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Institution: CABIMER
Research Groups: Epigenetics and Gene Expression
Position: IC
Contact email: jose.reyes@cabimer.es
BCB Committee: No committees assigned.
BCB Community: No communities assigned.
BCB Tools: CODfinder
BCB Services: No services assigned.
Research topics: Epigenomics, 3D chromatin structure, Chromatin accessibility, Histone structure and regulation, Genomics, Single-cell omics
Biography: Dr. Reyes have a PhD in Biological Sciences from the University of Seville. He did a PhD at the Institute of Plant Biochemistry and Photosynthesis (IBVF, Seville) between 1990 and 1994. After that, he did a postdoctoral stay of 3.5 years at the Pasteur Institute in Paris in Moshe Yaniv's laboratory, where he studied the SWI/SNF chromatin remodeling complexes in mammals. In 1998 he did a stay as visiting scientist at the National Institute of Health in Bethesda (USA) in Gordon Hager's laboratory, where he investigated the nuclear dynamics of GFP-fused chromatin remodelers. In 2000, he obtained a position at the CSIC and started his own laboratory at the IBVF where he began a line of research on chromatin remodeling in the model plant Arabidopsis thaliana. They were the first to describe and characterize the existence and functions of the SWI/SNF and SWR1 complexes in plants. In 2002, he obtained the prize for Young Investigators from the Seville Academy of Sciences. In 2006, he transferred his laboratory to the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER, Seville), of which he has been Vice Director from July 2016 to December 2020, and currently he is Director of the Department of Genome Biology. Dr. Reyes has published 80 papers, most of them in prestigious international journals. He is among the top 2% of the most cited world scientists of all scientific fields in the ranking by Meta-Research Innovation Center (METRICS) at Stanford University (Editions 2019, 2020 and 2021) (5300 Scopus cites, 7750 Google Scholar cites), which gives an idea of the international impact of his research.
His group combines genetic, molecular and computational biology methods to understand how chromatin of regulatory elements and gene bodies change during transcription, how these changes are regulated and inherited and what protein factors are responsible for them. We specially investigate how alteration of these chromatin mechanisms are implicated in human disease, particularly in cancer.
Publications
Peña-Gómez, M. J., Rodríguez-Martín, Y., del Rio Oliva, M., Wijesekara Hanthi, Y., Berrada, S., Freire, R., Masson, J. Y., Reyes, J. C., Costanzo, V., & Rosado, I. V. (2025). HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells. Science Advances, 11(13). https://doi.org/10.1126/sciadv.ads3227
Basurto-Cayuela, L., Guerrero-Martínez, J. A., Gómez-Marín, E., Sánchez-Escabias, E., Escaño-Maestre, M., Ceballos-Chávez, M., & Reyes, J. C. (2024). SWI/SNF-dependent genes are defined by their chromatin landscape. Cell Reports, 43(3), 113855. https://doi.org/10.1016/j.celrep.2024.113855
Polo-Generelo, S., Rodríguez-Mateo, C., Torres, B., Pintor-Tortolero, J., Guerrero-Martínez, J. A., König, J., Vázquez, J., Bonzón-Kulichenco, E., Padillo-Ruiz, J., de la Portilla, F., Reyes, J. C., & Pintor-Toro, J. A. (2024). Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas. Cell Death Discovery, 10(1). https://doi.org/10.1038/s41420-024-01886-8
Lara-Ureña, N., Gómez-Marín, E., Pozuelo-Sánchez, I., Reyes, J. C., & García-Domínguez, M. (2024). SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition. Cellular and Molecular Life Sciences, 81(1). https://doi.org/10.1007/s00018-024-05343-8
