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Institution: I2SYSBIO
Research Groups: TheSiMBioSys
Position: Group Leader/PI
Home page: http://www.thesimbiosys.com
Contact email: javier.buceta@csic.es
BCB Committee: No committees assigned.
BCB Community: No communities assigned.
BCB Tools: TiFoSi
BCB Services: No services assigned.
Research topics: Computational Methods, Computational models and simulations, Gene regulatory networks, Systems Biology, Statistical Methods for Biology, Bayesian statistics
Biography: I graduated in Physics (M.Sc. Theoretical Physics) in Madrid. In addition, I got a M.Sc. degree as Computer Analyst. During my Ph.D. thesis (Physics, Madrid), I researched on pattern formation, molecular motors, interfacial dynamics, and phase transitions using the Statistical Mechanics framework.
Afterwards, I moved to the University of California San Diego (Dept. of Chem. and Biochem. and the Institute for Nonlinear Science) as a postdoc (Prof. Lindenberg’s group) and worked on different topics (pattern formation, disease spreading, tumor growth...). Later, I was awarded by La Jolla Interfaces in Science/Centre for Theoretical Biological Physics programme to conduct research on ‘Left-Right Symmetry Breaking in Embryo Development’ at Salk Institute for Biological Studies/UCSD (J.C. Izpisua-Belmonte/K. Lindenberg).
In 2004 I moved to the Barcelona Science Park as a P.I. (“Ramón y Cajal” research fellow). I got tenured but in 2014 I accepted a position as Associate Professor at Lehigh University (PA, USA, Bioengineering Dpt. and Dpt. of Chemical and Biomolecular Engineering) where I was the founding D.T. & W.E. Schiesser Faculty Fellow. In 2020 I moved back to Spain to the Institute for Integrative Systems Biology (I2SysBio) at Valencia as a tenured scientist/P.I, where I am currently deputy director. Since 2022 I am member of the direction board of the Spanish Biophysical Society.
Publications
Anbari, S., Gómez-Gálvez, P., Vicente-Munuera, P., Escudero, L. M., & Buceta, J. (2025). Apico-basal intercalations enable the integrity of curved epithelia. Computational and Structural Biotechnology Journal, 27, 1204–1214. https://doi.org/10.1016/j.csbj.2025.03.011
Nadal, M., Guitou, L., Díez, I., Hurtado, J., Martínez, A., Grobas, I., & Buceta, J. (2025). Mechanical strain modulates Min patterning and division inE. colifilaments. https://doi.org/10.1101/2025.02.21.638242
López-Maroto, Á., Meijer, W. J. J., Buceta, J., & Ares, S. (2025). Spatial Dynamics and Emergent Properties of pLS20 Conjugation on Solid Surfaces. https://doi.org/10.1101/2025.02.27.640280
de la Viuda, V., Buceta, J., & Grobas, I. (2025). Physical communication pathways in bacteria: an extra layer to quorum sensing. Biophysical Reviews, 17(2), 667–685. https://doi.org/10.1007/s12551-025-01290-1
Mursel, S., Bocchini, P., & Buceta, J. (2024). Stochastic analysis of Ebola infection in small zoonotic niches. Royal Society Open Science, 11(11). https://doi.org/10.1098/rsos.240298
Buceta, J., & Guitou, L. (2023). Developmental Pattern Formation: Spanish Contributions from a Biophysical Perspective. Biophysica, 3(2), 335–347. https://doi.org/10.3390/biophysica3020022
Mursel, S., Conus, D., Huang, W., Buceta, J., & Bocchini, P. (2023). Random field calibration with data on irregular grid for regional analyses: A case study on the bare carrying capacity of bats in Africa. Ecology and Evolution, 13(9). Portico. https://doi.org/10.1002/ece3.10489
Jadhav, P., Chen, Y., Butzin, N., Buceta, J., & Urchueguía, A. (2022). Bacterial degrons in synthetic circuits. Open Biology, 12(8). https://doi.org/10.1098/rsob.220180
Mursel, S., Alter, N., Slavit, L., Smith, A., Bocchini, P., & Buceta, J. (2022). Estimation of Ebola’s spillover infection exposure in Sierra Leone based on sociodemographic and economic factors. PLOS ONE, 17(9), e0271886. https://doi.org/10.1371/journal.pone.0271886
