Institution: CNB
Research Groups: Structural Biology of Virus Proteins
Position: Científico Titular
Contact email: mjvanraaij@cnb.csic.es
BCB Committee: No committees assigned.
BCB Community: No communities assigned.
BCB Tools: No tools assigned.
BCB Services: No services assigned.
Research topics: Structural bioinformatics, Experimental structure determination, Structure-function relationship
Biography: My scientific career has developed at the interface of Biochemistry and Structural Biology. I did an
undergraduate project in the group of Barend Kraal (Leiden Univ) and collaborated with Jan Pieter
Abrahams, purifying translation factors and tRNAs from Escherichia coli to use them in enzymatic
assays, and for studying the EF-Tu/GMPPNP/aatRNA complex by NMR spectroscopy. After my
undergraduate degree, I started working as a non-clinical scientist in the laboratory of John Walker,
isolating mitochondria and purifying F1-ATPase for crystallization. From the crystals that I prepared,
the structure of the enzyme was solved. I also prepared expression vectors for the OSCP, F6 and inhibitor
subunits of ATP synthase. After one year, I obtained an MRC studentship and decided to start a PhD
degree. For my PhD I analysed different inhibitors of F1-ATPase. I determined the minimal inhibitory
sequence of the inhibitor subunit and co-crystallized F1-ATPase with aurovertin B and other inhibitors.
For my postdoc, I obtained a personal Marie Curie Biotech II fellowship and joined the group of
Stephen Cusack at the EMBL Grenoble outstation, working on the human adenovirus penton. I
determined structures for two domains of the human adenovirus 2 fibre and the structure of its receptor,
plus described the kinetic parameters for host cell receptor binding. In 2000, I joined Leiden University.
CV date 16/03/2025
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I identified two stable fragments of the bacteriophage T4 short fibre and solved their structures. In 2002,
I went to the University of Santiago de Compostela and continued my crystallographic studies on viral
host cell interaction proteins. I solved the structures of two avian reovirus proteins, the phage Det7
tailspike and several adenovirus proteins. I had a very fruitful collaboration with the group of Mark
Overhand of Leiden University on crystallography of gramicidin S and synthetic analogues of it.
At the CSIC, I have continued my studies on virus and bacteriophage proteins. I also started another
collaboration with Concepcion Gonzalez-Bello, for whom we solved structures of enzymes from
pathogenic bacteria bound to the inhibitors they synthesize. Since 2010, I am at the CNB, where we
have solved structures of the C-terminal domains of the fibres of the phages T4, T7, T5, K, epsilon15,
S24-1, as well as those of several Atadenovirus, Siadenovirus, Aviadenovirus and Mastadenovirus
fibres. We have also collaborated to solve the structures of several phage endolysin proteins.
My current research interests centre on the structural biology of virus and bacteriophage proteins,
with a special focus on their receptor-binding spikes and fibres, and their host peptidoglycan degradation
endolysins.
I am a member of the Asociación para el Avance de la Ciencia y Tecnología en España (treasurer
2007-2012), the Asociación de Investigadores Ramón y Cajal (vice-president and treasurer 2005-2007),
the Asociación de Utilizadores de Sinchrotones España (AUSE), the Sociedad Española de Bioquímica
y Biología Molecular, the Sociedad Española de Virología, the International Union of Crystallography,
the European Crystallographic Association and the Grupo Especializado de Cristalografía y Crecimiento
Cristalino.
From 2012 to 2018 I was Academic Editor of PLoS One, between 2012 and 2017 Associate Editor
of Virology Journal, from 2017 to 2018 Deputy Section Editor of Virology Journal and since April 2017
I am a Main Editor of the IUCr journal Acta Crystallographica F. I am a member of the Project
Evaluation Committee of the EMBL Hamburg beamlines since 2019, was a member of the FWO BIO1
evaluation panel (Research Foundation Flanders) from 2019 to 2024 and of the ANR evaluation panel
“Caractérisation des structures et relations structure-fonctions des macromolécules biologiques (France)
from 2020 to 2023.
