples Metabolism With Circadian Activity Through Hypothalamic Orexin Neurons. https://doi.org/10.1101/2021.02.07.429949
Zegarra‐Valdivia, J. A., Pignatelli, J., Fernandez de Sevilla, M. E., Fernandez, A. M., Munive, V., Martinez‐Rachadell, L., Nuñez, A., & Torres Aleman, I. (2020). Insulin‐like growth factor I modulates sleep through hypothalamic orexin neurons. The FASEB Journal, 34(12), 15975–15990. Portico. https://doi.org/10.1096/fj.202001281rr
Noriega-Prieto, J. A., Maglio, L. E., Zegarra-Valdivia, J. A., Pignatelli, J., Fernandez, A. M., Martinez-Rachadell, L., Fernandes, J., Núñez, Á., Araque, A., Alemán, I. T., & de Sevilla, D. F. (2020). IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation. https://doi.org/10.1101/2020.02.11.942532
Herrero-Labrador, R., Trueba-Saiz, A., Martinez-Rachadell, L., Fernandez de Sevilla, M. E., Zegarra-Valdivia, J. A., Pignatelli, J., Diaz-Pacheco, S., Fernandez, A. M., & Torres Aleman, I. (2020). Circulating Insulin-Like Growth Factor I is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance. International Journal of Molecular Sciences, 21(24), 9675. https://doi.org/10.3390/ijms21249675
Martinez-Rachadell, L., Aguilera, A., Perez-Domper, P., Pignatelli, J., Fernandez, A. M., & Torres-Aleman, I. (2019). Cell-specific expression of insulin/insulin-like growth factor-I receptor hybrids in the mouse brain. Growth Hormone & IGF Research, 45, 25–30. https://doi.org/10.1016/j.ghir.2019.02.003
Granja, A. G., Holland, J. W., Pignatelli, J., Secombes, C. J., & Tafalla, C. (2017). Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease. PLOS ONE, 12(3), e0174249. https://doi.org/10.1371/journal.pone.0174249
Afifi, H., Ebead, A., Pignatelli, J., & Lee-Ruff, E. (2015). Synthesis of Cyclobutane Nucleosides 2-Preparation of Thymine and Uracil Analogues. Nucleosides, Nucleotides and Nucleic Acids, 34(11), 786–798. https://doi.org/10.1080/15257770.2015.1075551
Castro, R., Abós, B., González, L., Aquilino, C., Pignatelli, J., & Tafalla, C. (2015). Molecular characterization of CD9 and CD63, two tetraspanin family members expressed in trout B lymphocytes. Developmental & Comparative Immunology, 51(1), 116–125. https://doi.org/10.1016/j.dci.2015.03.002
Granja, A. G., Leal, E., Pignatelli, J., Castro, R., Abós, B., Kato, G., Fischer, U., & Tafalla, C. (2015). Identification of Teleost Skin CD8α+ Dendritic-like Cells, Representing a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells. The Journal of Immunology, 195(4), 1825–1837. https://doi.org/10.4049/jimmunol.1500322
Pignatelli, J., Castro, R., González Granja, A., Abós, B., González, L., Jensen, L. B., & Tafalla, C. (2014). Immunological Characterization of the Teleost Adipose Tissue and Its Modulation in Response to Viral Infection and Fat-Content in the Diet. PLoS ONE, 9(10), e110920. https://doi.org/10.1371/journal.pone.0110920
Castro, R., Abós, B., Pignatelli, J., von Gersdorff Jørgensen, L., González Granja, A., Buchmann, K., & Tafalla, C. (2014). Early Immune Responses in Rainbow Trout Liver upon Viral Hemorrhagic Septicemia Virus (VHSV) Infection. PLoS ONE, 9(10), e111084. https://doi.org/10.1371/journal.pone.0111084
Castro, R., Bromage, E., Abós, B., Pignatelli, J., González Granja, A., Luque, A., & Tafalla, C. (2014). CCR7 Is Mainly Expressed in Teleost Gills, Where It Defines an IgD+IgM− B Lymphocyte Subset. The Journal of Immunology, 192(3), 1257–1266. https://doi.org/10.4049/jimmunol.1302471
Vergaño‐Vera, E., Díaz‐Guerra, E., Rodríguez‐Traver, E., Méndez‐Gómez, H. R., Solís, Ó., Pignatelli, J., Pickel, J., Lee, S., Moratalla, R., & Vicario‐Abejón, C. (2014). Nurr1 blocks the mitogenic effect of FGF‐2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic‐GABAergic neuronal phenotypes. Developmental Neurobiology, 75(8), 823–841. Portico. https://doi.org/10.1002/dneu.22251
Díaz‐Guerra, E., Pignatelli, J., Nieto‐Estévez, V., & Vicario‐Abejón, C. (2013). Transcriptional Regulation of Olfactory Bulb Neurogenesis. The Anatomical Record, 296(9), 1364–1382. Portico. https://doi.org/10.1002/ar.22733
Abós, B., Castro, R., Pignatelli, J., Luque, A., González, L., & Tafalla, C. (2013). Transcriptional Heterogeneity of IgM+ Cells in Rainbow Trout (Oncorhynchus mykiss) Tissues. PLoS ONE, 8(12), e82737. https://doi.org/10.1371/journal.pone.0082737
Pignatelli, J., Alonso-Padilla, J., & Rodríguez, D. (2013). Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein. Veterinary Research, 44(1). https://doi.org/10.1186/1297-9716-44-126
Nieto-Estévez, V., Pignatelli, J., Araúzo-Bravo, M. J., Hurtado-Chong, A., & Vicario-Abejón, C. (2013). A Global Transcriptome Analysis Reveals Molecular Hallmarks of Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation. PLoS ONE, 8(1), e53594. https://doi.org/10.1371/journal.pone.0053594
Alonso-Padilla, J., Pignatelli, J., Simon-Grifé, M., Plazuelo, S., Casal, J., & Rodríguez, D. (2012). Seroprevalence of porcine torovirus (PToV) in Spanish farms. BMC Research Notes, 5(1). https://doi.org/10.1186/1756-0500-5-675
Pignatelli, J., Grau-Roma, L., Jiménez, M., Segalés, J., & Rodríguez, D. (2010). Longitudinal serological and virological study on porcine torovirus (PToV) in piglets from Spanish farms. Veterinary Microbiology, 146(3–4), 260–268. https://doi.org/10.1016/j.vetmic.2010.05.023
Pignatelli, J., Jiménez, M., Grau-Roma, L., & Rodríguez, D. (2010). Detection of porcine torovirus by real time RT-PCR in piglets from a Spanish farm. Journal of Virological Methods, 163(2), 398–404. https://doi.org/10.1016/j.jviromet.2009.10.031
Pignatelli, J., Jimenez, M., Luque, J., Rejas, M. T., Lavazza, A., & Rodriguez, D. (2009). Molecular characterization of a new PToV strain. Evolutionary implications. Virus Research, 143(1), 33–43. https://doi.org/10.1016/j.virusres.2009.02.019
Garzón, A., Maestre, A. M., Pignatelli, J., Rejas, M. T., & Rodríguez, D. (2006). New Insights on the Structure and Morphogenesis of Berne Virus. The Nidoviruses, 175–180. https://doi.org/10.1007/978-0-387-33012-9_30
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Other Participation: international, csicpt