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A semi-empirical risk panel to monitor epidemics: multi-faceted tool to assist healthcare and public health professionals

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Country-report pattern corrections of new cases allow accurate 2-week predictions of COVID-19 evolution with the Gompertz model

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Mathematical modeling of SARS-CoV-2 variant substitutions in European countries: transmission dynamics and epidemiological insights

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Biophysical Modeling of Cardiac Cells: From Ion Channels to Tissue

research group

Computational Biology and Complex Systems

The Computational Biology and Complex systems group (BIOCOM-SC) involves researchers with a mathematical and/or physical...

project

Broad transformation of CSIC’s digital capabilities through dedicated AI support from BCBHub

This is a CSIC-funded project for the BCBHub in the framework of the Momentum Programme....

project

Promoting CSIC presence within ELIXIR-Spain

This is a CSIC-funded project to support CSIC groups participating in the EU infrastructure ELIXIR...

project

Conexión CSIC en Biología Computacional y Bioinformática (BCBHub)

This is a CSIC-funded project to build a community of experts and resources in Computational...

project

LongTREC: The Long Reads European Transcriptomics Consortium. The next generation transcriptome biology revealed by single molecule sequencing technologies

This project is a Marie Curie doctoral network that gathers 12 partners from 9 countries...

project

Cells2Spine: Spatial Transcriptomics and Cell Communication Models applied to tissue regeneration and treatment in Spinal Cord Injury with Precision Nanomedicine

In this project, we use spatial transcriptomics data to understand the process of tissue regeneration...

project

Genomic Insights into Three Locally Adapted Diatoms from the Albufera Coastal Lagoon

The goal of this project is to complete the genome sequence and the annotation of...

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A head-to-tail tandem organization of hsp70 genes in Trypanosoma cruzi

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Molecular cloning of a Drosophila potential Z-DNA forming sequence hybridizing in situ to a developmentally regulated subdivision of the polytene chromosomes

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Complete nucleotide sequence of the hsp70 gene of T.cruzi

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The heat shock protein hsp70 binds in vivo to subregions 2-48BC and 3-58D of the polytene chromosomes of Drosophila hydei

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Sequence and expression of the Drosophila phenylalanine hydroxylase mRNA

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The mRNA coding for the nucleosomal protein H2A of Leishmania is polyadenylated and has stem-loops at the 3′ end

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DNA binding properties and antileukemic (L1210) activity of a Pt-pentamidine complex

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A potential Z-DNA-forming sequence is located between two transcription units alternatively expressed during development of Drosophila hydei

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Regulation of hsp70 expression in Trypanosoma cruzi by temperature and growth phase

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Molecular characterization of a Leishmania donovani infantum antigen identified as histone H2A

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Characterization of a highly repeated interspersed DNA sequence of Trypanosoma cruzi: its potential use in diagnosis and strain classification

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Mapping of antigenic determinants of the T. cruzi HSP70 in chagasic and healthy individuals

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Isolation, characterization and analysis of the expression of the Leishmania ribosomal PO protein genes

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Cytoplasmic-Nuclear Translocation of the HSP70 Protein during Environmental Stress in Trypanosoma cruzi

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Binding of Pt-pentamidine to nucleosomal DNA. Studies of the antiproliferative activity of the drug against human cancer cells

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Bacteriophage λ: long-term stored stocks ready for lysis

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The Leishmania infantum histone H3 possesses an extremely divergent N-terminal domain

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Characterization of a short interspersed reiterated DNA sequence of Trypanosoma cruzi located at the 3′-end of a poly(A)⁺ transcript

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Molecular karyotype of clone CL Brener chosen for the Trypanosoma cruzi Genome Project

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Mapping of the linear antigenic determinants from the Leishmania infantum histone H2A recognized by sera from dogs with leishmaniasis

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Identification of the Leishmania infantum P0 ribosomal protein epitope in canine visceral leishmaniasis

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Assignment of genes to Leishmania infantum chromosomes: karyotype and ploidy

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Genomic repetitive DNA elements of Trypanosoma cruzi

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During canine leishmaniasis a protein belonging to the 83-kDa heat-shock protein family elicits a strong humoral response

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Molecular cloning and analysis of expression of the Leishmania infantum histone H4 genes

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Cloning of genes and expression and antigenicity analysis of the Leishmania infantum KMP-11 protein

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Characterization of an interspersed repetitive DNA element in the genome of Trypanosoma cruzi

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Analysis of post-transcriptional regulation operating on transcription products of the tandemly linked Leishmania infantum hsp70 genes

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A region containing repeated elements is associated with transcriptional termination of Leishmania infantum ribosomal RNA genes

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Polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients

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Cloning, sequencing, and expression of the PSA genes from Leishmania infantum

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Analysis of the antigenic properties of the L. infantum Hsp70: Design of synthetic peptides for specific serodiagnosis of human leishmaniasis

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Phage recovery by electroporation of naked DNA into host cells avoids the use of packaging extracts