ResearcherID B-3678-2009; ORCID 0000-0002-4781-1375; Scopus ID 7003305911
Google Scholar: https://scholar.google.es/citations?user=-sqtkycAAAAJ&hl=en
Publications
van Raaij, M. J. (2024). Private glycan investigations and public video content. Acta Crystallographica Section F Structural Biology Communications, 80(2), 28–29. https://doi.org/10.1107/s2053230x2400102x
van Raaij, M. J. (2024). The unbearable burden of peer review? Acta Crystallographica Section F Structural Biology Communications, 80(3), 52–52. https://doi.org/10.1107/s2053230x24002024
Nonato, M. C., van Raaij, M. J., & Agirre, J. (2024). Beyond publishing: introducing Interviews with authors. Acta Crystallographica Section F Structural Biology Communications, 80(4), 73–73. https://doi.org/10.1107/s2053230x24003339
Nonato, M. C., van Raaij, M. J., & Agirre, J. (2024). The importance of international collaborations in science and structural biology. Acta Crystallographica Section F Structural Biology Communications, 80(6), 116–116. https://doi.org/10.1107/s2053230x24005545
van Raaij, M. J. (2024). Tricks and tips for trips. Acta Crystallographica Section F Structural Biology Communications, 80(8), 164–164. https://doi.org/10.1107/s2053230x24007593
Agirre, J., Nonato, M. C., & van Raaij, M. J. (2024). Welcoming Alejandro Buschiazzo, Dorothee Liebschner and Stephen Muench as Co-editors of Acta Crystallographica F – Structural Biology Communications. Acta Crystallographica Section F Structural Biology Communications, 80(10), 234–235. https://doi.org/10.1107/s2053230x24009427
González‐Cabaleiro, L., Fernández‐Lodeiro, C., Vázquez‐Iglesias, L., Soriano‐Maldonado, P., van Raaij, M. J., Bodelón, G., Pérez‐Juste, J., & Pastoriza‐Santos, I. (2024). Pushing the Limits of Lateral Flow Immunoassay by Digital SERS for the Ultralow Detection of SARS‐CoV‐2 Virus. Small Science, 4(11). Portico. https://doi.org/10.1002/smsc.202400259
Read, R. J., Baker, E. N., Bond, C. S., Garman, E. F., & van Raaij, M. J. (2023). AlphaFold and the future of structural biology. Acta Crystallographica Section F Structural Biology Communications, 79(7), 166–168. https://doi.org/10.1107/s2053230x23004934
van Raaij, M. (2023). A triumvirate of Section Editors moving Structural Biology Communications ahead. Acta Crystallographica Section F Structural Biology Communications, 79(11), 276–277. https://doi.org/10.1107/s2053230x23009329
Vázquez, R., Seoane-Blanco, M., Rivero-Buceta, V., Ruiz, S., van Raaij, M. J., & García, P. (2022). Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain. Acta Crystallographica Section D Structural Biology, 78(4), 435–454. https://doi.org/10.1107/s2059798322000936
Helliwell, J. R., Newman, J., & van Raaij, M. J. (2021). Topical Reviews in Acta Crystallographica F Structural Biology Communications. Acta Crystallographica Section F Structural Biology Communications, 77(11), 385–385. https://doi.org/10.1107/s2053230x21011195
Baker, E. N., Bond, C. S., Garman, E. F., Newman, J., Read, R. J., & van Raaij, M. J. (2021). Submission of structural biology data for review purposes. Acta Crystallographica Section F Structural Biology Communications, 77(12), 435–436. https://doi.org/10.1107/s2053230x21012681
Lence, E., Maneiro, M., Sanz‐Gaitero, M., van Raaij, M. J., Thompson, P., Hawkins, A. R., & González‐Bello, C. (2020). Self‐Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product. Chemistry – A European Journal, 26(36), 8035–8044. Portico. https://doi.org/10.1002/chem.202000759
Lence, E., Maneiro, M., Sanz‐Gaitero, M., van Raaij, M. J., Thompson, P., Hawkins, A. R., & González‐Bello, C. (2020). Cover Feature: Self‐Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product (Chem. Eur. J. 36/2020). Chemistry – A European Journal, 26(36), 7962–7962. Portico. https://doi.org/10.1002/chem.202002101
