Research topics: Amplicon Sequencing, Applications of Computational Biology, Computational Methods, Computational models and simulations, Genome Assembly, Genome Sequencing, Genomic Annotation, Genomics, Mapping, Metabolic modelling, Metagenomics, Metatranscriptomics, Microbial communities, Microbial Communities, Molecular evolution, Omics, Phylogenetic Analysis, RNA Sequencing (RNA-seq), Sequence analysis, Transcriptomics
Publications
Müller, M.-C., Wissink, M., Mukherjee, P., Von Possel, N., Laso-Pérez, R., Engilberge, S., Carpentier, P., Kahnt, J., Wegener, G., Welte, C., & Wagner, T. (2025). Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal extensive post-translational modifications. https://doi.org/10.1101/2025.01.10.632498
Woods, P. H., Speth, D. R., Laso-Pérez, R., Utter, D. R., Ruff, S. E., & Orphan, V. J. (2025). Identification of key steps in the evolution of anaerobic methanotrophy in
Candidatus
Methanovorans (ANME-3) archaea. Science Advances, 11(25). https://doi.org/10.1126/sciadv.adq5232
Laso Pérez, R., Santisteban, J. R., Fernandez-Gonzalez, N., Mundy, C. J., Tamames, J., & Pedrós-Alió, C. (2024). Nitrogen cycling during an Arctic bloom: from chemolithotrophy to nitrogen assimilation. https://doi.org/10.1101/2024.02.27.582273
Rivas-Santisteban, J., Fernández-González, N., Laso-Pérez, R., Tamames, J., & Pedrós-Alió, C. (2024). Picoplankton nitrogen guilds in the tropical and subtropical oceans: from the surface to the deep. https://doi.org/10.1101/2024.03.05.583471
Woods, P. H., Speth, D. R., Laso-Pérez, R., Utter, D. R., Ruff, S. E., & Orphan, V. J. (2024). Convergence and horizontal gene transfer drive the evolution of anaerobic methanotrophy in archaea. https://doi.org/10.1101/2024.05.23.595608
Laso-Pérez, R., Wu, F., Crémière, A., Speth, D. R., Magyar, J. S., Zhao, K., Krupovic, M., & Orphan, V. J. (2023). Evolutionary diversification of methanotrophic ANME-1 archaea and their expansive virome. Nature Microbiology, 8(2), 231–245. https://doi.org/10.1038/s41564-022-01297-4
Zehnle, H., Laso-Pérez, R., Lipp, J., Riedel, D., Benito Merino, D., Teske, A., & Wegener, G. (2023). Candidatus Alkanophaga archaea from Guaymas Basin hydrothermal vent sediment oxidize petroleum alkanes. Nature Microbiology, 8(7), 1199–1212. https://doi.org/10.1038/s41564-023-01400-3
Molari, M., Hassenrueck, C., Laso-Pérez, R., Wegener, G., Offre, P., Scilipoti, S., & Boetius, A. (2023). A hydrogenotrophic Sulfurimonas is globally abundant in deep-sea oxygen-saturated hydrothermal plumes. Nature Microbiology, 8(4), 651–665. https://doi.org/10.1038/s41564-023-01342-w
Fernandez-Guerra, A., Wörmer, L., Borrel, G., Delmont, T. O., Elberling, B., Elvert, M., Eren, A. M., Gribaldo, S., Henriksen, R. A., Hinrichs, K.-U., Jochheim, A., Korneliussen, T. S., Krupovic, M., Larsen, N. K., Perez-Laso, R., Pedersen, M. W., Pedersen, V. K., Ruter, A. H., Sand, K. K., … Willerslev, E. (2023). Two-million-year-old microbial communities from the Kap København Formation in North Greenland. https://doi.org/10.1101/2023.06.10.544454
Murali, R., Yu, H., Speth, D. R., Wu, F., Metcalfe, K. S., Crémière, A., Laso-Pèrez, R., Malmstrom, R. R., Goudeau, D., Woyke, T., Hatzenpichler, R., Chadwick, G. L., & Orphan, V. J. (2022). Physiological adaptation of sulfate reducing bacteria in syntrophic partnership with anaerobic methanotrophic archaea. https://doi.org/10.1101/2022.11.23.517749
