Translational Medicinal and Biological Chemistry

Institution: Centro de Investigaciones Biológicas Margarita Salas (CIB)

Members (researchers): Carmen Gil, Lucia Baselga Bellosillo, Virginia García-Calvo Pérez-Cejuela, Ana Martínez

Home page: https://cib.csic.es/research/biomedicine/translational-medicinal-and-biological-chemistry
Contact email: ana.martinez@csic.es

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Research topics:

Applications of Computational Biology, Drug Discovery and design, Molecular Interactions/Docking, Structural bioinformatics

Publications

Silva-Llanes, I., Madruga, E., Martínez, A., & Lastres-Becker, I. (2025). RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection. Frontiers in Neuroscience, 18. https://doi.org/10.3389/fnins.2024.1530809

Zeni, M., Santi, M. D., Arredondo, F., Reyes, L., Bentura, M., Carvalho, D., Peralta, M., Ortega, M. G., Abin-Carriquiry, J. A., Martínez-Gonzalez, L., Gambini, J. P., Duarte, P., Martinez, A., Rey, A., & Giglio, J. (2025). 11C-Labeling of a Flavanone Extracted from a South American Native Species for Evaluation of Its Interaction with GSK-3β. Molecules, 30(4), 874. https://doi.org/10.3390/molecules30040874

Aledavood, E., Gil, C., Comabella, M., & Martinez, A. (2025). Discovery of Sphingosine-1-Phosphate Receptor Modulators as Potential CHI3L1 Inhibitors by Ligand-Based Virtual Screening and Molecular Dynamics Simulations. ACS Omega, 10(19), 19992–20000. https://doi.org/10.1021/acsomega.5c01968

Madruga, E., Sanchez-Santos, C., Valenzuela-Martínez, I., Ramírez, D., Gil, C., & Martínez, A. (2025). Discovery of a brain penetrant SGK1 inhibitor using a ligand- and structure-based virtual screening methodology. Journal of Enzyme Inhibition and Medicinal Chemistry, 40(1). https://doi.org/10.1080/14756366.2025.2546591

Zeni, M., Santi, Ma. D., Arredondo, F., Reyes, L., Bentura, M., Carvalho, D., Peralta, M., Ortega, M. G., Abin-Carriquiry, J. A., Martínez-Gonzalez, L., Gambini, J. P., Duarte, P., Martinez, A., Rey, A., & Giglio, J. (2024). 11C-Labeling of a Flavone Extracted from a South American Native Species for Evaluation of Its Interaction with Gsk-3β. https://doi.org/10.20944/preprints202411.0227.v1

Benítez‐Fernández, R., Josa‐Prado, F., Sánchez, E., Lao, Y., García‐Rubia, A., Cumella, J., Martínez, A., Palomo, V., & de Castro, F. (2024). Efficacy of a benzothiazole‐based <scp>LRRK2</scp> inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis. CNS Neuroscience & Therapeutics, 30(1). Portico. https://doi.org/10.1111/cns.14552

Morales-Tenorio, M., Lasala, F., Garcia-Rubia, A., Aledavood, E., Heung, M., Olal, C., Escudero-Pérez, B., Alonso, C., Martínez, A., Muñoz-Fontela, C., Delgado, R., & Gil, C. (2024). Discovery of Thiophene Derivatives as Potent, Orally Bioavailable, and Blood–Brain Barrier-Permeable Ebola Virus Entry Inhibitors. Journal of Medicinal Chemistry, 67(18), 16381–16402. https://doi.org/10.1021/acs.jmedchem.4c01267

Pérez de la Lastra Aranda, C., Tosat-Bitrián, C., Porras, G., Dafinca, R., Muñoz-Torrero, D., Talbot, K., Martín-Requero, Á., Martínez, A., & Palomo, V. (2024). Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation. ACS Chemical Neuroscience, 15(21), 3945–3953. https://doi.org/10.1021/acschemneuro.4c00328

Rojas-Prats, E., Martinez-Gonzalez, L., Gil, C., Ramírez, D., & Martinez, A. (2024). Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase. Journal of Enzyme Inhibition and Medicinal Chemistry, 39(1). https://doi.org/10.1080/14756366.2024.2301767

Tosat-Bitrián, C., Martínez-González, L., Cuevas, E. P., Martínez, A., & Palomo, V. (2024). TDP-43 Modulation for the Treatment of Neurodegenerative Diseases: Rationale and Assay Methodologies. Methods in Neurodegenerative Disease Drug Discovery, 87–104. https://doi.org/10.1007/978-1-0716-4232-0_4

Martinez-Gonzalez, L., & Martinez, A. (2023). Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis. Expert Opinion on Investigational Drugs, 32(2), 141–160. https://doi.org/10.1080/13543784.2023.2178416

Porras, G., Ruiz, S., Maestro, I., Borrego-Hernández, D., Redondo, A. G., Martínez, A., & Martín-Requero, Á. (2023). Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts. International Journal of Molecular Sciences, 24(3), 2847. https://doi.org/10.3390/ijms24032847

Rodríguez-Periñán, G., de la Encarnación, A., Moreno, F., López de Munain, A., Martínez, A., Martín-Requero, Á., Alquézar, C., & Bartolomé, F. (2023). Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions. Antioxidants, 12(3), 581. https://doi.org/10.3390/antiox12030581

Zheng, Y., Schroeder, S., Kanev, G. K., Botros, S. S., William, S., Sabra, A.-N. A., Maes, L., Caljon, G., Gil, C., Martinez, A., Salado, I. G., Augustyns, K., Edink, E., Sijm, M., de Heuvel, E., de Esch, I. J. P., van der Meer, T., Siderius, M., Sterk, G. J., … Leurs, R. (2023). To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A? International Journal of Molecular Sciences, 24(7), 6817. https://doi.org/10.3390/ijms24076817

Garcia-Rubia, A., Lasala, F., Ginex, T., Morales-Tenorio, M., Olal, C., Heung, M., Oquist, P., Galindo, I., Cuesta-Geijo, M. Á., Casasnovas, J. M., Campillo, N. E., Canales, Á., Alonso, C., Martínez, A., Muñoz-Fontela, C., Delgado, R., & Gil, C. (2023). N′-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile. Journal of Medicinal Chemistry, 66(8), 5465–5483. https://doi.org/10.1021/acs.jmedchem.2c01785

Moreno, R., Recio, J., Barber, S., Gil, C., & Martinez, A. (2023). The emerging role of mixed lineage kinase 3 (MLK3) and its potential as a target for neurodegenerative diseases therapies. European Journal of Medicinal Chemistry, 257, 115511. https://doi.org/10.1016/j.ejmech.2023.115511

Maestro, I., Madruga, E., Boya, P., & Martínez, A. (2023). Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 38(1). https://doi.org/10.1080/14756366.2022.2153841

Nozal, V., Martínez-González, L., Gomez-Almeria, M., Gonzalo-Consuegra, C., Santana, P., Chaikuad, A., Pérez-Cuevas, E., Knapp, S., Lietha, D., Ramírez, D., Petralla, S., Monti, B., Gil, C., Martín-Requero, A., Palomo, V., de Lago, E., & Martinez, A. (2022). TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. Journal of Medicinal Chemistry, 65(2), 1585–1607. https://doi.org/10.1021/acs.jmedchem.1c01942

Cuevas, E. P., Rodríguez-Fernández, A., Palomo, V., Martínez, A., & Martín-Requero, Á. (2022). TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer’s Disease Patients. Biomedicines, 10(2), 385. https://doi.org/10.3390/biomedicines10020385

Martín-Cámara, O., Arribas, M., Wells, G., Morales-Tenorio, M., Martín-Requero, Á., Porras, G., Martínez, A., Giorgi, G., López-Alvarado, P., Lastres-Becker, I., & Menéndez, J. C. (2022). Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis. Journal of Medicinal Chemistry, 65(3), 1867–1882. https://doi.org/10.1021/acs.jmedchem.1c01255

Méndez-Líter, J. A., Pozo-Rodríguez, A., Madruga, E., Rubert, M., Santana, A. G., de Eugenio, L. I., Sánchez, C., Martínez, A., Prieto, A., & Martínez, M. J. (2022). Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from Talaromyces amestolkiae: Potential Antiproliferative and Neuroprotective Effect of These Molecules. Antioxidants, 11(7), 1325. https://doi.org/10.3390/antiox11071325

Alegría-Arcos, M., Barbosa, T., Sepúlveda, F., Combariza, G., González, J., Gil, C., Martínez, A., & Ramírez, D. (2022). Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.952192

Lastres-Becker, I., de Lago, E., Martínez, A., & Fernández-Ruiz, J. (2022). New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Biomolecules, 12(9), 1200. https://doi.org/10.3390/biom12091200

Reggiori, F., Boya, P., da Costa, D., Elazar, Z., Eskelinen, E.-L., Farrés, J., Guettler, S., Kraft, C., Jungbluth, H., Martinez, A., Morel, E., Pless, O., Proikas-Cezanne, T., & Simonsen, A. (2022). The mechanism of macroautophagy: The movie. Autophagy Reports, 1(1), 414–417. https://doi.org/10.1080/27694127.2022.2096115

Maestro, I., de la Ballina, L. R., Porras, G., Corrochano, S., De Lago, E., Simonsen, A., Boya, P., & Martinez, A. (2022). Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations. International Journal of Molecular Sciences, 23(20), 12676. https://doi.org/10.3390/ijms232012676

Cogram, P., Fernández-Beltrán, L. C., Casarejos, M. J., Sánchez-Yepes, S., Rodríguez-Martín, E., García-Rubia, A., Sánchez-Barrena, M. J., Gil, C., Martínez, A., & Mansilla, A. (2022). The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.1007531

Benítez-Fernández, R., Gil, C., Guaza, C., Mestre, L., & Martínez, A. (2022). The Dual PDE7-GSK3β Inhibitor, VP3.15, as Neuroprotective Disease-Modifying Treatment in a Model of Primary Progressive Multiple Sclerosis. International Journal of Molecular Sciences, 23(22), 14378. https://doi.org/10.3390/ijms232214378

Vila Méndez, M. L., Antón Sanz, C., Cárdenas García, A. del R., Bravo Malo, A., Torres Martínez, F. J., Martín Moros, J. M., Real Torrijos, M., Vendrell Covisa, J. F. J., Guzmán Sierra, O., Molina Barcena, V., Viejo Pinero, N., Fernández Díaz, C., Arroyo Burguillo, P., Blanco Gallego, A. M., Guirao Sánchez, C., Montilla Bernabé, A., Villanueva Morán, M. del P., Juárez Antón, S., Fernández Rodríguez, Á., … Soler López, B. (2022). Efficacy of Bromhexine versus Standard of Care in Reducing Viral Load in Patients with Mild-to-Moderate COVID-19 Disease Attended in Primary Care: A Randomized Open-Label Trial. Journal of Clinical Medicine, 12(1), 142. https://doi.org/10.3390/jcm12010142

Rojas-Prats, E., Martinez-Gonzalez, L., Gonzalo-Consuegra, C., Liachko, N. F., Perez, C., Ramírez, D., Kraemer, B. C., Martin-Requero, Á., Perez, D. I., Gil, C., de Lago, E., & Martinez, A. (2021). Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis. European Journal of Medicinal Chemistry, 210, 112968. https://doi.org/10.1016/j.ejmech.2020.112968

Madruga, E., Maestro, I., & Martínez, A. (2021). Mitophagy Modulation, a New Player in the Race against ALS. International Journal of Molecular Sciences, 22(2), 740. https://doi.org/10.3390/ijms22020740

Rojas-Prats, E., Tosat-Bitrián, C., Martínez-González, L., Nozal, V., Pérez, D. I., & Martínez, A. (2021). Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles. Pharmaceutics, 13(2), 180. https://doi.org/10.3390/pharmaceutics13020180