Newman, J., & van Raaij, M. J. (2020). Innovation versus practice in biological crystallization. Acta Crystallographica Section F Structural Biology Communications, 76(7), 290–291. https://doi.org/10.1107/s2053230x20008869
Newman, J., & van Raaij, M. J. (2020). Contamination or serendipity – doing the wrong thing by chance. Acta Crystallographica Section F Structural Biology Communications, 76(9), 391–391. https://doi.org/10.1107/s2053230x20012029
Maneiro, M., Lence, E., Sanz-Gaitero, M., Otero, J. M., van Raaij, M. J., Thompson, P., Hawkins, A. R., & González-Bello, C. (2019). Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme. Organic Chemistry Frontiers, 6(17), 3127–3135. https://doi.org/10.1039/c9qo00453j
Mitra, A. K., & van Raaij, M. (2019). Acta Crystallographica Section F – another home for cryo-electron microscopy contributions. Acta Crystallographica Section F Structural Biology Communications, 75(1), 1–2. https://doi.org/10.1107/s2053230x18017806
van Raaij, M. J. (2019). Welcoming Janet Newman with a BLAST on crystallization strategy. Acta Crystallographica Section F Structural Biology Communications, 75(3), 147–147. https://doi.org/10.1107/s2053230x19003091
Korf, I. H. E., Meier-Kolthoff, J. P., Adriaenssens, E. M., Kropinski, A. M., Nimtz, M., Rohde, M., van Raaij, M. J., & Wittmann, J. (2019). Still Something to Discover: Novel Insights into Escherichia coli Phage Diversity and Taxonomy. Viruses, 11(5), 454. https://doi.org/10.3390/v11050454
Helliwell, J. R., Minor, W., Weiss, M. S., Garman, E. F., Read, R. J., Newman, J., van Raaij, M. J., Hajdu, J., & Baker, E. N. (2019). Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography. Acta Crystallographica Section D Structural Biology, 75(5), 455–457. https://doi.org/10.1107/s2059798319004844
Newman, J., & van Raaij, M. J. (2019). Introducing Methods Communications, a new category of contributions to Acta Crystallographica F. Acta Crystallographica Section F Structural Biology Communications, 75(8), 529–530. https://doi.org/10.1107/s2053230x19010306
van Raaij, M. J., & Newman, J. (2019). Taking biological structure communications into the third dimension. Acta Crystallographica Section F Structural Biology Communications, 75(11), 663–664. https://doi.org/10.1107/s2053230x19014754
Taylor, N. M. I., van Raaij, M. J., & Leiman, P. G. (2018). Contractile injection systems of bacteriophages and related systems. Molecular Microbiology, 108(1), 6–15. Portico. https://doi.org/10.1111/mmi.13921
Kokotidou, C., Jonnalagadda, S. V. R., Orr, A. A., Seoane‐Blanco, M., Apostolidou, C. P., van Raaij, M. J., Kotzabasaki, M., Chatzoudis, A., Jakubowski, J. M., Mossou, E., Forsyth, V. T., Mitchell, E. P., Bowler, M. W., Llamas‐Saiz, A. L., Tamamis, P., & Mitraki, A. (2018). A novel amyloid designable scaffold and potential inhibitor inspired by GAIIG of amyloid beta and the HIV‐1 V3 loop. FEBS Letters, 592(11), 1777–1788. Portico. https://doi.org/10.1002/1873-3468.13096
Agirre, J., & van Raaij, M. J. (2018). Carbohydrate structure hits the groove. Acta Crystallographica Section F Structural Biology Communications, 74(8), 441–442. https://doi.org/10.1107/s2053230x18010853
van Raaij, M. J. (2018). Quo vadis, Acta Crystallographica F? Acta Crystallographica Section F Structural Biology Communications, 74(11), 688–689. https://doi.org/10.1107/s2053230x18015340
San Martín, C., & van Raaij, M. J. (2018). The so far farthest reaches of the double jelly roll capsid protein fold. Virology Journal, 15(1). https://doi.org/10.1186/s12985-018-1097-1
