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Institution: IIM
Research Groups: Biosystem & Bioprocesses Engineering
Position: CT
Home page: https://bio2eng.csic.es/
Contact email: miriamr@iim.csic.es
BCB Committee: Outreach
BCB Community: No communities assigned.
BCB Tools: No tools assigned.
BCB Services: No services assigned.
Research topics: Food safety, Microbial Communities, Population dynamics, Biosystems Modeling, Evolutionary modelling, Network Biology
Publications
Pedreira, A., Martínez-López, N., Vázquez, J. A., & García, M. R. (2024). Modelling the antimicrobial effect of food preservatives in bacteria: Application to Escherichia coli and Bacillus cereus inhibition with carvacrol. Journal of Food Engineering, 361, 111734. https://doi.org/10.1016/j.jfoodeng.2023.111734
Pedreira, A., Fernandes, S., Simões, M., García, M. R., & Vázquez, J. A. (2024). Synergistic Bactericidal Effects of Quaternary Ammonium Compounds with Essential Oil Constituents. Foods, 13(12), 1831. https://doi.org/10.3390/foods13121831
Pedreira, A., Vázquez, J. A., Romanenko, A., & García, M. R. (2024). Design and Validation of a PLC-Controlled Morbidostat for Investigating Bacterial Drug Resistance. Bioengineering, 11(8), 815. https://doi.org/10.3390/bioengineering11080815
Martínez-López, N., Vilas, C., & García, M. R. (2024). A birth–death model to understand bacterial antimicrobial heteroresistance from time-kill curves. Mathematical Biosciences, 376, 109278. https://doi.org/10.1016/j.mbs.2024.109278
Pérez-Rodríguez, M., López Cabo, M., Balsa-Canto, E., & García, M. R. (2023). Mechanisms of Listeria monocytogenes Disinfection with Benzalkonium Chloride: From Molecular Dynamics to Kinetics of Time-Kill Curves. International Journal of Molecular Sciences, 24(15), 12132. https://doi.org/10.3390/ijms241512132
Egea, J. A., García, M. R., & Vilas, C. (2023). Dynamic Modelling and Simulation of Food Systems: Recent Trends and Applications. Foods, 12(3), 557. https://doi.org/10.3390/foods12030557
Falcó, I., Tudela, J. A., Hernández, N., Pérez-Cataluña, A., García, M. R., Truchado, P., Garrido, A., Allende, A., Sánchez, G., & Gil, M. I. (2023). Antiviral capacity of sanitizers against infectious viruses in process water from the produce industry under batch and continuous conditions. Food Control, 150, 109738. https://doi.org/10.1016/j.foodcont.2023.109738
Pedreira, A., Vázquez, J. A., & García, M. R. (2022). Kinetics of Bacterial Adaptation, Growth, and Death at Didecyldimethylammonium Chloride sub-MIC Concentrations. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.758237
Pérez-Rodríguez, M., Cabo, M. L., Balsa-Canto, E., & R. García, M. (2022). Mechanisms ofListeria monocytogenesdisinfection with Benzalkonium chloride: from molecular dynamics to kinetics of time-kill curves. https://doi.org/10.1101/2022.06.21.497115
García, M. R., Ferez-Rubio, J. A., & Vilas, C. (2022). Assessment and Prediction of Fish Freshness Using Mathematical Modelling: A Review. Foods, 11(15), 2312. https://doi.org/10.3390/foods11152312
EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Chemaly, M., Davies, R., De Cesare, A., Herman, L., Hilbert, F., Lindqvist, R., Nauta, M., Peixe, L., Ru, G., Simmons, M., Skandamis, P., Suffredini, E., Bekaert, K., Cropotova, J., et al. (2021). The use of the so‐called ‘superchilling’ technique for the transport of fresh fishery products [JB]. EFSA Journal, 19(1). https://doi.org/10.2903/j.efsa.2021.6378
