Institution: CBM

Research Groups: Molecular Modeling Group

Position: Research Scientist CSIC

Home page: http://bioweb.cbm.uam.es/

Contact email: pagomez@cbm.csic.es

ORCID: https://orcid.org/0000-0003-3131-729X

BCB Committee: No committees assigned.

BCB Community: No communities assigned.

BCB Tools: MEPSA: Minimum Energy Pathway Analysis for energy landscapes., MEPSAnd: minimum energy path surface analysis over n-dimensional surfaces.

BCB Services:

Research topics: Biomolecular simulation, Protein/Nucleic Acid design, Structure prediction, Structure-function relationship

Biography: Paulino Gómez-Puertas (León, Spain; 1965) holds a PhD in Biochemistry and Molecular Biology by the Universidad Autónoma de Madrid. His doctoral work was awarded with the UAM Doctorate Prize in 1992. He obtained the "Juan Abelló" Biochemistry Award in 1994 by the Spanish Royal Academy of Doctors. Senior Scientist at the CSIC, since 2002, he is Head of the Molecular Modeling Group at the Center for Molecular Biology "Severo Ochoa" (CBMSO, CSIC-UAM) in Madrid. Honorary Teacher at the Autonomous University of Madrid from 2003 to 2007. Associate Researcher at the Institute for Health Research of La Paz University Hospital (IdiPAZ) since 2012. Member of the CSIC networks: "Cancer Hub", "Rare Diseases" and "Computational Biology and Bioinformatics".

Publications
Displayed publications: 135

Moreno-Jiménez, S., Lopez-Cantillo, G., Arevalo-Romero, J. A., Perdomo-Arciniegas, A. M., Moreno-Gonzalez, A. M., Devia-Mejia, B., Camacho, B. A., Gómez-Puertas, P., & Ramirez-Segura, C. A. (2025). An engineered miniACE2 protein secreted by mesenchymal stromal cells effectively neutralizes multiple SARS-CoV- 2 variants in vitro. Molecular Medicine, 31(1). https://doi.org/10.1186/s10020-025-01190-w

Hildonen, M., Ciolfi, A., Ferilli, M., Cappelletti, C., Al Alam, C., Amor, D. J., Barakat, T. S., Benoit, V., Birk, O. S., Callewaert, B., Cazurro-Gutiérrez, A., De Wachter, M., Doco-Fenzy, M., Gómez-Puertas, P., Hammer, T. B., Jamra, R. A., Kaiyrzhanov, R., Kameyama, S., Keren, B., … Tartaglia, M. (2025). Biallelic loss-of-function variants in ZNF142 are associated with a robust DNA methylation signature affecting a limited number of genomic loci. European Journal of Human Genetics, 33(7), 896–903. https://doi.org/10.1038/s41431-025-01876-z

Gil-Salvador, M., Trujillano, L., Lucia-Campos, C., Del Rincón, J., Pamplona, P., Arnedo, M., Puisac, B., Marcos-Alcalde, Í., Gómez-Puertas, P., Ramos, F. J., Pié, J., & Latorre-Pellicer, A. (2025). Postzygotic mosaicism in SMC1A and the first reported case of a female with Cornelia de Lange syndrome. Scientific Reports, 15(1). https://doi.org/10.1038/s41598-025-07268-z

Ros-Pardo, D., Gómez-Puertas, P., & Marcos-Alcalde, Í. (2024). STAG2: Computational Analysis of Missense Variants Involved in Disease. International Journal of Molecular Sciences, 25(2), 1280. https://doi.org/10.3390/ijms25021280

Campos-Díaz, A., Morejón-García, P., Monte-Serrano, E., Ros-Pardo, D., Marcos-Alcalde, I., Gómez-Puertas, P., & Lazo, P. A. (2024). Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy. Journal of Molecular Medicine, 102(6), 801–817. https://doi.org/10.1007/s00109-024-02442-8

Furia, F., Levy, A. M., Theunis, M., Bamshad, M. J., Bartos, M. N., Bijlsma, E. K., Brancati, F., Cejudo, L., Chong, J. X., De Luca, C., Dean, S. J., Egense, A., Goel, H., Guenzel, A. J., Hüffmeier, U., Legius, E., Mancini, G. M. S., Marcos‐Alcalde, I., Niclass, T., … Tümer, Z. (2024). The phenotypic and genotypic spectrum of individuals with mono‐ or biallelic ANK3 variants. Clinical Genetics, 106(5), 574–584. Portico. https://doi.org/10.1111/cge.14587

Ros-Pardo, D., Gómez-Puertas, P., & Marcos-Alcalde, Í. (2024). STAG2-RAD21 complex: A unidirectional DNA ratchet mechanism in loop extrusion. International Journal of Biological Macromolecules, 276, 133822. https://doi.org/10.1016/j.ijbiomac.2024.133822

Escrig, J., Marcos-Alcalde, íñigo, Domínguez-Zotes, S., Abia, D., Gómez-Puertas, P., Valbuena, A., & Mateu, M. G. (2024). Structural Basis for Alternative Self-Assembly Pathways Leading to Different Human Immunodeficiency Virus Capsid-Like Nanoparticles. ACS Nano, 18(40), 27465–27478. https://doi.org/10.1021/acsnano.4c07948

Arévalo-Romero, J. A., López-Cantillo, G., Moreno-Jiménez, S., Marcos-Alcalde, Í., Ros-Pardo, D., Camacho, B. A., Gómez-Puertas, P., & Ramírez-Segura, C. A. (2024). In Silico Design of miniACE2 Decoys with In Vitro Enhanced Neutralization Activity against SARS-CoV-2, Encompassing Omicron Subvariants. International Journal of Molecular Sciences, 25(19), 10802. https://doi.org/10.3390/ijms251910802

Oltra, S. S., Colomo, S., Sin, L., Pérez-López, M., Lázaro, S., Molina-Crespo, A., Choi, K.-H., Ros-Pardo, D., Martínez, L., Morales, S., González-Paramos, C., Orantes, A., Soriano, M., Hernández, A., Lluch, A., Rojo, F., Albanell, J., Gómez-Puertas, P., Ko, J.-K., … Moreno-Bueno, G. (2023). Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Cell Death & Differentiation, 30(5), 1366–1381. https://doi.org/10.1038/s41418-023-01143-y

Luque, J., Mendes, I., Gómez, B., Morte, B., López de Heredia, M., Herreras, E., Corrochano, V., Bueren, J., Gallano, P., Artuch, R., Fillat, C., Pérez‐Jurado, L. A., Montoliu, L., Carracedo, Á., Millán, J. M., Webb, S. M., Palau, F., & Lapunzina, P. (2022). CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative. Clinical Genetics, 101(5–6), 481–493. Portico. https://doi.org/10.1111/cge.14113

Levy, A. M., Gomez-Puertas, P., & Tümer, Z. (2022). Neurodevelopmental Disorders Associated with PSD-95 and Its Interaction Partners. International Journal of Molecular Sciences, 23(8), 4390. https://doi.org/10.3390/ijms23084390