Granell, M., Namura, M., Alvira, S., Kanamaru, S., & Van Raaij, M. (2017). Crystal Structure of the Carboxy-Terminal Region of the Bacteriophage T4 Proximal Long Tail Fiber Protein Gp34. Viruses, 9(7), 168. https://doi.org/10.3390/v9070168
Kryshtafovych, A., Albrecht, R., Baslé, A., Bule, P., Caputo, A. T., Carvalho, A. L., Chao, K. L., Diskin, R., Fidelis, K., Fontes, C. M. G. A., Fredslund, F., Gilbert, H. J., Goulding, C. W., Hartmann, M. D., Hayes, C. S., Herzberg, O., Hill, J. C., Joachimiak, A., Kohring, G., … Schwede, T. (2017). Target highlights from the first post‐PSI CASP experiment (CASP12, May–August 2016). Proteins: Structure, Function, and Bioinformatics, 86(S1), 27–50. Portico. https://doi.org/10.1002/prot.25392
Hyman, P., & van Raaij, M. (2017). Bacteriophage T4 long tail fiber domains. Biophysical Reviews, 10(2), 463–471. https://doi.org/10.1007/s12551-017-0348-5
Perczel, A., Atanasov, A., Sklenář, V., Nováček, J., Papoušková, V., Kadeřávek, P., Žídek, L., Kozłowski, H., Wątły, J., Hecel, A., Kołkowska, P., Koča, J., Svobodová-Vařeková, R., Pravda, L., Sehnal, D., Horský, V., Geidl, S., Enriz, R., Matějka, P., … Jampílek, J. (2016). The Eighth Central European Conference “Chemistry towards Biology”: Snapshot. Molecules, 21(10), 1381. https://doi.org/10.3390/molecules21101381
(2015). Correction: Crystal Structure of the Fibre Head Domain of the Atadenovirus Snake Adenovirus 1. PLOS ONE, 10(3), e0120613. https://doi.org/10.1371/journal.pone.0120613
Kryshtafovych, A., Moult, J., Bales, P., Bazan, J. F., Biasini, M., Burgin, A., Chen, C., Cochran, F. V., Craig, T. K., Das, R., Fass, D., Garcia‐Doval, C., Herzberg, O., Lorimer, D., Luecke, H., Ma, X., Nelson, D. C., van Raaij, M. J., Rohwer, F., … Schwede, T. (2014). Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10. Proteins: Structure, Function, and Bioinformatics, 82(S2), 26–42. Portico. https://doi.org/10.1002/prot.24489
Blanco, B., Sedes, A., Peón, A., Otero, J. M., van Raaij, M. J., Thompson, P., Hawkins, A. R., & González-Bello, C. (2014). Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors. Journal of Medicinal Chemistry, 57(8), 3494–3510. https://doi.org/10.1021/jm500175z
Ares, P., Garcia-Doval, C., Llauró, A., Gómez-Herrero, J., van Raaij, M. J., & de Pablo, P. J. (2014). Interplay between the mechanics of bacteriophage fibers and the strength of virus-host links. Physical Review E, 89(5). https://doi.org/10.1103/physreve.89.052710
Pénzes, J. J., Menéndez-Conejero, R., Condezo, G. N., Ball, I., Papp, T., Doszpoly, A., Paradela, A., Pérez-Berná, A. J., López-Sanz, M., Nguyen, T. H., van Raaij, M. J., Marschang, R. E., Harrach, B., Benkő, M., & San Martín, C. (2014). Molecular Characterization of a Lizard Adenovirus Reveals the First Atadenovirus with Two Fiber Genes and the First Adenovirus with Either One Short or Three Long Fibers per Penton. Journal of Virology, 88(19), 11304–11314. https://doi.org/10.1128/jvi.00306-14
Llamas‐Saiz, A. L., & van Raaij, M. J. (2013). X‐Ray Crystallography of Biological Macromolecules: Fundamentals and Applications. Proteins in Solution and at Interfaces, 1–22. Portico. https://doi.org/10.1002/9781118523063.ch1
van Raaij, M. J., & Mitraki, A. (2013). Natural Fibrous Proteins: Structural Analysis, Assembly, and Applications. Proteins in Solution and at Interfaces, 219–232. Portico. https://doi.org/10.1002/9781118523063.ch11
Otero, J. M., van der Knaap, M., Llamas-Saiz, A. L., van Raaij, M. J., Amorín, M., Granja, J. R., Filippov, D. V., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2013). Design, Synthesis, and Structural Analysis of Turn Modified cyclo-(αβ3αβ2α)2 Peptide Derivatives toward Crystalline Hexagon-Shaped Cationic Nanochannel Assemblies. Crystal Growth & Design, 13(10), 4355–4367. https://doi.org/10.1021/cg4007108