Le, T. T. Y., Grabner, D., Nachev, M., García, M. R., Balsa-Canto, E., Peijnenburg, W. J. G. M., Hendriks, A. J., & Sures, B. (2021). Development of a toxicokinetic-toxicodynamic model simulating chronic copper toxicity to the Zebra mussel based on subcellular fractionation. Aquatic Toxicology, 241, 106015. https://doi.org/10.1016/j.aquatox.2021.106015
García, M. R., Suffredini, E., Messens, W., & Bover-Cid, S. (2021). Heat transfer model tool for the heat absorption capacity of superchilled fresh fishery products (HTM-SFFP Tool). Zenodo. https://doi.org/10.5281/ZENODO.4304283
Pedreira, A., Taşkın, Y., & García, M. R. (2021). A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry. Foods, 10(2), 283. https://doi.org/10.3390/foods10020283
Le, T. T. Y., Nachev, M., Grabner, D., Garcia, M. R., Balsa-Canto, E., Hendriks, A. J., Peijnenburg, W. J. G. M., & Sures, B. (2021). Modelling chronic toxicokinetics and toxicodynamics of copper in mussels considering ionoregulatory homeostasis and oxidative stress. Environmental Pollution, 287, 117645. https://doi.org/10.1016/j.envpol.2021.117645
Vilas, C., Mauricio-Iglesias, M., & García, M. R. (2020). Model-based design of smart active packaging systems with antimicrobial activity. Food Packaging and Shelf Life, 24, 100446. https://doi.org/10.1016/j.fpsl.2019.100446
Valcarcel, J., García, M. R., Varela, U. R., & Vázquez, J. A. (2020). Hyaluronic acid of tailored molecular weight by enzymatic and acid depolymerization. International Journal of Biological Macromolecules, 145, 788–794. https://doi.org/10.1016/j.ijbiomac.2019.12.221
Procopio, A., Cosentino, C., De Rosa, S., Garcia, M. R., Covello, C., Merola, A., Sabatino, J., De Luca, A., Indolfi, C., & Amato, F. (2020). Experimental Modeling and Identification of Cardiac Biomarkers Release in Acute Myocardial Infarction. IEEE Transactions on Control Systems Technology, 28(1), 183–195. https://doi.org/10.1109/tcst.2018.2849068
Valcarcel, J., García, M. R., Sampayo, L. F., & Vázquez, J. A. (2020). Marine chondroitin sulfate of defined molecular weight by enzymatic depolymerization. Carbohydrate Polymers, 229, 115450. https://doi.org/10.1016/j.carbpol.2019.115450
Yen Le, T. T., García, M. R., Grabner, D., Nachev, M., Balsa-Canto, E., Hendriks, A. J., Zimmermann, S., & Sures, B. (2020). Mechanistic simulation of bioconcentration kinetics of waterborne Cd, Ag, Pd, and Pt in the zebra mussel Dreissena polymorpha. Chemosphere, 242, 124967. https://doi.org/10.1016/j.chemosphere.2019.124967
García, M. R., Bekaert, K., Messens, W., & Bover-Cid, S. (2020). Temperature simulator of fish stored in tubs and boxes (FishT-TaB Simulator). Zenodo. https://doi.org/10.5281/ZENODO.3725616
EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Chemaly, M., Davies, R., De Cesare, A., Herman, L., Hilbert, F., Lindqvist, R., Nauta, M., Peixe, L., Ru, G., Simmons, M., Skandamis, P., Suffredini, E., Arason, S., Bekaert, K., et al. (2020). The use of the so‐called ‘tubs’ for transporting and storing fresh fishery products [JB]. EFSA Journal, 18(4). https://doi.org/10.2903/j.efsa.2020.6091
Iglesias, M. M., Vilas, C., & García, M. R. (2019). "Model-based design of smart active packaging systems with antimicrobial activity" Matlab codes. Zenodo. https://doi.org/10.5281/ZENODO.3244153