Sola-García, A., Cáliz-Molina, M. Á., Espadas, I., Petr, M., Panadero-Morón, C., González-Morán, D., Martín-Vázquez, M. E., Narbona-Pérez, Á. J., López-Noriega, L., Martínez-Corrales, G., López-Fernández-Sobrino, R., Castillo-Peña, A., Carmona-Marin, L. M., Martínez-Force, E., Yanes, O., Vinaixa, M., López-López, D., Reyes, J. C., Dopazo, J., … Martín-Montalvo, A. (2023). Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging. Communications Biology, 6(1). https://doi.org/10.1038/s42003-023-04625-4
Sánchez-Escabias, E., Guerrero-Martínez, J. A., & Reyes, J. C. (2022). Co-transcriptional splicing efficiency is a gene-specific feature that can be regulated by TGFβ. Communications Biology, 5(1). https://doi.org/10.1038/s42003-022-03224-z
Polo-Generelo, S., Torres, B., Guerrero-Martínez, J. A., Camafeita, E., Vázquez, J., Reyes, J. C., & Pintor-Toro, J. A. (2022). TGF-β-Upregulated Lnc-Nr6a1 Acts as a Reservoir of miR-181 and Mediates Assembly of a Glycolytic Complex. Non-Coding RNA, 8(5), 62. https://doi.org/10.3390/ncrna8050062
Gómez-Marín, E., Posavec-Marjanović, M., Zarzuela, L., Basurto-Cayuela, L., Guerrero-Martínez, J. A., Arribas, G., Yerbes, R., Ceballos-Chávez, M., Rodríguez-Paredes, M., Tomé, M., Durán, R. V., Buschbeck, M., & Reyes, J. C. (2022). The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways. Nucleic Acids Research, 50(17), 9838–9857. https://doi.org/10.1093/nar/gkac766
Gallardo-Chamizo, F., Lara-Ureña, N., Correa-Vázquez, J. F., Reyes, J. C., Gauthier, B. R., & García-Domínguez, M. (2022). SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer. Genes & Diseases, 9(6), 1419–1422. https://doi.org/10.1016/j.gendis.2022.02.019
Lorenzo, P. I., Martin Vazquez, E., López-Noriega, L., Fuente-Martín, E., Mellado-Gil, J. M., Franco, J. M., Cobo-Vuilleumier, N., Guerrero Martínez, J. A., Romero-Zerbo, S. Y., Perez-Cabello, J. A., Rivero Canalejo, S., Campos-Caro, A., Lachaud, C. C., Crespo Barreda, A., Aguilar-Diosdado, M., García Fuentes, E., Martin-Montalvo, A., Álvarez Dolado, M., Martin, F., … Gauthier, B. R. (2021). The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity. Theranostics, 11(14), 6983–7004. https://doi.org/10.7150/thno.57237
Payán-Bravo, L., Fontalva, S., Peñate, X., Cases, I., Guerrero-Martínez, J. A., Pareja-Sánchez, Y., Odriozola-Gil, Y., Lara, E., Jimeno-González, S., Suñé, C., Muñoz-Centeno, M. C., Reyes, J. C., & Chávez, S. (2021). Human prefoldin modulates co-transcriptional pre-mRNA splicing. Nucleic Acids Research, 49(11), 6267–6280. https://doi.org/10.1093/nar/gkab446
Guerrero-Martínez, J. A., Ceballos-Chávez, M., Koehler, F., Peiró, S., & Reyes, J. C. (2020). TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-19877-5
Rivero, S., Gómez-Marín, E., Guerrero-Martínez, J. A., García-Martínez, J., & Reyes, J. C. (2019). TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells. Cell Death & Disease, 10(2). https://doi.org/10.1038/s41419-019-1310-1
Luna-Peláez, N., March-Díaz, R., Ceballos-Chávez, M., Guerrero-Martínez, J. A., Grazioli, P., García-Gutiérrez, P., Vaccari, T., Massa, V., Reyes, J. C., & García-Domínguez, M. (2019). The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes. Cell Death & Disease, 10(8). https://doi.org/10.1038/s41419-019-1792-x
Soler-Oliva, M. E., Guerrero-Martínez, J. A., Bachetti, V., & Reyes, J. C. (2017). Analysis of the relationship between coexpression domains and chromatin 3D organization. PLOS Computational Biology, 13(9), e1005708. https://doi.org/10.1371/journal.pcbi.1005708
Research lines:
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Participation in:
National Research Networks: AEI-MICINN Genomic Regulation Network (R2G2). CSIC Cancer-Connection network.
Other Participation: csicconexion