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Modelling the Electrical Activity of the Heart

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Combining Polynomial Chaos Expansions and Genetic Algorithm for the Coupling of Electrophysiological Models

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Robust estimation of diagnostic rate and real incidence of COVID-19 for European policymakers

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Modeling cell crawling strategies with a bistable model: From amoeboid to fan-shaped cell motion

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How cortical waves drive fission of motile cells

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Empiric model for short-time prediction of COVID-19 spreading

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Modelling the dynamics of tuberculosis lesions in a virtual lung: Role of the bronchial tree in endogenous reinfection

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A reaction-diffusion model to understand granulomas formation inside secondary lobule during tuberculosis infection

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Empirical model for short-time prediction of COVID-19 spreading

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Risk Diagrams Based on Primary Care Electronic Medical Records and Linked Real-Time PCR Data to Monitor Local COVID-19 Outbreaks During the Summer 2020: A Prospective Study Including 7,671,862 People in Catalonia

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Monitoring and Analysis of COVID-19 Pandemic: The Need for an Empirical Approach

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Diffusivity Estimation for Activator–Inhibitor Models: Theory and Application to Intracellular Dynamics of the Actin Cytoskeleton

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Age-dependency of the Propagation Rate of Coronavirus Disease 2019 Inside School Bubble Groups in Catalonia, Spain

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Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Children in Summer Schools Applying Stringent Control Measures in Barcelona, Spain

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Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis

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Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

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Corrigendum: Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis(Front. Public Health, (2022), 10, (961030), 10.3389/fpubh.2022.961030)

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From Single to Collective Motion of Social Amoebae: A Computational Study of Interacting Cells

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Individual prevention and containment measures in schools in Catalonia, Spain, and community transmission of SARS-CoV-2 after school re-opening

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An ensemble of parameters from a robust Markov-based model reproduces L-type calcium currents from different human cardiac myocytes

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Mass-Conservation Increases Robustness in Stochastic Reaction-Diffusion Models of Cell Crawling

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Assessing wastewater-based epidemiology for the prediction of SARS-CoV-2 incidence in Catalonia

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Spontaneous transitions between amoeboid and keratocyte-like modes of migration

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Complex Excitable Media: Activators Design, While Inhibitors Embellish

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Low transmission of SARS-CoV-2 derived from children in family clusters: An observational study of family households in the Barcelona Metropolitan Area, Spain

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Unravelling the role of the mandatory use of face covering masks for the control of SARS-CoV-2 in schools: A quasi-experimental study nested in a population-based cohort in Catalonia (Spain)

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Black and gray box learning of amplitude equations: Application to phase field systems

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SARS-CoV-2 transmission in teenagers and young adults in Fútbol Club Barcelona’s Multidisciplinary Sports Training Academy

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Generation of a Virtual Cell using a Phase Field Approach to Model Amoeboid Crawling

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A semi-empirical risk panel to monitor epidemics: multi-faceted tool to assist healthcare and public health professionals

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Country-report pattern corrections of new cases allow accurate 2-week predictions of COVID-19 evolution with the Gompertz model

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Mathematical modeling of SARS-CoV-2 variant substitutions in European countries: transmission dynamics and epidemiological insights

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Biophysical Modeling of Cardiac Cells: From Ion Channels to Tissue

research group

Computational Biology and Complex Systems

The Computational Biology and Complex systems group (BIOCOM-SC) involves researchers with a mathematical and/or physical...

project

Broad transformation of CSIC’s digital capabilities through dedicated AI support from BCBHub

This is a CSIC-funded project for the BCBHub in the framework of the Momentum Programme....

project

Promoting CSIC presence within ELIXIR-Spain

This is a CSIC-funded project to support CSIC groups participating in the EU infrastructure ELIXIR...

project

Conexión CSIC en Biología Computacional y Bioinformática (BCBHub)

This is a CSIC-funded project to build a community of experts and resources in Computational...

project

LongTREC: The Long Reads European Transcriptomics Consortium. The next generation transcriptome biology revealed by single molecule sequencing technologies

This project is a Marie Curie doctoral network that gathers 12 partners from 9 countries...

project

Cells2Spine: Spatial Transcriptomics and Cell Communication Models applied to tissue regeneration and treatment in Spinal Cord Injury with Precision Nanomedicine

In this project, we use spatial transcriptomics data to understand the process of tissue regeneration...

project

Genomic Insights into Three Locally Adapted Diatoms from the Albufera Coastal Lagoon

The goal of this project is to complete the genome sequence and the annotation of...