Lasala, F., García-Rubia, A., Requena, C., Galindo, I., Cuesta-Geijo, M. A., García-Dorival, I., Bueno, P., Labiod, N., Luczkowiak, J., Martinez, A., Campillo, N. E., Alonso, C., Delgado, R., & Gil, C. (2021). Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Research, 186, 105011. https://doi.org/10.1016/j.antiviral.2021.105011

Davies, M. P., Benitez, R., Perez, C., Jakupovic, S., Welsby, P., Rzepecka, K., Alder, J., Davidson, C., Martinez, A., & Hayes, J. M. (2021). Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β. Journal of Medicinal Chemistry, 64(3), 1497–1509. https://doi.org/10.1021/acs.jmedchem.0c01568

Benítez-Fernández, R., Melero-Jerez, C., Gil, C., de la Rosa, E. J., Martínez, A., & de Castro, F. (2021). Dynamics of Central Remyelination and Treatment Evolution in a Model of Multiple Sclerosis with Optic Coherence Tomography. International Journal of Molecular Sciences, 22(5), 2440. https://doi.org/10.3390/ijms22052440

Lastres-Becker, I., Porras, G., Arribas-Blázquez, M., Maestro, I., Borrego-Hernández, D., Boya, P., Cerdán, S., García-Redondo, A., Martínez, A., & Martin-Requero, Á. (2021). Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy. International Journal of Molecular Sciences, 22(6), 3007. https://doi.org/10.3390/ijms22063007

Nozal, V., Rojas-Prats, E., Maestro, I., Gil, C., Perez, D., & Martinez, A. (2021). Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles. International Journal of Molecular Sciences, 22(6), 3206. https://doi.org/10.3390/ijms22063206

Grieco, I., Bissaro, M., Tiz, D. B., Perez, D. I., Perez, C., Martinez, A., Redenti, S., Mariotto, E., Bortolozzi, R., Viola, G., Cozza, G., Spalluto, G., Moro, S., & Federico, S. (2021). Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems. European Journal of Medicinal Chemistry, 216, 113331. https://doi.org/10.1016/j.ejmech.2021.113331

Ginex, T., Garaigorta, U., Ramírez, D., Castro, V., Nozal, V., Maestro, I., García-Cárceles, J., Campillo, N. E., Martinez, A., Gastaminza, P., & Gil, C. (2021). Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods. Pharmaceuticals, 14(4), 332. https://doi.org/10.3390/ph14040332

Rico, A., Guembelzu, G., Palomo, V., Martínez, A., Aiastui, A., Casas-Fraile, L., Valls, A., López de Munain, A., & Sáenz, A. (2021). Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related. International Journal of Molecular Sciences, 22(14), 7367. https://doi.org/10.3390/ijms22147367

Gil, C., & Martinez, A. (2021). Is drug repurposing really the future of drug discovery or is new innovation truly the way forward? Expert Opinion on Drug Discovery, 16(8), 829–831. https://doi.org/10.1080/17460441.2021.1912733

Martínez-González, L., Gonzalo-Consuegra, C., Gómez-Almería, M., Porras, G., de Lago, E., Martín-Requero, Á., & Martínez, A. (2021). Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences, 22(16), 8975. https://doi.org/10.3390/ijms22168975

Nozal, V., García‐Rubia, A., Cuevas, E. P., Pérez, C., Tosat‐Bitrián, C., Bartolomé, F., Carro, E., Ramírez, D., Palomo, V., & Martínez, A. (2021). From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer’s Disease using Protein‐Templated Synthesis. Angewandte Chemie, 133(35), 19493–19503. Portico. https://doi.org/10.1002/ange.202106295

García-Dorival, I., Cuesta-Geijo, M. Á., Barrado-Gil, L., Galindo, I., Garaigorta, U., Urquiza, J., Puerto, A. del, Campillo, N. E., Martínez, A., Gastaminza, P., Gil, C., & Alonso, C. (2021). Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. Antiviral Research, 194, 105167. https://doi.org/10.1016/j.antiviral.2021.105167

Berenguer, E., Carneros, E., Pérez-Pérez, Y., Gil, C., Martínez, A., & Testillano, P. S. (2021). Small molecule inhibitors of mammalian GSK-3β promote in vitro plant cell reprogramming and somatic embryogenesis in crop and forest species. Journal of Experimental Botany, 72(22), 7808–7825. https://doi.org/10.1093/jxb/erab365

Maestro, I., de la Ballina, L. R., Simonsen, A., Boya, P., & Martinez, A. (2021). Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson’s Disease. ACS Chemical Neuroscience, 12(24), 4512–4523. https://doi.org/10.1021/acschemneuro.1c00529

Alaohali, A., Salzlechner, C., Zaugg, L. K., Suzano, F., Martinez, A., Gentleman, E., & Sharpe, P. T. (2021). GSK3 Inhibitor-Induced Dentinogenesis Using a Hydrogel. Journal of Dental Research, 101(1), 46–53. https://doi.org/10.1177/00220345211020652

García-Cárceles, J., Caballero, E., Gil, C., & Martínez, A. (2021). Kinase Inhibitors as Underexplored Antiviral Agents. Journal of Medicinal Chemistry, 65(2), 935–954. https://doi.org/10.1021/acs.jmedchem.1c00302

Giglio, J., Fernandez, S., Martinez, A., Zeni, M., Reyes, L., Rey, A., & Cerecetto, H. (2021). Glycogen Synthase Kinase-3 Maleimide Inhibitors As Potential PET-Tracers for Imaging Alzheimer’s Disease: 11C-Synthesis and In Vivo Proof of Concept. Journal of Medicinal Chemistry, 65(2), 1342–1351. https://doi.org/10.1021/acs.jmedchem.1c00769

Kocak, M., Ezazi Erdi, S., Jorba, G., Maestro, I., Farrés, J., Kirkin, V., Martinez, A., & Pless, O. (2021). Targeting autophagy in disease: established and new strategies. Autophagy, 18(3), 473–495. https://doi.org/10.1080/15548627.2021.1936359

Lassagne, F., Duguépéroux, C., Roca, C., Perez, C., Martinez, A., Baratte, B., Robert, T., Ruchaud, S., Bach, S., Erb, W., Roisnel, T., & Mongin, F. (2020). From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3). Organic & Biomolecular Chemistry, 18(1), 154–162. https://doi.org/10.1039/c9ob02002k

Sebastian-Perez, V., García-Rubia, A., Seif el-Din, S. H., Sabra, A.-N. A., El-Lakkany, N. M., William, S., Blundell, T. L., Maes, L., Martinez, A., Campillo, N. E., Botros, S. S., & Gil, C. (2020). Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 511–523. https://doi.org/10.1080/14756366.2020.1712595

Maestro, I., Boya, P., & Martinez, A. (2020). Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases. Expert Opinion on Therapeutic Targets, 24(3), 231–243. https://doi.org/10.1080/14728222.2020.1730328

Martínez-González, L., Rodríguez-Cueto, C., Cabezudo, D., Bartolomé, F., Andrés-Benito, P., Ferrer, I., Gil, C., Martín-Requero, Á., Fernández-Ruiz, J., Martínez, A., & de Lago, E. (2020). Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-61265-y

Peřinová, R., Maafi, N., Korábečný, J., Kohelová, E., De Simone, A., Al Mamun, A., Hulcová, D., Marková, J., Kučera, T., Jun, D., Šafratová, M., Maříková, J., Andrisano, V., Jenčo, J., Kuneš, J., Martinez, A., Nováková, L., & Cahlíková, L. (2020). Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease. Bioorganic Chemistry, 100, 103928. https://doi.org/10.1016/j.bioorg.2020.103928

Di Martino, R. M. C., Pruccoli, L., Bisi, A., Gobbi, S., Rampa, A., Martinez, A., Pérez, C., Martinez-Gonzalez, L., Paglione, M., Di Schiavi, E., Seghetti, F., Tarozzi, A., & Belluti, F. (2020). Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease. ACS Chemical Neuroscience, 11(17), 2728–2740. https://doi.org/10.1021/acschemneuro.0c00363

Gil, C., Ginex, T., Maestro, I., Nozal, V., Barrado-Gil, L., Cuesta-Geijo, M. Á., Urquiza, J., Ramírez, D., Alonso, C., Campillo, N. E., & Martinez, A. (2020). COVID-19: Drug Targets and Potential Treatments. Journal of Medicinal Chemistry, 63(21), 12359–12386. https://doi.org/10.1021/acs.jmedchem.0c00606

Castro-Sánchez, S., Zaldivar-Diez, J., Luengo, E., López, M. G., Gil, C., Martínez, A., & Lastres-Becker, I. (2020). Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model. Neurobiology of Aging, 96, 148–154. https://doi.org/10.1016/j.neurobiolaging.2020.09.006

Vaca, G., Martinez‐Gonzalez, L., Fernandez, A., Rojas‐Prats, E., Porras, G., Cuevas, E. P., Gil, C., Martinez, A., & Martin‐Requero, Á. (2020). Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Journal of Neurochemistry, 156(3), 379–390. Portico. https://doi.org/10.1111/jnc.15118

Palomo, V., Nozal, V., Rojas‐Prats, E., Gil, C., & Martinez, A. (2020). Protein kinase inhibitors for amyotrophic lateral sclerosis therapy. British Journal of Pharmacology, 178(6), 1316–1335. Portico. https://doi.org/10.1111/bph.15221

Gürbüz, P., Martinez, A., Pérez, C., Martínez-González, L., Göger, F., & Ayran, İ. (2019). Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ. Industrial Crops and Products, 138, 111431. https://doi.org/10.1016/j.indcrop.2019.05.080

de Andrade, P., Mantoani, S. P., Gonçalves Nunes, P. S., Magadán, C. R., Pérez, C., Xavier, D. J., Hojo, E. T. S., Campillo, N. E., Martínez, A., & Carvalho, I. (2019). Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 27(6), 931–943. https://doi.org/10.1016/j.bmc.2018.12.030

Sánchez-Cruz, A., Martínez, A., de la Rosa, E. J., & Hernández-Sánchez, C. (2019). GSK-3 Inhibitors: From the Brain to the Retina and Back Again. Retinal Degenerative Diseases, 437–441. https://doi.org/10.1007/978-3-030-27378-1_72

Sebastián-Pérez, V., Schroeder, S., Munday, J. C., van der Meer, T., Zaldívar-Díez, J., Siderius, M., de Koning, H. P., Brown, D., Martínez, A., Campillo, N. E., Leurs, R., & Gil, C. (2019). Discovery of NovelSchistosoma MansoniPDE4A Inhibitors as Potential Agents against Schistosomiasis. Future Medicinal Chemistry, 11(14), 1703–1720. https://doi.org/10.4155/fmc-2018-0592

Wang, M., Weng, W.-C., Stock, L., Lindquist, D., Martinez, A., Gourdon, G., Timchenko, N., Snape, M., & Timchenko, L. (2019). Correction of Glycogen Synthase Kinase 3β in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice. Molecular and Cellular Biology, 39(21). https://doi.org/10.1128/mcb.00155-19

Martinez, A., & Gil, C. (2019). Protein Kinase Inhibitors for the Treatment of Multiple Sclerosis. Emerging Drugs and Targets for Multiple Sclerosis, 170–196. https://doi.org/10.1039/9781788016070-00170

Redenti, S., Marcovich, I., De Vita, T., Pérez, C., De Zorzi, R., Demitri, N., Perez, D. I., Bottegoni, G., Bisignano, P., Bissaro, M., Moro, S., Martinez, A., Storici, P., Spalluto, G., Cavalli, A., & Federico, S. (2019). A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. ChemMedChem, 14(3), 310–314. Portico. https://doi.org/10.1002/cmdc.201800778

Venter, J., Perez, C., van Otterlo, W. A. L., Martínez, A., & Blackie, M. A. L. (2019). 1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters, 29(13), 1597–1600. https://doi.org/10.1016/j.bmcl.2019.04.049

Nozal, V., & Martinez, A. (2019). Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases. European Journal of Medicinal Chemistry, 161, 39–47. https://doi.org/10.1016/j.ejmech.2018.10.030

