Roberto Melero
Biography
|
Staff Scientist (PostDoc) at the Biocomputing Unit of the National Centre for Biotechnology (CNB-CSIC). (Description curated from publicly available data.) |
Profile
| Institution | CNB |
| Position | Staff Scientist (PostDoc) |
| Home page | https://www.linkedin.com/in/roberto-melero-35b39735/ |
| Contact email | rmelero@cnb.csic.es |
| ORCID | 0000-0001-9467-9381 |
BCB Hub
| BCB Committee | Not a member |
| BCB Tools | |
| BCB Services | Instruct Image Processing Center (I2PC) at CNB |
Publications 60 entries
- Insights from aquaporin structures into drug-resistant sleeping sickness Article · 14 Jan 2026
- Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation Article · 25 Jul 2025
- Cryo‐ EM structures of engineered Shiga toxin‐based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against hemolytic uremic syndrome Article · 24 May 2025
- Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains Article · 3 Jul 2024
- Scipion Flexibility Hub: an integrative framework for advanced analysis of conformational heterogeneity in cryoEM Article · 16 Jun 2023
View all (55 more)
- A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers Article · 25 Apr 2023
- Scipion3: A workflow engine for cryo-electron microscopy image processing and structural biology Software · 2023
- Correction: The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Article · 23 Nov 2022
- ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation Article · Sep 2022
- The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Article · 11 Jul 2022
- On bias, variance, overfitting, gold standard and consensus in single-particle analysis by cryo-electron microscopy Article · 16 Mar 2022
- Structural analysis of receptors and actin polarity in platelet protrusions Article · 9 Sep 2021
- 3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme Article · 3 Jun 2021
- Cryo-EM and Single-Particle Analysis with Scipion Article · 29 May 2021
- Author Correction: Self-assembly and regulation of protein cages from pre-organised coiled-coil modules Article · 16 Mar 2021
- Algorithmic robustness to preferred orientations in single particle analysis by CryoEM Article · Mar 2021
- Self-assembly and regulation of protein cages from pre-organised coiled-coil modules Article · 11 Feb 2021
- Image Processing in Cryo-Electron Microscopy of Single Particles: The Power of Combining Methods Book / chapter · 2021
- Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures Article · 29 Sep 2020
- Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells Article · 3 Apr 2020
- Re-examining the spectra of macromolecules. Current practice of spectral quasi B-factor flattening Article · Mar 2020
- Integration of Cryo-EM Model Building Software in Scipion Article · 29 Jan 2020
- Measurement of local resolution in electron tomography Article · 2020
- Flexible workflows for on-the-fly electron-microscopy single-particle image processing using Scipion Article · 1 Oct 2019
- Automatic local resolution-based sharpening of cryo-EM maps Article · 26 Aug 2019
- Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein Article · 26 Jun 2019
- Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes Article · 10 May 2019
- Frozen‐hydrated chromatin from metaphase chromosomes has an interdigitated multilayer structure Article · 4 Jan 2019
- Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy Article · 1 Jan 2019
- Using Scipion for stream image processing at Cryo-EM facilities Article · Dec 2018
- Validation of electron microscopy initial models via small angle X-ray scattering curves Article · 30 Nov 2018
- A new algorithm for high-resolution reconstruction of single particles by electron microscopy Article · Nov 2018
- Blind estimation of DED camera gain in Electron Microscopy Article · Aug 2018
- Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis Article · 18 Jun 2018
- MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps Article · Feb 2018
- Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo Article · 16 Oct 2017
- Pea PSII-LHCII supercomplexes form pairs by making connections across the stromal gap Article · 30 Aug 2017
- Quantitative analysis of 3D alignment quality: its impact on soft-validation, particle pruning and homogeneity analysis Article · 24 Jul 2017
- Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins Article · Jul 2017
- A Survey of the Use of Iterative Reconstruction Algorithms in Electron Microscopy Article · 2017
- Fast and automatic identification of particle tilt pairs based on Delaunay triangulation Article · Dec 2016
- Local analysis of strains and rotations for macromolecular electron microscopy maps Article · Jul 2016
- Denoising of high-resolution single-particle electron-microscopy density maps by their approximation using three-dimensional Gaussian functions Article · Jun 2016
- The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation Article · 4 Feb 2016
- Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex Article · 5 Jan 2016
- Cryo-EM and the elucidation of new macromolecular structures: Random Conical Tilt revisited Article · 22 Sep 2015
- Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE Article · Apr 2015
- Structure and Assembly of the PI3K-like Protein Kinases (PIKKs) Revealed by Electron Microscopy Article · 2015
- Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD Article · Aug 2014
- Flexible tethering of primase and DNA Pol α in the eukaryotic primosome Article · 1 May 2012
- The cryo-EM structure of the UPF–EJC complex shows UPF1 poised toward the RNA 3′ end Article · 22 Apr 2012
- Molecular Architecture and Structural Transitions of a Clostridium thermocellum Mini-Cellulosome Article · Apr 2011
- Ancient watercourses and biogeography of the Sahara explain the peopling of the desert Article · 27 Dec 2010
- Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA Article · 22 Dec 2010
- Electric-potential reconstructions of single particles using L2-gradient flows Conference paper · Oct 2010
- A clustering approach to multireference alignment of single-particle projections in electron microscopy Article · Aug 2010
- Averaging of Electron Subtomograms and Random Conical Tilt Reconstructions through Likelihood Optimization Article · Dec 2009
- Quaternary structures of tumor suppressor p53 and a specific p53–DNA complex Article · 24 Jul 2007
- Role of Group VIA Calcium-independent Phospholipase A2 in Arachidonic Acid Release, Phospholipid Fatty Acid Incorporation, and Apoptosis in U937 Cells Responding to Hydrogen Peroxide Article · Sep 2004
- Isolation, Characterization, and Evaluation of Metallothionein in Renal Transplant Patients Article · Jan 2003