Wegener, G., Laso-Pérez, R., Orphan, V. J., & Boetius, A. (2022). Anaerobic Degradation of Alkanes by Marine Archaea. Annual Review of Microbiology, 76(1), 553–577. https://doi.org/10.1146/annurev-micro-111021-045911
Laso-Pérez, R., Wu, F., Crémière, A., Speth, D. R., Magyar, J. S., Krupovic, M., & Orphan, V. J. (2022). Evolutionary Diversification of MethanotrophicCa. Methanophagales (ANME-1) and Their Expansive Virome. https://doi.org/10.1101/2022.07.04.498658
Zehnle, H., Laso-Pérez, R., Lipp, J., Teske, A., & Wegener, G. (2022). Candidatus Alkanophaga archaea from heated hydrothermal vent sediment oxidize petroleum alkanes. https://doi.org/10.21203/rs.3.rs-2096998/v1
Chadwick, G. L., Skennerton, C. T., Laso-Pérez, R., Leu, A. O., Speth, D. R., Yu, H., Morgan-Lang, C., Hatzenpichler, R., Goudeau, D., Malmstrom, R., Brazelton, W. J., Woyke, T., Hallam, S. J., Tyson, G. W., Wegener, G., Boetius, A., & Orphan, V. J. (2021). Comparative genomics reveals electron transfer and syntrophic mechanisms differentiating methanotrophic and methanogenic archaea. https://doi.org/10.1101/2021.09.25.461819
Zhou, Z., Zhang, C., Liu, P., Fu, L., Laso-Pérez, R., Yang, L., Bai, L., Li, J., Yang, M., Lin, J., Wang, W., Wegener, G., Li, M., & Cheng, L. (2021). Non-syntrophic methanogenic hydrocarbon degradation by an archaeal species. Nature, 601(7892), 257–262. https://doi.org/10.1038/s41586-021-04235-2
Hoffmann, K., Bienhold, C., Buttigieg, P. L., Knittel, K., Laso-Pérez, R., Rapp, J. Z., Boetius, A., & Offre, P. (2020). Diversity and metabolism of Woeseiales bacteria, global members of marine sediment communities. The ISME Journal, 14(4), 1042–1056. https://doi.org/10.1038/s41396-020-0588-4
Hahn, C. J., Laso-Pérez, R., Vulcano, F., Vaziourakis, K.-M., Stokke, R., Steen, I. H., Teske, A., Boetius, A., Liebeke, M., Amann, R., Knittel, K., & Wegener, G. (2020). CandidatusEthanoperedens, a thermophilic genus of archaea mediating the anaerobic oxidation of ethane. https://doi.org/10.1101/2020.03.21.999862
Hahn, C. J., Laso-Pérez, R., Vulcano, F., Vaziourakis, K.-M., Stokke, R., Steen, I. H., Teske, A., Boetius, A., Liebeke, M., Amann, R., Knittel, K., & Wegener, G. (2020). “
Candidatus
Ethanoperedens,” a Thermophilic Genus of
Archaea
Mediating the Anaerobic Oxidation of Ethane. MBio, 11(2). https://doi.org/10.1128/mbio.00600-20
Laso-Pérez, R., Hahn, C., van Vliet, D. M., Tegetmeyer, H. E., Schubotz, F., Smit, N. T., Pape, T., Sahling, H., Bohrmann, G., Boetius, A., Knittel, K., & Wegener, G. (2019). Anaerobic Degradation of Non-Methane Alkanes by “
Candidatus
Methanoliparia” in Hydrocarbon Seeps of the Gulf of Mexico. MBio, 10(4). https://doi.org/10.1128/mbio.01814-19
Laso-Pérez, R., Krukenberg, V., Musat, F., & Wegener, G. (2018). Establishing anaerobic hydrocarbon-degrading enrichment cultures of microorganisms under strictly anoxic conditions. Nature Protocols, 13(6), 1310–1330. https://doi.org/10.1038/nprot.2018.030
Laso-Pérez, R., Wegener, G., Knittel, K., Widdel, F., Harding, K. J., Krukenberg, V., Meier, D. V., Richter, M., Tegetmeyer, H. E., Riedel, D., Richnow, H.-H., Adrian, L., Reemtsma, T., Lechtenfeld, O. J., & Musat, F. (2016). Thermophilic archaea activate butane via alkyl-coenzyme M formation. Nature, 539(7629), 396–401. https://doi.org/10.1038/nature20152