García, M. R., Vázquez, J. A., Teixeira, I. G., & Alonso, A. A. (2018). Stochastic Individual-Based Modeling of Bacterial Growth and Division Using Flow Cytometry. Frontiers in Microbiology, 8. https://doi.org/10.3389/fmicb.2017.02626
García, M. R., & Cabo, M. L. (2018). Optimization of E. coli Inactivation by Benzalkonium Chloride Reveals the Importance of Quantifying the Inoculum Effect on Chemical Disinfection. Frontiers in Microbiology, 9. https://doi.org/10.3389/fmicb.2018.01259
Le, T. T. Y., García, M. R., Nachev, M., Grabner, D., Balsa-Canto, E., Hendriks, A. J., & Sures, B. (2018). Development of a PBPK Model for Silver Accumulation in Chub Infected with Acanthocephalan Parasites. Environmental Science & Technology, 52(21), 12514–12525. https://doi.org/10.1021/acs.est.8b04022
García, M. R., Vázquez, J. A., Teixeira, I. G., & Alonso, A. A. (2018). Corrigendum: Stochastic Individual-Based Modeling of Bacterial Growth and Division Using Flow Cytometry. Frontiers in Microbiology, 9. https://doi.org/10.3389/fmicb.2018.00633
Vilas, C., Alonso, A. A., Herrera, J. R., Bernárdez, M., & García, M. R. (2018). A mathematical model to predict early quality attributes in hake during storage at low temperature. Journal of Food Engineering, 222, 11–19. https://doi.org/10.1016/j.jfoodeng.2017.11.005
García, M. R., Alonso, A. A., & Balsa-Canto, E. (2017). A Normalisation Strategy to Optimally Design Experiments in Computational Biology. 11th International Conference on Practical Applications of Computational Biology & Bioinformatics, 126–136. https://doi.org/10.1007/978-3-319-60816-7_16
Vilas, C., Alonso, A. A., Herrera, J. R., García-Blanco, A., & García, M. R. (2017). A model for the biochemical degradation of inosine monophosphate in hake ( Merluccius merluccius ). Journal of Food Engineering, 200, 95–101. https://doi.org/10.1016/j.jfoodeng.2016.12.016
García, M. R., Cabo, M. L., Herrera, J. R., Ramilo-Fernández, G., Alonso, A. A., & Balsa-Canto, E. (2017). Smart sensor to predict retail fresh fish quality under ice storage. Journal of Food Engineering, 197, 87–97. https://doi.org/10.1016/j.jfoodeng.2016.11.006
Balsa-Canto, E., Alonso, A. A., Arias-Méndez, A., García, M. R., López-Núñez, A., Mosquera-Fernández, M., Vázquez, C., & Vilas, C. (2016). Modeling and Optimization Techniques with Applications in Food Processes, Bio-processes and Bio-systems. Numerical Simulation in Physics and Engineering, 187–216. https://doi.org/10.1007/978-3-319-32146-2_4
Vilas, C., Arias-Méndez, A., García, M. R., Alonso, A. A., & Balsa-Canto, E. (2016). Toward predictive food process models: A protocol for parameter estimation. Critical Reviews in Food Science and Nutrition, 1–14. https://doi.org/10.1080/10408398.2016.1186591
García, M. R., Vilas, C., Herrera, J. R., Bernárdez, M., Balsa-Canto, E., & Alonso, A. A. (2015). Quality and shelf-life prediction for retail fresh hake (Merluccius merluccius). International Journal of Food Microbiology, 208, 65–74. https://doi.org/10.1016/j.ijfoodmicro.2015.05.012
Lopez-Caamal, F., Oyarzun, D. A., Middleton, R. H., & Garcia, M. R. (2014). Spatial Quantification of Cytosolic Ca<inline-formula><tex-math>$^{2+}$</tex-math></inline-formula> Accumulation in Nonexcitable Cells:An Analytical Study. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 11(3), 592–603. https://doi.org/10.1109/tcbb.2014.2316010