Rodríguez Cerro, Á., Sancho, S., Rodríguez, M., Gamón, M. A., Guitou, L., Martínez, R. J., & Buceta, J. (2022). ANISE: an application to design mechanobiology simulations of planar epithelia. Bioinformatics, 38(17), 4246–4247. https://doi.org/10.1093/bioinformatics/btac511
Álvarez-Rodríguez, B., Buceta, J., & Geller, R. (2022). Comprehensive profiling of polyclonal sera targeting a non-enveloped viral capsid. https://doi.org/10.1101/2022.12.21.521426
Gómez-Gálvez, P., Vicente-Munuera, P., Anbari, S., Buceta, J., & Escudero, L. M. (2021). The complex three-dimensional organization of epithelial tissues. Development, 148(1). https://doi.org/10.1242/dev.195669
Gómez-Gálvez, P., Anbari, S., Escudero, L. M., & Buceta, J. (2021). Mechanics and self-organization in tissue development. Seminars in Cell & Developmental Biology, 120, 147–159. https://doi.org/10.1016/j.semcdb.2021.07.003
Canela-Xandri, O., Anbari, S., & Buceta, J. (2020). TiFoSi: an efficient tool for mechanobiology simulations of epithelia. Bioinformatics, 36(16), 4525–4526. https://doi.org/10.1093/bioinformatics/btaa592
Chen, Y., & Buceta, J. (2019). A non-linear analysis of Turing pattern formation. PLOS ONE, 14(8), e0220994. https://doi.org/10.1371/journal.pone.0220994
Anbari, S., & Buceta, J. (2019). Self-sustained Planar Intercalations due to Mechanosignaling Feedbacks Lead to Robust Axis Extension during Morphogenesis. https://doi.org/10.1101/837450
Gómez-Gálvez, P., Vicente-Munuera, P., Tagua, A., Forja, C., Castro, A. M., Letrán, M., Valencia-Expósito, A., Grima, C., Bermúdez-Gallardo, M., Serrano-Pérez-Higueras, Ó., Cavodeassi, F., Sotillos, S., Martín-Bermudo, M. D., Márquez, A., Buceta, J., & Escudero, L. M. (2018). Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-06671-7
Li, H., Multari, C., Palego, C., Ma, X., Du, X., Ning, Y., Buceta, J., Hwang, J. C. M., & Cheng, X. (2018). Differentiation of live and heat-killed E. coli by microwave impedance spectroscopy. Sensors and Actuators B: Chemical, 255, 1614–1622. https://doi.org/10.1016/j.snb.2017.08.179
Chen, Y., Baños, R., & Buceta, J. (2018). A Markovian Approach towards Bacterial Size Control and Homeostasis in Anomalous Growth Processes. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-27748-9
Gómez-Gálvez, P., Vicente-Munuera, P., Tagua, A., Forja, C., Castro, A. M., Letrán, M., Valencia-Expósito, A., Grima, C., Bermúdez-Gallardo, M., Serrano-Pérez-Higueras, Ó., Cavodeassi, F., Sotillos, S., Martín-Bermudo, M. D., Márquez, A., Buceta, J., & Escudero, L. M. (2018). Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-05376-1
Buceta, J., & Johnson, K. (2017). Modeling the Ebola zoonotic dynamics: Interplay between enviroclimatic factors and bat ecology. PLOS ONE, 12(6), e0179559. https://doi.org/10.1371/journal.pone.0179559
Buceta, J. (2017). Finite cell-size effects on protein variability in Turing patterned tissues. Journal of The Royal Society Interface, 14(133), 20170316. https://doi.org/10.1098/rsif.2017.0316
Weber, M., & Buceta, J. (2016). The cellular Ising model: a framework for phase transitions in multicellular environments. Journal of The Royal Society Interface, 13(119), 20151092. https://doi.org/10.1098/rsif.2015.1092
Weber, M., & Buceta, J. (2013). Stochastic Stabilization of Phenotypic States: The Genetic Bistable Switch as a Case Study. PLoS ONE, 8(9), e73487. https://doi.org/10.1371/journal.pone.0073487
Gómez-Llobregat, J., Buceta, J., & Reigada, R. (2013). Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering. Scientific Reports, 3(1). https://doi.org/10.1038/srep02608
Weber, M., & Buceta, J. (2013). Dynamics of the quorum sensing switch: stochastic and non-stationary effects. BMC Systems Biology, 7(1), 6. https://doi.org/10.1186/1752-0509-7-6
Saade, M., Gutiérrez-Vallejo, I., Le Dréau, G., Rabadán, M. A., Miguez, D. G., Buceta, J., & Martí, E. (2013). Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System. Cell Reports, 4(3), 492–503. https://doi.org/10.1016/j.celrep.2013.06.038