Sebastián-Pérez, V., Martínez, M. J., Gil, C., Campillo, N. E., Martínez, A., & Ponzoni, I. (2019). QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson’s Disease. Journal of Integrative Bioinformatics, 16(1). https://doi.org/10.1515/jib-2018-0063

Palomo, V., Tosat-Bitrian, C., Nozal, V., Nagaraj, S., Martin-Requero, A., & Martinez, A. (2019). TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis. ACS Chemical Neuroscience, 10(3), 1183–1196. https://doi.org/10.1021/acschemneuro.9b00026

Canal-Martín, A., Sastre, J., Sánchez-Barrena, M. J., Canales, A., Baldominos, S., Pascual, N., Martínez-González, L., Molero, D., Fernández-Valle, M. E., Sáez, E., Blanco-Gabella, P., Gómez-Rubio, E., Martín-Santamaría, S., Sáiz, A., Mansilla, A., Cañada, F. J., Jiménez-Barbero, J., Martínez, A., & Pérez-Fernández, R. (2019). Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library. Nature Communications, 10(1). https://doi.org/10.1038/s41467-019-10627-w

Morales-Navarro, S., Prent-Peñaloza, L., Rodríguez Núñez, Y. A., Sánchez-Aros, L., Forero-Doria, O., González, W., Campilllo, N. E., Reyes-Parada, M., Martínez, A., & Ramírez, D. (2019). Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases. Processes, 7(12), 940. https://doi.org/10.3390/pr7120940

Martínez de Iturrate, P., Sebastián-Pérez, V., Nácher-Vázquez, M., Tremper, C. S., Smirlis, D., Martín, J., Martínez, A., Campillo, N. E., Rivas, L., & Gil, C. (2019). Towards discovery of new leishmanicidal scaffolds able to inhibitLeishmaniaGSK-3. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 199–210. https://doi.org/10.1080/14756366.2019.1693704

Zaldivar-Diez, J., Li, L., Garcia, A. M., Zhao, W.-N., Medina-Menendez, C., Haggarty, Stephen. J., Gil, C., Morales, A. V., & Martinez, A. (2019). Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate. Journal of Medicinal Chemistry, 63(5), 2638–2655. https://doi.org/10.1021/acs.jmedchem.9b01752

Cheng, Y., Desse, S., Martinez, A., Worthen, R. J., Jope, R. S., & Beurel, E. (2018). TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice. Brain, Behavior, and Immunity, 69, 556–567. https://doi.org/10.1016/j.bbi.2018.02.003

Sebastián-Pérez, V., Hendrickx, S., Munday, J. C., Kalejaiye, T., Martínez, A., Campillo, N. E., de Koning, H., Caljon, G., Maes, L., & Gil, C. (2018). Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy. Antimicrobial Agents and Chemotherapy, 62(10). https://doi.org/10.1128/aac.00603-18

Chierrito, T. P. C., Pedersoli-Mantoani, S., Roca, C., Sebastian-Pérez, V., Martínez-Gonzalez, L., Pérez, D. I., Perez, C., Canales, A., Cañada, F. J., Campillo, N. E., Carvalho, I., & Martinez, A. (2018). Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 145, 431–444. https://doi.org/10.1016/j.ejmech.2018.01.007

Bartolome, F., de la Cueva, M., Pascual, C., Antequera, D., Fernandez, T., Gil, C., Martinez, A., & Carro, E. (2018). Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimer’s Research & Therapy, 10(1). https://doi.org/10.1186/s13195-018-0352-4

Roca, C., Requena, C., Sebastián-Pérez, V., Malhotra, S., Radoux, C., Pérez, C., Martinez, A., Antonio Páez, J., Blundell, T. L., & Campillo, N. E. (2018). Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 1034–1047. https://doi.org/10.1080/14756366.2018.1476502

Benek, O., Hroch, L., Aitken, L., Gunn-Moore, F., Vinklarova, L., Kuca, K., Perez, D. I., Perez, C., Martinez, A., Fisar, Z., & Musilek, K. (2018). 1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 665–670. https://doi.org/10.1080/14756366.2018.1445736

Sánchez-Cruz, A., Villarejo-Zori, B., Marchena, M., Zaldivar-Díez, J., Palomo, V., Gil, C., Lizasoain, I., de la Villa, P., Martínez, A., de la Rosa, E. J., & Hernández-Sánchez, C. (2018). Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa. Molecular Neurodegeneration, 13(1). https://doi.org/10.1186/s13024-018-0251-y

Decara, J., Serrano, A., Pavón, F. J., Rivera, P., Arco, R., Gavito, A., Vargas, A., Navarro, J. A., Tovar, R., Lopez-Gambero, A. J., Martínez, A., Suárez, J., Rodríguez de Fonseca, F., & Baixeras, E. (2018). The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-27871-7

Posa, D., Martínez-González, L., Bartolomé, F., Nagaraj, S., Porras, G., Martínez, A., & Martín-Requero, Á. (2018). Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients. Molecular Neurobiology, 56(4), 2424–2432. https://doi.org/10.1007/s12035-018-1249-8

Roca, C., Martinez-González, L., Daniel-Mozo, M., Sastre, J., Infantes, L., Mansilla, A., Chaves-Sanjuan, A., González-Rubio, J. M., Gil, C., Cañada, F. J., Martinez, A., Sanchez-Barrena, M. J., & Campillo, N. E. (2018). Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. Journal of Medicinal Chemistry, 61(14), 5910–5921. https://doi.org/10.1021/acs.jmedchem.8b00088

Gandini, A., Bartolini, M., Tedesco, D., Martinez-Gonzalez, L., Roca, C., Campillo, N. E., Zaldivar-Diez, J., Perez, C., Zuccheri, G., Miti, A., Feoli, A., Castellano, S., Petralla, S., Monti, B., Rossi, M., Moda, F., Legname, G., Martinez, A., & Bolognesi, M. L. (2018). Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors. Journal of Medicinal Chemistry, 61(17), 7640–7656. https://doi.org/10.1021/acs.jmedchem.8b00610

Alten, B., Yesiltepe, M., Bayraktar, E., Tas, S. T., Gocmen, A. Y., Kursungoz, C., Martinez, A., & Sara, Y. (2018). High‐fructose corn syrup consumption in adolescent rats causes bipolar‐like behavioural phenotype with hyperexcitability in hippocampal CA3‐CA1 synapses. British Journal of Pharmacology, 175(24), 4450–4463. Portico. https://doi.org/10.1111/bph.14500

Sebastián-Pérez, V., Martínez, M. J., Gil, C., Campillo, N. E., Martínez, A., & Ponzoni, I. (2018). QSAR Modelling for Drug Discovery: Predicting the Activity of LRRK2 Inhibitors for Parkinson’s Disease Using Cheminformatics Approaches. Practical Applications of Computational Biology and Bioinformatics, 12th International Conference, 63–70. https://doi.org/10.1007/978-3-319-98702-6_8

Sciú, M. L., Sebastián-Pérez, V., Martinez-Gonzalez, L., Benitez, R., Perez, D. I., Pérez, C., Campillo, N. E., Martinez, A., & Moyano, E. L. (2018). Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 87–96. https://doi.org/10.1080/14756366.2018.1530223

Uliassi, E., Peña-Altamira, L. E., Morales, A. V., Massenzio, F., Petralla, S., Rossi, M., Roberti, M., Martinez Gonzalez, L., Martinez, A., Monti, B., & Bolognesi, M. L. (2018). A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential. ACS Chemical Neuroscience, 10(1), 279–294. https://doi.org/10.1021/acschemneuro.8b00242

Kraft, C., Boya, P., Codogno, P., Elazar, Z., Eskelinen, E.-L., Farrés, J., Kirkin, V., Jungbluth, H., Martinez, A., Pless, O., Primard, C., Proikas-Cezanne, T., Simonsen, A., & Reggiori, F. (2018). Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy. Autophagy, 15(2), 347–351. https://doi.org/10.1080/15548627.2018.1515532

Pérez-Domper, P., Palomo, V., Gradari, S., Gil, C., de Ceballos, M. L., Martínez, A., & Trejo, J. L. (2017). The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis. Neuropharmacology, 116, 174–187. https://doi.org/10.1016/j.neuropharm.2016.12.019

Marchena, M., Villarejo-Zori, B., Zaldivar-Diez, J., Palomo, V., Gil, C., Hernández-Sánchez, C., Martínez, A., & de la Rosa, E. J. (2017). Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 522–526. https://doi.org/10.1080/14756366.2016.1265522

Medina-Rodríguez, E. M., Bribián, A., Boyd, A., Palomo, V., Pastor, J., Lagares, A., Gil, C., Martínez, A., Williams, A., & de Castro, F. (2017). Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Scientific Reports, 7(1). https://doi.org/10.1038/srep43545

García, A. M., Salado, I. G., Perez, D. I., Brea, J., Morales-García, J. A., González-García, A., Cadavid, M. I., Loza, M. I., Luque, F. J., Perez-Castillo, A., Martinez, A., & Gil, C. (2017). Pharmacological Tools Based on Imidazole Scaffold Proved the Utility of Pde10A Inhibitors for Parkinson’S Disease. Future Medicinal Chemistry, 9(8), 731–748. https://doi.org/10.4155/fmc-2017-0005

Salado, I. G., Zaldivar-Diez, J., Sebastián-Pérez, V., Li, L., Geiger, L., González, S., Campillo, N. E., Gil, C., Morales, A. V., Perez, D. I., & Martinez, A. (2017). Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents. European Journal of Medicinal Chemistry, 138, 328–342. https://doi.org/10.1016/j.ejmech.2017.06.060

Pardo, M., Cheng, Y., Velmeshev, D., Magistri, M., Eldar-Finkelman, H., Martinez, A., Faghihi, M. A., Jope, R. S., & Beurel, E. (2017). Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. JCI Insight, 2(6). https://doi.org/10.1172/jci.insight.91782

Mansilla, A., Chaves-Sanjuan, A., Campillo, N. E., Semelidou, O., Martínez-González, L., Infantes, L., González-Rubio, J. M., Gil, C., Conde, S., Skoulakis, E. M. C., Ferrús, A., Martínez, A., & Sánchez-Barrena, M. J. (2017). Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proceedings of the National Academy of Sciences, 114(6). https://doi.org/10.1073/pnas.1611089114

Contreras, A., Del Rio, D., Martínez, A., Gil, C., Morales, L., Ruiz-Gayo, M., & Del Olmo, N. (2017). Inhibition of hippocampal long-term potentiation by high-fat diets. NeuroReport, 28(6), 354–359. https://doi.org/10.1097/wnr.0000000000000774

Huang, S., Wang, H., Turlova, E., Abussaud, A., Ji, X., Britto, L. R., Miller, S. P., Martinez, A., Sun, H., & Feng, Z. (2017). <scp>GSK</scp>‐3β inhibitor <scp>TDZD</scp>‐8 reduces neonatal hypoxic‐ischemic brain injury in mice. CNS Neuroscience & Therapeutics, 23(5), 405–415. Portico. https://doi.org/10.1111/cns.12683

Chierrito, T. P. C., Pedersoli-Mantoani, S., Roca, C., Requena, C., Sebastian-Perez, V., Castillo, W. O., Moreira, N. C. S., Pérez, C., Sakamoto-Hojo, E. T., Takahashi, C. S., Jiménez-Barbero, J., Cañada, F. J., Campillo, N. E., Martinez, A., & Carvalho, I. (2017). From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer’s disease. European Journal of Medicinal Chemistry, 139, 773–791. https://doi.org/10.1016/j.ejmech.2017.08.051

Martinez, A., Palomo Ruiz, M. del V., Perez, D. I., & Gil, C. (2017). Drugs in clinical development for the treatment of amyotrophic lateral sclerosis. Expert Opinion on Investigational Drugs, 26(4), 403–414. https://doi.org/10.1080/13543784.2017.1302426

Martinez, A., & Gil, C. (2017). Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs. Drug Discovery for Leishmaniasis, 153–178. https://doi.org/10.1039/9781788010177-00153

