SSCPE

The framework SSCPE.pl infers Maximum Likelihood (ML) phylogenetic trees adoping the Structure and Stability constrained model of protein evolution (SSCPE) [1] that predicts site-specific selective pressures by fitting only two global parameters for the whole protein: the selection strength Lambda_str for maintaining protein structure and Lambda_stab for maintaining the protein folding stability against unfolding and misfolding [5,6].

Info

Members (researchers): Ugo Bastolla

Research Groups: Computational biology and Bioinformatics (CBM): from Proteins to Ecosystems

Contact Email: ubastolla@cbm.csic.es

Tool Repository: https://github.com/ugobas/SSCPE

Documentation: https://github.com/ugobas/SSCPE

Publications DOI: doi:10.1101/2023.01.22.525075

Institution: Centro de Biología Molecular Severo Ochoa (CBM)

Application domain:

Evolutionary rates, Molecular evolution, Phylogenetic Analysis

Technical details
Type of application
  • Package for compiling the executable program
Software compatibility
  • Linux
Hardware requirements
  • Any linux computer
Programming language
  • C
  • Perl
Type of containerization
  • None
Wrapper type
  • None
Input file formats
  • fasta
  • pdb
Output file formats
  • Other
Compatibility with other tools
  • RAxML-NG for maximum likelihood phylogenetic inference