Fernández‐Justel, D., Marcos‐Alcalde, Í., Abascal, F., Vidaña, N., Gómez‐Puertas, P., Jiménez, A., Revuelta, J. L., & Buey, R. M. (2022). Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase. Protein Science, 31(5). Portico. https://doi.org/10.1002/pro.4314

Dahdouh, E., Allander, L., Falgenhauer, L., Iorga, B. I., Lorenzetti, S., Marcos-Alcalde, Í., Martin, N. I., Martínez-Martínez, L., Mingorance, J., Naas, T., Rubin, J. E., Spyrakis, F., Tängdén, T., & Gómez-Puertas, P. (2022). Computational Modeling and Design of New Inhibitors of Carbapenemases: A Discussion from the EPIC Alliance Network. International Journal of Molecular Sciences, 23(17), 9746. https://doi.org/10.3390/ijms23179746

Christensen, M. B., Levy, A. M., Mohammadi, N. A., Niceta, M., Kaiyrzhanov, R., Dentici, M. L., Al Alam, C., Alesi, V., Benoit, V., Bhatia, K. P., Bierhals, T., Boßelmann, C. M., Buratti, J., Callewaert, B., Ceulemans, B., Charles, P., De Wachter, M., Dehghani, M., D’haenens, E., … Tümer, Z. (2022). Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder. Clinical Genetics, 102(2), 98–109. Portico. https://doi.org/10.1111/cge.14165

Lucia-Campos, C., Valenzuela, I., Latorre-Pellicer, A., Ros-Pardo, D., Gil-Salvador, M., Arnedo, M., Puisac, B., Castells, N., Plaja, A., Tenes, A., Cuscó, I., Trujillano, L., Ramos, F. J., Tizzano, E. F., Gómez-Puertas, P., & Pié, J. (2022). A Novel Intragenic Duplication in the HDAC8 Gene Underlying a Case of Cornelia de Lange Syndrome. Genes, 13(8), 1413. https://doi.org/10.3390/genes13081413

Arnedo, M., Ascaso, Á., Latorre-Pellicer, A., Lucia-Campos, C., Gil-Salvador, M., Ayerza-Casas, A., Pablo, M. J., Gómez-Puertas, P., Ramos, F. J., Bueno-Lozano, G., Pié, J., & Puisac, B. (2022). Molecular Basis of the Schuurs–Hoeijmakers Syndrome: What We Know about the Gene and the PACS-1 Protein and Novel Therapeutic Approaches. International Journal of Molecular Sciences, 23(17), 9649. https://doi.org/10.3390/ijms23179649

Latorre‐Pellicer, A., Ascaso, Á., Lucia‐Campos, C., Gil‐Salvador, M., Arnedo, M., Antoñanzas, R., Ayerza‐Casas, A., Marcos‐Alcalde, I., Gómez‐Puertas, P., Ramos, F. J., Pié, J., & Puisac, B. (2021). Things are not always what they seem: From Cornelia de Lange to KBG phenotype in a girl with genetic variants in NIPBL and ANKRD11. Molecular Genetics & Genomic Medicine, 9(11). Portico. https://doi.org/10.1002/mgg3.1826

Rodríguez-Palmero, A., Boerrigter, M. M., Gómez-Andrés, D., Aldinger, K. A., Marcos-Alcalde, Í., Popp, B., Everman, D. B., Lovgren, A. K., Arpin, S., Bahrambeigi, V., Beunders, G., Bisgaard, A.-M., Bjerregaard, V. A., Bruel, A.-L., Challman, T. D., Cogné, B., Coubes, C., de Man, S. A., Denommé-Pichon, A.-S., … Tümer, Z. (2021). DLG4-related synaptopathy: a new rare brain disorder. Genetics in Medicine, 23(5), 888–899. https://doi.org/10.1038/s41436-020-01075-9

Latorre-Pellicer, A., Gil-Salvador, M., Parenti, I., Lucia-Campos, C., Trujillano, L., Marcos-Alcalde, I., Arnedo, M., Ascaso, Á., Ayerza-Casas, A., Antoñanzas-Pérez, R., Gervasini, C., Piccione, M., Mariani, M., Weber, A., Kanber, D., Kuechler, A., Munteanu, M., Khuller, K., Bueno-Lozano, G., … Pié, J. (2021). Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-94958-z

Morejon-Garcia, P., Keren, B., Marcos-Alcalde, I., Gomez-Puertas, P., Mochel, F., & Lazo, Pedro. A. (2021). Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia. Neurology Genetics, 7(5). https://doi.org/10.1212/nxg.0000000000000624

García-Hernández, J. L., Corchete, L. A., Marcos-Alcalde, Í., Gómez-Puertas, P., Fons, C., & Lazo, P. A. (2021). Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome. Human Genomics, 15(1). https://doi.org/10.1186/s40246-021-00309-4

Kumble, S., Levy, A. M., Punetha, J., Gao, H., Ah Mew, N., Anyane‐Yeboa, K., Benke, P. J., Berger, S. M., Bjerglund, L., Campos‐Xavier, B., Ciliberto, M., Cohen, J. S., Comi, A. M., Curry, C., Damaj, L., Denommé‐Pichon, A., Emrick, L., Faivre, L., Fasano, M. B., … Tümer, Z. (2021). The clinical and molecular spectrum of QRICH1 associated neurodevelopmental disorder. Human Mutation, 43(2), 266–282. Portico. https://doi.org/10.1002/humu.24308

Latorre-Pellicer, A., Ascaso, Á., Trujillano, L., Gil-Salvador, M., Arnedo, M., Lucia-Campos, C., Antoñanzas-Pérez, R., Marcos-Alcalde, I., Parenti, I., Bueno-Lozano, G., Musio, A., Puisac, B., Kaiser, F. J., Ramos, F. J., Gómez-Puertas, P., & Pié, J. (2020). Evaluating Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes. International Journal of Molecular Sciences, 21(3), 1042. https://doi.org/10.3390/ijms21031042

Krab, L. C., Marcos-Alcalde, I., Assaf, M., Balasubramanian, M., Andersen, J. B., Bisgaard, A.-M., Fitzpatrick, D. R., Gudmundsson, S., Huisman, S. A., Kalayci, T., Maas, S. M., Martinez, F., McKee, S., Menke, L. A., Mulder, P. A., Murch, O. D., Parker, M., Pie, J., Ramos, F. J., … Hennekam, R. C. (2020). Delineation of phenotypes and genotypes related to cohesin structural protein RAD21. Human Genetics, 139(5), 575–592. https://doi.org/10.1007/s00439-020-02138-2

Marcos, A. T., Martín‐Doncel, E., Morejón‐García, P., Marcos‐Alcalde, I., Gómez‐Puertas, P., Segura‐Puimedon, M., Armengol, L., Navarro‐Pando, J. M., & Lazo, P. A. (2020). VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy. Annals of Clinical and Translational Neurology, 7(5), 808–818. Portico. https://doi.org/10.1002/acn3.51050