Martín-Álvarez, R., Paúl-Fernández, N., Palomo, V., Gil, C., Martínez, A., & Mengod, G. (2017). A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice. Journal of Chemical Neuroanatomy, 80, 27–36. https://doi.org/10.1016/j.jchemneu.2016.12.001

Palomo, V., Perez, D. I., Roca, C., Anderson, C., Rodríguez-Muela, N., Perez, C., Morales-Garcia, J. A., Reyes, J. A., Campillo, N. E., Perez-Castillo, A. M., Rubin, L. L., Timchenko, L., Gil, C., & Martinez, A. (2017). Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. Journal of Medicinal Chemistry, 60(12), 4983–5001. https://doi.org/10.1021/acs.jmedchem.7b00395

Morales-Garcia, J. A., Salado, I. G., Sanz-San Cristobal, M., Gil, C., Pérez-Castillo, A., Martínez, A., & Pérez, D. I. (2017). Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson’s Disease. ACS Omega, 2(8), 5215–5220. https://doi.org/10.1021/acsomega.7b00869

García, A., Brea, J., González-García, A., Pérez, C., Cadavid, M. I., Loza, M. I., Martinez, A., & Gil, C. (2017). Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects. Molecules, 22(9), 1472. https://doi.org/10.3390/molecules22091472

Sebastián-Pérez, V., Roca, C., Awale, M., Reymond, J.-L., Martinez, A., Gil, C., & Campillo, N. E. (2017). Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits. Journal of Chemical Information and Modeling, 57(9), 2143–2151. https://doi.org/10.1021/acs.jcim.7b00401

Di Martino, R. M. C., De Simone, A., Andrisano, V., Bisignano, P., Bisi, A., Gobbi, S., Rampa, A., Fato, R., Bergamini, C., Perez, D. I., Martinez, A., Bottegoni, G., Cavalli, A., & Belluti, F. (2016). Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors. Journal of Medicinal Chemistry, 59(2), 531–544. https://doi.org/10.1021/acs.jmedchem.5b00894

Wang, H., Huang, S., Yan, K., Fang, X., Abussaud, A., Martinez, A., Sun, H.-S., & Feng, Z.-P. (2016). Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice. Biochimica et Biophysica Acta (BBA) - General Subjects, 1860(10), 2076–2085. https://doi.org/10.1016/j.bbagen.2016.06.027

Alquezar, C., Salado, I. G., de la Encarnación, A., Pérez, D. I., Moreno, F., Gil, C., de Munain, A. L., Martínez, A., & Martín-Requero, Á. (2016). Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia. Molecular Neurodegeneration, 11(1). https://doi.org/10.1186/s13024-016-0102-7

Cheng, Y., Pardo, M., Armini, R. de S., Martinez, A., Mouhsine, H., Zagury, J.-F., Jope, R. S., & Beurel, E. (2016). Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain, Behavior, and Immunity, 53, 207–222. https://doi.org/10.1016/j.bbi.2015.12.012

de Munck, E., Palomo, V., Muñoz-Sáez, E., Perez, D. I., Gómez-Miguel, B., Solas, M. T., Gil, C., Martínez, A., & Arahuetes, R. M. (2016). Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy. PLOS ONE, 11(9), e0162723. https://doi.org/10.1371/journal.pone.0162723

Mantoani, S., Chierrito, T., Vilela, A., Cardoso, C., Martínez, A., & Carvalho, I. (2016). Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors. Molecules, 21(2), 193. https://doi.org/10.3390/molecules21020193

M. Garcia, A., Martinez, A., & Gil, C. (2016). Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders. Current Topics in Medicinal Chemistry, 16(29), 3527–3535. https://doi.org/10.2174/1568026616666160426151306

Silva, T., Mohamed, T., Shakeri, A., Rao, P. P. N., Martínez-González, L., Pérez, D. I., Martínez, A., Valente, M. J., Garrido, J., Uriarte, E., Serrão, P., Soares-da-Silva, P., Remião, F., & Borges, F. (2016). Development of Blood–Brain Barrier Permeable Nitrocatechol-Based CatecholO-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity. Journal of Medicinal Chemistry, 59(16), 7584–7597. https://doi.org/10.1021/acs.jmedchem.6b00666

Morales-Garcia, J. A., Echeverry-Alzate, V., Alonso-Gil, S., Sanz-SanCristobal, M., Lopez-Moreno, J. A., Gil, C., Martinez, A., Santos, A., & Perez-Castillo, A. (2016). Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo. Stem Cells, 35(2), 458–472. https://doi.org/10.1002/stem.2480

Morales-Garcia, J. A., Aguilar-Morante, D., Hernandez-Encinas, E., Alonso-Gil, S., Gil, C., Martinez, A., Santos, A., & Perez-Castillo, A. (2015). Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. Neurobiology of Aging, 36(2), 1160–1173. https://doi.org/10.1016/j.neurobiolaging.2014.10.008

Morales-Garcia, J. A., Alonso-Gil, S., Gil, C., Martinez, A., Santos, A., & Perez-Castillo, A. (2015). Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats. Stem Cells Translational Medicine, 4(6), 564–575. https://doi.org/10.5966/sctm.2014-0277

Mestre, L., Redondo, M., Carrillo‐Salinas, F. J., Morales‐García, J. A., Alonso‐Gil, S., Pérez‐Castillo, A., Gil, C., Martínez, A., & Guaza, C. (2015). <scp>PDE</scp>7 inhibitor <scp>TC</scp>3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis. British Journal of Pharmacology, 172(17), 4277–4290. Portico. https://doi.org/10.1111/bph.13192

de Munck, E., Muñoz-Sáez, E., Miguel, B. G., Solas, M. T., Martínez, A., & Arahuetes, R. M. (2015). Morphometric and neurochemical alterations found in l-BMAA treated rats. Environmental Toxicology and Pharmacology, 39(3), 1232–1245. https://doi.org/10.1016/j.etap.2015.04.022

Pardo, M., King, M. K., Perez-Costas, E., Melendez-Ferro, M., Martinez, A., Beurel, E., & Jope, R. S. (2015). Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3. Frontiers in Behavioral Neuroscience, 9. https://doi.org/10.3389/fnbeh.2015.00055

Perez, D., Martinez, A., Gil, C., & Campillo, N. (2015). From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer’s Disease. Current Medicinal Chemistry, 22(33), 3789–3806. https://doi.org/10.2174/0929867322666150812145825

Martinez, A., & Gil, C. (2015). Chapter 9. Heterocycles Containing Nitrogen and Sulfur as Potent Biologically Active Scaffolds. Privileged Scaffolds in Medicinal Chemistry, 231–261. https://doi.org/10.1039/9781782622246-00231

Silva, T., Bravo, J., Summavielle, T., Remião, F., Pérez, C., Gil, C., Martínez, A., & Borges, F. (2015). Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity. RSC Advances, 5(21), 15800–15811. https://doi.org/10.1039/c4ra15164j

Muñoz-Sáez, E., de Munck García, E., Arahuetes Portero, R. M., Martínez, A., Solas Alados, M. T., & Miguel, B. G. (2015). Analysis of β-N-methylamino- l -alanine (L-BMAA) neurotoxicity in rat cerebellum. NeuroToxicology, 48, 192–205. https://doi.org/10.1016/j.neuro.2015.04.001

Prati, F., De Simone, A., Armirotti, A., Summa, M., Pizzirani, D., Scarpelli, R., Bertozzi, S. M., Perez, D. I., Andrisano, V., Perez-Castillo, A., Monti, B., Massenzio, F., Polito, L., Racchi, M., Sabatino, P., Bottegoni, G., Martinez, A., Cavalli, A., & Bolognesi, M. L. (2015). 3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease. ACS Chemical Neuroscience, 6(10), 1665–1682. https://doi.org/10.1021/acschemneuro.5b00121

Sastre, A., Campillo, N. E., Gil, C., & Martinez, A. (2015). Therapeutic approaches for the future treatment of Fragile X. Current Opinion in Behavioral Sciences, 4, 6–21. https://doi.org/10.1016/j.cobeha.2015.01.003

Martinez, A., & Gil, C. (2014). cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents, 24(12), 1311–1321. https://doi.org/10.1517/13543776.2014.968127

Salado, I. G., Redondo, M., Bello, M. L., Perez, C., Liachko, N. F., Kraemer, B. C., Miguel, L., Lecourtois, M., Gil, C., Martinez, A., & Perez, D. I. (2014). Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis. Journal of Medicinal Chemistry, 57(6), 2755–2772. https://doi.org/10.1021/jm500065f

Garcia, A. M., Redondo, M., Martinez, A., & Gil, C. (2014). Phosphodiesterase 10 Inhibitors: New Disease Modifying Drugs for Parkinson’s Disease? Current Medicinal Chemistry, 21(10), 1171–1187. https://doi.org/10.2174/0929867321666131228221749

García, A. M., Brea, J., Morales-García, J. A., Perez, D. I., González, A., Alonso-Gil, S., Gracia-Rubio, I., Ros-Simó, C., Conde, S., Cadavid, M. I., Loza, M. I., Perez-Castillo, A., Valverde, O., Martinez, A., & Gil, C. (2014). Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors. Journal of Medicinal Chemistry, 57(20), 8590–8607. https://doi.org/10.1021/jm501090m

Franklin, A. V., King, M. K., Palomo, V., Martinez, A., McMahon, L. L., & Jope, R. S. (2014). Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice. Biological Psychiatry, 75(3), 198–206. https://doi.org/10.1016/j.biopsych.2013.08.003

Morales-Garcia, J. A., Palomo, V., Redondo, M., Alonso-Gil, S., Gil, C., Martinez, A., & Perez-Castillo, A. (2014). Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders. ACS Chemical Neuroscience, 5(3), 194–204. https://doi.org/10.1021/cn400166d

Vida, M., Rivera, P., Gavito, A. L., Suárez, J., Pavón, F. J., Arrabal, S., Romero-Cuevas, M., Bautista, D., Martínez, A., de Fonseca, F. R., Serrano, A., & Baixeras, E. (2014). CB1 Blockade Potentiates Down-Regulation of Lipogenic Gene Expression in Perirenal Adipose Tissue in High Carbohydrate Diet-Induced Obesity. PLoS ONE, 9(2), e90016. https://doi.org/10.1371/journal.pone.0090016

Prati, F., De Simone, A., Bisignano, P., Armirotti, A., Summa, M., Pizzirani, D., Scarpelli, R., Perez, D. I., Andrisano, V., Perez‐Castillo, A., Monti, B., Massenzio, F., Polito, L., Racchi, M., Favia, A. D., Bottegoni, G., Martinez, A., Bolognesi, M. L., & Cavalli, A. (2014). Multitarget Drug Discovery for Alzheimer’s Disease: Triazinones as BACE‐1 and GSK‐3β Inhibitors. Angewandte Chemie International Edition, 54(5), 1578–1582. Portico. https://doi.org/10.1002/anie.201410456

de Munck, E., Muñoz-Sáez, E., Miguel, B. G., Solas, M. T., Ojeda, I., Martínez, A., Gil, C., & Arahuetes, R. M. (2013). β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS. Environmental Toxicology and Pharmacology, 36(2), 243–255. https://doi.org/10.1016/j.etap.2013.04.007

Redondo, M., Soteras, I., Brea, J., González-García, A., Cadavid, M. I., Loza, M. I., Martinez, A., Gil, C., & Campillo, N. E. (2013). Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities. European Journal of Medicinal Chemistry, 70, 781–788. https://doi.org/10.1016/j.ejmech.2013.10.035

Beurel, E., Kaidanovich-Beilin, O., Yeh, W.-I., Song, L., Palomo, V., Michalek, S. M., Woodgett, J. R., Harrington, L. E., Eldar-Finkelman, H., Martinez, A., & Jope, R. S. (2013). Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3. The Journal of Immunology, 190(10), 5000–5011. https://doi.org/10.4049/jimmunol.1203057

