Carlos Oscar Sorzano
Biocomputing Unit at CNB · CNB
Instruct Image Processing Center (I2PC) at CNB · CNB
Biography
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[EN] Carlos Óscar S. Sorzano's research interests include image and data analysis in Structural, Molecular, and Cell Biology. He is an expert in Image Processing for Cryo-Electron Microscopy and the Statistical Design of Experiments with Research Animals, particularly in strategies to reduce the number of animals used through improved statistical design. He is a permanent staff member of CSIC, where he was appointed Científico Titular in 2017 and Investigador Científico in 2022. He is the co-principal investigator of the Biocomputing Unit and director of the Instruct Image Processing Center, both at the Natl. Center of Biotechnology, CSIC. Since 2011, he has coordinated the service of image processing and statistical analysis at the CNB. He is recognized among the most influential computer scientists in Spain, and he appears in rankings such as the top 2% of Spanish scientists in all domains and Stanford's top 2% of researchers in the world. He was accredited as a Full Professor in Information and Communications Theory in 2013. He also served as president of the National Association of Ramón y Cajal researchers in 2011 and 2012. In 2008, he became a senior member of the IEEE. Two years earlier, in 2006, he received the Ángel Herrera research prize. Between 2004 and 2009, he held various academic and administrative roles at Universidad CEU-San Pablo (Madrid), including coordinator of the Section on Signal and Communications Theory, secretary of the Department of Engineering of Electronic and Telecommunication Systems, director of the Summerschool on Advanced Data Analysis and Modelling, head of the Bioengineering Laboratory, and co-director of the Master in Computational Biotechnology. He pursued a postdoctoral position at the Biomedical Imaging Group of the Swiss Federal Institute of Technology Lausanne (EPFL) between 2003 and 2004. Before, he had conducted his Ph.D. at the Biocomputing Unit of the National Center of Biotechnology (CSIC) between 1997 and 2002. His educational background includes a Ph.D. in Biomedical Engineering from Universidad Politécnica de Madrid, a Ph.D. in Pharmacy from Universidad San Pablo-CEU, a B.Sc. and M.Sc. in Mathematics with a specialization in Statistics from UNED, a B.Sc. in Computer Science from Universidad de Málaga, and a B.Sc. and M.Sc. in Electrical Engineering with specializations in Electronics and Networking from Universidad de Málaga. [ES] Los intereses de investigación de Carlos Óscar S. Sorzano incluyen el análisis de imágenes y datos en Biología Estructural, Molecular y Celular. Es experto en Procesamiento de Imágenes para Criomicroscopía Electrónica y en el Diseño Estadístico de Experimentos con Animales de Laboratorio, particularmente en estrategias para reducir el número de animales utilizados mediante un mejor diseño estadístico. Es miembro del personal permanente del CSIC, donde fue nombrado Científico Titular en 2017 e Investigador Científico en 2022. Es coinvestigador principal de la Biocomputing Unit y director del Instruct Image Processing Center, ambos en el Centro Nacional de Biotecnología (CNB-CSIC). Desde 2011, coordina el servicio de procesamiento de imágenes y análisis estadístico del CNB. Es reconocido entre los científicos más influyentes en informática de España y aparece en rankings como el top 2% de científicos españoles en todas las áreas y en el top 2% de investigadores más citados del mundo según Stanford. En 2013, obtuvo la acreditación por parte de la ANECA como Catedrático en Teoría de la Información y las Comunicaciones. También fue presidente de la Asociación Nacional de Investigadores Ramón y Cajal en 2011 y 2012. En 2008, se convirtió en miembro senior del IEEE. Dos años antes, en 2006, recibió el premio de investigación Ángel Herrera. Entre 2004 y 2009, ocupó diversos cargos académicos y administrativos en la Universidad CEU-San Pablo (Madrid), incluyendo coordinador de la Sección de Teoría de la Señal y Comunicaciones, secretario del Departamento de Ingeniería de Sistemas Electrónicos y de Telecomunicación, director de la Escuela de Verano sobre Análisis Avanzado de Datos y Modelización, jefe del Laboratorio de Bioingeniería y codirector del Máster en Biotecnología Computacional. Entre 2003 y 2004, realizó una estancia posdoctoral en el Grupo de Imágenes Biomédicas de la Escuela Politécnica Federal de Lausana (EPFL). Previamente, entre 1997 y 2002, llevó a cabo su doctorado en la Biocomputing Unit del Centro Nacional de Biotecnología (CSIC). Su formación académica incluye un doctorado en Ingeniería Biomédica por la Universidad Politécnica de Madrid, un doctorado en Farmacia por la Universidad San Pablo-CEU, una licenciatura en Matemáticas con especialización en Estadística por la UNED, una ingeniería técnica en Informática por la Universidad de Málaga, y una Ingeniería superior de Telecomunicación con especialización en Electrónica y Redes por la Univ. de Málaga. |
Profile
| Institution | CNB |
| Position | Investigador Científico (CSIC); co-PI of the Biocomputing Unit and director of the Instruct Image Processing Center (CNB-CSIC) |