Garcia-Doval, C., & van Raaij, M. J. (2013). Bacteriophage Receptor Recognition and Nucleic Acid Transfer. Structure and Physics of Viruses, 489–518. https://doi.org/10.1007/978-94-007-6552-8_17
Blanco, B., Prado, V., Lence, E., Otero, J. M., Garcia-Doval, C., van Raaij, M. J., Llamas-Saiz, A. L., Lamb, H., Hawkins, A. R., & González-Bello, C. (2013). Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover. Journal of the American Chemical Society, 135(33), 12366–12376. https://doi.org/10.1021/ja405853p
Sanz-Gaitero, M., Keary, R., Garcia-Doval, C., Coffey, A., & van Raaij, M. J. (2013). Crystallization of the CHAP domain of the endolysin fromStaphylococcus aureusbacteriophage K. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 69(12), 1393–1396. https://doi.org/10.1107/s1744309113030133
Cuervo, A., Pulido-Cid, M., Chagoyen, M., Arranz, R., González-García, V. A., Garcia-Doval, C., Castón, J. R., Valpuesta, J. M., van Raaij, M. J., Martín-Benito, J., & Carrascosa, J. L. (2013). Structural Characterization of the Bacteriophage T7 Tail Machinery. Journal of Biological Chemistry, 288(36), 26290–26299. https://doi.org/10.1074/jbc.m113.491209
Garcia-Doval, C., & van Raaij, M. J. (2012). Structure of the receptor-binding carboxy-terminal domain of bacteriophage T7 tail fibers. Proceedings of the National Academy of Sciences, 109(24), 9390–9395. https://doi.org/10.1073/pnas.1119719109
Otero, J. M., Noël, A.-J., Guardado-Calvo, P., Llamas-Saiz, A. L., Wende, W., Schierling, B., Pingoud, A., & van Raaij, M. J. (2012). High-resolution structures ofThermus thermophilusenoyl-acyl carrier protein reductase in the apo form, in complex with NAD+and in complex with NAD+and triclosan. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 68(10), 1139–1148. https://doi.org/10.1107/s1744309112033982
van der Knaap, M., Otero, J. M., Llamas-Saiz, A., van Raaij, M. J., Lageveen, L. I., Busscher, H. J., Grotenbreg, G. M., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2012). Design, synthesis and structural analysis of mixed α/β-peptides that adopt stable cyclic hairpin-like conformations. Tetrahedron, 68(10), 2391–2400. https://doi.org/10.1016/j.tet.2012.01.015
Kapoerchan, V. V., Knijnenburg, A. D., Keizer, P., Spalburg, E., de Neeling, A. J., Mars-Groenendijk, R. H., Noort, D., Otero, J. M., Llamas-Saiz, A. L., van Raaij, M. J., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2012). ‘Inverted’ analogs of the antibiotic gramicidin S with an improved biological profile. Bioorganic & Medicinal Chemistry, 20(20), 6059–6062. https://doi.org/10.1016/j.bmc.2012.08.038
Lence, E., Tizón, L., Otero, J. M., Peón, A., Prazeres, V. F. V., Llamas-Saiz, A. L., Fox, G. C., van Raaij, M. J., Lamb, H., Hawkins, A. R., & González-Bello, C. (2012). Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids. ACS Chemical Biology, 8(3), 568–577. https://doi.org/10.1021/cb300493s
Kryshtafovych, A., Moult, J., Bartual, S. G., Bazan, J. F., Berman, H., Casteel, D. E., Christodoulou, E., Everett, J. K., Hausmann, J., Heidebrecht, T., Hills, T., Hui, R., Hunt, J. F., Seetharaman, J., Joachimiak, A., Kennedy, M. A., Kim, C., Lingel, A., Michalska, K., … Schwede, T. (2011). Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins: Structure, Function, and Bioinformatics, 79(S10), 6–20. Portico. https://doi.org/10.1002/prot.23196
Knijnenburg, A. D., Kapoerchan, V. V., Grotenbreg, G. M., Spalburg, E., de Neeling, A. J., Mars-Groenendijk, R. H., Noort, D., Otero, J. M., Llamas-Saiz, A. L., van Raaij, M. J., Ravensbergen, B., Nibbering, P. H., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2011). Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives. Bioorganic & Medicinal Chemistry, 19(11), 3402–3409. https://doi.org/10.1016/j.bmc.2011.04.031