Weber, M., & Buceta, J. (2011). Noise regulation by quorum sensing in low mRNA copy number systems. BMC Systems Biology, 5(1). https://doi.org/10.1186/1752-0509-5-11
Canela-Xandri, O., Sagués, F., Casademunt, J., & Buceta, J. (2011). Dynamics and Mechanical Stability of the Developing Dorsoventral Organizer of the Wing Imaginal Disc. PLoS Computational Biology, 7(9), e1002153. https://doi.org/10.1371/journal.pcbi.1002153
Canela-Xandri, O., Sagués, F., & Buceta, J. (2010). Interplay between Intrinsic Noise and the Stochasticity of the Cell Cycle in Bacterial Colonies. Biophysical Journal, 98(11), 2459–2468. https://doi.org/10.1016/j.bpj.2010.02.045
van Zanten, T. S., Gómez, J., Manzo, C., Cambi, A., Buceta, J., Reigada, R., & Garcia-Parajo, M. F. (2010). Direct mapping of nanoscale compositional connectivity on intact cell membranes. Proceedings of the National Academy of Sciences, 107(35), 15437–15442. https://doi.org/10.1073/pnas.1003876107
Ullner, E., Buceta, J., Díez-Noguera, A., & García-Ojalvo, J. (2009). Noise-Induced Coherence in Multicellular Circadian Clocks. Biophysical Journal, 96(9), 3573–3581. https://doi.org/10.1016/j.bpj.2009.02.031
Reigada, R., Buceta, J., Gómez, J., Sagués, F., & Lindenberg, K. (2008). Phase separation in three-component lipid membranes: From Monte Carlo simulations to Ginzburg-Landau equations. The Journal of Chemical Physics, 128(2). https://doi.org/10.1063/1.2817333
Canela-Xandri, O., Sagués, F., Reigada, R., & Buceta, J. (2008). A Spatial Toggle Switch Drives Boundary Formation in Development. Biophysical Journal, 95(11), 5111–5120. https://doi.org/10.1529/biophysj.108.133306
Buceta, J., Herranz, H., Canela-Xandri, O., Reigada, R., Sagués, F., & Milán, M. (2007). Robustness and Stability of the Gene Regulatory Network Involved in DV Boundary Formation in the Drosophila Wing. PLoS ONE, 2(7), e602. https://doi.org/10.1371/journal.pone.0000602
Buceta, J., Wood, K., & Lindenberg, K. (2006). Noise-induced oscillatory behavior in field-dependent relaxational dynamics. Physical Review E, 73(4). https://doi.org/10.1103/physreve.73.042101
Wood, K., Buceta, J., & Lindenberg, K. (2006). Comprehensive study of pattern formation in relaxational systems. Physical Review E, 73(2). https://doi.org/10.1103/physreve.73.022101
Reigada, R., Buceta, J., & Lindenberg, K. (2005). Nonequilibrium patterns and shape fluctuations in reactive membranes. Physical Review E, 71(5). https://doi.org/10.1103/physreve.71.051906
Buceta, J., Ibañes, M., Rasskin-Gutman, D., Okada, Y., Hirokawa, N., & Izpisúa-Belmonte, J. C. (2005). Nodal Cilia Dynamics and the Specification of the Left/Right Axis in Early Vertebrate Embryo Development. Biophysical Journal, 89(4), 2199–2209. https://doi.org/10.1529/biophysj.105.063743
Reigada, R., Buceta, J., & Lindenberg, K. (2005). Generation of dynamic structures in nonequilibrium reactive bilayers. Physical Review E, 72(5). https://doi.org/10.1103/physreve.72.051921
Reigada, R., Buceta, J., & Lindenberg, K. (2005). Erratum: Nonequilibrium patterns and shape fluctuations in reactive membranes [Phys. Rev. E 71, 051906 (2005)]. Physical Review E, 72(3). https://doi.org/10.1103/physreve.72.039901
Buceta, J., & Galeano, J. (2005). Comments on the Article “The Universal Dynamics of Tumor Growth” by A. Brú et al. Biophysical Journal, 88(5), 3734–3736. https://doi.org/10.1529/biophysj.104.043463
SÁNCHEZ, A., MORALES-MOLINA, L., MERTENS, F. G., QUINTERO, N. R., BUCETA, J., & LINDENBERG, K. (2004). RATCHETS IN HOMOGENEOUS EXTENDED SYSTEMS: INTERNAL MODES AND THE ROLE OF NOISE. Fluctuation and Noise Letters, 04(04), L571–L584. https://doi.org/10.1142/s0219477504002208
Buceta, J., & Lindenberg, K. (2004). Phase transitions in relaxational systems with field-dependent coefficients. Noise in Complex Systems and Stochastic Dynamics II, 5471, 91. https://doi.org/10.1117/12.545828
Buceta, J., Escudero, C., de la Rubia, F. J., & Lindenberg, K. (2004). Outbreaks of Hantavirus induced by seasonality. Physical Review E, 69(2). https://doi.org/10.1103/physreve.69.021906