| Home page | https://i2pc.es/coss/ |
| Contact email | coss@cnb.csic.es |
| ORCID | 0000-0002-9473-283X |
BCB Hub
| BCB Committee | Expertise mapping, Outreach |
| BCB Tools | Scipion, Xmipp, 3DBionotes, COVID-19 Structural Hub, (cryo-EM) Validation Report Service, Scipion-Chem |
| BCB Services | Instruct Image Processing Center (I2PC) at CNB |
Research
Research topics
Research lines
Projects, networks, transfer & teaching
Research networks
National
- Spanish Microscopy Society (SME)
- Ethical Committee for Animal Experimentation of the CNB-CSIC (member since 2011)
International
- Instruct-ERIC: technical director of the Instruct Image Processing Centre (I2PC) since 2010
- ELIXIR (ELIXIR-STEERS)
- European Open Science Cloud - EOSC (EOSC-Life, EOSC Beyond, EOSC Data Commons)
- FELASA Working Group on Experimental Design in Education and Training
- FELASA Working Group on Harmful and non-harmful phenotypes of mice
- European Microscopy Society (EMS)
- IEEE Senior Member; IEEE Bio Imaging and Signal Processing Technical Committee (2013-2014, 2019-2021)
Industry & knowledge transfer
Collaborating companies
- Puxano
- Gandeeva Therapeutics (research contract, 2021-2022)
- Astex Therapeutics (research contract, 2023-2024)
- Andor Technology (technology transfer in image processing, 2009)
- Halotech (technology transfer in image processing, 2010-2012)
- Integromics (statistical consultant, 2007-2011)
Spin-offs
- KineStat Pharma (co-founder)
Teaching
Master programs
- Master in Computational Biotechnology, Universidad San Pablo-CEU (co-director, 2007-2009)
Funded projects 58
- A synergistic approach toward understanding receptor signaling in the cell at very high resolution
- Providing an open collaborative space for digital biology in Europe
- Fully three-dimensional image reconstruction from transmission electron-microscopy projections
- Bioimage: A european database of biological volume images
View all (54 more)
- Desarrollo y aplicación al sistema de las helicasas hexaméricas de nuevas estrategias de reconstrucción tridimensional a resolución macromolecular
- Análisis estructural del antígeno T de SV40: Su caracterización estructural y el desarrollo de nuevas técnicas de procesamiento de imágenes multidimensionales
- Reconstrucción tridimensional en microscopía electrónica: Organización de volúmenes en la base de datos BioImage, desarrollo de nuevas metodologías de procesamiento de imagenm y aplicación al estudio estructural de diversas helicasas hexaméricas
- Integration of information about macromolecular structure
- Image processing in biological 3D electron microscopy
- Análisis estructural a resolución media de macromoléculas biológicas: una aproximación conjunta desde la biología y la bioinformática estructural
- Desarrollo de técnicas de eliminación de ruido en imágenes y aplicación a microscopía electrónica y astronomía
- Replication initiation proteins as new targets for bacterial growth inhibition
- Red temática FIS IM3: Imagen médica molecular y multimodalidad. Análisis y tratamiento de imagen médica
- Doped derivative-free algorithms for medical-image registration
- Hacia la comprensión de la riqueza estructural de las nanomáquinas moleculares
- Técnicas de procesamiento de señales multidimensionales aplicadas a biología estructural mediante microscopía electrónica
- New electron microscopy approaches for studying protein complexes and cellular supramolecular architecture
- Generación automática de correspondencias entre ontologías con aplicación al análisis de bases de datos de genómica y proteómica
- Reconstrucción tridimensional de alta resolución en cámaras PET para animales pequeños
- Técnicas de procesamiento de señales multidimensionales aplicadas a biología estructural mediante microscopía electrónica
- Herramientas para el análisis y estudio de registros polisomnográficos de pacientes con alteraciones cardiopulmonares del sueño
- Image Processing in Biological 3D Electron Microscopy
- Centrosoma 3D
- Hacia la proteómica funcional: una aproximacion conjunta desde la proteómica, la bioinformática y la biología estructural
- Análisis de grandes cantidades de imágenes de microscopia electrónica tridimensional: desarrollo de métodos y aplicación al análisis del replisoma
- Consorcio para el Desarrollo de Tecnología Avanzada de Imagen Médica
- Tomografía de rayos X: una herramienta de integración entre biología molecular y celular
- Associated Center for Image Processing in Microscopy for Structural Biology
- Four-dimensional cryo-transmission electron microscopy of large macromolecular assemblies
- Parallel-Scalable Single-Particle Analysis in 3D Electron Microscopy
- Puesta en marcha del Centro Asociado INSTRUCT en procesamiento de imágenes en Microscopía
- Hacia una microscopía electrónica tridimensional de alto rendimiento
- Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray facilities
- Comienzo de la fase operativa del Instruct Image Processing Center
- Four-dimensional transmission electron microscopy of macromolecular assemblies
- Procesamiento tridimensional de imagen robusto y automatizado en Biología Estructural
- Engaging the EGI Community towards an Open Science Commons
- Coordinated Research Infrastructures Building Enduring Life-science services