Lazo, P. A., García, J. L., Gómez-Puertas, P., Marcos-Alcalde, Í., Arjona, C., Villarroel, A., González-Sarmiento, R., & Fons, C. (2020). Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome. International Journal of Molecular Sciences, 21(12), 4447. https://doi.org/10.3390/ijms21124447

Ruiz-Márvez, E., Ramírez, C. A., Rodríguez, E. R., Flórez, M. M., Delgado, G., Guzmán, F., Gómez-Puertas, P., Requena, J. M., & Puerta, C. J. (2020). Molecular Characterization of Tc964, A Novel Antigenic Protein from Trypanosoma cruzi. International Journal of Molecular Sciences, 21(7), 2432. https://doi.org/10.3390/ijms21072432

Gudmundsson, S., Annerén, G., Marcos-Alcalde, Í., Wilbe, M., Melin, M., Gómez-Puertas, P., & Bondeson, M.-L. (2019). A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 – Review of the literature. European Journal of Medical Genetics, 62(6), 103526. https://doi.org/10.1016/j.ejmg.2018.08.007

Marcos-Alcalde, I., López-Viñas, E., & Gómez-Puertas, P. (2019). MEPSAnd: minimum energy path surface analysis overn-dimensional surfaces. Bioinformatics, 36(3), 956–958. https://doi.org/10.1093/bioinformatics/btz649

Arnedo, M., Latorre-Pellicer, A., Lucia-Campos, C., Gil-Salvador, M., Antoñanzas-Peréz, R., Gómez-Puertas, P., Bueno-Lozano, G., Puisac, B., & Pié, J. (2019). More Than One HMG-CoA Lyase: The Classical Mitochondrial Enzyme Plus the Peroxisomal and the Cytosolic Ones. International Journal of Molecular Sciences, 20(24), 6124. https://doi.org/10.3390/ijms20246124

López-Camacho, E., Paño-Pardo, J. R., Ruiz-Carrascoso, G., Wesselink, J.-J., Lusa-Bernal, S., Ramos-Ruiz, R., Ovalle, S., Gómez-Gil, R., Pérez-Blanco, V., Pérez-Vázquez, M., Gómez-Puertas, P., & Mingorance, J. (2018). Population structure of OXA-48-producing Klebsiella pneumoniae ST405 isolates during a hospital outbreak characterised by genomic typing. Journal of Global Antimicrobial Resistance, 15, 48–54. https://doi.org/10.1016/j.jgar.2018.06.008

Puisac, B., Marcos-Alcalde, I., Hernández-Marcos, M., Tobajas Morlana, P., Levtova, A., Schwahn, B., DeLaet, C., Lace, B., Gómez-Puertas, P., & Pié, J. (2018). Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients. International Journal of Molecular Sciences, 19(4), 1010. https://doi.org/10.3390/ijms19041010

Reis, F. P., Bárria, C., Gomez‐Puertas, P., Gomes, C. M., & Arraiano, C. M. (2018). Identification of temperature‐sensitive mutations and characterization of thermolabile RNase II variants. FEBS Letters, 593(3), 352–360. Portico. https://doi.org/10.1002/1873-3468.13313

Puisac, B., Teresa-Rodrigo, M.-E., Hernández-Marcos, M., Baquero-Montoya, C., Gil-Rodríguez, M.-C., Visnes, T., Bot, C., Gómez-Puertas, P., Kaiser, F., Ramos, F., Ström, L., & Pié, J. (2017). mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de Lange Syndrome. International Journal of Molecular Sciences, 18(3), 481. https://doi.org/10.3390/ijms18030481

Marcos-Alcalde, Í., Mendieta-Moreno, J. I., Puisac, B., Gil-Rodríguez, M. C., Hernández-Marcos, M., Soler-Polo, D., Ramos, F. J., Ortega, J., Pié, J., Mendieta, J., & Gómez-Puertas, P. (2017). Two-step ATP-driven opening of cohesin head. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-03118-9

Buey, R. M., Fernández-Justel, D., Marcos-Alcalde, Í., Winter, G., Gómez-Puertas, P., de Pereda, J. M., & Luis Revuelta, J. (2017). A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-02805-x

Mendieta-Moreno, J. I., Trabada, D. G., Mendieta, J., Lewis, J. P., Gómez-Puertas, P., & Ortega, J. (2016). Quantum Mechanics/Molecular Mechanics Free Energy Maps and Nonadiabatic Simulations for a Photochemical Reaction in DNA: Cyclobutane Thymine Dimer. The Journal of Physical Chemistry Letters, 7(21), 4391–4397. https://doi.org/10.1021/acs.jpclett.6b02168

Pié, J., Puisac, B., Hernández‐Marcos, M., Teresa‐Rodrigo, M. E., Gil‐Rodríguez, M., Baquero‐Montoya, C., Ramos‐Cáceres, M., Bernal, M., Ayerza‐Casas, A., Bueno, I., Gómez‐Puertas, P., & Ramos, F. J. (2016). Special cases in Cornelia de Lange syndrome: The Spanish experience. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 172(2), 198–205. Portico. https://doi.org/10.1002/ajmg.c.31501

Aguilera Rossi, C. G., Gómez-Puertas, P., & Ayala Serrano, J. A. (2016). In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa. BMC Microbiology, 16(1). https://doi.org/10.1186/s12866-016-0853-x

Reis, F. P., Barbas, A., Klauer-King, A. A., Tsanova, B., Schaeffer, D., López-Viñas, E., Gómez-Puertas, P., van Hoof, A., & Arraiano, C. M. (2015). Correction: Modulating the RNA Processing and Decay by the Exosome: Altering Rrp44/Dis3 Activity and End-Product. PLOS ONE, 10(8), e0136810. https://doi.org/10.1371/journal.pone.0136810

Martín-García, F., Papaleo, E., Gomez-Puertas, P., Boomsma, W., & Lindorff-Larsen, K. (2015). Comparing Molecular Dynamics Force Fields in the Essential Subspace. PLOS ONE, 10(3), e0121114. https://doi.org/10.1371/journal.pone.0121114

Mendieta-Moreno, J. I., Marcos-Alcalde, I., Trabada, D. G., Gómez-Puertas, P., Ortega, J., & Mendieta, J. (2015). A Practical Quantum Mechanics Molecular Mechanics Method for the Dynamical Study of Reactions in Biomolecules. Combined Quantum Mechanical and Molecular Mechanical Modelling of Biomolecular Interactions, 67–88. https://doi.org/10.1016/bs.apcsb.2015.06.003