(2014). Correction: A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation. PLoS ONE, 9(8), e106145. https://doi.org/10.1371/journal.pone.0106145
Alonso, A. A., Arias-Méndez, A., Balsa-Canto, E., García, M. R., Molina, J. I., Vilas, C., & Villafín, M. (2013). Real time optimization for quality control of batch thermal sterilization of prepackaged foods. Food Control, 32(2), 392–403. https://doi.org/10.1016/j.foodcont.2013.01.002
Oyarzún, D. A., López-Caamal, F., García, M. R., Middleton, R. H., & Weiße, A. Y. (2013). Cumulative Signal Transmission in Nonlinear Reaction-Diffusion Networks. PLoS ONE, 8(5), e62834. https://doi.org/10.1371/journal.pone.0062834
García, M. R., Pearlmutter, B. A., Wellstead, P. E., & Middleton, R. H. (2013). A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation. PLoS ONE, 8(9), e73456. https://doi.org/10.1371/journal.pone.0073456
Francis, F., García, M. R., & Middleton, R. H. (2013). A single compartment model of pacemaking in dissasociated Substantia nigra neurons. Journal of Computational Neuroscience, 35(3), 295–316. https://doi.org/10.1007/s10827-013-0453-9
Lopez-Caamal, F., Garcia, M. R., & Middleton, R. H. (2012). Reducing computational time via order reduction of a class of reaction-diffusion systems. 2012 American Control Conference (ACC), 1494–1499. https://doi.org/10.1109/acc.2012.6315103
Francis, F., García, M. R., & Middleton, R. H. (2012). Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons. Systems Biology of Parkinson’s Disease, 81–109. https://doi.org/10.1007/978-1-4614-3411-5_5
Lopez-Caamal, F., Garcia, M. R., Oyarzun, D. A., & Middleton, R. H. (2012). Analytic computation of the integrated response in nonlinear reaction-diffusion systems. 2012 IEEE 51st IEEE Conference on Decision and Control (CDC), 1047–1052. https://doi.org/10.1109/cdc.2012.6426397
García, M. R., Vilas, C., Santos, L. O., & Alonso, A. A. (2012). A robust multi-model predictive controller for distributed parameter systems. Journal of Process Control, 22(1), 60–71. https://doi.org/10.1016/j.jprocont.2011.10.008
López-Caamal, F., García, M. R., Middleton, R. H., & Huber, H. J. (2012). Positive feedback in the Akt/mTOR pathway and its implications for growth signal progression in skeletal muscle cells: An analytical study. Journal of Theoretical Biology, 301, 15–27. https://doi.org/10.1016/j.jtbi.2012.01.026
Garcia, M. R., Verwoerd, M., Pearlmutter, B. A., Wellstead, P. E., & Middleton, R. H. (2011). Deep brain stimulation may reduce tremor by preferential blockade of slower axons via antidromic activation. IEEE Conference on Decision and Control and European Control Conference, 6481–6486. https://doi.org/10.1109/cdc.2011.6160710
Alonso, A. A., García, M. R., & Vilas, C. (2010). Dynamic Modeling and Simulation for Robust Control of Distributed Processes and Bioprocesses. Process Systems Engineering, 369–401. Portico. https://doi.org/10.1002/9783527631209.ch71
Escaño, J. M., Bordons, C., Vilas, C., García, M. R., & Alonso, A. A. (2009). Neurofuzzy model based predictive control for thermal batch processes. Journal of Process Control, 19(9), 1566–1575. https://doi.org/10.1016/j.jprocont.2009.07.016
Garcia, M. R., Vilas, C., Alonso, A. A., & Balsa-Canto, E. (2008). REAL TIME OPTIMIZATION OF THE THERMAL PROCESSING OF BIOPRODUCTS. Acta Horticulturae, 802, 155–162. https://doi.org/10.17660/actahortic.2008.802.18
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