Perez-Gonzalez, R., Pascual, C., Antequera, D., Bolos, M., Redondo, M., Perez, D. I., Pérez-Grijalba, V., Krzyzanowska, A., Sarasa, M., Gil, C., Ferrer, I., Martinez, A., & Carro, E. (2013). Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer’s disease. Neurobiology of Aging, 34(9), 2133–2145. https://doi.org/10.1016/j.neurobiolaging.2013.03.011

Martinez, A., Perez, D., & Gil, C. (2013). Lessons Learnt from Glycogen Synthase Kinase 3 Inhibitors Development for Alzheimer’s Disease. Current Topics in Medicinal Chemistry, 13(15), 1808–1819. https://doi.org/10.2174/15680266113139990138

Medina-Rodríguez, E. M., Arenzana, F. J., Pastor, J., Redondo, M., Palomo, V., García de Sola, R., Gil, C., Martínez, A., Bribián, A., & de Castro, F. (2013). Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival. Cellular and Molecular Life Sciences, 70(18), 3449–3462. https://doi.org/10.1007/s00018-013-1340-2

Bidon-Chanal, A., Fuertes, A., Alonso, D., Pérez, D. I., Martínez, A., Luque, F. J., & Medina, M. (2013). Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin. European Journal of Medicinal Chemistry, 60, 479–489. https://doi.org/10.1016/j.ejmech.2012.12.014

Lipina, T. V., Palomo, V., Gil, C., Martinez, A., & Roder, J. C. (2013). Dual inhibitor of PDE7 and GSK-3 – VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice. Neuropharmacology, 64, 205–214. https://doi.org/10.1016/j.neuropharm.2012.06.032

González‐García, C., Bravo, B., Ballester, A., Gómez‐Pérez, R., Eguiluz, C., Redondo, M., Martínez, A., Gil, C., & Ballester, S. (2013). Comparative assessment of <scp>PDE</scp> 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis. British Journal of Pharmacology, 170(3), 602–613. Portico. https://doi.org/10.1111/bph.12308

Martinez, A., & Gil, C. (2013). Phosphodiesterase Inhibitors as a New Therapeutic Approach for the Treatment of Parkinson’s Disease. Emerging Drugs and Targets for Parkinson’s Disease, 294–307. https://doi.org/10.1039/9781849737357-00294

Staderini, M., Aulić, S., Bartolini, M., Tran, H. N. A., González-Ruiz, V., Pérez, D. I., Cabezas, N., Martínez, A., Martín, M. A., Andrisano, V., Legname, G., Menéndez, J. C., & Bolognesi, M. L. (2013). A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases. ACS Medicinal Chemistry Letters, 4(2), 225–229. https://doi.org/10.1021/ml3003605

Susín, C., Morales‐Garcia, J. A., Aguilar‐Morante, D., Palomo, V., Sanz‐Sancristobal, M., Alonso‐Gil, S., Gil, C., Santos, A., Martinez, A., & Perez‐Castillo, A. (2012). The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury. Journal of Neurochemistry, 122(6), 1193–1202. Portico. https://doi.org/10.1111/j.1471-4159.2012.07866.x

Redondo, M., Zarruk, J. G., Ceballos, P., Pérez, D. I., Pérez, C., Perez-Castillo, A., Moro, M. A., Brea, J., Val, C., Cadavid, M. I., Loza, M. I., Campillo, N. E., Martínez, A., & Gil, C. (2012). Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. European Journal of Medicinal Chemistry, 47, 175–185. https://doi.org/10.1016/j.ejmech.2011.10.040

Redondo, M., Palomo, V., Brea, J., Pérez, D. I., Martín-Álvarez, R., Pérez, C., Paúl-Fernández, N., Conde, S., Cadavid, M. I., Loza, M. I., Mengod, G., Martínez, A., Gil, C., & Campillo, N. E. (2012). Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice. ACS Chemical Neuroscience, 3(10), 793–803. https://doi.org/10.1021/cn300105c

Morales-Garcia, J. A., Luna-Medina, R., Alonso-Gil, S., Sanz-SanCristobal, M., Palomo, V., Gil, C., Santos, A., Martinez, A., & Perez-Castillo, A. (2012). Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo. ACS Chemical Neuroscience, 3(11), 963–971. https://doi.org/10.1021/cn300110c

Redondo, M., Brea, J., Perez, D. I., Soteras, I., Val, C., Perez, C., Morales-García, J. A., Alonso-Gil, S., Paul-Fernandez, N., Martin-Alvarez, R., Cadavid, M. I., Loza, M. I., Perez-Castillo, A., Mengod, G., Campillo, N. E., Martinez, A., & Gil, C. (2012). Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds. Journal of Medicinal Chemistry, 55(7), 3274–3284. https://doi.org/10.1021/jm201720d

Serrano, A., Pavón, F. J., Suarez, J., Rivera, P., Vida, M., Bermúdez-Silva, F. J., Alonso, M., Martínez, A., López-Ogalla, J., Alonso-Gascón, M., Santamaría, G., Romero-Cuevas, M., Pérez-Valero, V., Baixeras, E., & Rodríguez de Fonseca, F. (2012). Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals. American Journal of Physiology-Endocrinology and Metabolism, 302(7), E817–E830. https://doi.org/10.1152/ajpendo.00468.2011

Chiriano, G., De Simone, A., Mancini, F., Perez, D. I., Cavalli, A., Bolognesi, M. L., Legname, G., Martinez, A., Andrisano, V., Carloni, P., & Roberti, M. (2012). A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry, 48, 206–213. https://doi.org/10.1016/j.ejmech.2011.12.016

Pérez, D. I., Pistolozzi, M., Palomo, V., Redondo, M., Fortugno, C., Gil, C., Felix, G., Martinez, A., & Bertucci, C. (2012). 5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood–brain barrier penetration and binding to human serum albumin. European Journal of Pharmaceutical Sciences, 45(5), 677–684. https://doi.org/10.1016/j.ejps.2012.01.007

Palomo, V., Perez, D. I., Perez, C., Morales-Garcia, J. A., Soteras, I., Alonso-Gil, S., Encinas, A., Castro, A., Campillo, N. E., Perez-Castillo, A., Gil, C., & Martinez, A. (2012). 5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3. Journal of Medicinal Chemistry, 55(4), 1645–1661. https://doi.org/10.1021/jm201463v

Morales-García, J. A., Susín, C., Alonso-Gil, S., Pérez, D. I., Palomo, V., Pérez, C., Conde, S., Santos, A., Gil, C., Martínez, A., & Pérez-Castillo, A. (2012). Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease. ACS Chemical Neuroscience, 4(2), 350–360. https://doi.org/10.1021/cn300182g

Palomo, V., I. Perez, D., Gil, C., & Martinez, A. (2011). The Potential Role of Glycogen Synthase Kinase 3 Inhibitors as Amyotrophic Lateral Sclerosis Pharmacological Therapy. Current Medicinal Chemistry, 18(20), 3028–3034. https://doi.org/10.2174/092986711796391697

Perez, D. I., Palomo, V., Pérez, C., Gil, C., Dans, P. D., Luque, F. J., Conde, S., & Martínez, A. (2011). Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds. Journal of Medicinal Chemistry, 54(12), 4042–4056. https://doi.org/10.1021/jm1016279

Crespillo, A., Alonso, M., Vida, M., Pavón, F., Serrano, A., Rivera, P., Romero‐Zerbo, Y., Fernández‐Llebrez, P., Martínez, A., Pérez‐Valero, V., Bermúdez‐Silva, F., Suárez, J., & de Fonseca, F. (2011). Reduction of body weight, liver steatosis and expression of stearoyl‐CoA desaturase 1 by the isoflavone daidzein in diet‐induced obesity. British Journal of Pharmacology, 164(7), 1899–1915. Portico. https://doi.org/10.1111/j.1476-5381.2011.01477.x

Perez, D. I., Gil, C., & Martinez, A. (2011). Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases. Medicinal Research Reviews, 31(6), 924–954. Portico. https://doi.org/10.1002/med.20207

Morales-Garcia, J. A., Redondo, M., Alonso-Gil, S., Gil, C., Perez, C., Martinez, A., Santos, A., & Perez-Castillo, A. (2011). Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease. PLoS ONE, 6(2), e17240. https://doi.org/10.1371/journal.pone.0017240

Paterniti, I., Mazzon, E., Gil, C., Impellizzeri, D., Palomo, V., Redondo, M., Perez, D. I., Esposito, E., Martinez, A., & Cuzzocrea, S. (2011). PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury. PLoS ONE, 6(1), e15937. https://doi.org/10.1371/journal.pone.0015937

Crouch, P., Cole, A., Cousin, M., Martinez, A., & Kanninen, K. (2011). Glycogen Synthase Kinase‐3. International Journal of Alzheimer’s Disease, 2011(1). Portico. https://doi.org/10.4061/2011/279234

Martinez, A., Gil, C., & Perez, D. I. (2011). Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment. International Journal of Alzheimer’s Disease, 2011(1). Portico. https://doi.org/10.4061/2011/280502

Eldar-Finkelman, H., & Martinez, A. (2011). GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Frontiers in Molecular Neuroscience, 4. https://doi.org/10.3389/fnmol.2011.00032

Palomo, V., Soteras, I., Perez, D. I., Perez, C., Gil, C., Campillo, N. E., & Martinez, A. (2011). Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities. Journal of Medicinal Chemistry, 54(24), 8461–8470. https://doi.org/10.1021/jm200996g

Ermondi, G., Caron, G., Pintos, I. G., Gerbaldo, M., Pérez, M., Pérez, D. I., Gándara, Z., Martínez, A., Gómez, G., & Fall, Y. (2011). An application of two MIFs-based tools (Volsurf+ and Pentacle) to binary QSAR: The case of a palinurin-related data set of non-ATP competitive Glycogen Synthase Kinase 3β (GSK-3β) inhibitors. European Journal of Medicinal Chemistry, 46(3), 860–869. https://doi.org/10.1016/j.ejmech.2010.12.024

Martinez, A. (Ed.). (2010). Emerging Drugs and Targets for Alzheimer’s Disease. Drug Discovery. https://doi.org/10.1039/9781849731072

Perez, D. I., Gil, C., & Martinez, A. (2010). Chapter 9. Tau Protein Kinases Inhibitors: From the Bench to the Clinical Trials. Emerging Drugs and Targets for Alzheimer’s Disease, 173–194. https://doi.org/10.1039/9781849731065-00173

Perez, D. I., Conde, S., Pérez, C., Gil, C., Simon, D., Wandosell, F., Moreno, F. J., Gelpí, J. L., Luque, F. J., & Martínez, A. (2009). Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools. Bioorganic & Medicinal Chemistry, 17(19), 6914–6925. https://doi.org/10.1016/j.bmc.2009.08.042

Pérez, M., Pérez, D. I., Martínez, A., Castro, A., Gómez, G., & Fall, Y. (2009). The first enantioselective synthesis of palinurin. Chemical Communications, 22, 3252. https://doi.org/10.1039/b822679b

Fernández‐Bachiller, M. I., Pérez, C., Campillo, N. E., Páez, J. A., González‐Muñoz, G. C., Usán, P., García‐Palomero, E., López, M. G., Villarroya, M., García, A. G., Martínez, A., & Rodríguez‐Franco, M. I. (2009). Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer’s Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties. ChemMedChem, 4(5), 828–841. Portico. https://doi.org/10.1002/cmdc.200800414

Castaño, T., Wang, H., Campillo, N. E., Ballester, S., González‐García, C., Hernández, J., Pérez, C., Cuenca, J., Pérez‐Castillo, A., Martínez, A., Huertas, O., Gelpí, J. L., Luque, F. J., Ke, H., & Gil, C. (2009). Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors. ChemMedChem, 4(5), 866–876. Portico. https://doi.org/10.1002/cmdc.200900043