Gil-Rodríguez, M. C., Deardorff, M. A., Ansari, M., Tan, C. A., Parenti, I., Baquero-Montoya, C., Ousager, L. B., Puisac, B., Hernández-Marcos, M., Teresa-Rodrigo, M. E., Marcos-Alcalde, I., Wesselink, J.-J., Lusa-Bernal, S., Bijlsma, E. K., Braunholz, D., Bueno-Martinez, I., Clark, D., Cooper, N. S., Curry, C. J., … Pié, J. (2015). De NovoHeterozygous Mutations inSMC3Cause a Range of Cornelia de Lange Syndrome-Overlapping Phenotypes. Human Mutation, 36(4), 454–462. Portico. https://doi.org/10.1002/humu.22761

Valdivieso, E., Perteguer, M. J., Hurtado, C., Campioli, P., Rodríguez, E., Saborido, A., Martínez-Sernández, V., Gómez-Puertas, P., Ubeira, F. M., & Gárate, T. (2015). ANISERP: a new serpin from the parasite Anisakis simplex. Parasites & Vectors, 8(1). https://doi.org/10.1186/s13071-015-1006-z

Salvarelli, E., Krupka, M., Rivas, G., Mingorance, J., Gómez-Puertas, P., Alfonso, C., & Rico, A. I. (2015). The Cell Division Protein FtsZ from Streptococcus pneumoniae Exhibits a GTPase Activity Delay. Journal of Biological Chemistry, 290(41), 25081–25089. https://doi.org/10.1074/jbc.m115.650077

Marcos-Alcalde, I., Setoain, J., Mendieta-Moreno, J. I., Mendieta, J., & Gómez-Puertas, P. (2015). MEPSA: minimum energy pathway analysis for energy landscapes. Bioinformatics, 31(23), 3853–3855. https://doi.org/10.1093/bioinformatics/btv453

Iozzo, P., Holmes, M., Schmidt, M. V., Cirulli, F., Guzzardi, M. A., Berry, A., Balsevich, G., Andreassi, M. G., Wesselink, J.-J., Liistro, T., Gómez-Puertas, P., Eriksson, J. G., & Seckl, J. (2014). Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN. Obesity Facts, 7(2), 130–151. Portico. https://doi.org/10.1159/000362656

González de Prado Salas, P., Hörger, I., Martín-García, F., Mendieta, J., Alonso, Á., Encinar, M., Gómez-Puertas, P., Vélez, M., & Tarazona, P. (2014). Torsion and curvature of FtsZ filaments. Soft Matter, 10(12), 1977. https://doi.org/10.1039/c3sm52516c

Mendieta-Moreno, J. I., Walker, R. C., Lewis, J. P., Gómez-Puertas, P., Mendieta, J., & Ortega, J. (2014). fireball/amber: An Efficient Local-Orbital DFT QM/MM Method for Biomolecular Systems. Journal of Chemical Theory and Computation, 10(5), 2185–2193. https://doi.org/10.1021/ct500033w

Betancor, G., Nevot, M., Mendieta, J., Gómez-Puertas, P., Martínez, M. A., & Menéndez-Arias, L. (2014). Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients. Antiviral Research, 106, 42–52. https://doi.org/10.1016/j.antiviral.2014.03.004

Baquero-Montoya, C., Gil-Rodríguez, M.-C., Hernández-Marcos, M., Teresa-Rodrigo, M.-E., Vicente-Gabas, A., Bernal, M.-L., Casale, C.-H., Bueno-Lozano, G., Bueno-Martínez, I., Queralt, E., Villa, O., Hernando-Davalillo, C., Armengol, L., Gómez-Puertas, P., Puisac, B., Selicorni, A., Ramos, F. J., & Pié, J. (2014). Severe ipsilateral musculoskeletal involvement in a Cornelia de Lange patient with a novel NIPBL mutation. European Journal of Medical Genetics, 57(9), 503–509. https://doi.org/10.1016/j.ejmg.2014.05.006

López-Camacho, E., Rentero, Z., Ruiz-Carrascoso, G., Wesselink, J.-J., Pérez-Vázquez, M., Lusa-Bernal, S., Gómez-Puertas, P., Kingsley, R. A., Gómez-Sánchez, P., Campos, J., Oteo, J., & Mingorance, J. (2014). Design of clone-specific probes from genome sequences for rapid PCR-typing of outbreak pathogens. Clinical Microbiology and Infection, 20(11), O891–O893. https://doi.org/10.1111/1469-0691.12616

Baquero‐Montoya, C., Gil‐Rodríguez, M. C., Braunholz, D., Teresa‐Rodrigo, M. E., Obieglo, C., Gener, B., Schwarzmayr, T., Strom, T. M., Gómez‐Puertas, P., Puisac, B., Gillessen‐Kaesbach, G., Musio, A., Ramos, F. J., Kaiser, F. J., & Pié, J. (2014). Somatic mosaicism in a Cornelia de Lange syndrome patient with NIPBL mutation identified by different next generation sequencing approaches. Clinical Genetics, 86(6), 595–597. Portico. https://doi.org/10.1111/cge.12333

Martín-García, F., Mendieta-Moreno, J. I., Marcos-Alcalde, Í., Gómez-Puertas, P., & Mendieta, J. (2013). Simulation of Catalytic Water Activation in Mitochondrial F1-ATPase Using a Hybrid Quantum Mechanics/Molecular Mechanics Approach: An Alternative Role for β-Glu 188. Biochemistry, 52(5), 959–966. https://doi.org/10.1021/bi301109x

Perteguer, M. J., Gómez-Puertas, P., Cañavate, C., Dagger, F., Gárate, T., & Valdivieso, E. (2013). Ddi1-like protein from Leishmania major is an active aspartyl proteinase. Cell Stress and Chaperones, 18(2), 171–181. https://doi.org/10.1007/s12192-012-0368-9

Puisac, B., Teresa-Rodrigo, M. E., Arnedo, M., Gil-Rodríguez, M. C., Pérez-Cerdá, C., Ribes, A., Pié, Á., Bueno, G., Gómez-Puertas, P., & Pié, J. (2013). Analysis of aberrant splicing and nonsense-mediated decay of the stop codon mutations c.109G>T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency. Molecular Genetics and Metabolism, 108(4), 232–240. https://doi.org/10.1016/j.ymgme.2013.01.019

Ramos, M., Menao, S., Arnedo, M., Puisac, B., Gil-Rodríguez, M. C., Teresa-Rodrigo, M. E., Hernández-Marcos, M., Pierre, G., Ramaswami, U., Baquero-Montoya, C., Bueno, G., Casale, C., Hegardt, F. G., Gómez-Puertas, P., & Pié, J. (2013). New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations. European Journal of Medical Genetics, 56(8), 411–415. https://doi.org/10.1016/j.ejmg.2013.05.008

Martín-García, F., Mendieta-Moreno, J. I., López-Viñas, E., Gómez-Puertas, P., & Mendieta, J. (2012). The Role of Gln61 in HRas GTP Hydrolysis: A Quantum Mechanics/Molecular Mechanics Study. Biophysical Journal, 102(1), 152–157. https://doi.org/10.1016/j.bpj.2011.11.4005