Tizón, L., Otero, J. M., Prazeres, V. F. V., Llamas-Saiz, A. L., Fox, G. C., van Raaij, M. J., Lamb, H., Hawkins, A. R., Ainsa, J. A., Castedo, L., & González-Bello, C. (2011). A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors. Journal of Medicinal Chemistry, 54(17), 6063–6084. https://doi.org/10.1021/jm2006063
Knijnenburg, A. D., Tuin, A. W., Spalburg, E., de Neeling, A. J., Mars‐Groenendijk, R. H., Noort, D., Otero, J. M., Llamas‐Saiz, A. L., van Raaij, M. J., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2011). Exploring the Conformational and Biological Versatility of β‐Turn‐Modified Gramicidin S by Using Sugar Amino Acid Homologues that Vary in Ring Size. Chemistry – A European Journal, 17(14), 3995–4004. Portico. https://doi.org/10.1002/chem.201002895
van der Knaap, M., Lageveen, L. T., Busscher, H. J., Mars‐Groenendijk, R., Noort, D., Otero, J. M., Llamas‐Saiz, A. L., van Raaij, M. J., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2011). Evaluation of Readily Accessible Azoles as Mimics of the Aromatic Ring ofD‐Phenylalanine in the Turn Region of Gramicidin S. ChemMedChem, 6(5), 840–847. Portico. https://doi.org/10.1002/cmdc.201000539
Peón, A., Otero, J. M., Tizón, L., Prazeres, V. F. V., Llamas‐Saiz, A. L., Fox, G. C., van Raaij, M. J., Lamb, H., Hawkins, A. R., Gago, F., Castedo, L., & González‐Bello, C. (2010). Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)‐2‐Benzyl‐3‐dehydroquinic Acids. ChemMedChem, 5(10), 1726–1733. Portico. https://doi.org/10.1002/cmdc.201000281
Leiman, P. G., Arisaka, F., van Raaij, M. J., Kostyuchenko, V. A., Aksyuk, A. A., Kanamaru, S., & Rossmann, M. G. (2010). Morphogenesis of the T4 tail and tail fibers. Virology Journal, 7(1). https://doi.org/10.1186/1743-422x-7-355
Kapoerchan, V. V., Spalburg, E., de Neeling, Albert. J., Mars‐Groenendijk, R. H., Noort, D., Otero, J. M., Ferraces‐Casais, P., Llamas‐Saiz, A. L., van Raaij, M. J., van Doorn, J., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2010). Gramicidin S Derivatives Containing cis‐ and trans‐Morpholine Amino Acids (MAAs) as Turn Mimetics. Chemistry – A European Journal, 16(14), 4259–4265. Portico. https://doi.org/10.1002/chem.200902984
Álvarez, X. A., Cabrera-Poch, N., Canda-Sánchez, A., Fenollosa, C., Piñero, E., van Raaij, M. J., Cobos, E. S., Pérez, I. S., Tapiador, F. J., & Agrasar, A. M. T. (2010). Spain’s Budget Neglects Research. Science, 327(5969), 1078–1079. https://doi.org/10.1126/science.327.5969.1078-b
Galan Bartual, S., Garcia-Doval, C., Alonso, J., Schoehn, G., & van Raaij, M. J. (2010). Two-chaperone assisted soluble expression and purification of the bacteriophage T4 long tail fibre protein gp37. Protein Expression and Purification, 70(1), 116–121. https://doi.org/10.1016/j.pep.2009.11.005
Guardado-Calvo, P., Muñoz, E. M., Llamas-Saiz, A. L., Fox, G. C., Kahn, R., Curiel, D. T., Glasgow, J. N., & van Raaij, M. J. (2010). Crystallographic Structure of Porcine Adenovirus Type 4 Fiber Head and Galectin Domains. Journal of Virology, 84(20), 10558–10568. https://doi.org/10.1128/jvi.00997-10
Kapoerchan, V. V., Knijnenburg, A. D., Niamat, M., Spalburg, E., de Neeling, A. J., Nibbering, P. H., Mars‐Groenendijk, R. H., Noort, D., Otero, J. M., Llamas‐Saiz, A. L., van Raaij, M. J., van der Marel, G. A., Overkleeft, H. S., & Overhand, M. (2010). An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity. Chemistry – A European Journal, 16(40), 12174–12181. Portico. https://doi.org/10.1002/chem.201001686
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