- Infrastructure for NMR, EM and X-ray crystallography for translational research
- World-wide E-infrastructure for structural biology
- Análisis en alto rendimiento de flexibilidad estructural tanto por criomicroscopía electrónica como por criomicroscopía de rayos X blandos
- Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research
- The European Open Science Cloud for Research Pilot Project
- Infrastructure for transnational access and discovery in structural biology
- Procesamiento de imagen avanzado orientado al análisis de partículas individuales en microscopía electrónica en condiciones criogénicas
- Towards enhancing throughput in streaming cryo Electron Microscopy lmage Processing
- Beyond COVID
- From fragments to high affinity binders interfacing integrated structural biology, medicinal chemistry and artificial intelligence
- Integrated Services for Infectious Disease Outbreak Research
- Mejorando la capacidad de análisis estructural de la criomicroscopía electrónica
- Improving the quality of global and ligand-centric features in cryo-EM maps
- Food, health and environment research infrastructures to tackle emerging priorities
- ELIXIR-STEERS
- EOSC Beyond: advancing innovation and collaboration for research
- A Hybrid AI-model for Resolving Molecular Structures integrating sequence and Cryo-Electron Microscopy data
- Computational search of ligands for macromolecular targets
- Services for inter- and cross-disciplinary data discovery, access, sharing and reuse in the EOSC Federation
- Advancing photonic sensor systems for a smarter and safer food and poultry future
Publications 275 entries
- BCell-Epitope-Prediction: A local, reproducible pipeline for multi-epitope vaccine design: integration and structural validation against a panel of PDB antigen-antibody complexes Preprint · 14 Oct 2026
- Ab initio CryoEM maps minimizing preferred orientation problems in heterogeneous mixtures: ReconSIREN Preprint · 10 Oct 2026
- An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM Article · 28 Jul 2026
- AlignPCA -2 D : PCA-reduced Euclidean vector alignment for 2D classification in cryo-EM Article · 8 Jun 2026
- Rational acquisition of laboratory equipment: an accurate mathematical model to estimate the trade-offs in shared and nonshared equipment Article · 8 May 2026
View all (270 more)
- Research Funding as a Decision Problem Under Heavy-Tailed Uncertainty Preprint · 2026
- Membrane and vesicle structure detection in cryo-electron tomography based on deep learning Article · Dec 2025
- Merging conformational landscapes in a single consensus space with FlexConsensus algorithm Article · 25 Sep 2025
- How many (distinguishable) classes can we identify in single-particle analysis? Article · 9 Sep 2025
- Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation Article · 25 Jul 2025
- ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 Article · 27 Jun 2025
- Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN Article · 22 Apr 2025
- Unraveling the power of NAP-CNB’s machine learning-enhanced tumor neoantigen prediction Article · 11 Mar 2025
- Automatic detection of alignment errors in cryo-electron tomography Article · Mar 2025
- Validation methods in cryo-electron tomography Book / chapter · 2025
- B and T Cell Bi-Cistronic Multiepitopic Vaccine Induces Broad Immunogenicity and Provides Protection Against SARS-CoV-2 Article · 25 Oct 2024
- Animal researchers’ views on the publication of negative results and subsequent policy adoptions Article · 24 Oct 2024
- Deep learning algorithms in single-particle analysis by cryo-electron microscopy Article · 26 Aug 2024
- Heterologous mRNA/MVA delivering trimeric-RBD as effective vaccination regimen against SARS-CoV-2: COVARNA Consortium Article · 8 Aug 2024
- Statistical design for health monitoring in laboratory animal facilities using sentinel animals Article · 5 Aug 2024
- Fast Global Image Alignment Algorithm for CryoEM through Vector Compression Conference paper · 27 May 2024
- Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium Article · 18 May 2024
- Discrimination of Etiologically Different Cholestasis by Modeling Proteomics Datasets Article · 26 Mar 2024
- Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium Article · 6 Mar 2024
- A deep learning approach to the automatic detection of alignment errors in cryo-electron tomographic reconstructions Article · Mar 2024
- Scipion-Chem: An Open Platform for Virtual Drug Screening Software · 5 Dec 2023
- Local defocus estimation in single particle analysis in cryo-electron microscopy Article · Dec 2023
- A new algorithm for particle weighted subtraction to decrease signals from unwanted components in single particle analysis Article · Dec 2023
- Performance and Quality Comparison of Movie Alignment Software for Cryogenic Electron Microscopy Article · 26 Sep 2023
- Scipion-EM-ProDy: A Graphical Interface for the ProDy Python Package within the Scipion Workflow Engine Enabling Integration of Databases, Simulations and Cryo-Electron Microscopy Image Processing Article · 18 Sep 2023
- Zernike3Deep: a semi-classical AI approach for improved heterogeneity analysis Article · 22 Aug 2023