Martín-García, F., Mendieta-Moreno, J. I., Mendieta, J., & Gómez-Puertas, P. (2012). Molecular dynamics analysis of conformational change of paramyxovirus F protein during the initial steps of membrane fusion. Biochemical and Biophysical Research Communications, 420(1), 42–47. https://doi.org/10.1016/j.bbrc.2012.02.112

Martín-García, F., Mendieta-Moreno, J. I., López-Viñas, E., Gómez-Puertas, P., & Mendieta, J. (2012). Correction. Biophysical Journal, 102(5), 1234. https://doi.org/10.1016/j.bpj.2012.01.025

Martín-García, F., Salvarelli, E., Mendieta-Moreno, J. I., Vicente, M., Mingorance, J., Mendieta, J., & Gómez-Puertas, P. (2012). Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ. FEBS Letters, 586(8), 1236–1239. Portico. https://doi.org/10.1016/j.febslet.2012.03.042

Ahijado-Guzmán, R., Gómez-Puertas, P., Alvarez-Puebla, R. A., Rivas, G., & Liz-Marzán, L. M. (2012). Surface-Enhanced Raman Scattering-Based Detection of the Interactions between the Essential Cell Division FtsZ Protein and Bacterial Membrane Elements. ACS Nano, 6(8), 7514–7520. https://doi.org/10.1021/nn302825u

Matos, R. G., López-Viñas, E., Goméz-Puertas, P., & Arraiano, C. M. (2012). The only exoribonuclease present in Haloferax volcanii has an unique response to temperature changes. Biochimica et Biophysica Acta (BBA) - General Subjects, 1820(10), 1543–1552. https://doi.org/10.1016/j.bbagen.2012.06.009

González-Magaldi, M., Postigo, R., de la Torre, B. G., Vieira, Y. A., Rodríguez-Pulido, M., López-Viñas, E., Gómez-Puertas, P., Andreu, D., Kremer, L., Rosas, M. F., & Sobrino, F. (2012). Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity. Journal of Virology, 86(20), 11013–11023. https://doi.org/10.1128/jvi.00580-12

Arnedo, M., Menao, S., Puisac, B., Teresa-Rodrigo, M. E., Gil-Rodríguez, M. C., López-Viñas, E., Gómez-Puertas, P., Casals, N., Casale, C. H., Hegardt, F. G., & Pié, J. (2012). Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol. Journal of Lipid Research, 53(10), 2046–2056. https://doi.org/10.1194/jlr.m025700

Wesselink, J.-J., López-Camacho, E., de la Peña, S., Ramos-Ruiz, R., Ruiz-Carrascoso, G., Lusa-Bernal, S., Fernández-Soria, V. M., Gómez-Gil, R., Gomez-Puertas, P., & Mingorance, J. (2012). Genome Sequence of OXA-48 Carbapenemase-Producing Klebsiella pneumoniae KpO3210. Journal of Bacteriology, 194(24), 6981–6981. https://doi.org/10.1128/jb.01897-12

López, E., Wesselink, J.-J., López, I., Mendieta, J., Gómez-Puertas, P., & Muñoz, S. (2011). Technical phosphoproteomic and bioinformatic tools useful in cancer research. Journal of Clinical Bioinformatics, 1(1), 26. https://doi.org/10.1186/2043-9113-1-26

Oroz, J., Valbuena, A., Vera, A. M., Mendieta, J., Gómez-Puertas, P., & Carrión-Vázquez, M. (2011). Nanomechanics of the Cadherin Ectodomain. Journal of Biological Chemistry, 286(11), 9405–9418. https://doi.org/10.1074/jbc.m110.170399

Matos, R. G., Barbas, A., Gómez‐Puertas, P., & Arraiano, C. M. (2011). Swapping the domains of exoribonucleases RNase II and RNase R: Conferring upon RNase II the ability to degrade ds RNA. Proteins: Structure, Function, and Bioinformatics, 79(6), 1853–1867. Portico. https://doi.org/10.1002/prot.23010

Puisac, B., Ramos, M., Arnedo, M., Menao, S., Gil-Rodríguez, M. C., Teresa-Rodrigo, M. E., Pié, A., de Karam, J. C., Wesselink, J.-J., Giménez, I., Ramos, F. J., Casals, N., Gómez-Puertas, P., Hegardt, F. G., & Pié, J. (2011). Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway. Molecular Biology Reports, 39(4), 4777–4785. https://doi.org/10.1007/s11033-011-1270-8

Hurtado, C., Bustos, M. J., Granja, A. G., de León, P., Sabina, P., López-Viñas, E., Gómez-Puertas, P., Revilla, Y., & Carrascosa, A. L. (2010). The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens. Archives of Virology, 156(2), 219–234. https://doi.org/10.1007/s00705-010-0846-2

Pié, J., Gil‐Rodríguez, M. C., Ciero, M., López‐Viñas, E., Ribate, M. P., Arnedo, M., Deardorff, M. A., Puisac, B., Legarreta, J., de Karam, J. C., Rubio, E., Bueno, I., Baldellou, A., Calvo, M. T., Casals, N., Olivares, J. L., Losada, A., Hegardt, F. G., Krantz, I. D., … Ramos, F. J. (2010). Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome. American Journal of Medical Genetics Part A, 152A(4), 924–929. Portico. https://doi.org/10.1002/ajmg.a.33348

Romanelli, V., Belinchón, A., Benito‐Sanz, S., Martínez‐Glez, V., Gracia‐Bouthelier, R., Heath, K. E., Campos‐Barros, A., García‐Miñaur, S., Fernandez, L., Meneses, H., López‐Siguero, J. P., Guillén‐Navarro, E., Gómez‐Puertas, P., Wesselink, J., Mercado, G., Esteban‐Marfil, V., Palomo, R., Mena, R., Sánchez, A., … Lapunzina, P. (2010). CDKN1C (p57Kip2) analysis in Beckwith–Wiedemann syndrome (BWS) patients: Genotype–phenotype correlations, novel mutations, and polymorphisms. American Journal of Medical Genetics Part A, 152A(6), 1390–1397. Portico. https://doi.org/10.1002/ajmg.a.33453

Mingorance, J., Rivas, G., Vélez, M., Gómez-Puertas, P., & Vicente, M. (2010). Strong FtsZ is with the force: mechanisms to constrict bacteria. Trends in Microbiology, 18(8), 348–356. https://doi.org/10.1016/j.tim.2010.06.001

Magro, M., Andreu, D., Gómez-Puertas, P., Melero, J. A., & Palomo, C. (2010). Neutralization of Human Respiratory Syncytial Virus Infectivity by Antibodies and Low-Molecular-Weight Compounds Targeted against the Fusion Glycoprotein. Journal of Virology, 84(16), 7970–7982. https://doi.org/10.1128/jvi.00447-10

