Begoña Aguado Orea †
In memoriam
Regulation of gene expression in Leishmania · CBM
Biocomputing and Omics Integration Facility (SBIO) at CBM · CBM
Biography
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Tenured Scientist (Científica Titular) of the Spanish National Research Council (CSIC) at the Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM), with a career linked to science, technology and innovation. She graduated in Biology from the Universidad Autónoma de Madrid (UAM), obtained her PhD from the University of Oxford and worked for thirteen years in the United Kingdom, where she was a principal investigator at the Medical Research Council (MRC) in Cambridge and specialised in the analysis of the human genome. Back in Spain, she joined the CBM, where she was scientific head of the Genomics and Massive Sequencing service, and for four years she was scientific coordinator of the Research and Innovation Infrastructures of the UAM+CSIC Campus. During the COVID-19 pandemic she took an active part in the development of new diagnostic tests and in the analysis of viral genomes. In recent years her work focused on the One Health strategy, co-leading the research group Regulation of Gene Expression in Leishmania and applying artificial intelligence and data science tools to anticipate future pandemic threats. From February 2026 she was Vice-Rector for Research, Postgraduate Studies and Lifelong Learning at the Universidad Internacional Menéndez Pelayo (UIMP). She was a beloved member of the BCBHub Executive Committee from the beginnings of the Connection, which she strongly helped to drive forward. She passed away in June 2026. Obituary: Fallecimiento de Begoña Aguado (Conexión BCB, 19 June 2026). |
Profile
| Institution | CBM |
| Position | Tenured Scientist (Científica Titular), CSIC |
| Home page | https://www.cbm.uam.es/es/investigacion/servicios-cientificos/genomica-y-secuenciacion-masiva |
| Contact email | baguado@cbm.csic.es |
| ORCID | 0000-0003-4043-6944 |
BCB Hub
| BCB Committee | Expertise mapping, Outreach |
| BCB Tools | |
| BCB Services | Biocomputing and Omics Integration Facility (SBIO) at CBM |
Research
Research topics
Research lines
None
Projects, networks, transfer & teaching
Industry & knowledge transfer
Collaborating companies
- LetiPharma, como Servicio
Publications 57 entries
- Searching for high pathogenicity avian influenza virus in Antarctica Article · 20 Nov 2024
- A Proteogenomic Approach to Unravel New Proteins Encoded in the Leishmania donovani (HU3) Genome Article · 13 Jun 2024
- Datasets of Iso-Seq transcripts for decoding transcriptome complexity in four Leishmania species Article · Feb 2024
- Refinement of Leishmania donovani Genome Annotations in the Light of Ribosome-Protected mRNAs Fragments (Ribo-Seq Data) Article · 17 Aug 2023
- Leishmania infantum (JPCM5) Transcriptome, Gene Models and Resources for an Active Curation of Gene Annotations Article · 4 Apr 2023
View all (52 more)
- Assembly of a Large Collection of Maxicircle Sequences and Their Usefulness for Leishmania Taxonomy and Strain Typing Article · 15 Jun 2022
- The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania Article · 23 Apr 2022
- Variability of the Pr77 sequence of L1Tc retrotransposon among six T. cruzi strains belonging to different discrete typing units (DTUs) Article · Oct 2021
- The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant Article · 30 Sep 2021
- Gene Annotation and Transcriptome Delineation on a De Novo Genome Assembly for the Reference Leishmania major Friedlin Strain Article · 29 Aug 2021
- ARAMIS: From systematic errors of NGS long reads to accurate assemblies Software · 19 May 2021
- Proteins interacting with Leishmania major PUF1: A proteomic dataset Article · Dec 2020
- Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat Article · Nov 2020
- The Experimental Proteome of Leishmania infantum Promastigote and Its Usefulness for Improving Gene Annotations Article · 2 Sep 2020
- Trypanosoma cruzi Ikiakarora (TcIII) Draft Genome Sequence Article · 2 Jul 2020
- Draft Genome Sequence of the Trypanosoma cruzi B. M. López Strain (TcIa), Isolated from a Colombian Patient Article · 30 Apr 2020
- Leishmania Mitochondrial Genomes: Maxicircle Structure and Heterogeneity of Minicircles Article · 26 Sep 2019
- Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major Article · 6 May 2019
- Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation Article · 16 Apr 2019
- Complete and de novo assembly of the Leishmania braziliensis (M2904) genome Article · 2019
- Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs Article · Aug 2018
- Deep-Sequencing Analysis of the Dynamics of HIV-1 Quasiespecies in Naive Patients during a Short Exposure to Maraviroc Article · Jun 2018
- Liquid biopsy by NGS : differential presence of exons ( DPE ) in cell‐free DNA reveals different patterns in metastatic and nonmetastatic colorectal cancer Article · 23 Mar 2018
- Resequencing of the Leishmania infantum (strain JPCM5) genome and de novo assembly into 36 contigs Article · 22 Dec 2017
- Human genomics projects and precision medicine Article · 14 Aug 2017
- Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing Article · 3 May 2017
- Dataset for distribution of SIDER2 elements in the Leishmania major genome and transcriptome Article · Apr 2017
- Genomic cartography and proposal of nomenclature for the repeated, interspersed elements of the Leishmania major SIDER2 family and identification of SIDER2-containing transcripts Article · Mar 2017
- ChimPipe: accurate detection of fusion genes and transcription-induced chimeras from RNA-seq data Article · 3 Jan 2017
- RNA-Seq Based Transcriptome Analysis of the Type I Interferon Host Response upon Vaccinia Virus Infection of Mouse Cells Article · 2017
- Resequencing and assembly of seven complex loci to improve the Leishmania major (Friedlin strain) reference genome Article · 8 Feb 2016
- DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance Article · Jun 2015
- Global variability in gene expression and alternative splicing is modulated by mitochondrial content Article · 23 Mar 2015
- Complex Tissue-Specific Patterns and Distribution of Multiple RAGE Splice Variants in Different Mammals Article · 22 Nov 2013
- The need for transparency and good practices in the qPCR literature Article · 30 Oct 2013
- The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq. Article · 4 Apr 2013
- Intron retention and transcript chimerism conserved across mammals: Ly6g5b and Csnk2b-Ly6g5b as examples Article · 22 Mar 2013
- Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients Article · 8 Nov 2012
- A FRET-based assay for characterization of alternative splicing events using peptide nucleic acid fluorescence in situ hybridization Article · 26 Jun 2009
- Differential Splicing, Disease and Drug Targets Article · 1 Dec 2008
- Regulation of expression of two LY-6 family genes by intron retention and transcription induced chimerism Article · 2008
- Characterization of the five novel Ly‐6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands Article · Oct 2006
- NKp30 (NCR3) is a Pseudogene in 12 Inbred and Wild Mouse Strains, but an Expressed Gene in Mus caroli Article · 27 Apr 2005
- The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin Article · 25 Mar 2005
- A genome annotation-driven approach to cloning the human ORFeome Article · 30 Sep 2004
- Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse Article · 1 Dec 2003
- Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC Article · 1 Oct 2003
- Molecular characterization of the novel rat NK receptor 1C7 Article · 20 Jan 2003
- Transcriptional Analysis of a Novel Cluster of LY-6 Family Members in the Human and Mouse Major Histocompatibility Complex: Five Genes with Many Splice Forms Article · Jul 2002
- G6b, a Novel Immunoglobulin Superfamily Member Encoded in the Human Major Histocompatibility Complex, Interacts with SHP-1 and SHP-2 Article · Nov 2001
- Complete sequence and gene map of a human major histocompatibility complex Article · Oct 1999
- Characterization of a human MHC class III region gene product with S-thioesterase activity Article · 26 Jul 1999
- Characterization of a Human Lysophosphatidic Acid Acyltransferase That Is Encoded by a Gene Located in the Class III Region of the Human Major Histocompatibility Complex Article · Feb 1998
- 56 Human lysophosphatidic acid acyltransferase is encoded by a gene located in the Major Histocompatibility Complex Article · 1 Nov 1997
- The novel gene g17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein Article · Feb 1995
- Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus Article · 1 Nov 1992
- African swine fever virus fatty acid acylated proteins Article · Dec 1991