- Scipion Flexibility Hub: an integrative framework for advanced analysis of conformational heterogeneity in cryoEM Article · 16 Jun 2023
- Statistical experiment design for animal research Preprint · 2 Jun 2023
- ZART: A Novel Multiresolution Reconstruction Algorithm with Motion-blur Correction for Single Particle Analysis Article · May 2023
- Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials Article · 11 Jan 2023
- Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction Article · Jan 2023
- Scipion3: A workflow engine for cryo-electron microscopy image processing and structural biology Software · 2023
- Cryo-Electron Microscopy: The field of 1,000+ methods Article · Sep 2022
- ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation Article · Sep 2022
- Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming Preprint · 22 Aug 2022
- Higher resolution in cryo-EM by the combination of macromolecular prior knowledge and image-processing tools Article · 3 Aug 2022
- The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Article · 11 Jul 2022
- Emerging Themes in CryoEM─Single Particle Analysis Image Processing Article · 4 Jul 2022
- BIPSPI+: Mining Type-Specific Datasets of Protein Complexes to Improve Protein Binding Site Prediction Article · Jun 2022
- Protein dynamics developments for the large scale and cryoEM: case study of ProDy 2.0 Article · 16 Mar 2022
- On bias, variance, overfitting, gold standard and consensus in single-particle analysis by cryo-electron microscopy Article · 16 Mar 2022
- Automatic determination of the handedness of Single-Particle maps of macromolecules solved by CryoEM Preprint · 4 Mar 2022
- Cell-TypeAnalyzer: A flexible Fiji/ImageJ plugin to classify cells according to user-defined criteria Article · 2022
- Image processing tools for the validation of CryoEM maps Software · 2022
- Cryo-EM density maps adjustment for subtraction, consensus and sharpening Article · Dec 2021
- PDBe-KB: collaboratively defining the biological context of structural data Article · 10 Nov 2021
- Advances in Xmipp for Cryo–Electron Microscopy: From Xmipp to Scipion Software · 15 Oct 2021
- A genome-wide analysis identifies DIDO3 binding at active chromatin and topological boundaries in mouse stem cells Preprint · 29 Sep 2021
- Structural analysis of receptors and actin polarity in platelet protrusions Article · 9 Sep 2021
- ENRICH: A fast method to improve the quality of flexible macromolecular reconstructions Article · Sep 2021
- Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen Article · 27 Aug 2021
- FSC-Q: Analyzing the quality of cryoEM-derived models Article · 30 Jul 2021
- Electron Tomography Workflows using Scipion Article · 30 Jul 2021
- Continuous heterogeneity analysis of CryoEM images through Zernike polynomials and spherical harmonics Article · 30 Jul 2021
- DeepEMhancer: a deep learning solution for cryo-EM volume post-processing Article · 15 Jul 2021
- Scipion PKPD: an Open-Source Platform for Biopharmaceutics, Pharmacokinetics and Pharmacodynamics Data Analysis Article · 23 Jun 2021
- DeepAlign, a 3D alignment method based on regionalized deep learning for Cryo-EM Article · Jun 2021
- Cryo-EM and Single-Particle Analysis with Scipion Article · 29 May 2021
- 3DBionotes COVID-19 edition Software · 20 May 2021
- Principal component analysis is limited to low-resolution analysis in cryoEM Article · 19 May 2021
- A Signal Processing Approach to Pharmacokinetic Data Analysis Article · 22 Mar 2021
- State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps Article · Mar 2021
- Algorithmic robustness to preferred orientations in single particle analysis by CryoEM Article · Mar 2021
- FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation Article · 4 Jan 2021
- Image Processing in Cryo-Electron Microscopy of Single Particles: The Power of Combining Methods Book / chapter · 2021
- Cryo-EM Structure of a Tetrameric Photosystem I from Chroococcidiopsis TS-821, a Thermophilic, Non-heterocyst-forming Cyanobacteria Preprint · 19 Oct 2020
- Local resolution estimates of cryoEM reconstructions Article · Oct 2020
- Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures Article · 29 Sep 2020
- Optimized Hepatitis C Virus (HCV) E2 Glycoproteins and their Immunogenicity in Combination with MVA-HCV Article · 5 Aug 2020
- Multitarget Virtual Screening for Drug Repurposing in COVID19 Preprint · 17 Jul 2020
- FlexAlign: An Accurate and Fast Algorithm for Movie Alignment in Cryo-Electron Microscopy Article · 23 Jun 2020
- MicrographCleaner: A python package for cryo-EM micrograph cleaning using deep learning Article · Jun 2020
- Improvements on marker-free images alignment for electron tomography Preprint · 24 May 2020
- Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism Article · 9 Mar 2020
- Re-examining the spectra of macromolecules. Current practice of spectral quasi B-factor flattening Article · Mar 2020
- Sensory Acceptance, Appetite Control and Gastrointestinal Tolerance of Yogurts Containing Coffee-Cascara Extract and Inulin Article · 27 Feb 2020
- Deletion of Vaccinia Virus A40R Gene Improves the Immunogenicity of the HIV-1 Vaccine Candidate MVA-B Article · 6 Feb 2020
- Integration of Cryo-EM Model Building Software in Scipion Article · 29 Jan 2020
