Detalle de: Optimizing the Synechococcus-driven microbial Consortia with biotechnological applications by using Systems and Synthetic Biology tools (SyCoSys)

PI: Juan Nogales (CNB-CSIC).

SyCoSys aims to dissect, streamline, and model the intricate energy and matter flows within engineered synthetic consortia, all while optimizing operational conditions within innovative microbial community-based bioreactors. By synergizing systems and synthetic biology methodologies, SyCoSys strives to yield mechanistic insights into the engineering of synthetic microbiomes. A pioneering feature of SyCoSys involves the development of a net-zero CO2 emissions bioprocess, leveraging engineered cyanobacteria to facilitate the conversion of CO2 into readily metabolizable sugars. In a continuous operation, the organic carbon produced by cyanobacteria will serve as nourishment for P. putida, acting as a specialized cell factory optimized for the overproduction of cyclic terpenoid precursors, essential components of terephthalic acid—an integral constituent of the widely utilized plastic, Polyethylene terephthalate (PET). Consequently, SyCoSys marks a significant stride towards the realization of Biobased-PET production.