Escudero, C., Buceta, J., de la Rubia, F. J., & Lindenberg, K. (2004). Habitat size and extinction in population dynamics. Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II, 5467, 112. https://doi.org/10.1117/12.537570
Escudero, C., Buceta, J., de la Rubia, F. J., & Lindenberg, K. (2004). Extinction in population dynamics. Physical Review E, 69(2). https://doi.org/10.1103/physreve.69.021908
Lindenberg, K., Escudero, C., Buceta, J., & de la Rubia, F. J. (2004). Effects of seasonality and of internal fluctuations on the spreading of Hantavirus. Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II, 5467, 98. https://doi.org/10.1117/12.548714
Escudero, C., Buceta, J., de la Rubia, F., & Lindenberg, K. (2004). Effects of internal fluctuations on the spreading of Hantavirus. Physical Review E, 70(6). https://doi.org/10.1103/physreve.70.061907
Buceta, J., & Lindenberg, K. (2004). Comprehensive study of phase transitions in relaxational systems with field-dependent coefficients. Physical Review E, 69(1). https://doi.org/10.1103/physreve.69.011102
Buceta, J., & Lindenberg, K. (2003). Spatial patterns induced purely by dichotomous disorder. Physical Review E, 68(1). https://doi.org/10.1103/physreve.68.011103
Buceta, J., & Lindenberg, K. (2003). Patterns in reaction–diffusion systems generated by global alternation of dynamics. Physica A: Statistical Mechanics and Its Applications, 325(1–2), 230–242. https://doi.org/10.1016/s0378-4371(03)00202-4
Buceta, J., Ibañes, M., Sancho, J. M., & Lindenberg, K. (2003). Noise-driven mechanism for pattern formation. Physical Review E, 67(2). https://doi.org/10.1103/physreve.67.021113
Rosas, A., Buceta, J., & Lindenberg, K. (2003). Dynamics of two granules. Physical Review E, 68(2). https://doi.org/10.1103/physreve.68.021303
Galeano, J., Buceta, J., Juarez, K., Pumariño, B., Torre, J. de la, & Iriondo, J. M. (2003). Dynamical scaling analysis of plant callus growth. Europhysics Letters (EPL), 63(1), 83–89. https://doi.org/10.1209/epl/i2003-00481-1
Buceta, J., & Lindenberg, K. (2002). Switching-induced Turing instability. Physical Review E, 66(4). https://doi.org/10.1103/physreve.66.046202
Buceta, J., Lindenberg, K., & Parrondo, J. M. R. (2002). Pattern formation induced by nonequilibrium global alternation of dynamics. Physical Review E, 66(3). https://doi.org/10.1103/physreve.66.036216
Buceta, J., Lindenberg, K., & Parrondo, J. M. R. (2002). Erratum: Pattern formation induced by nonequilibrium global alternation of dynamics [Phys. Rev. E66, 036216 (2002)]. Physical Review E, 66(6). https://doi.org/10.1103/physreve.66.069902
Vives, E., & Planes, A. (2001). Is Tsallis Thermodynamics Nonextensive? Physical Review Letters, 88(2). https://doi.org/10.1103/physrevlett.88.020601
Buceta, J., Parrondo, J. M., Van den Broeck, C., & de la Rubia, F. J. (2000). Negative resistance and anomalous hysteresis in a collective molecular motor. Physical Review E, 61(6), 6287–6293. https://doi.org/10.1103/physreve.61.6287
Buceta, J., Pastor, J., Rubio, M. A., & Rubia, F. J. de la. (2000). Finite resolution effects in the analysis of the scaling behavior of rough surfaces. Physical Review E, 61(5), 6015–6018. https://doi.org/10.1103/physreve.61.6015
Buceta, J., Pastor, J. M., Rubio, M. A., & de la Rubia, F. J. (1998). Small scale properties of the stochastic stabilized Kuramoto-Sivashinsky equation. Physica D: Nonlinear Phenomena, 113(2–4), 166–171. https://doi.org/10.1016/s0167-2789(97)00265-0
Buceta, J., Pastor, J., Rubio, M. A., & Javier de la Rubia, F. (1997). The stochastic stabilized Kuramoto-Sivashinsky equation: a model for compact electrodeposition growth. Physics Letters A, 235(5), 464–468. https://doi.org/10.1016/s0375-9601(97)00633-6
Parrondo, J. M. R., van den Broeck, C., Buceta, J., & de la Rubia, F. J. (1996). Noise-induced spatial patterns. Physica A: Statistical Mechanics and Its Applications, 224(1–2), 153–161. https://doi.org/10.1016/0378-4371(95)00350-9
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