- Measuring local-directional resolution and local anisotropy in cryo-EM maps Article · 2 Jan 2020
- Measurement of local resolution in electron tomography Article · 2020
- Improvements on marker-free images alignment for electron tomography Article · 2020
- An MVA Vector Expressing HIV-1 Envelope under the Control of a Potent Vaccinia Virus Promoter as a Promising Strategy in HIV/AIDS Vaccine Design Article · 6 Dec 2019
- Flexible workflows for on-the-fly electron-microscopy single-particle image processing using Scipion Article · 1 Oct 2019
- DeepRes : a new deep-learning- and aspect-based local resolution method for electron-microscopy maps Article · 18 Sep 2019
- Automatic local resolution-based sharpening of cryo-EM maps Article · 26 Aug 2019
- Induction of Broad and Polyfunctional HIV-1-Specific T Cell Responses by the Multiepitopic Protein TMEP-B Vectored by MVA Virus Article · 29 Jun 2019
- Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein Article · 26 Jun 2019
- A GPU acceleration of 3-D Fourier reconstruction in cryo-EM Article · 11 Mar 2019
- A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses Article · 16 Feb 2019
- 3DBIONOTES v3.0: crossing molecular and structural biology data with genomic variations Software · 15 Feb 2019
- Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy Article · 1 Jan 2019
- Fast multiscale reconstruction for Cryo-EM Article · Dec 2018
- Map challenge: Analysis using a pair comparison method based on Fourier shell correlation Article · Dec 2018
- Using Scipion for stream image processing at Cryo-EM facilities Article · Dec 2018
- Validation of electron microscopy initial models via small angle X-ray scattering curves Article · 30 Nov 2018
- The first single particle analysis Map Challenge: A summary of the assessments Article · Nov 2018
- A new algorithm for high-resolution reconstruction of single particles by electron microscopy Article · Nov 2018
- Deep Consensus , a deep learning-based approach for particle pruning in cryo-electron microscopy Article · 30 Oct 2018
- Advances in image processing for single-particle analysis by electron cryomicroscopy and challenges ahead Article · Oct 2018
- X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action Article · 13 Sep 2018
- Potent HIV-1-Specific CD8 T Cell Responses Induced in Mice after Priming with a Multiepitopic DNA-TMEP and Boosting with the HIV Vaccine MVA-B Article · 13 Aug 2018
- Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression Article · 8 Aug 2018
- Blind estimation of DED camera gain in Electron Microscopy Article · Aug 2018
- Improving 3D reconstructions of macromolecular conformations Article · 20 Jul 2018
- BIPSPI: a method for the prediction of partner-specific protein–protein interfaces Article · 18 Jul 2018
- Reconstruction From Multiple Particles for 3D Isotropic Resolution in Fluorescence Microscopy Article · May 2018
- Correction: Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization Article · 10 Apr 2018
- Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function Article · Apr 2018
- MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps Article · Feb 2018
- Immune Modulation of NYVAC-Based HIV Vaccines by Combined Deletion of Viral Genes that Act on Several Signalling Pathways Article · 27 Dec 2017
- 3DCONS-DB: A Database of Position-Specific Scoring Matrices in Protein Structures Article · 15 Dec 2017
- Scipion web tools: Easy to use cryo‐EM image processing over the web Article · 6 Nov 2017
- Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization Article · 24 Oct 2017
- ScipionCloud: An integrative and interactive gateway for large scale cryo electron microscopy image processing on commercial and academic clouds Article · Oct 2017
- Pea PSII-LHCII supercomplexes form pairs by making connections across the stromal gap Article · 30 Aug 2017
- Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis Article · Aug 2017
- 3DBIONOTES v2.0: a web server for the automatic annotation of macromolecular structures Article · 28 Jul 2017
- Quantitative analysis of 3D alignment quality: its impact on soft-validation, particle pruning and homogeneity analysis Article · 24 Jul 2017
- Monocytes Phenotype and Cytokine Production in Human Immunodeficiency Virus-1 Infected Patients Receiving a Modified Vaccinia Ankara-Based HIV-1 Vaccine: Relationship to CD300 Molecules Expression Article · 21 Jul 2017
- Distinct Roles of Vaccinia Virus NF-κB Inhibitor Proteins A52, B15, and K7 in the Immune Response Article · Jul 2017
- Gene signature associated with benign neurofibroma transformation to malignant peripheral nerve sheath tumors Article · 24 May 2017
- A Prime/Boost PfCS14K M /MVA-sPfCS M Vaccination Protocol Generates Robust CD8 + T Cell and Antibody Responses to Plasmodium falciparum Circumsporozoite Protein and Protects Mice against Malaria Article · May 2017
- XTEND: Extending the depth of field in cryo soft X-ray tomography Article · 4 Apr 2017
- Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome Article · 27 Mar 2017
- A review of resolution measures and related aspects in 3D Electron Microscopy Article · Mar 2017
- A Survey of the Use of Iterative Reconstruction Algorithms in Electron Microscopy Article · 2017