Valero, T., del Barrio, L., Egea, J., Cañas, N., Martínez, A., García, A. G., Villarroya, M., & López, M. G. (2009). NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells. European Journal of Pharmacology, 607(1–3), 47–53. https://doi.org/10.1016/j.ejphar.2009.02.021

Morales‐Garcia, J. A., Luna‐Medina, R., Martinez, A., Santos, A., & Perez‐Castillo, A. (2009). Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid‐induced seizures in rats. Journal of Neuroscience Research, 87(16), 3687–3696. Portico. https://doi.org/10.1002/jnr.22165

Martinez, A., Lahiri, D., Giacobini, E., & Greig, N. (2009). Editorial [Hot Topic:Advances in Alzheimer Therapy: Understanding Pharmacological Approaches to the Disease (Guest Editors: Ana Martinez, Debomoy K. Lahiri, Ezio Giacobini and Nigel H. Greig)]. Current Alzheimer Research, 6(2), 83–85. https://doi.org/10.2174/156720509787602924

Martinez, A. (2008). Preclinical efficacy on GSK‐3 inhibitors: Towards a future generation of powerful drugs. Medicinal Research Reviews, 28(5), 773–796. Portico. https://doi.org/10.1002/med.20119

García-Palomero, E., Muñoz, P., Usan, P., Garcia, P., Delgado, E., De Austria, C., Valenzuela, R., Rubio, L., Medina, M., & Martínez, A. (2008). Potent β-Amyloid Modulators. Neurodegenerative Diseases, 5(3–4), 153–156. Portico. https://doi.org/10.1159/000113688

Gil, C., Campillo, N. E., Perez, D. I., & Martinez, A. (2008). PDE7 inhibitors as new drugs for neurological and inflammatory disorders. Expert Opinion on Therapeutic Patents, 18(10), 1127–1139. https://doi.org/10.1517/13543776.18.10.1127

Castro, A., Encinas, A., Gil, C., Bräse, S., Porcal, W., Pérez, C., Moreno, F. J., & Martínez, A. (2008). Non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: Study of structural requirements for thiadiazolidinone derivatives. Bioorganic & Medicinal Chemistry, 16(1), 495–510. https://doi.org/10.1016/j.bmc.2007.09.016

Rosa, A. O., Egea, J., Martínez, A., García, A. G., & López, M. G. (2008). Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: Implication of ERK1/2 and PPARγ receptors. Experimental Neurology, 212(1), 93–99. https://doi.org/10.1016/j.expneurol.2008.03.008

Martinez, A., & Perez, D. I. (2008). GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer’s Disease? Journal of Alzheimer’s Disease, 15(2), 181–191. https://doi.org/10.3233/jad-2008-15204

Castro, A., Jerez, M. J., Gil, C., Calderón, F., Doménech, T., Nueda, A., & Martínez, A. (2008). CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example. European Journal of Medicinal Chemistry, 43(7), 1349–1359. https://doi.org/10.1016/j.ejmech.2007.10.027

Rosa, A. O., Kaster, M. P., Binfaré, R. W., Morales, S., Martín-Aparicio, E., Navarro-Rico, M. L., Martinez, A., Medina, M., García, A. G., López, M. G., & Rodrigues, A. L. S. (2008). Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(6), 1549–1556. https://doi.org/10.1016/j.pnpbp.2008.05.020

Martinez, A. (2008). S4‐02–03: TDZDS: Can we target tau, beta‐amyloid and neurodegeneration simultaneously? Alzheimer’s & Dementia, 4(4S_Part_5). Portico. https://doi.org/10.1016/j.jalz.2008.05.481

Luna-Medina, R., Cortes-Canteli, M., Sanchez-Galiano, S., Morales-Garcia, J. A., Martinez, A., Santos, A., & Perez-Castillo, A. (2007). NP031112, a Thiadiazolidinone Compound, Prevents Inflammation and Neurodegeneration under Excitotoxic Conditions: Potential Therapeutic Role in Brain Disorders. The Journal of Neuroscience, 27(21), 5766–5776. https://doi.org/10.1523/jneurosci.1004-07.2007

Hamann, M., Alonso, D., Martín-Aparicio, E., Fuertes, A., Pérez-Puerto, M. J., Castro, A., Morales, S., Navarro, M. L., del Monte-Millán, M., Medina, M., Pennaka, H., Balaiah, A., Peng, J., Cook, J., Wahyuono, S., & Martínez, A. (2007). Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease. Journal of Natural Products, 70(9), 1397–1405. https://doi.org/10.1021/np060092r

Castro, A., & Martinez, A. (2006). Targeting Beta-Amyloid Pathogenesis Through Acetylcholinesterase Inhibitors. Current Pharmaceutical Design, 12(33), 4377–4387. https://doi.org/10.2174/138161206778792985

Alonso, D., & Martínez, A. (2006). Marine Compounds as a New Source for Glycogen Synthase Kinase 3 Inhibitors. Glycogen Synthase Kinase 3 (GSK‐3) and Its Inhibitors, 307–331. Portico. https://doi.org/10.1002/0470052171.ch16

Rao, K. V., Donia, M. S., Peng, J., Garcia-Palomero, E., Alonso, D., Martinez, A., Medina, M., Franzblau, S. G., Tekwani, B. L., Khan, S. I., Wahyuono, S., Willett, K. L., & Hamann, M. T. (2006). Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity against Infectious, Tropical Parasitic, and Alzheimer’s Diseases. Journal of Natural Products, 69(7), 1034–1040. https://doi.org/10.1021/np0601399

Maraschiello, C., Vilageliu, J., Dorronsoro, I., Martinez, A., Floriano, P., & Gómez‐Acebo, E. (2006). Enantioselective LC/MS method for the determination of an antimalarial agent Fenozan B07 in dog plasma. Chirality, 18(5), 297–305. Portico. https://doi.org/10.1002/chir.20253

Martinez, A. (2006). S4–04–06: Thiadiazolidindiones, selective glycogen synthase kinase–3 inhibitors as potential therapeutic agents for Alzheimer’s disease and other tauopathies. Alzheimer’s & Dementia, 2(3S_Part_3). Portico. https://doi.org/10.1016/j.jalz.2006.05.289

Martinez, A., Alonso, M., Castro, A., Dorronsoro, I., Gelpí, J. L., Luque, F. J., Pérez, C., & Moreno, F. J. (2005). SAR and 3D-QSAR Studies on Thiadiazolidinone Derivatives:  Exploration of Structural Requirements for Glycogen Synthase Kinase 3 Inhibitors. Journal of Medicinal Chemistry, 48(23), 7103–7112. https://doi.org/10.1021/jm040895g

Luna-Medina, R., Cortes-Canteli, M., Alonso, M., Santos, A., Martínez, A., & Perez-Castillo, A. (2005). Regulation of Inflammatory Response in Neural Cells in Vitro by Thiadiazolidinones Derivatives through Peroxisome Proliferator-activated Receptor γ Activation. Journal of Biological Chemistry, 280(22), 21453–21462. https://doi.org/10.1074/jbc.m414390200

Poltev, V. I., Gonzalez, E., Deriabina, A. S., Lozano, L., Martinez, A., Robinson, T., Gorb, L., & Leszczynski, J. (2005). Molecular mechanics description of cytosine energy and geometry using preliminary ab initio results. Journal of Molecular Structure: THEOCHEM, 729(1–2), 59–64. https://doi.org/10.1016/j.theochem.2004.12.045

Alonso, D., Castro, A., & Martinez, A. (2005). Marine compounds for the therapeutic treatment of neurological disorders. Expert Opinion on Therapeutic Patents, 15(10), 1377–1386. https://doi.org/10.1517/13543776.15.10.1377

Gil, C., Dorronsoro, I., Castro, A., & Martinez, A. (2005). Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques. Bioorganic & Medicinal Chemistry Letters, 15(7), 1919–1921. https://doi.org/10.1016/j.bmcl.2005.01.081

Muñoz-Ruiz, P., Rubio, L., García-Palomero, E., Dorronsoro, I., del Monte-Millán, M., Valenzuela, R., Usán, P., de Austria, C., Bartolini, M., Andrisano, V., Bidon-Chanal, A., Orozco, M., Luque, F. J., Medina, M., & Martínez, A. (2005). Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors:  New Disease-Modifying Agents for Alzheimer’s Disease. Journal of Medicinal Chemistry, 48(23), 7223–7233. https://doi.org/10.1021/jm0503289

Rodríguez-Franco, M. I., Fernández-Bachiller, M. I., Pérez, C., Castro, A., & Martínez, A. (2005). Design and synthesis of N-benzylpiperidine–purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase. Bioorganic & Medicinal Chemistry, 13(24), 6795–6802. https://doi.org/10.1016/j.bmc.2005.07.019

Alonso, D., Dorronsoro, I., Rubio, L., Muñoz, P., García-Palomero, E., Del Monte, M., Bidon-Chanal, A., Orozco, M., Luque, F. J., Castro, A., Medina, M., & Martínez, A. (2005). Donepezil–tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. Bioorganic & Medicinal Chemistry, 13(24), 6588–6597. https://doi.org/10.1016/j.bmc.2005.09.029

Martinez, A., & Castro, A. (2005). Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer’s disease. Expert Opinion on Investigational Drugs, 15(1), 1–12. https://doi.org/10.1517/13543784.15.1.1

Rodrigo, J., Fernández-Vizarra, P., Castro-Blanco, S., Bentura, M. L., Nieto, M., Gómez-Isla, T., MartÍnez-Murillo, R., MartÍnez, A., Serrano, J., & Fernández, A. P. (2004). Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice. Neuroscience, 128(1), 73–89. https://doi.org/10.1016/j.neuroscience.2004.06.030

Alonso, M., & Martinez, A. (2004). GSK-3 Inhibitors: Discoveries and Developments. Current Medicinal Chemistry, 11(6), 755–763. https://doi.org/10.2174/0929867043455738

Dorronsoro, I., Chana, A., Abasolo, M. I., Castro, A., Gil, C., Stud, M., & Martinez, A. (2004). CODES/Neural Network Model: a Useful Tool for in Silico Prediction of Oral Absorption and Blood‐Brain Barrier Permeability of Structurally Diverse Drugs. QSAR & Combinatorial Science, 23(2–3), 89–98. Portico. https://doi.org/10.1002/qsar.200330858

Castro, A., Jerez, M. J., Gil, C., & Martinez, A. (2004). Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors. Medicinal Research Reviews, 25(2), 229–244. Portico. https://doi.org/10.1002/med.20020

Conde, S., Pérez, D. I., Martínez, A., Perez, C., & Moreno, F. J. (2003). Thienyl and Phenyl α-Halomethyl Ketones:  New Inhibitors of Glycogen Synthase Kinase (GSK-3β) from a Library of Compound Searching. Journal of Medicinal Chemistry, 46(22), 4631–4633. https://doi.org/10.1021/jm034108b

Rodrı́guez-Franco, M. I., Dorronsoro, I., Castro, A., Martı́nez, A., Badı́a, A., & Baños, J. E. (2003). Synthesis and muscarinic activities of O-[(Benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone. Bioorganic & Medicinal Chemistry, 11(10), 2263–2268. https://doi.org/10.1016/s0968-0896(03)00111-1

Martinez, A., Gil, C., Castro, A., Pérez, C., Prieto, C., & Otero, J. (2003). Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity☆. Bioorganic & Medicinal Chemistry, 11(11), 2395–2402. https://doi.org/10.1016/s0968-0896(03)00148-2

Morales-Alcelay, S., Rubio, L., & Martinez, A. (2003). AMPA Glutamate Receptors and Neuropathic Pain. Mini-Reviews in Medicinal Chemistry, 3(7), 757–763. https://doi.org/10.2174/1389557033487719

Castro, A., Conde, S., Rodriguez-Franco, M., & Martinez, A. (2002). Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimers Disease. Mini-Reviews in Medicinal Chemistry, 2(1), 37–50. https://doi.org/10.2174/1389557023406610