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Immunostimulatory properties of the Leishmania infantum heat shock proteins HSP70 and HSP83

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Antigenicity of the Leishmania infantum histones H2B and H4 during canine viscerocutaneous leishmaniasis

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Analysis of the humoral immune response against total and recombinant antigens of Leishmania infantum: Correlation with disease progression in canine experimental leishmaniasis

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The Leishmania infantum acidic ribosomal protein LiP2a induces a prominent humoral response in vivo and stimulates cell proliferation in vitro and interferon-gamma (IFN-γ) production by murine splenocytes

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Leishmania infantum: Gene cloning of the GRP94 homologue, its expression as recombinant protein, and analysis of antigenicity

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Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model

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Identification of a putative regulatory element in the 3'-untranslated region that controls expression of HSP70 in Leishmania infantum

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Histone synthesis in Leishmania infantum is tightly linked to DNA replication by a translational control

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Evolutionarily conserved proteins as prominent immunogens during Leishmania infections

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Analysis of the adjuvant effect of recombinant Leishmania infantum Hsp83 protein as a tool for vaccination

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Antigenic properties of the Leishmania infantum GRP94 and mapping of linear B-cell epitopes.

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Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani

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Leishmania infantum possesses a complex family of histone H2A genes: Structural characterization and analysis of expression

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Identification of a gene in Leishmania infantum encoding a protein that contains a SP-RING/MIZ zinc finger domain

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A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum

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Conserved nucleotides surrounding the trans-splicing acceptor site and the translation initiation codon in Leishmania genes.

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High-efficiency plating method for Leishmania infantum.

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Adjuvant guided polarization of the immune humoral response against a protective multicomponent antigenic protein (Q) from Leishmania infantum. A CpG + Q mix protects Balb/c mice from infection

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Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum.

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The expression of HSP83 genes in Leishmania infantum is affected by temperature and by stage-differentiation and is regulated at the levels of mRNA stability and translation.

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Vaccination with a plasmid DNA cocktail encoding the nucleosomal histones of Leishmania confers protection against murine cutaneous leishmaniosis.

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Recent advances in vaccines for leishmaniasis.

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Genomic DNA macroarrays as a tool for analysis of gene expression in Leishmania.

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The translational efficiencies of the two Leishmania infantum HSP70 mRNAs, differing in their 3'-untranslated regions, are affected by shifts in the temperature of growth through different mechanisms.

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Immunohistological features of visceral leishmaniasis in BALB/c mice

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Genomic organization and expression of the HSP70 locus in New and Old World Leishmania species

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A postgenomic view of the heat shock proteins in kinetoplastids.

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Pitfalls of the CAT reporter gene for analyzing translational regulation in Leishmania.

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Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis

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Effects of the disruption of the HSP70-II gene on the growth, morphology, and virulence of Leishmania infantum promastigotes

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The SIDER2 elements, interspersed repeated sequences that populate the Leishmania genomes, constitute subfamilies showing chromosomal proximity relationship.

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The Leishmania infantum PUF proteins are targets of the humoral response during visceral leishmaniasis.

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Lights and shadows on gene organization and regulation of gene expression in Leishmania.

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Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation.

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Identification of the HSP70-II gene in Leishmania braziliensis HSP70 locus: genomic organization and UTRs characterization.

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Evidence of RNA editing in Leishmania braziliensis promastigotes.

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Indotecan (LMP400) and AM13-55: Two novel indenoisoquinolines show potential for treating visceral leishmaniasis

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Appraisal of a Leishmania major Strain Stably Expressing mCherry Fluorescent Protein for Both In Vitro and In Vivo Studies of Potential Drugs and Vaccine against Cutaneous Leishmaniasis

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Sequence analysis of the 3'-untranslated region of HSP70 (type I) genes in the genus Leishmania: its usefulness as a molecular marker for species identification.

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Immunity to visceral leishmaniasis.

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Identification of proteins interacting with HSP70 mRNAs in Leishmania Braziliensis

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Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect

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The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq.

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Alpha tubulin genes from Leishmania braziliensis: genomic organization, gene structure and insights on their expression.

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Evolution and species discrimination according to the Leishmania heat-shock protein 20 gene.

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Leishmania braziliensis replication protein A subunit 1: Molecular modelling, protein expression and analysis of its affinity for both DNA and RNA

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Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes

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Resequencing and assembly of seven complex loci to improve the Leishmania major (Friedlin strain) reference genome

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A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage

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Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models

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Genomic cartography and proposal of nomenclature for the repeated, interspersed elements of the Leishmania major SIDER2 family and identification of SIDER2-containing transcripts

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Dataset for distribution of SIDER2 elements in the Leishmania major genome and transcriptome

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Characterization of the mRNA untranslated regions [UTR] of the Trypanosoma cruzi LYT1 isoforms derived by alternative trans-splicing

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Identificación de proteínas reguladoras de la expresión génica en tripanosomátidos

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Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major

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Leishmania Mitochondrial Genomes: Maxicircle Structure and Heterogeneity of Minicircles