orcid publication

Metabarcoding analysis on European coastal samples reveals new molecular metazoan diversity

orcid publication

Identifying protist consumers of photosynthetic picoeukaryotes in the surface ocean using stable isotope probing

orcid publication

High-throughput environmental sequencing reveals high diversity of litter and moss associated protist communities along a gradient of drainage and tree productivity

orcid publication

EukRef: phylogenetic curation of ribosomal RNA to enhance understanding of eukaryotic diversity and distribution

orcid publication

The evolution of ecological flexibility, large brains, and long lives: capuchin monkey genomics revealed with fecalFACS

orcid publication

Validation of a universal set of primers to study animal -associated microeukaryotic communities

orcid publication

The Starlet Sea Anemone,Nematostella vectensis, possesses body region-specific bacterial associations with spirochetes dominating the capitulum

orcid publication

Mediocremonas mediterraneus, a New Member within the Developea

orcid publication

The eukaryome: Diversity and role of microeukaryotic organisms associated with animal hosts

orcid publication

Microeukaryotes in animal and plant microbiomes: Ecologies of disease?

orcid publication

The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

orcid publication

A meta-analysis of the stony coral tissue loss disease microbiome finds key bacteria in lesions and unaffected tissue of diseased colonies

orcid publication

Apicomplexans predict thermal stress mortality in the Mediterranean coralParamuricea clavata

orcid publication

Beyond the Symbiodiniaceae: diversity and role of microeukaryotic coral symbionts

orcid publication

Fireworms are a reservoir and potential vector for coral-infecting apicomplexans

orcid publication

The Sea Cucumber‐Infecting Parasite Apostichocystis gudetama gen. nov. sp. nov. Expands Marine‐Host‐Specific Clade of Apicomplexans

research group

Mosquito molecular neuroscience

orcid publication

Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum

orcid publication

Biochemical characterization of the catalytic domains of three different clostridial collagenases

orcid publication

A universal strategy for high-yield production of soluble and functional clostridial collagenases in E. coli

orcid publication

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

orcid publication

Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment

orcid publication

Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1

orcid publication

Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation

orcid publication

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T

orcid publication

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen

orcid publication

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity

orcid publication

Cleavage Specificity Analysis of Six Type II Transmembrane Serine Proteases (TTSPs) Using PICS with Proteome-Derived Peptide Libraries

orcid publication

TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage

orcid publication

The Human Dental Pulp Proteome and N-Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues

orcid publication

TAILS N-terminomic and proteomic datasets of healthy human dental pulp

orcid publication

Protein Termini and Their Modifications Revealed by Positional Proteomics

orcid publication

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

orcid publication

Positional proteomics in the era of the human proteome project on the doorstep of precision medicine

orcid publication

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

orcid publication

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

orcid publication

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

orcid publication

Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2)

orcid publication

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella

orcid publication

The Human Odontoblast Cell Layer and Dental Pulp Proteomes and N-Terminomes

orcid publication

TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation

orcid publication

Proteolytic Cleavage-Mechanisms, Function, and "Omic" Approaches for a Near-Ubiquitous Posttranslational Modification

orcid publication

A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function

orcid publication

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

orcid publication

Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase

orcid publication

Identification and characterization of the proteolytic flagellin from the common freshwater bacterium Hylemonella gracilis

orcid publication

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

orcid publication

Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring—An Inactive Enzyme with Intact Substrate Binding

orcid publication

Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the secretion

orcid publication

The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin β by endogenous fetuin-B

orcid publication

Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications

orcid publication

Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches

orcid publication

Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis

orcid publication

An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin

orcid publication

An Introduction to Bacterial Biofilms and Their Proteases, and Their Roles in Host Infection and Immune Evasion

orcid publication

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy

orcid publication

De novo design of immunoglobulin-like domains

orcid publication

Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl–fluoride inhibitor of serine peptidases

orcid publication

A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia

orcid publication

Advanced Binary Guanosine and Guanosine 5'-Monophosphate Cell-Laden Hydrogels for Soft Tissue Reconstruction by 3D Bioprinting

orcid publication

Conditional language models enable the efficient design of proficient enzymes

orcid publication

Structural and functional insights into the C-terminal signal domain of the Bacteroidetes type-IX secretion system

orcid publication

Dissecting Cytophagalysin: Structural and Biochemical Studies of a Bacterial Pappalysin-Family Metallopeptidase

project

Momentum Program: Omics Technologies and new computational challenges

In recent years, omics technologies have become common practice in the field of neuroscience. Multiple...