Dorronsoro, I., Castro, A., & Martinez, A. (2002). Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs? Expert Opinion on Therapeutic Patents, 12(10), 1527–1536. https://doi.org/10.1517/13543776.12.10.1527

Martinez, A., Castro, A., Dorronsoro, I., & Alonso, M. (2002). Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Medicinal Research Reviews, 22(4), 373–384. Portico. https://doi.org/10.1002/med.10011

Martinez, A., Alonso, M., Castro, A., Pérez, C., & Moreno, F. J. (2002). First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors:  Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer’s Disease. Journal of Medicinal Chemistry, 45(6), 1292–1299. https://doi.org/10.1021/jm011020u

Silva, A. M. S., Pinto, D. C. G. A., Cavaleiro, J. A. S., Martínez, A., Castro, A., & Elguero, J. (2002). An Experimental NMR and Semi-Empirical Theoretical Study of the Conformation of Styrylchromones and Styryl Alkyl or Aryl Ketones (Benzylidene Ketones). Journal of Chemical Research, 2002(4), 162–164. https://doi.org/10.3184/030823402103171735

Martinez, A., Castro, A., Gil, C., & Perez, C. (2001). Recent strategies in the development of new human cytomegalovirus inhibitors. Medicinal Research Reviews, 21(3), 227–244. Portico. https://doi.org/10.1002/med.1008

Castro, A., & Martinez, A. (2001). Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease. Mini-Reviews in Medicinal Chemistry, 1(3), 267–272. https://doi.org/10.2174/1389557013406864

Rodríguez-Franco, M. I., Dorronsoro, I., & Martínez, A. (2001). O-Pyrazolylpropynyl-Hydroxylamines as Versatile Intermediates in the Synthesis of Compounds of Pharmacological Interest. Synthesis, 2001(11), 1711–1715. https://doi.org/10.1055/s-2001-16768

Castro, A. (2001). CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-a]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors. European Journal of Medicinal Chemistry, 36(4), 333–338. https://doi.org/10.1016/s0223-5234(01)01227-2

Martinez, A., Gil, C., Castro, A., Perez, C., Witvrouw, M., Pannecouque, C., Balzarini, J., & De Clercq, E. (2001). Anti-HIV-1 Activity of Benzothiadiazine Dioxide. Antiviral Chemistry and Chemotherapy, 12(6), 347–351. https://doi.org/10.1177/095632020101200604

Martinez, A., Esteban, A., Gil, C., Conde, S., Andrei, G., Snoeck, R., Balzarini, J., & De Clercq, E. (2000). Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity. Antiviral Chemistry and Chemotherapy, 11(3), 221–230. https://doi.org/10.1177/095632020001100305

Conde, S., López-Serrano, P., & Martı́nez, A. (2000). Regioselective lipase-catalysed γ-monoamidation of d-glutamic acid diesters: effect of the N-protecting group. Tetrahedron: Asymmetry, 11(12), 2537–2545. https://doi.org/10.1016/s0957-4166(00)00210-x

Castro, A., & Martinez, A. (2000). Novel agents for the treatment of human cytomegalovirus infection. Expert Opinion on Therapeutic Patents, 10(2), 165–177. https://doi.org/10.1517/13543776.10.2.165

Martinez, A., Gil, C., Perez, C., Castro, A., Prieto, C., Otero, J., Andrei, G., Snoeck, R., Balzarini, J., & De Clercq, E. (2000). Nonnucleoside Human Cytomegalovirus Inhibitors:  Synthesis and Antiviral Evaluation of (Chlorophenylmethyl)benzothiadiazine Dioxide Derivatives. Journal of Medicinal Chemistry, 43(17), 3267–3273. https://doi.org/10.1021/jm000118q

Martinez, A., Fernandez, E., Castro, A., Conde, S., Rodriguez-Franco, I., Baños, J.-E., & Badia, A. (2000). N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 35(10), 913–922. https://doi.org/10.1016/s0223-5234(00)01166-1

Martı́nez, A., Lanot, C., Perez, C., Castro, A., López-Serrano, P., & Conde, S. (2000). Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives. Bioorganic & Medicinal Chemistry, 8(4), 731–738. https://doi.org/10.1016/s0968-0896(00)00020-1

Rodrı́guez-Franco, M. I., Dorronsoro, I., Castro, A., & Martı́nez, A. (2000). Hindered Inversion/Rotation in Diheteroaryl Alkyl Amines with a N-(1-Pyrazolyl) Group: Dynamic NMR and Molecular Modelling Studies. Tetrahedron, 56(12), 1739–1743. https://doi.org/10.1016/s0040-4020(99)01086-8

Martínez, A., Castro, A., Gil, C., Miralpeix, M., Segarra, V., Doménech, T., Beleta, J., Palacios, J. M., Ryder, H., Miró, X., Bonet, C., Casacuberta, J. M., Azorín, F., Piña, B., & Puigdoménech, P. (2000). Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides:  First Phosphodiesterase 7 Inhibitors. Journal of Medicinal Chemistry, 43(4), 683–689. https://doi.org/10.1021/jm990382n

Martinez, A., Gil, C., Abasolo, M. I., Castro, A., Bruno, A. M., Perez, C., Prieto, C., & Otero, J. (2000). Benzothiadiazine Dioxide Dibenzyl Derivatives as Potent Human Cytomegalovirus Inhibitors:  Synthesis and Comparative Molecular Field Analysis. Journal of Medicinal Chemistry, 43(17), 3218–3225. https://doi.org/10.1021/jm000033p

Castro, A., & Martinez, A. (2000). Inhibition of tau phosphorylation: a new therapeutic strategy for the treatment of Alzheimer’s disease and other neurodegenerative disorders. Expert Opinion on Therapeutic Patents, 10(10), 1519–1527. https://doi.org/10.1517/13543776.10.10.1519

Rodríguez-Franco, M. I., San Lorenzo, P., Martínez, A., & Navarro, P. (1999). Selective dopamine receptors: Synthesis, complexing properties, and molecular modelling studies of new podands derived from 4-hydroxy-1H-pyrazole. Tetrahedron, 55(9), 2763–2772. https://doi.org/10.1016/s0040-4020(99)00047-2

Castro, A., Gil, C., & Martínez, A. (1999). On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds. Tetrahedron, 55(42), 12405–12410. https://doi.org/10.1016/s0040-4020(99)00723-1

Martinez, A., Esteban, A. I., Castro, A., Gil, C., Conde, S., Andrei, G., Snoeck, R., Balzarini, J., & De Clercq, E. (1999). Novel Potential Agents for Human Cytomegalovirus Infection:  Synthesis and Antiviral Activity Evaluation of Benzothiadiazine Dioxide Acyclonucleosides. Journal of Medicinal Chemistry, 42(7), 1145–1150. https://doi.org/10.1021/jm980327z

Castro, A., & Martinez, A. (1999). Intramolecular oxidative cyclizations in heteroarylthioureas: A versatile pathway to bridgehead heterocyclic systems. Journal of Heterocyclic Chemistry, 36(4), 991–995. Portico. https://doi.org/10.1002/jhet.5570360427

Martı́nez, A., Esteban, A. I., Herrero, A., Ochoa, C., Andrei, G., Snoeck, R., Balzarini, J., & Clercq, E. D. (1999). Imidazothiadiazine dioxides: synthesis and antiviral activity. Bioorganic & Medicinal Chemistry, 7(8), 1617–1623. https://doi.org/10.1016/s0968-0896(99)00114-5

Martinez, A., Gil, C., Perez, C., Castro, A., Prieto, C., & Otero, J. (1999). Chlorophenylmethyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors. Bioorganic & Medicinal Chemistry Letters, 9(21), 3133–3136. https://doi.org/10.1016/s0960-894x(99)00538-7

Conde, S., López-Serrano, P., & Martı́nez, A. (1999). Candida antarctica lipase B catalysed amidation of pyroglutamic acid derivatives. A reaction survey. Journal of Molecular Catalysis B: Enzymatic, 7(5–6), 299–306. https://doi.org/10.1016/s1381-1177(99)00051-x

Juanes, O., Goya, P., & Martinez, A. (1998). Towards lipophilic derivatives of S‐adenosyl‐L‐methionine. Journal of Heterocyclic Chemistry, 35(3), 727–730. Portico. https://doi.org/10.1002/jhet.5570350338

Martinez, A., Castro, A., Arán, V. J., Cardelús, I., Llenas, J., & Palacios, J. M. (1998). Synthesis of nonsymmetrically 3,4‐disubstituted 1,2,5‐thiadiazole dioxides. Journal of Heterocyclic Chemistry, 35(2), 297–300. Portico. https://doi.org/10.1002/jhet.5570350206

Conde, S., Fierros, M., Rodrı́guez-Franco, M. I., & Puig, C. (1998). Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol by lipase mediated enantioselective alcoholysis, hydrolysis and acylation. Tetrahedron: Asymmetry, 9(13), 2229–2232. https://doi.org/10.1016/s0957-4166(98)00252-3

Segarra, V., Isabel Crespo, M., Pujol, F., Beleta, J., Doménech, T., Miralpeix, M., Palacios, J. M., Castro, A., & Martinez, A. (1998). Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds. Bioorganic & Medicinal Chemistry Letters, 8(5), 505–510. https://doi.org/10.1016/s0960-894x(98)00058-4

Conde, S., López-Serrano, P., & Martínez, A. (1998). Lipase catalysed amidation of diethyl glutamate derivatives; peculiarities of ethyl S- and R-pyroglutamate. Biotechnology Letters, 20(3), 261–263. https://doi.org/10.1023/a:1005330003201

Conde, S., Esteban, A. I., Alonso, D., López-Serrano, P., & Martı́nez, A. (1998). Enzymatic alcoholysis of SO2-uracil analog diacyclonucleosides. Long-distance effect of the substituents on the regioselectivity. Journal of Molecular Catalysis B: Enzymatic, 4(5–6), 295–302. https://doi.org/10.1016/s1381-1177(98)00068-x

Esteban, A. I., Clercq, E. D., & Martinez, A. (1997). Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides. Nucleosides and Nucleotides, 16(3), 265–276. https://doi.org/10.1080/07328319708001347

Rodríguez-Franco, M. I., Fierros, M., Martínez, A., Navarro, P., & Conde, S. (1997). Selective carriers of norepinephrine and ammonium ions: Ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit. Bioorganic & Medicinal Chemistry, 5(2), 363–367. https://doi.org/10.1016/s0968-0896(96)00250-7

Conde, S., López-Serrano, P., Fierros, M., Biezma, M. I., Martínez, A., & Rodríguez-Franco, M. I. (1997). Regioselective lipase-catalyzed synthesis of l-glutamic α-monoamide derivatives. Effect of the N-blocking group. Tetrahedron, 53(34), 11745–11752. https://doi.org/10.1016/s0040-4020(97)00741-2

Conde, S., Fierros, M., Dorronsoro, I., Luisa Jimeno, M., & Rodríguez-Franco, M. I. (1997). Regioselective lipase catalyzed synthesis of diester crowns. New asymmetric macrocycles containing a 1,3-bis(1H-pyrazol-1-yl)propane unit. Tetrahedron, 53(33), 11481–11488. https://doi.org/10.1016/s0040-4020(97)00727-8

Alcalde, E., Barat, A., Goya, P., Martinez, A., Ramirez, G., Roca, T., & Rozas, I. (1997). Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase. Bioorganic & Medicinal Chemistry, 5(5), 949–954. https://doi.org/10.1016/s0968-0896(97)00033-3

Martínez, A., Ochoa, C., Rodríguez, J., Rodríguez, M., Castro, A., González, M., & Martínez, M. M. (1997). Comparative Molecular Field Analysis (CoMFA) on [6] + [6] Fused Pyrazines with Nematocide Properties. Quantitative Structure-Activity Relationships, 16(5), 372–376. Portico. https://doi.org/10.1002/qsar.19970160504

Martinez, A., Esteban, A. I., & Clercq, E. D. (1997). Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infections. Bioorganic & Medicinal Chemistry Letters, 7(8), 1031–1032. https://doi.org/10.1016/s0960-894x(97)00149-2

