Developing a DNA biofoundry towards the AI-guided exploration of microbial chemical space.

We are actively involved in the development of a DNA biofoundry (CNBio) that integrates advanced automation, synthetic biology, evolutionary engineering and artificial intelligence (AI) to explore the untapped potential of microbial metabolism. Our goal is to go beyond the limited set of known biochemical transformations and uncover new metabolic pathways that can expand the metabolic space suitable for biotechnological and medical applications. Through the use of advanced automation and synthetic biology techniques, we can design and build genetic circuits and pathways in a systematic and precise manner. This allows us to engineer microorganisms with enhanced metabolic capabilities, opening up new possibilities for the production of valuable compounds. Furthermore, the AI-guided approach enables us to explore the vast chemical landscape of potential transformations and accelerate the discovery and optimization of novel microbial metabolic capabilities.

Members (researchers): Juan Nogales Enrique

Research Groups: Systems Biotechnology Group