Menao, S., López-Viñas, E., Mir, C., Puisac, B., Gratacós, E., Arnedo, M., Carrasco, P., Moreno, S., Ramos, M., Gil, M. C., Pié, Á., Ribes, A., Pérez-Cerda, C., Ugarte, M., Clayton, P. T., Korman, S. H., Serra, D., Asins, G., Ramos, F. J., … Pié, J. (2009). Ten novelHMGCLmutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria. Human Mutation, 30(3), E520–E529. Portico. https://doi.org/10.1002/humu.20966

Mera, P., Bentebibel, A., López-Viñas, E., Cordente, A. G., Gurunathan, C., Sebastián, D., Vázquez, I., Herrero, L., Ariza, X., Gómez-Puertas, P., Asins, G., Serra, D., García, J., & Hegardt, F. G. (2009). C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight. Biochemical Pharmacology, 77(6), 1084–1095. https://doi.org/10.1016/j.bcp.2008.11.020

Mendieta, J., Rico, A. I., López-Viñas, E., Vicente, M., Mingorance, J., & Gómez-Puertas, P. (2009). Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin. Journal of Molecular Biology, 390(1), 17–25. https://doi.org/10.1016/j.jmb.2009.05.018

Barbas, A., Matos, R. G., Amblar, M., López-Viñas, E., Gomez-Puertas, P., & Arraiano, C. M. (2009). Determination of Key Residues for Catalysis and RNA Cleavage Specificity. Journal of Biological Chemistry, 284(31), 20486–20498. https://doi.org/10.1074/jbc.m109.020693

Atrian, S., López‐Viñas, E., Gómez‐Puertas, P., Chabás, A., Vilageliu, L., & Grinberg, D. (2008). An evolutionary and structure‐based docking model for glucocerebrosidase–saposin C and glucocerebrosidase–substrate interactions—Relevance for Gaucher disease. Proteins: Structure, Function, and Bioinformatics, 70(3), 882–891. Portico. https://doi.org/10.1002/prot.21554

Asenjo, A., Mendieta, J., Gómez-Puertas, P., & Villanueva, N. (2008). Residues in human respiratory syncytial virus P protein that are essential for its activity on RNA viral synthesis. Virus Research, 132(1–2), 160–173. https://doi.org/10.1016/j.virusres.2007.11.013

Barbas, A., Matos, R. G., Amblar, M., López-Viñas, E., Gomez-Puertas, P., & Arraiano, C. M. (2008). New Insights into the Mechanism of RNA Degradation by Ribonuclease II. Journal of Biological Chemistry, 283(19), 13070–13076. https://doi.org/10.1074/jbc.m709989200

Cuéllar, J., Martín-Benito, J., Scheres, S. H. W., Sousa, R., Moro, F., López-Viñas, E., Gómez-Puertas, P., Muga, A., Carrascosa, J. L., & Valpuesta, J. M. (2008). The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Nature Structural & Molecular Biology, 15(8), 858–864. https://doi.org/10.1038/nsmb.1464

Llorente, M. T., Taylor, I. A., López‐Viñas, E., Gomez‐Puertas, P., Calder, L. J., García‐Barreno, B., & Melero, J. A. (2008). Structural properties of the human respiratory syncytial virus P protein: Evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors. Proteins: Structure, Function, and Bioinformatics, 72(3), 946–958. Portico. https://doi.org/10.1002/prot.21988

Amblar, M., Barbas, A., Gomez-Puertas, P., & Arraiano, C. M. (2007). The role of the S1 domain in exoribonucleolytic activity: Substrate specificity and multimerization. RNA, 13(3), 317–327. https://doi.org/10.1261/rna.220407

Contreras, L., Gomez-Puertas, P., Iijima, M., Kobayashi, K., Saheki, T., & Satrústegui, J. (2007). Ca2+ Activation Kinetics of the Two Aspartate-Glutamate Mitochondrial Carriers, Aralar and Citrin. Journal of Biological Chemistry, 282(10), 7098–7106. https://doi.org/10.1074/jbc.m610491200

Agirrezabala, X., Velázquez-Muriel, J. A., Gómez-Puertas, P., Scheres, S. H. W., Carazo, J. M., & Carrascosa, J. L. (2007). Quasi-Atomic Model of Bacteriophage T7 Procapsid Shell: Insights into the Structure and Evolution of a Basic Fold. Structure, 15(4), 461–472. https://doi.org/10.1016/j.str.2007.03.004

Cava, F., Laptenko, O., Borukhov, S., Chahlafi, Z., Blas‐Galindo, E., Gómez‐Puertas, P., & Berenguer, J. (2007). Control of the respiratory metabolism of Thermus thermophilus by the nitrate respiration conjugative element NCE. Molecular Microbiology, 64(3), 630–646. Portico. https://doi.org/10.1111/j.1365-2958.2007.05687.x

López-Viñas, E., Bentebibel, A., Gurunathan, C., Morillas, M., de Arriaga, D., Serra, D., Asins, G., Hegardt, F. G., & Gómez-Puertas, P. (2007). Definition by Functional and Structural Analysis of Two Malonyl-CoA Sites in Carnitine Palmitoyltransferase 1A. Journal of Biological Chemistry, 282(25), 18212–18224. https://doi.org/10.1074/jbc.m700885200

Carrasco, P., Menao, S., López-Viñas, E., Santpere, G., Clotet, J., Sierra, A. Y., Gratacós, E., Puisac, B., Gómez-Puertas, P., Hegardt, F. G., Pie, J., & Casals, N. (2007). C-Terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity. Molecular Genetics and Metabolism, 91(2), 120–127. https://doi.org/10.1016/j.ymgme.2007.03.007

Pié, J., López-Viñas, E., Puisac, B., Menao, S., Pié, A., Casale, C., Ramos, F. J., Hegardt, F. G., Gómez-Puertas, P., & Casals, N. (2007). Molecular genetics of HMG-CoA lyase deficiency. Molecular Genetics and Metabolism, 92(3), 198–209. https://doi.org/10.1016/j.ymgme.2007.06.020

Ortiz, A., Gomez-Puertas, P., Leo-Macias, A., Lopez-Romero, P., Lopez-Vinas, E., Morreale, A., Murcia, M., & Wang, K. (2006). Computational Approaches to Model Ligand Selectivity in Drug Design. Current Topics in Medicinal Chemistry, 6(1), 41–55. https://doi.org/10.2174/156802606775193338

Mir, C., Lopez‐Viñas, E., Aledo, R., Puisac, B., Rizzo, C., Dionisi‐Vici, C., Deodato, F., Pié, J., Gomez‐Puertas, P., Hegardt, F. G., & Casals, N. (2006). A single‐residue mutation, G203E, causes 3‐hydroxy‐3‐methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG‐CoA lyase. Journal of Inherited Metabolic Disease, 29(1), 64–70. Portico. https://doi.org/10.1007/s10545-006-0138-x

