We study microbial pathogens of relevance in global public health in the context of their host and disease integrating omics data from an evolutionary perspective. Our main goal is to understand the basis of virulence in a given host, for a better understanding of the virulence of the pathogen. Our research addresses the two most deadliest pathogens worldwide: Mycobacterium tuberculosis and SARS-CoV-2.
Analysis packages (R, Python, etc.), Annotation tools, Bioinformatics education, Biological Databases, Containers Computing, Data Analysis, Evolutionary rates, Genome Assembly, Genome Sequencing, Genomic Annotation, Genomics, High-performance Computing, Mapping, Metabolic modelling, Metabolomics, Molecular evolution, Phylogenetic Analysis, Population genomics, RNA Sequencing (RNA-seq), Sequence Alignment, Sequence analysis, Statistical Methods for Biology, Variant calling, Workflow managers
Publications
Álvarez-Herrera, M., Ruiz-Rodriguez, P., Navarro-Domínguez, B., Zulaica, J., Grau, B., Bracho, M. A., Guerreiro, M., Aguilar-Gallardo, C., González-Candelas, F., Comas, I., Geller, R., & Coscollá, M. (2025). Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein. Virus Evolution, 11(1). https://doi.org/10.1093/ve/veaf015
Ruiz-Rodriguez, P., Caballer-Gual, M., Santamaria, G., Hiza, H., & Coscolla, M. (2024). Host-strain compatibility influences transcriptional responses inMycobacterium tuberculosisinfections. https://doi.org/10.1101/2024.05.21.595142
Álvarez-Herrera, M., Sevilla, J., Ruiz-Rodriguez, P., Vergara, A., Vila, J., Cano-Jiménez, P., González-Candelas, F., Comas, I., & Coscollá, M. (2024). VIPERA: Viral Intra-Patient Evolution Reporting and Analysis. Virus Evolution, 10(1). https://doi.org/10.1093/ve/veae018
Loperena-Barber, M., Elizalde-Bielsa, A., Salvador-Bescós, M., Ruiz-Rodríguez, P., Pellegrini, J. M., Renau-Mínguez, C., Lancaster, R., Zúñiga-Ripa, A., Iriarte, M., Bengoechea, J. A., Coscollá, M., Gorvel, J.-P., Moriyón, I., & Conde-Álvarez, R. (2024). “Phylogenomic insights into brucellaceae: The Pseudochrobactrum algeriensis case.” Infection, Genetics and Evolution, 123, 105625. https://doi.org/10.1016/j.meegid.2024.105625
Renau-Mínguez, C., Herrero-Abadía, P., Ruiz-Rodriguez, P., Sentandreu, V., Torrents, E., Chiner-Oms, Á., Torres-Puente, M., Comas, I., Julián, E., & Coscolla, M. (2023). Genomic analysis of Mycobacterium brumae sustains its nonpathogenic and immunogenic phenotype. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.982679
Cabañero-Navalon, M. D., Garcia-Bustos, V., Ruiz-Rodriguez, P., Comas, I., Coscollá, M., Martinez-Priego, L., Todolí, J., & Moral Moral, P. (2022). Persistent SARS-CoV-2 infection with repeated clinical recurrence in a patient with common variable immunodeficiency. Clinical Microbiology and Infection, 28(2), 308–310. https://doi.org/10.1016/j.cmi.2021.10.021
Ginex, T., Marco-Marín, C., Wieczór, M., Mata, C. P., Krieger, J., Ruiz-Rodriguez, P., López-Redondo, M. L., Francés-Gómez, C., Melero, R., Sánchez-Sorzano, C. Ó., Martínez, M., Gougeard, N., Forcada-Nadal, A., Zamora-Caballero, S., Gozalbo-Rovira, R., Sanz-Frasquet, C., Arranz, R., Bravo, J., Rubio, V., … Carazo, J.-M. (2022). The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation. PLOS Pathogens, 18(7), e1010631. https://doi.org/10.1371/journal.ppat.1010631
Santamaria, G., Ruiz-Rodriguez, P., Renau-Mínguez, C., Pinto, F. R., & Coscollá, M. (2022). In Silico Exploration of Mycobacterium tuberculosis Metabolic Networks Shows Host-Associated Convergent Fluxomic Phenotypes. Biomolecules, 12(3), 376. https://doi.org/10.3390/biom12030376
Hodcroft, E. B., Zuber, M., Nadeau, S., Vaughan, T. G., Crawford, K. H. D., Althaus, C. L., Reichmuth, M. L., Bowen, J. E., Walls, A. C., Corti, D., Bloom, J. D., Veesler, D., Mateo, D., Hernando, A., Comas, I., González-Candelas, F., González-Candelas, F., Goig, G. A., … Neher, R. A. (2021). Spread of a SARS-CoV-2 variant through Europe in the summer of 2020. Nature, 595(7869), 707–712. https://doi.org/10.1038/s41586-021-03677-y
López, M. G., Chiner-Oms, Á., García de Viedma, D., Ruiz-Rodriguez, P., Bracho, M. A., Cancino-Muñoz, I., D’Auria, G., de Marco, G., García-González, N., Goig, G. A., Gómez-Navarro, I., Jiménez-Serrano, S., Martinez-Priego, L., Ruiz-Hueso, P., Ruiz-Roldán, L., Torres-Puente, M., Alberola, J., Albert, E., Aranzamendi Zaldumbide, M., … Comas, I. (2021). The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant. Nature Genetics, 53(10), 1405–1414. https://doi.org/10.1038/s41588-021-00936-6
Ruiz-Rodriguez, P., Francés-Gómez, C., Chiner-Oms, Á., López, M. G., Jiménez-Serrano, S., Cancino-Muñoz, I., Ruiz-Hueso, P., Torres-Puente, M., Bracho, M. A., D’Auria, G., Martinez-Priego, L., Guerreiro, M., Montero-Alonso, M., Gómez, M. D., Piñana, J. L., González-Candelas, F., Comas, I., Marina, A., … Coscolla, M. (2021). Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2. MBio, 12(6). https://doi.org/10.1128/mbio.02315-21
Alm, E., Broberg, E. K., Connor, T., Hodcroft, E. B., Komissarov, A. B., Maurer-Stroh, S., Melidou, A., Neher, R. A., O’Toole, Á., & Pereyaslov, D. (2020). Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance, 25(32). https://doi.org/10.2807/1560-7917.es.2020.25.32.2001410
Error fetching reference data.
