Genome dynamics and function

Institution: Centro de Biología Molecular Severo Ochoa (CBM)

Members (researchers): Alicia Gallego Jiménez

Home page: https://www.cbm.uam.es/index.php/programas-cientificos/dinamica-y-funcion-del-genoma/?lang=es
Contact email: cgutierrez@cbm.csic.es

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Research topics:

Epigenomics, Green Computing, Machine Learning in Biology, Sequence analysis, Transcriptomics

Publications

Matamoros-Recio, A., Merino, J., Gallego-Jiménez, A., Conde-Alvarez, R., Fresno, M., & Martín-Santamaría, S. (2023). Immune evasion through Toll-like receptor 4: The role of the core oligosaccharides from α2-Proteobacteria atypical lipopolysaccharides. Carbohydrate Polymers, 318, 121094. https://doi.org/10.1016/j.carbpol.2023.121094

Francisco, S., Billod, J.-M., Merino, J., Punzón, C., Gallego, A., Arranz, A., Martin-Santamaria, S., & Fresno, M. (2022). Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.748303

Villegas-Mirón, P., Gallego, A., Bertranpetit, J., Laayouni, H., & Espinosa-Parrilla, Y. (2022). Signatures of genetic variation in human microRNAs point to processes of positive selection and population-specific disease risks. Human Genetics, 141(10), 1673–1693. https://doi.org/10.1007/s00439-021-02423-8

Gallego, A., Fernández-Justel, J. M., Martín-Vírgala, S., Maslon, M. M., & Gómez, M. (2022). Slow RNAPII Transcription Elongation Rate, Low Levels of RNAPII Pausing, and Elevated Histone H1 Content at Promoters Associate with Higher m6A Deposition on Nascent mRNAs. Genes, 13(9), 1652. https://doi.org/10.3390/genes13091652

Gallego, A., Hartasánchez, D. A., Brasó-Vives, M., Garcia-Ramallo, E., Lopez-Valenzuela, M., Baena, N., Guitart, M., Fernández-Bellon, H., Kondova, I., Bontrop, R., Kawahara, Y., & Espinosa-Parrilla, Y. (2017). RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin. Gene, 628, 109–116. https://doi.org/10.1016/j.gene.2017.07.032

Gallego, A., Melé, M., Balcells, I., García-Ramallo, E., Torruella-Loran, I., Fernández-Bellon, H., Abelló, T., Kondova, I., Bontrop, R., Hvilsom, C., Navarro, A., Marquès-Bonet, T., & Espinosa-Parrilla, Y. (2016). Functional Implications of Human-Specific Changes in Great Ape microRNAs. PLOS ONE, 11(4), e0154194. https://doi.org/10.1371/journal.pone.0154194

Torruella-Loran, I., Laayouni, H., Dobon, B., Gallego, A., Balcells, I., Garcia-Ramallo, E., & Espinosa-Parrilla, Y. (2016). MicroRNA Genetic Variation: From Population Analysis to Functional Implications of Three Allele Variants Associated with Cancer. Human Mutation, 37(10), 1060–1073. Portico. https://doi.org/10.1002/humu.23045

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