Martínez, A., Castro, A., Cardelús, I., Llenas, J., & Palacios, JoséM. (1997). Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers. Bioorganic & Medicinal Chemistry, 5(7), 1275–1283. https://doi.org/10.1016/s0968-0896(97)00077-1

Linares, A., Acosta, J. L., Martinez, A., & García-Laureiro, J. I. (1997). Applications of a statistical model to the analysis of the kinetic parameters in isothermal and non-isothermal crystallization of polymer blends based on PVDF. Polymer, 38(11), 2741–2746. https://doi.org/10.1016/s0032-3861(97)85609-1

Martinez, A., Castro, A., & Fayet, J. P. (1997). Base promoted transformation on thiadiazolopyridinium chlorides. Journal of Heterocyclic Chemistry, 34(1), 337–340. Portico. https://doi.org/10.1002/jhet.5570340153

Martinez, A., Castro, A., Fonseca, I., Martinez-Ripoll, M., H. Cano, F., & Albert, A. (1996). New Synthetic Route to of 1,2,4-Thiadiazolines and 1,3-Thiazolines via Thiadiazolopyridinium Salts. HETEROCYCLES, 43(12), 2657. https://doi.org/10.3987/com-96-7593

Singh, S. P., Kumar, D., Kumar, D., Martínez, A., & Elguero, J. (1996). Conformation and ortho steric effects in a series of 2‐(pyrazol‐1‐yl)quinolines. Journal of Heterocyclic Chemistry, 33(2), 323–326. Portico. https://doi.org/10.1002/jhet.5570330219

Kumar, D., Singh, S. P., Martínez, A., Fruchier, A., Elguero, J., Martínez-Ripoll, M., Carrió, J. S., & Virgili, A. (1995). The structure of the compounds resulting from the reaction of arylhydrazines with dehydroacetic acid: an NMR and crystallographic study. Tetrahedron, 51(16), 4891–4906. https://doi.org/10.1016/0040-4020(95)00172-5

Alcaide, B. (1995). The Regio- and Stereocontrolled Ring Opening of Heteroarylglycidates with Nitrogen Nucleophiles. Tetrahedron Letters, 36(30), 5417–5420. https://doi.org/10.1016/00404-0399(50)0994n-

Llamas-Saiz, A. L., Foces-Foces, C., Martínez, A., & Elguero, J. (1995). Semiempirical (AM1, PM3 and SAM1) calculations of the protonation enthalpies of proton sponges related to 1,8-diaminonaphthalene. Estimation of the aqueous basicity of new designed superbases. J. Chem. Soc., Perkin Trans. 2, 5, 923–927. https://doi.org/10.1039/p29950000923

Fierros, M., Conde, S., Martínez, A., Navarro, P., & Rodríguez-Franco, M. I. (1995). Regioselective Mucor miehei lipase catalyzed synthesis of podands containing a 1,3-bis(1H-Pyrazol-1-yl)propane unit. Tetrahedron, 51(8), 2417–2426. https://doi.org/10.1016/0040-4020(94)01106-a

Esteban, A. I., Juanes, O., Conde, S., Goya, P., De Clercq, E., & Martínez, A. (1995). New 1,2,6-thiadiazine dioxide acyclonucleosides: Synthesis and antiviral evaluation. Bioorganic & Medicinal Chemistry, 3(11), 1527–1535. https://doi.org/10.1016/0968-0896(95)00140-c

Castro, A., Martínez, A., Cardelús, I., & Llenas, J. (1995). Dioxides of bicyclic thiadiazines: a new family of smooth muscle relaxants. Bioorganic & Medicinal Chemistry, 3(2), 179–185. https://doi.org/10.1016/0968-0896(95)00012-6

Castro, A., & Martínez, A. (1994). Tautomerism of benzo- and cyclopenta-[1,2,6]thiadiazine S,S-dioxides. J. Chem. Soc., Perkin Trans. 2, 7, 1561–1564. https://doi.org/10.1039/p29940001561

Esteban, A. I., Juanes, O., Martínez, A., & Conde, S. (1994). Regioselective lipase-mediated acylation-deacylation in thiadiazine diacyclonucleosides. Tetrahedron, 50(48), 13865–13870. https://doi.org/10.1016/s0040-4020(01)85694-5

Avendaño, C., Espada, M., Ocaña, B., García-Granda, S., Díaz, M. del R., Tejerina, B., Gómez-Beltrán, F., Martínez, A., & Elguero, J. (1993). The problem of the existence of C(Ar)–H ⋯ N intramolecular hydrogen bonds in a family of 9-azaphenyl-9H-carbazoles. J. Chem. Soc., Perkin Trans. 2, 8, 1547–1555. https://doi.org/10.1039/p29930001547

Perrin, M., Thozet, A., Lecocq, S., Elguero, J., Martinez, A., & Fruchier, A. (1993). The molecular structure of 3(5)-methyl-4,5(3)-trimethylenepyrazole hydrochloride and its13C and15N NMR spectroscopy. Journal of Crystallographic and Spectroscopic Research, 23(12), 961–965. https://doi.org/10.1007/bf01185544

de la Cruz, A., Elguero, J., Goya, P., Martineza, A., & De Clercq, E. (1993). Synthesis and biological evaluation of 4-quinolone ribosides. Journal of the Chemical Society, Perkin Transactions 1, 7, 845. https://doi.org/10.1039/p19930000845

Klein, J. F., Pommelet, J. C., Chuche, J., Elguero, J., Goya, P., & Martinez, A. (1993). SO2 extrusion in 1,2,6-thiadiazine 1,1-dioxides: a novel synthesis of pyrazoles. Canadian Journal of Chemistry, 71(3), 410–412. https://doi.org/10.1139/v93-060

Brenner, I. B., & Dorfman, E. (1993). Application of ultrasonic nebulization for the determination of rare earth elements in phosphates and related sedimentary rocks using inductively coupled plasma atomic emission spectrometry with comments on dissolution procedures. Journal of Analytical Atomic Spectrometry, 8(6), 833. https://doi.org/10.1039/ja9930800833

de la Cruz, A., Elguero, J., Goya, P., Martínez, A., & Pfleiderer, W. (1992). Tautomerism and acidity in 4-quinolone-3-carboxylic acid derivatives. Tetrahedron, 48(29), 6135–6150. https://doi.org/10.1016/s0040-4020(01)89860-4

Alcalde, E., Roca, T., Barat, A., Ramirez, G., Goya, P., & Martinez, A. (1992). (E)-1-alkyl-[2-(1H-azol-2-yl)vinyl]pyridinium salts: theoretical analysis, synthesis and evaluation of their interaction with choline acetyltransferase. Bioorganic & Medicinal Chemistry Letters, 2(12), 1493–1496. https://doi.org/10.1016/s0960-894x(00)80415-1

Elguero, J., Martinez, A., Singh, S. P., & Kumar, D. (1991). Synthesis and NMR spectroscopy (1H 13C) of 1‐(2′‐benzothiazolyl)‐3(5),4‐polymethylenepyrazoles and related compounds. Journal of Heterocyclic Chemistry, 28(3), 647–651. Portico. https://doi.org/10.1002/jhet.5570280319

Herranz, R., Suárez-Gea, M. L., Vinuesa, S., García-López, M. T., & Martínez, A. (1991). Synthesis of Ψ[CH(CN)NH] pseudopeptides. A new peptide bond surrogate. Tetrahedron Letters, 32(51), 7579–7582. https://doi.org/10.1016/0040-4039(91)80539-i

de la Cruz, A., Elguero, J., Gotor, V., Goya, P., Martínez, A., & Moris, F. (1991). Lipase-Mediated Acylation of Acyclonucleosides. Application to Novel Fluoroquinolone Derivatives. Synthetic Communications, 21(14), 1477–1480. https://doi.org/10.1080/00397919108016421

de la Cruz, A., Elguero, J., Goya, P., & Martinez, A. (1990). Synthesis of a Valuable Precursor for the Preparation of Novel Quinolone Glycosides. Synlett, 1990(12), 753–754. https://doi.org/10.1055/s-1990-21239

Elguero, J., Goya, P., Martínez, A., Rozas, I., Mó, O., De Paz, J. L. G., & Yáñez, M. (1990). Structure of 1,2,6‐thiadiazine 1,1‐dioxides. Journal of Physical Organic Chemistry, 3(7), 470–476. Portico. https://doi.org/10.1002/poc.610030709

Goya, P., Martinez, A., & Jimeno, M. L. (1990). Rotational isomerism in 6-β-<scp>D</scp>-glucopyranosides of methyl-1,2,6-thiadiazin-3(2H)-one 1,1-dioxides. J. Chem. Soc., Perkin Trans. 2, 5, 783–786. https://doi.org/10.1039/p29900000783

Cruz, A. de la, Goya, P., Martínez, A., & Páez, J. A. (1990). Glycosides of Pyrido [2,3-<u>c</u>]-1,2,6-thiadiazine 2,2-Dioxides. Nucleosides and Nucleotides, 9(1), 69–79. https://doi.org/10.1080/07328319008045110

Elguero, J., Martíanez, A., Singh, S. P., Grover, M., & Tarar, L. S. (1990). A 1H and 13c Nmr study of the structure and tautomerism of 4‐pyrazolylpyrazolinones. Journal of Heterocyclic Chemistry, 27(4), 865–870. Portico. https://doi.org/10.1002/jhet.5570270409

Singh, S. P., Tarar, L. S., Vaid, R. K., Elguero, J., & Martínez, A. (1989). Reaction of 4‐hydrazinoquinolines with β‐diketones. Synthesis and spectroscopy (1h, 13c nmr, ms) of some pyrazolylquinolines. Journal of Heterocyclic Chemistry, 26(3), 733–738. Portico. https://doi.org/10.1002/jhet.5570260340

Elguero, J., Goya, P., Martinez, A., & Rozas, I. (1989). On the Tautomerism of 2‐Phenacyl‐4‐pyrimidinones and Related Compounds. Chemische Berichte, 122(5), 919–924. Portico. https://doi.org/10.1002/cber.19891220521

De La Cruz, A., Elguero, J., Goya, P., & Martinez, A. (1988). Synthesis and spectroscopic properties of N‐azolylpropanamides. Journal of Heterocyclic Chemistry, 25(1), 225–229. Portico. https://doi.org/10.1002/jhet.5570250135

Goya, P., & Martínez, A. (1988). Synthesis and Cytostatic Screening of an SO2 Analogue of Doridosine. Archiv Der Pharmazie, 321(2), 99–101. Portico. https://doi.org/10.1002/ardp.19883210213

Goya, P., Martínez, A., & Ochoa, C. (1987). Synthesis of 2S-Dioxo Isosteres of Purine and Pyrimidine Nucleosides IV. Selective Glycosylation of 4-Amino-5H-Imidazo [4, 5-c]-1, 2, 6-Thiadiazine 2, 2-Dioxide. Nucleosides, Nucleotides and Nucleic Acids, 6(3), 631–642. https://doi.org/10.1080/07328318708069992

Goya, P., & Martinez, A. (1986). N-Glucosyl-5-amino-4-carbamoyl- and 4-Ethoxycarbonylimidazoles as Potential Precursors of 4-Oxoimdazo[4,5-c]-1,2,6-thiadiazine 2,2-Dioxides. HETEROCYCLES, 24(12), 3451. https://doi.org/10.3987/r-1986-12-3451

Goya, P., Martinez, A., Ochoa, C., Stud, M., Jimeno, M. L., Foces-Foces, C., Cano, F. H., & Martinez-Ripoll, M. (1985). Synthesis and intramolecular cyclization of bisthiadiazinylmethane derivatives. Tetrahedron, 41(15), 3105–3116. https://doi.org/10.1016/s0040-4020(01)96663-3

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    Collaborating Companies: MOLEFY PHARMA, AMO PHARMA

    Spin-off: ANKAR PHARMA, MOLEFY PHARMA