- Soft X ‐ray tomography enhancement by focal series projections Other · 20 Dec 2016
- Foil-hole and data image quality assessment in 3DEM: Towards high-throughput image acquisition in the electron microscope Article · Dec 2016
- Fast and automatic identification of particle tilt pairs based on Delaunay triangulation Article · Dec 2016
- Characterization of transfer function, resolution and depth of field of a soft X-ray microscope applied to tomography enhancement by Wiener deconvolution Article · 14 Nov 2016
- Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge Article · 25 Aug 2016
- NYVAC vector modified by C7L viral gene insertion improves T cell immune responses and effectiveness against leishmaniasis Article · Jul 2016
- Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy Software · Jul 2016
- Local analysis of strains and rotations for macromolecular electron microscopy maps Article · Jul 2016
- Denoising of high-resolution single-particle electron-microscopy density maps by their approximation using three-dimensional Gaussian functions Article · Jun 2016
- 3DBIONOTES: A unified, enriched and interactive view of macromolecular information Article · May 2016
- StructMap: Elastic Distance Analysis of Electron Microscopy Maps for Studying Conformational Changes Article · Apr 2016
- Cryo-soft X-ray tomography as a quantitative three-dimensional tool to model nanoparticle:cell interaction Article · 3 Mar 2016
- System models for PET statistical iterative reconstruction: A review Article · Mar 2016
- Particle alignment reliability in single particle electron cryomicroscopy: a general approach Article · 22 Feb 2016
- Introduction to the Issue on Advanced Signal Processing in Microscopy and Cell Imaging Article · Feb 2016
- Coarse-Graining of Volumes for Modeling of Structure and Dynamics in Electron Microscopy: Algorithm to Automatically Control Accuracy of Approximation Article · Feb 2016
- A Guided Tour of Selected Image Processing and Analysis Methods for Fluorescence and Electron Microscopy Article · Feb 2016
- 3DIANA: 3D Domain Interaction Analysis: A Toolbox for Quaternary Structure Modeling Article · Feb 2016
- Versatility of Approximating Single-Particle Electron Microscopy Density Maps Using Pseudoatoms and Approximation-Accuracy Control Article · 2016
- A Phase I Randomized Therapeutic MVA-B Vaccination Improves the Magnitude and Quality of the T Cell Immune Responses in HIV-1-Infected Subjects on HAART Article · 6 Nov 2015
- A fast iterative convolution weighting approach for gridding-based direct Fourier three-dimensional reconstruction with correction for the contrast transfer function Article · Oct 2015
- Cryo-EM and the elucidation of new macromolecular structures: Random Conical Tilt revisited Article · 22 Sep 2015
- Undergraduate Students Compete in the IEEE Signal Processing Cup: Part 2 [sp Education] Article · Sep 2015
- Three-dimensional reconstruction methods in Single Particle Analysis from transmission electron microscopy data Article · Sep 2015
- Modification of promoter spacer length in vaccinia virus as a strategy to control the antigen expression Article · 1 Aug 2015
- Iterative reconstruction for pet scanners with continuous scintillators Conference paper · Aug 2015
- A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen Article · 24 Jul 2015
- Undergraduate Students Compete in the IEEE Signal Processing Cup: Part 1 [sp Education] Article · Jul 2015
- Cost-Constrained Optimal Sampling for System Identification in Pharmacokinetics Applications with Population Priors and Nuisance Parameters Article · Jun 2015
- CTF Challenge: Result summary Article · Jun 2015
- NFFinder: an online bioinformatics tool for searching similar transcriptomics experiments in the context of drug repositioning Article · 4 May 2015
- Measurement of the modulation transfer function of an X-ray microscope based on multiple Fourier orders analysis of a Siemens star Article · 6 Apr 2015
- Using neighborhood cohesiveness to infer interactions between protein domains Article · 2 Apr 2015
- NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses Article · 4 Mar 2015
- Alignment of direct detection device micrographs using a robust Optical Flow approach Article · Mar 2015
- A statistical approach to the initial volume problem in Single Particle Analysis by Electron Microscopy Article · Mar 2015
- Safety and immunogenicity of a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1 Article · 26 Feb 2015
- Virological and Immunological Characterization of Novel NYVAC-Based HIV/AIDS Vaccine Candidates Expressing Clade C Trimeric Soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as Virus-Like Particles Article · 15 Jan 2015
- Fast and accurate conversion of atomic models into electron density maps Article · 2015
- Improving miRNA-mRNA interaction predictions Article · Dec 2014
- Hybrid Electron Microscopy Normal Mode Analysis graphical interface and protocol Article · Nov 2014
- Elastic image registration to fully explore macromolecular dynamics by electron microscopy Conference paper · Oct 2014
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- An image processing approach to the simulation of electron microscopy volumes of atomic structures Conference paper · Oct 2014
- Comparing scientific performance among equals Article · 29 Jul 2014
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- 3D Cryo-Electron Reconstruction of BmrA, a Bacterial Multidrug ABC Transporter in an Inward-Facing Conformation and in a Lipidic Environment Article · May 2014
- Miro-1 Links Mitochondria and Microtubule Dynein Motors To Control Lymphocyte Migration and Polarity Article · Apr 2014
- Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens Article · 15 Mar 2014
- A Novel Poxvirus-Based Vaccine, MVA-CHIKV, Is Highly Immunogenic and Protects Mice against Chikungunya Infection Article · 15 Mar 2014
- Iterative Elastic 3D-to-2D Alignment Method Using Normal Modes for Studying Structural Dynamics of Large Macromolecular Complexes Article · Mar 2014
- New vaccinia virus promoter as a potential candidate for future vaccines Article · 1 Dec 2013
- Involvement of the Cellular Phosphatase DUSP1 in Vaccinia Virus Infection Article · 14 Nov 2013
- Xmipp 3.0: An improved software suite for image processing in electron microscopy Software · Nov 2013
- Soft X-Ray Tomography Imaging for Biological Samples Book / chapter · 29 Oct 2013
- Interchanging Geometry Conventions in 3DEM: Mathematical Context for the Development of Standards Book / chapter · 29 Oct 2013
- Deletion of the Vaccinia Virus Gene A46R, Encoding for an Inhibitor of TLR Signalling, Is an Effective Approach to Enhance the Immunogenicity in Mice of the HIV/AIDS Vaccine Candidate NYVAC-C Article · 17 Sep 2013
- Error analysis of the principal component analysis demodulation algorithm Article · 14 Sep 2013
- Particle quality assessment and sorting for automatic and semiautomatic particle-picking techniques Article · Sep 2013
- PI3K p110δ Is Expressed by gp38−CD31+ and gp38+CD31+ Spleen Stromal Cells and Regulates Their CCL19, CCL21, and LTβR mRNA Levels Article · 29 Aug 2013
- Three-Dimensional Chemical Mapping by EFTEM-TomoJ Including Improvement of SNR by PCA and ART Reconstruction of Volume by Noise Suppression Article · 28 Aug 2013
- A pattern matching approach to the automatic selection of particles from low-contrast electron micrographs Article · 19 Aug 2013
- Variable Internal Flexibility Characterizes the Helical Capsid Formed by Agrobacterium VirE2 Protein on Single-Stranded DNA Article · Jul 2013
- High, Broad, Polyfunctional, and Durable T Cell Immune Responses Induced in Mice by a Novel Hepatitis C Virus (HCV) Vaccine Candidate (MVA-HCV) Based on Modified Vaccinia Virus Ankara Expressing the Nearly Full-Length HCV Genome Article · Jul 2013
- Chromothripsis: Breakage-fusion-bridge over and over again Article · Jul 2013
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- Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways Article · 27 Jun 2013
- 3DEM Loupe: analysis of macromolecular dynamics using structures from electron microscopy Article · 11 May 2013
- Quadrature Component Analysis for interferometry Article · May 2013
- On the development of three new tools for organizing and sharing information in three-dimensional electron microscopy Article · 19 Apr 2013
- Correction Article · Apr 2013
- BRANCHED1 Promotes Axillary Bud Dormancy in Response to Shade in Arabidopsis Article · 1 Mar 2013
- FASTDEF: Fast defocus and astigmatism estimation for high-throughput transmission electron microscopy Article · Feb 2013
- Generalization of the Principal Component Analysis algorithm for interferometry Article · Jan 2013
- Data management challenges in three-dimensional EM Article · Dec 2012
- Corrigendum to “Fast, robust and accurate determination of transmission electron microscopy contrast transfer function” [J. Struct. Biol. 160 (2007) 249–262] Article · Nov 2012
- Deletion of the Viral Anti-Apoptotic Gene F1L in the HIV/AIDS Vaccine Candidate MVA-C Enhances Immune Responses against HIV-1 Antigens Article · 31 Oct 2012
- Shack–Hartmann centroid detection using the spiral phase transform Article · 18 Oct 2012
- Semiautomatic, High-Throughput, High-Resolution Protocol for Three-Dimensional Reconstruction of Single Particles in Electron Microscopy Book / chapter · 18 Sep 2012
- Multiplicative phase-shifting interferometry using optical flow Article · 16 Aug 2012
- High Quality Long-Term CD4+ and CD8+ Effector Memory Populations Stimulated by DNA-LACK/MVA-LACK Regimen in Leishmania major BALB/c Model of Infection Article · 8 Jun 2012
- Adjuvant-like Effect of Vaccinia Virus 14K Protein: A Case Study with Malaria Vaccine Based on the Circumsporozoite Protein Article · Jun 2012
- Removal of Vaccinia Virus Genes That Block Interferon Type I and II Pathways Improves Adaptive and Memory Responses of the HIV/AIDS Vaccine Candidate NYVAC-C in Mice Article · May 2012
- Image formation in cellular X-ray microscopy Article · Apr 2012
- Two-step demodulation based on the Gram–Schmidt orthonormalization method Article · 1 Feb 2012
- Processing of Transmission Electron Microscopy Images for Single-Particle Analysis of Macromolecular Complexes Book / chapter · 2012
- Single-particle reconstruction using L2-gradient flow Article · Dec 2011
- The HIV/AIDS Vaccine Candidate MVA-B Administered as a Single Immunogen in Humans Triggers Robust, Polyfunctional, and Selective Effector Memory T Cell Responses to HIV-1 Antigens Article · Nov 2011