Bentebibel, A., Sebastián, D., Herrero, L., López-Viñas, E., Serra, D., Asins, G., Gómez-Puertas, P., & Hegardt, F. G. (2006). Novel Effect of C75 on Carnitine Palmitoyltransferase I Activity and Palmitate Oxidation. Biochemistry, 45(14), 4339–4350. https://doi.org/10.1021/bi052186q

Cordente, A. G., López-Viñas, E., Vázquez, M. I., Gómez-Puertas, P., Asins, G., Serra, D., & Hegardt, F. G. (2006). Mutagenesis of Specific Amino Acids Converts Carnitine Acetyltransferase into Carnitine Palmitoyltransferase. Biochemistry, 45(19), 6133–6141. https://doi.org/10.1021/bi0602664

Rodríguez-Pombo, P., Navarrete, R., Merinero, B., Gómez-Puertas, P., & Ugarte, M. (2006). Mutational spectrum of maple syrup urine disease in Spain. Human Mutation, 27(7), 715–715. https://doi.org/10.1002/humu.9428

Puisac, B., López-Viñas, E., Moreno, S., Mir, C., Pérez-Cerdá, C., Menao, S., Lluch, D., Pié, A., Gómez-Puertas, P., Casals, N., Ugarte, M., Hegardt, FaustoG., & Pié, J. (2005). Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM Barrel model of HL. Biophysical Chemistry, 115(2–3), 241–245. https://doi.org/10.1016/j.bpc.2004.12.031

Tress, M., de Juan, D., Graña, O., Gómez, M. J., Gómez‐Puertas, P., González, J. M., López, G., & Valencia, A. (2005). Scoring docking models with evolutionary information. Proteins: Structure, Function, and Bioinformatics, 60(2), 275–280. Portico. https://doi.org/10.1002/prot.20570

Pérez, B., Desviat, L. R., Gómez-Puertas, P., Martínez, A., Stevens, R. C., & Ugarte, M. (2005). Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients. Molecular Genetics and Metabolism, 86, 11–16. https://doi.org/10.1016/j.ymgme.2005.06.009

Gómez‐Puertas, P., Martín‐Benito, J., Carrascosa, J. L., Willison, K. R., & Valpuesta, J. M. (2004). The substrate recognition mechanisms in chaperonins. Journal of Molecular Recognition, 17(2), 85–94. Portico. https://doi.org/10.1002/jmr.654

Gil, J., García, M. A., Gomez-Puertas, P., Guerra, S., Rullas, J., Nakano, H., Alcamí, J., & Esteban, M. (2004). TRAF Family Proteins Link PKR with NF-κB Activation. Molecular and Cellular Biology, 24(10), 4502–4512. https://doi.org/10.1128/mcb.24.10.4502-4512.2004

MORILLAS, M., LÓPEZ-VIÑAS, E., VALENCIA, A., SERRA, D., GÓMEZ-PUERTAS, P., HEGARDT, F. G., & ASINS, G. (2004). Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochemical Journal, 379(3), 777–784. https://doi.org/10.1042/bj20031373

Cordente, A. G., López-Viñas, E., Vázquez, M. I., Swiegers, J. H., Pretorius, I. S., Gómez-Puertas, P., Hegardt, F. G., Asins, G., & Serra, D. (2004). Redesign of Carnitine Acetyltransferase Specificity by Protein Engineering. Journal of Biological Chemistry, 279(32), 33899–33908. https://doi.org/10.1074/jbc.m402685200

Gomez‐Puertas, P., & Valencia, A. (2003). ESF programme on ‘Integrated Approaches for Functional Genomics’ workshop on ‘Modelling of Molecular Networks.’ Comparative and Functional Genomics, 4(1), 144–147. Portico. https://doi.org/10.1002/cfg.224

Morillas, M., Gómez-Puertas, P., Bentebibel, A., Sellés, E., Casals, N., Valencia, A., Hegardt, F. G., Asins, G., & Serra, D. (2003). Identification of Conserved Amino Acid Residues in Rat Liver Carnitine Palmitoyltransferase I Critical for Malonyl-CoA Inhibition. Journal of Biological Chemistry, 278(11), 9058–9063. https://doi.org/10.1074/jbc.m209999200

Casals, N., Gómez-Puertas, P., Pié, J., Mir, C., Roca, R., Puisac, B., Aledo, R., Clotet, J., Menao, S., Serra, D., Asins, G., Till, J., Elias-Jones, A. C., Cresto, J. C., Chamoles, N. A., Abdenur, J. E., Mayatepek, E., Besley, G., Valencia, A., & Hegardt, F. G. (2003). Structural (βα)8 TIM Barrel Model of 3-Hydroxy-3-methylglutaryl-Coenzyme A Lyase. Journal of Biological Chemistry, 278(31), 29016–29023. https://doi.org/10.1074/jbc.m304276200

González, J. M., Gomez-Puertas, P., Cavanagh, D., Gorbalenya, A. E., & Enjuanes, L. (2003). A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Archives of Virology, 148(11), 2207–2235. https://doi.org/10.1007/s00705-003-0162-1

S�nchez-Torres, C., G�mez-Puertas, P., G�mez-del-Moral, M., Alonso, F., Escribano, J. M., Ezquerra, A., & Dom�nguez, J. (2003). Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Archives of Virology, 148(12), 2307–2323. https://doi.org/10.1007/s00705-003-0188-4

Morillas, M., Gómez-Puertas, P., Rubı́, B., Clotet, J., Ariño, J., Valencia, A., Hegardt, F. G., Serra, D., & Asins, G. (2002). Structural Model of a Malonyl-CoA-binding Site of Carnitine Octanoyltransferase and Carnitine Palmitoyltransferase I. Journal of Biological Chemistry, 277(13), 11473–11480. https://doi.org/10.1074/jbc.m111628200

Valpuesta, J. M., Martı́n-Benito, J., Gómez-Puertas, P., Carrascosa, J. L., & Willison, K. R. (2002). Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT. FEBS Letters, 529(1), 11–16. Portico. https://doi.org/10.1016/s0014-5793(02)03180-0

Martin-Benito, J. (2002). Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. The EMBO Journal, 21(23), 6377–6386. https://doi.org/10.1093/emboj/cdf640

Carettoni, D., Gómez‐Puertas, P., Yim, L., Mingorance, J., Massidda, O., Vicente, M., Valencia, A., Domenici, E., & Anderluzzi, D. (2002). Phage‐display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA. Proteins: Structure, Function, and Bioinformatics, 50(2), 192–206. Portico. https://doi.org/10.1002/prot.10244

Barderas, M. G., Rodríguez, F., Gómez-Puertas, P., Avilés, M., Beitia, F., Alonso, C., & Escribano, J. M. (2001). Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins. Archives of Virology, 146(9), 1681–1691. https://doi.org/10.1007/s007050170056

Bullido, R., Gómez-Puertas, P., Saiz, M. J., & Portela, A. (2001). Influenza A Virus NEP (NS2 Protein) Downregulates RNA Synthesis of Model Template RNAs. Journal of Virology, 75(10), 4912–4917. https://doi.org/10.1128/jvi.75.10.4912-4917.2001

