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Institution: IBMB
Research Groups: Synthetic Structural Biology, Protein Design and Modeling
Position: Momentum
Home page: https://mlmmicrobio.wixsite.com/mario-lopez-martin
Contact email: mlmcri@ibmb.csic.es
BCB Committee: No committees assigned.
BCB Community: No communities assigned.
BCB Tools: No tools assigned.
BCB Services: No services assigned.
Research topics: Drug Discovery and design, Biomolecular simulation, Structural bioinformatics, Molecular Interactions/Docking, Mutation Analysis and design, Structure prediction
Biography: Graduated in BSc Microbiology by the Universitat Autònoma de Barcelona with Honours and MSc Molecular Medical Microbiology by the University of Nottingham. PhD in Molecular Microbiology in the University of Nottingham working with quorum sensing in Acinetobacter baumannii. MSc in Bioinformatics at the Universitat Autònoma de Barcelona. Margarita Salas Postdoctoral Researcher at Prof. Àlex Peràlvarez-Marín group at UAB studying neuronal membrane proteins and peptides using a computational approach.
Currently using computational and experimental approaches to redesign enzymes for biomedical and biotechnological applications at the Institute of Molecular Biology of Barcelona (IBMB-CSIC) as part of the Momentum-CSIC program in the groups of Synthetic Structural Biology (Prof. Ulrich Eckhard) and Protein Design and Modelling (Prof. Enrique Marcos).
I am an enthusiast about molecular biology, biophysics, microbiology, bioinformatics and structural biology.
Publications
Catalina-Hernandez, E., Aguilella-Arzo, M., Peralvarez-Marin, A., & Lopez-Martin, M. (2025). Computational Insights into Membrane Disruption by Cell-Penetrating Peptides. Journal of Chemical Information and Modeling, 65(3), 1549–1559. https://doi.org/10.1021/acs.jcim.4c01940
Catalina-Hernandez, E., Lopez-Martin, M., Aguilella-Arzo, M., & Peralvarez-Marin, A. (2025). Membrane disruption potential of endogenous opioid neuropeptide Dynorphin A and related clinical variants. International Journal of Biological Macromolecules, 316, 144567. https://doi.org/10.1016/j.ijbiomac.2025.144567
Habibnia, M., Catalina-Hernandez, E., Lopez-Martin, M., Masnou-Sanchez, D., & Peralvarez-Marin, A. (2024). Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway. IScience, 27(11), 111187. https://doi.org/10.1016/j.isci.2024.111187
Catalina-Hernández, È., López-Martín, M., Masnou-Sánchez, D., Martins, M., Lorenz-Fonfria, V. A., Jiménez-Altayó, F., Hellmich, U. A., Inada, H., Alcaraz, A., Furutani, Y., Nonell-Canals, A., Vázquez-Ibar, J. L., Domene, C., Gaudet, R., & Perálvarez-Marín, A. (2024). Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold. Computational and Structural Biotechnology Journal, 23, 473–482. https://doi.org/10.1016/j.csbj.2023.12.028
López-Martín, M., Renault, P., Giraldo, J., Vázquez-Ibar, J. L., & Perálvarez-Marín, A. (2022). In Silico Assessment of the Lipid Fingerprint Signature of ATP2, the Essential P4-ATPase of Malaria Parasites. Membranes, 12(7), 702. https://doi.org/10.3390/membranes12070702
López-Martín, M., Dubern, J.-F., Alexander, M. R., & Williams, P. (2021). AbaM Regulates Quorum Sensing, Biofilm Formation, and Virulence in Acinetobacter baumannii. Journal of Bacteriology, 203(8). https://doi.org/10.1128/jb.00635-20
Mayer, C., Romero, M., López-Martín, M., Muras, A., & Otero, A. (2020). Quorum Sensing inAcinetobacterVirulence. Quorum Sensing: Microbial Rules of Life, 115–137. https://doi.org/10.1021/bk-2020-1374.ch007
Aranda, J., López, M., Leiva, E., Magán, A., Adler, B., Bou, G., & Barbé, J. (2014). Role of Acinetobacter baumannii UmuD Homologs in Antibiotic Resistance Acquired through DNA Damage-Induced Mutagenesis. Antimicrobial Agents and Chemotherapy, 58(3), 1771–1773. https://doi.org/10.1128/aac.02346-13
Research lines:
There are no lines of investigation associated with this user.