research line

OMICS TECHNOLOGIES AND NEW COMPUTATIONAL CHALLENGES

In recent years, omics technologies have become common practice in the field of neuroscience. Multiple...

orcid publication

Stable expression of bioactive recombinant pleurocidin in a fish cell line

orcid publication

Identification of selective inhibitors of VHSV from biased combinatorial libraries of N,N '-disubstituted 2,5-piperazinediones

orcid publication

Dual antiviral activity of human alpha-defensin-1 against viral haemorrhagic septicaemia rhabdovirus (VHSV): Inactivation of virus particles and induction of a type I interferon-related response

orcid publication

In vivo modulation of the rainbow trout (Oncorhynchus mykiss) immune response by the human alpha defensin 1, HNP 1

orcid publication

Expression and antiviral activity of a beta-defensin-like peptide identified in the rainbow trout (Oncorhynchus mykiss) EST sequences

orcid publication

Transfection improvements of fish cell lines by using deacylated polyethylenimine of selected molecular weights

orcid publication

The rainbow trout TLR9 gene and its role in the immune responses elicited by a plasmid encoding the glycoprotein G of the viral haemorrhagic septicaemia rhabdovirus (VHSV)

orcid publication

The immunogenicity of viral haemorragic septicaemia rhabdovirus (VHSV) DNA vaccines can depend on plasmid regulatory sequences

orcid publication

Antimicrobial peptides as model molecules for the development of novel antiviral agents in aquaculture

orcid publication

Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level

orcid publication

Pepscan Mapping of Viral Hemorrhagic Septicemia Virus Glycoprotein G Major Lineal Determinants Implicated in Triggering Host Cell Antiviral Responses Mediated by Type I Interferon

orcid publication

Mytilus galloprovincialis Myticin C: A Chemotactic Molecule with Antiviral Activity and Immunoregulatory Properties

orcid publication

In vitro analysis of the factors contributing to the antiviral state induced by a plasmid encoding the viral haemorrhagic septicaemia virus glycoprotein G in transfected trout cells

orcid publication

Characterization of an infectious pancreatic necrosis (IPN) virus carrier cell culture with resistance to superinfection with heterologous viruses

orcid publication

The influence of dietary beta-glucan, PAMP exposure and Aeromonas salmonicida on apoptosis modulation in common carp (Cyprinus carpio)

orcid publication

Reduced inflammatory response to Aeromonas salmonicida infection in common carp (Cyprinus carpio L.) fed with β-glucan supplements

orcid publication

Protection and antibody response induced by intramuscular DNA vaccine encoding for viral haemorrhagic septicaemia virus (VHSV) G glycoprotein in turbot (Scophthalmus maximus)

orcid publication

Melittin-loaded immunoliposomes against viral surface proteins, a new approach to antiviral therapy

orcid publication

In vitro neutralization of viral hemorrhagic septicemia virus by plasma from immunized zebrafish

orcid publication

Dietary β-glucan stimulate complement and C-reactive protein acute phase responses in common carp (Cyprinus carpio) during an Aeromonas salmonicida infection

orcid publication

Accessory molecules for Toll-like receptors in Teleost fish. Identification of TLR4 interactor with leucine-rich repeats (TRIL)

orcid publication

β-Glucan-supplemented diets increase poly(I:C)-induced gene expression of Mx, possibly via Tlr3-mediated recognition mechanism in common carp (Cyprinus carpio)

orcid publication

Feeding common carp Cyprinus carpio with β-glucan supplemented diet stimulates C-reactive protein and complement immune acute phase responses following PAMPs injection

orcid publication

TNF alpha Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response

orcid publication

Selective recognition and imaging of bacterial model membranes over mammalian ones by using cationic conjugated polyelectrolytes

orcid publication

Structure and functionalities of the human c-reactive protein compared to the zebrafish multigene family of c-reactive-like proteins

orcid publication

Neutralization of viral infectivity by zebrafish c-reactive protein isoforms.

orcid publication

Poly(methyl vinyl ether-alt-maleic acid) and ethyl monoester as building polymers for drug-loadable electrospun nanofibers

orcid publication

Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response

orcid publication

25-Hydroxyl-cholesterol Binds and Enhance Anti-viral Effects of Zebrafish Monomeric C-reactive Proteins

orcid publication

Advantageous Microwave-Assisted Suzuki Polycondensation for the Synthesis of Aniline-Fluorene Alternate Copolymers as Molecular Model with Solvent Sensing Properties

orcid publication

Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV)

orcid publication

Synthesis and Characterization of a Novel Green Cationic Polyfluorene and Its Potential Use as a Fluorescent Membrane Probe

orcid publication

Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms

orcid publication

Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment