researcher

Miguel Lopez

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Seasonal grouping dynamics in a territorial vulture: ecological drivers and social consequences

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Too Much is Bad: Increasing Numbers of Livestock and Conspecifics Reduce Body Mass in an Avian Scavenger

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Insularity determines nestling sex ratio variation in Egyptian vulture populations

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Blood lead levels in an endangered vulture decline following changes in hunting activity

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Food predictability and social status drive individual resource specializations in a territorial vulture

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Probing into farmers’ perceptions of a globally endangered ecosystem service provider

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Evaluating European LIFE conservation projects: Improvements in survival of an endangered vulture

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Vultures and Livestock: The Where, When, and Why of Visits to Farms

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Use of avian GPS tracking to mitigate human fatalities from bird strikes caused by large soaring birds

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Disentangling drivers of power line use by vultures: Potential to reduce electrocutions

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Vultures feeding on the dark side: current sanitary regulations may not be enough

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MicroRNA mapping of bronchial aspirate for molecular phenotyping and prognostication in patients on mechanical ventilation

researcher

Marina García Alfonso

researcher

Miguel Sánchez Rodríguez

researcher

rsancho

tool

MateR

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The Web of Life

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Mutualistic interactions reshuffle the effects of climate change on plants across the tree of life

researcher

Raúl Ortega

researcher

Roberto Sevilla

researcher

mar_villar

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Robust membrane detection based on tensor voting for electron tomography

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Fast tomographic reconstruction on multicore computers

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The structure of basal body inner junctions from Tetrahymena revealed by electron cryo-tomography

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Disruption of the mitochondrial network in a mouse model of Huntington's disease visualized by in-tissue multiscale 3D electron microscopy

project

Towards computer-aided analysis of subcellular architecture as a tool for disease diagnosis (ComArc)

project

Synthetic biology-based tools for Correlative Light-Electron Microscopy (SynCLEM)

research line

High performance computing

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Advanced 2D/3D image processing and analysis

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Analysis of microtubule-organizing centers with cryo-ET

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Analysis of subcellular architecture with nanotomography and image processing

tool

Tomo3DEM

Tomo3DEM is a software suite for in situ structural analysis of the subcellular architecture and...

research group

Subcellular architecture

Our research interest is mainly focused on the study of the subcellular architecture and exploration...

project

GRUPO DE INVESTIGACIÓN RECONOCIDO BIOINFORMATICA ESTRUCTURAL, MODELADO Y MECANISMOS BIOLOGICOS

project

ONETICK: AN INTEGRATED ONE HEALTH APPROACH FOR PREVENTION, DETECTION AND TREATMENT OF TICK-BORNE DISEASES IN URBAN AND PERI-URBAN ENVIRONMENTS

project

BIOINFORMÁTICA, ANÁLISIS DE DATOS Y MODELIZACIÓN PARA EL AVANCE DE LA VITIVINICULTURA

project

NUEVAS TECNOLOGÍAS DIGITALES Y DE PROTEÍNAS EN PROCESOS DE VINIFICACIÓN PARA ABORDAR LOS RETOS DEL SECTOR ENOLÓGICO EN EL TERRITORIO POCTEFA (OENOPROT)

project

NEW METHODS FOR BIOLOGICAL MODELING: PROTEIN INTERACTIONS, MUTATIONS, POLYPHENOLS AND HEALTH (BIOMODELPROT)

research line

Multi-scale of complex biological data in One Health

Development of probabilistic models for the description of population dynamics, like COVID-19 transmision. We are...

research line

Molecular modeling of biological processes and mechanisms

We are modeling the interaction of polyphenols with relevant targets in human health, like the...

research line

Development of new methodology for the energetic description of protein interactions

We are exploring the use of pyDock energy-based function to describe the energetics of protein-protein...

research line

New AI-based methods for the structural modeling of protein assemblies: integration of pyDock and AlphaFold

We are using AI-based methods like AlphaFold to improve structural modeling of protein-protein complexes. Our...

tool

pyDock

Protein-protein docking pipeline using FFT-based sampling and energy-based scoring.

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The Tryptophan/Histidine interaction in α-helices

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Corrigendum: The tryptophan/histidine interaction in α-helices (J. Mol. Biol. (1997) 267 (184-197))

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Investigation of the diaphorase reaction of ferredoxin-NADP⁺ reductase by electrochemical methods

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Intrahelical side chain interactions in α-helices: Poor correlation between energetics and frequency

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Apoflavodoxin: Structure, stability, and FMN binding

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Energetics of a hydrogen bond (charged and neutral) and of a cation-π interaction in apoflavodoxin

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Modulation of electroenzymatic NADPH oxidation through oriented immobilization of ferredoxin:NADP⁺ reductase onto modified gold electrodes

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Apoflavodoxin folding mechanism: An α/β protein with an essentially off-pathway intermediate

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Soft protein-protein docking in internal coordinates

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ICM-DISCO docking by global energy optimization with fully flexible side-chains

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The long and short flavodoxins: II. The role of the differentiating loop in apoflavodoxin stability and folding mechanism

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The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity

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A model of a transmembrane drug-efflux pump from Gram-negative bacteria

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The polygalacturonase-inhibiting protein PGIP2 of Phaseolus vulgaris has evolved a mixed mode of inhibition of endopolygalacturonase PG1 of Botrytis cinerea

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The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 Å resolution

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Optimal docking area: A new method for predicting protein-protein interaction sites

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Improving CAPRI predictions: Optimized desolvation for rigid-body docking

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Predicting protein-protein interface using desolvation energy similarity matching

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Polygalacturonase inhibiting proteins: Players in plant innate immunity?

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New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: Analysis by SARs and computational docking

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Identifying interaction motifs in CK2β - a ubiquitous kinase regulatory subunit

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Efficient restraints for protein-protein docking by comparison of observed amino acid substitution patterns with those predicted from local environment

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Data mining of molecular dynamic trajectories of nucleic acids

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Cell biology: Brief encounters bolster contacts

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The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane

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Structural and functional characterization of binding sites in metallocarboxypeptidases based on optimal docking area analysis

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Recognition and Cooperation Between the ATP-dependent RNA Helicase RhlB and Ribonuclease RNase E

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PyDock: Electrostatics and desolvation for effective scoring of rigid-body protein-protein docking

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Prediction and scoring of docking poses with pyDock

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Structural assembly of two-domain proteins by rigid-body docking

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In silico docking of urokinase plasminogen activator and integrins

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Identification of hot-spot residues in protein-protein interactions by computational docking

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Editorial

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Docking of cytochrome c₆ and plastocyanin to the aa ₃-type cytochrome c oxidase in the cyanobacterium Phormidium laminosum

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Docking analysis of transient complexes: Interaction of ferredoxin-NADP⁺ reductase with ferredoxin and flavodoxin

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Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid)

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Crystal structure of the endopolygalacturonase from the phytopathogenic fungus Colletotrichum lupini and its interaction with polygalacturonase- inhibiting proteins

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Assembly and Channel Opening in a Bacterial Drug Efflux Machine

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Structural characterization of unphosphorylated STAT5a oligomerization equilibrium in solution by small-angle X-ray scattering

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Pushing structural information into the yeast interactome by high-throughput protein docking experiments

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Predicting protein protein interfaces as clusters of Optimal Docking Area points

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Integration of evolutionary and desolvation energy analysis identifies functional sites in a plant immunity protein

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Docking and scoring: Applications to drug discovery in the interactomics era

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Theory and simulation: integrating models into experimental scenarios

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The 4th meeting on the Critical Assessment of PRedicted Interaction (CAPRI) held at the Mare Nostrum, Barcelona

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Structural characterization of protein-protein complexes by integrating computational docking with small-angle scattering data

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Protein docking by Rotation-Based Uniform Sampling (RotBUS) with fast computing of intermolecular contact distance and residue desolvation

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Present and future chanllenges and limitations in protein-Protein clocking

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Optimization of pyDock for the new CAPRI challenges: Docking of homology-based models, domain-domain assembly and protein-RNA binding

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Optimal protein-RNA area, OPRA: A propensity-based method to identify RNA-binding sites on proteins

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Mapping of interaction sites of the Schizosaccharomyces pombe protein translin with nucleic acids and proteins: A combined molecular genetics and bioinformatics study

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Interdomain conformations in the full-length MMP-2 enzyme explored by protein-protein docking calculations using pyDock

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Helix propensities of conformationally restricted amino acids. Non-natural substitutes for helix breaking proline and helix forming alanine

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Drug design on the cell BE

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Dissection and prediction of RNA-binding sites on proteins

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Scoring by intermolecular pairwise propensities of exposed residues (SIPPER): A new efficient potential for protein-protein docking