Mingorance, J., Rueda, S., Gómez‐Puertas, P., Valencia, A., & Vicente, M. (2001). Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover. Molecular Microbiology, 41(1), 83–91. Portico. https://doi.org/10.1046/j.1365-2958.2001.02498.x

Llorca, O., Martín-Benito, J., Gómez-Puertas, P., Ritco-Vonsovici, M., Willison, K. R., Carrascosa, J. L., & Valpuesta, J. M. (2001). Analysis of the Interaction between the Eukaryotic Chaperonin CCT and Its Substrates Actin and Tubulin. Journal of Structural Biology, 135(2), 205–218. https://doi.org/10.1006/jsbi.2001.4359

Morillas, M., Gómez-Puertas, P., Roca, R., Serra, D., Asins, G., Valencia, A., & Hegardt, F. G. (2001). Structural Model of the Catalytic Core of Carnitine Palmitoyltransferase I and Carnitine Octanoyltransferase (COT). Journal of Biological Chemistry, 276(48), 45001–45008. https://doi.org/10.1074/jbc.m106920200

Bullido, R., Gómez-Puertas, P., Albo, C., & Portela, A. (2000). Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoprotein. Microbiology, 81(1), 135–142. https://doi.org/10.1099/0022-1317-81-1-135

Gómez-Puertas, P., Leahy, M. B., Nuttall, P. A., & Portela, A. (2000). Rescue of synthetic RNAs into Thogoto and influenza A virus particles using core proteins purified from Thogoto virus. Virus Research, 67(1), 41–48. https://doi.org/10.1016/s0168-1702(00)00127-1

Gómez-Puertas, P., Albo, C., Pérez-Pastrana, E., Vivo, A., & Portela, A. (2000). Influenza Virus Matrix Protein Is the Major Driving Force in Virus Budding. Journal of Virology, 74(24), 11538–11547. https://doi.org/10.1128/jvi.74.24.11538-11547.2000

G√≥mez-Puertas, P., Mena, I., Castillo, M., Vivo, A., P√©rez-Pastrana, E., & Portela, A. (1999). Efficient formation of influenza virus-like particles: dependence on the expression levels of viral proteins. Journal of General Virology, 80(7), 1635–1645. https://doi.org/10.1099/0022-1317-80-7-1635

Fabregas, J., Garcı́a, D., Fernandez-Alonso, M., Rocha, A. I., Gómez-Puertas, P., Escribano, J. M., Otero, A., & Coll, J. M. (1999). In vitro inhibition of the replication of haemorrhagic septicaemia virus (VHSV) and African swine fever virus (ASFV) by extracts from marine microalgae. Antiviral Research, 44(1), 67–73. https://doi.org/10.1016/s0166-3542(99)00049-2

Gómez-Puertas, P., Oviedo, J. M., Rodrı́guez, F., Coll, J., & Escribano, J. M. (1997). Neutralization Susceptibility of African Swine Fever Virus Is Dependent on the Phospholipid Composition of Viral Particles. Virology, 228(2), 180–189. https://doi.org/10.1006/viro.1996.8391

Oviedo, J. M., Rodriguez, F., Gómez-Puertas, P., Brun, A., Gómez, N., Alonso, C., & Escribano, J. M. (1997). High level expression of the major antigenic African swine fever virus proteins p54 and p30 in baculovirus and their potential use as diagnostic reagents. Journal of Virological Methods, 64(1), 27–35. https://doi.org/10.1016/s0166-0934(96)02140-4

Gómez-Puertas, P., & Escribano, J. M. (1997). Blocking antibodies inhibit complete African swine fever virus neutralization. Virus Research, 49(2), 115–122. https://doi.org/10.1016/s0168-1702(97)01463-9

Gómez-Puertas, P., Rodríguez, F., Oviedo, J. M., Ramiro-Ibáñez, F., Ruiz-Gonzalvo, F., Alonso, C., & Escribano, J. M. (1996). Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization. Journal of Virology, 70(8), 5689–5694. https://doi.org/10.1128/jvi.70.8.5689-5694.1996

Rodriguez, F., Ley, V., Gómez-Puertas, P., García, R., Rodriguez, JoséF., & Escribano, JoséM. (1996). The structural protein p54 is essential for African swine fever virus viability. Virus Research, 40(2), 161–167. https://doi.org/10.1016/0168-1702(95)01268-0

Gómez-Puertas, P., Rodríguez, F., Ortega, A., Oviedo, J. M., Alonso, C., & Escribano, J. M. (1995). Improvement of African swine fever virus neutralization assay using recombinant viruses expressing chromogenic marker genes. Journal of Virological Methods, 55(2), 271–279. https://doi.org/10.1016/0166-0934(95)00055-y

Blanco, P., Huidobro, A., Villalba, M., Gómez-Puertas, P., Bogónez, E., Pereira, R., Martínez-Serrano, A., Aparicio, J. J., & Satrústegui, J. (1994). The activity of synaptosomal calcium channels is inversely correlated with working memory performance in memory impaired, aged rats. Neuroscience Letters, 165(1–2), 5–8. https://doi.org/10.1016/0304-3940(94)90696-3

Huidobro, A., Blanco, P., Villalba, M., Gómez-Puertas, P., Villa, A., Pereira, R., Bogónez, E., Martínez-Serrano, A., Aparicio, J. J., & Satrústegui, J. (1993). Age-related changes in calcium homeostatic mechanisms in synaptosomes in relation with working memory deficiency. Neurobiology of Aging, 14(5), 479–486. https://doi.org/10.1016/0197-4580(93)90106-l

Bogónez, E., Gómez-Puertas, P., & Satrústegui, J. (1992). Pyruvate dehydrogenase dephosphorylation in rat brain synaptosomes and mitochondria: Evidence for a calcium-mediated effect in response to depolarization, and variations due to ageing. Neuroscience Letters, 142(2), 123–127. https://doi.org/10.1016/0304-3940(92)90354-a

Gómez‐Puertas, P., Martínez‐Serrano, A., Blanco, P., Satrústegui, J., & Bogónez, E. (1991). Conditions Restricting Depolarization‐Dependent Calcium Influx in Synaptosomes Reveal a Graded Response of P96 Dephosphorylation and a Transient Dephosphorylation of P65. Journal of Neurochemistry, 56(6), 2039–2047. Portico. https://doi.org/10.1111/j.1471-4159.1991.tb03464.x

López-Viñas, E., & Gómez-Puertas, P. (n.d.). Sequence and structural alignments of eukaryotic and prokaryotic cytoskeletal proteins. Molecules in Time and Space, 155–172. https://doi.org/10.1007/0-306-48579-6_8

Mingorance, J., Rico, A., & GÓmez-Puertas, P. (n.d.). Bacterial morphogenes. Molecules in Time and Space, 173–194. https://doi.org/10.1007/0-306-48579-6_9


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