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- Immunogenic Profiling in Mice of a HIV/AIDS Vaccine Candidate (MVA-B) Expressing Four HIV-1 Antigens and Potentiation by Specific Gene Deletions Article · 24 Aug 2010
- A clustering approach to multireference alignment of single-particle projections in electron microscopy Article · Aug 2010
- Insertion of Vaccinia Virus C7L Host Range Gene into NYVAC-B Genome Potentiates Immune Responses against HIV-1 Antigens Article · 30 Jun 2010
- Automatic particle selection from electron micrographs using machine learning techniques Article · Sep 2009
- Clustering of biomedical scientific papers Conference paper · Aug 2009
- Effects of the downsampling scheme on three-dimensional electron microscopy of single particles Conference paper · Aug 2009
- Marker-free image registration of electron tomography tilt-series Article · 27 Apr 2009
- A theoretical model for EM-ML reconstruction algorithms applied to rotating PET scanners Article · 5 Mar 2009
- Exploiting desktop supercomputing for three-dimensional electron microscopy reconstructions using ART with blobs Article · Jan 2009
- Error analysis in the determination of the electron microscopical contrast transfer function parameters from experimental power Spectra Article · 2009
- Comparison of single‐particle analysis and electron tomography approaches: an overview Article · 27 Nov 2008
- Quantitative morphometrical characterization of human pronuclear zygotes Article · 20 Jun 2008
- Image processing for electron microscopy single-particle analysis using XMIPP Article · 15 May 2008
- A Fuzzy Constraint Satisfaction Approach to Identify and Characterize Apnea Episodes Conference paper · May 2008
- Flexible image registration for the identification of best fitted protein models in 3D-EM maps Conference paper · May 2008
- Volumetric restrictions in single particle 3DEM reconstruction Article · Feb 2008
- Elastic image registration of 2‐D gels for differential and repeatability studies Article · 19 Dec 2007
- Fast, robust, and accurate determination of transmission electron microscopy contrast transfer function Article · Nov 2007
- TomoJ: tomography software for three-dimensional reconstruction in transmission electron microscopy Article · 6 Aug 2007
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- A novel method for improvement of visualization of power spectra for sorting cryo-electron micrographs and their local areas Article · Jan 2007
- Intelligent alarms for patient supervision Conference paper · 2007
- Optimization problems in electron microscopy of single particles Article · 22 Aug 2006
- Improved Bayesian image denoising based on wavelets with applications to electron microscopy Article · Jun 2006
- Image processing and 3-D reconstruction in electron microscopy Article · May 2006
- Algorithm for spline-based elastic registration in application to confocal images of gene expression Article · Jan 2006
- Consistent and Elastic Registration of Histological Sections Using Vector-Spline Regularization Book / chapter · 2006
- Multiobjective algorithm parameter optimization using multivariate statistics in three-dimensional electron microscopy reconstruction Article · Dec 2005
- Spline-based image-to-volume registration for three-dimensional electron microscopy Article · Jul 2005
- Elastic Registration of Biological Images Using Vector-Spline Regularization Article · Apr 2005
- Spectral signal-to-noise ratio and resolution assessment of 3D reconstructions Article · Mar 2005
- SPI-EM: Towards a Tool For Predicting CATH Superfamilies in 3D-EM Maps Article · Jan 2005
- XMIPP: a new generation of an open-source image processing package for electron microscopy Article · Nov 2004
- Normalizing projection images: a study of image normalizing procedures for single particle three-dimensional electron microscopy Article · Nov 2004
- Phan3D: design of biological phantoms in 3D electron microscopy Article · 23 Jun 2004
- A multiresolution approach to orientation assignment in 3D electron microscopy of single particles Article · Jun 2004
- 3-D Reconstruction of 2-D Crystals in Real Space Article · Apr 2004
- Transfer function restoration in 3D electron microscopy via iterative data refinement Article · 26 Jan 2004
- Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication Article · 1 Dec 2003
- Three-dimensional reconstruction by Chahine s method from electron microscopic projections corrupted by instrumental aberrations Article · 21 Jul 2003
- A method for estimating the CTF in electron microscopy based on ARMA models and parameter adjustment Article · Jul 2003
- Command‐line interfaces can be efficiently brought to graphics: COLIMATE (the COmmand LIne MATE) Article · 21 Jun 2002
- The Effect of Overabundant Projection Directions on 3D Reconstruction Algorithms Article · Feb 2001
- Discrete Tomography in Electron Microscopy Book / chapter · 1999
- Volumetric constraints in 3D tomography applied to electron microscopy Conference paper
- Grid Computing in 3D-EM Image Processing Using Xmipp Conference paper
- Algorithms for Three-dimensional Reconstruction From the Imperfect Projection Data Provided by Electron Microscopy Book / chapter