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A head-to-tail tandem organization of hsp70 genes in Trypanosoma cruzi

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Molecular cloning of a Drosophila potential Z-DNA forming sequence hybridizing in situ to a developmentally regulated subdivision of the polytene chromosomes

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Complete nucleotide sequence of the hsp70 gene of T.cruzi

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The heat shock protein hsp70 binds in vivo to subregions 2-48BC and 3-58D of the polytene chromosomes of Drosophila hydei

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Sequence and expression of the Drosophila phenylalanine hydroxylase mRNA

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The mRNA coding for the nucleosomal protein H2A of Leishmania is polyadenylated and has stem-loops at the 3′ end

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DNA binding properties and antileukemic (L1210) activity of a Pt-pentamidine complex

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A potential Z-DNA-forming sequence is located between two transcription units alternatively expressed during development of Drosophila hydei

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Regulation of hsp70 expression in Trypanosoma cruzi by temperature and growth phase

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Molecular characterization of a Leishmania donovani infantum antigen identified as histone H2A

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Characterization of a highly repeated interspersed DNA sequence of Trypanosoma cruzi: its potential use in diagnosis and strain classification

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Mapping of antigenic determinants of the T. cruzi HSP70 in chagasic and healthy individuals

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Isolation, characterization and analysis of the expression of the Leishmania ribosomal PO protein genes

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Cytoplasmic-Nuclear Translocation of the HSP70 Protein during Environmental Stress in Trypanosoma cruzi

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Binding of Pt-pentamidine to nucleosomal DNA. Studies of the antiproliferative activity of the drug against human cancer cells

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Bacteriophage λ: long-term stored stocks ready for lysis

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The Leishmania infantum histone H3 possesses an extremely divergent N-terminal domain

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Characterization of a short interspersed reiterated DNA sequence of Trypanosoma cruzi located at the 3′-end of a poly(A)⁺ transcript

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Molecular karyotype of clone CL Brener chosen for the Trypanosoma cruzi Genome Project

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Mapping of the linear antigenic determinants from the Leishmania infantum histone H2A recognized by sera from dogs with leishmaniasis

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Identification of the Leishmania infantum P0 ribosomal protein epitope in canine visceral leishmaniasis

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Assignment of genes to Leishmania infantum chromosomes: karyotype and ploidy

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Genomic repetitive DNA elements of Trypanosoma cruzi

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During canine leishmaniasis a protein belonging to the 83-kDa heat-shock protein family elicits a strong humoral response

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Molecular cloning and analysis of expression of the Leishmania infantum histone H4 genes

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Cloning of genes and expression and antigenicity analysis of the Leishmania infantum KMP-11 protein

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Characterization of an interspersed repetitive DNA element in the genome of Trypanosoma cruzi

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Analysis of post-transcriptional regulation operating on transcription products of the tandemly linked Leishmania infantum hsp70 genes

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A region containing repeated elements is associated with transcriptional termination of Leishmania infantum ribosomal RNA genes

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Polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients

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Cloning, sequencing, and expression of the PSA genes from Leishmania infantum

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Analysis of the antigenic properties of the L. infantum Hsp70: Design of synthetic peptides for specific serodiagnosis of human leishmaniasis

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Phage recovery by electroporation of naked DNA into host cells avoids the use of packaging extracts

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Immunostimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83

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Antigenicity of the Leishmania infantum histones H2B and H4 during canine viscerocutaneous leishmaniasis

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Analysis of the humoral immune response against total and recombinant antigens of Leishmania infantum: Correlation with disease progression in canine experimental leishmaniasis

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The Leishmania infantum acidic ribosomal protein LiP2a induces a prominent humoral response in vivo and stimulates cell proliferation in vitro and interferon-gamma (IFN-γ) production by murine splenocytes

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Leishmania infantum: Gene cloning of the GRP94 homologue, its expression as recombinant protein, and analysis of antigenicity

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Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model

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Identification of a putative regulatory element in the 3'-untranslated region that controls expression of HSP70 in Leishmania infantum

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Histone synthesis in Leishmania infantum is tightly linked to DNA replication by a translational control

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Evolutionarily conserved proteins as prominent immunogens during Leishmania infections

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Analysis of the adjuvant effect of recombinant Leishmania infantum Hsp83 protein as a tool for vaccination

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Antigenic properties of the Leishmania infantum GRP94 and mapping of linear B-cell epitopes.

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Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani

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Leishmania infantum possesses a complex family of histone H2A genes: Structural characterization and analysis of expression

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Identification of a gene in Leishmania infantum encoding a protein that contains a SP-RING/MIZ zinc finger domain

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A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum

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Conserved nucleotides surrounding the trans-splicing acceptor site and the translation initiation codon in Leishmania genes.

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High-efficiency plating method for Leishmania infantum.

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Adjuvant guided polarization of the immune humoral response against a protective multicomponent antigenic protein (Q) from Leishmania infantum. A CpG + Q mix protects Balb/c mice from infection

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Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum.

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The expression of HSP83 genes in Leishmania infantum is affected by temperature and by stage-differentiation and is regulated at the levels of mRNA stability and translation.

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Vaccination with a plasmid DNA cocktail encoding the nucleosomal histones of Leishmania confers protection against murine cutaneous leishmaniosis.

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Recent advances in vaccines for leishmaniasis.

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Genomic DNA macroarrays as a tool for analysis of gene expression in Leishmania.

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The translational efficiencies of the two Leishmania infantum HSP70 mRNAs, differing in their 3'-untranslated regions, are affected by shifts in the temperature of growth through different mechanisms.

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Immunohistological features of visceral leishmaniasis in BALB/c mice

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Genomic organization and expression of the HSP70 locus in New and Old World Leishmania species

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A postgenomic view of the heat shock proteins in kinetoplastids.