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Page 5 of 47

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Novel agents for the treatment of human cytomegalovirus infection

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Nonnucleoside human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives

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N-benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors

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Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives

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Hindered inversion/rotation in diheteroaryl alkyl amines with a N-(1-pyrazolyl) group: Dynamic NMR and molecular modelling studies

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Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors

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Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: Synthesis and comparative molecular field analysis

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Inhibition of tau phosphorylation: a new therapeutic strategy for the treatment of Alzheimer's disease and other neurodegenerative disorders

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Recent strategies in the development of new human cytomegalovirus inhibitors

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Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimer's Disease

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O-Pyrazolylpropynyl-Hydroxylamines as Versatile Intermediates in the Synthesis of Compounds of Pharmacological Interest

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CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-a]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors

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Anti-HIV-1 Activity of Benzothiadiazine Dioxide

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Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimer's Disease

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Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?

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Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

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First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3 beta) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

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An experimental NMR and semi-empirical theoretical study of the conformation of styrylchromones and styryl alkyl or aryl ketones (benzylidene ketones)

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APPLICATION OF ULTRASONIC NEBULIZATION FOR THE DETERMINATION OF RARE-EARTH ELEMENTS IN PHOSPHATES AND RELATED SEDIMENTARY-ROCKS USING INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRY WITH COMMENTS ON DISSOLUTION PROCEDURES

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Thienyl and phenyl alpha-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching

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Synthesis and muscarinic activities of O-[benzyl- or benzoylpyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone

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Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. Study of structural requirements for biological activity

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AMPA glutamate receptors and neuropathic pain.

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Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice

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GSK-3 inhibitors: Discoveries and developments

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CODES/Neural network model: a useful tool for in silico prediction of oral absorption and blood-brain barrier permeability of structurally diverse drugs

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SAR and 3D-QSAR studies on thiadiazolidinone derivatives: Exploration of structural requirements for glycogen synthase kinase 3 inhibitors

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Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation

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Molecular mechanics description of cytosine energy and geometry using preliminary ab initio results

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Marine compounds for the therapeutic treatment of neurological disorders

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Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques

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Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: New disease-modifying agents for Alzheimer's disease

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Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyryleholinesterase

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Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors

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Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE

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Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors

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Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease

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Marine Compounds as a New Source for Glycogen Synthase Kinase 3 Inhibitors

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Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases

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Enantioselective LC/MS method for the determination of an antimalarial agent fenozan B07 in dog plasma

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S4-04-06

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NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disorders

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Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease

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Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs

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Potent beta-amyloid modulators

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PDE7 inhibitors as new drugs for neurological and inflammatory disorders

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Non-ATP competitive glycogen synthase kinase 3 beta (GSK-3 beta) inhibitors: Study of structural requirements for thiadiazolidinone derivatives

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Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: Implication of ERK1/2 and PPAR gamma receptors

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GSK-3 inhibitors: A ray of hope for the treatment of Alzheimer's disease?

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CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

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Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

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S4-02-03: TDZDS: Can we target tau, beta-amyloid and neurodegeneration simultaneously?

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Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools

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The first enantioselective synthesis of palinurin

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Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

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Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

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NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells

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Anticonvulsant and Neuroprotective Effects of the Novel Calcium Antagonist NP04634 on Kainic Acid-Induced Seizures in Rats

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Advances in alzheimer therapy:Understanding Pharmacological approaches to the disease

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Emerging Drugs and Targets for Alzheimer's Disease

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Chapter 9. Tau Protein Kinases Inhibitors: From the Bench to the Clinical Trials

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The potential role of glycogen synthase kinase 3 inhibitors as Amyotrophic lateral sclerosis pharmacological therapy

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Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds

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Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity

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Protein Kinases CK1 and CK2 as New Targets for Neurodegenerative Diseases

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Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

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PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

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Glycogen synthase kinase-3.

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Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.

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GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS.

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Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities

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An application of two MIFs-based tools (Volsurf plus and Pentacle) to binary QSAR: The case of a palinurin-related data set of non-ATP competitive Glycogen Synthase Kinase 3 beta (GSK-3 beta) inhibitors

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The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

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Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice

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Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo

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Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds

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Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals

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A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

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5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3 beta (GSK-3 beta) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood-brain barrier penetration and binding to human serum albumin

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5-Imino-1,2,4-thiadiazoles: First small molecules As substrate competitive inhibitors of glycogen synthase kinase 3

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beta-N-methylamino-L-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS

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Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

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Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

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Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

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Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease

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Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

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Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease.

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Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin

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Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

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Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis

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CHAPTER 12. Phosphodiesterase Inhibitors as a New Therapeutic Approach for the Treatment of Parkinson’s Disease

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A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

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cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases.

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Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis

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Phosphodiesterase 10 inhibitors: New disease modifying drugs for Parkinson's disease?

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Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors

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Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice

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Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders

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CB1 Blockade Potentiates Down-Regulation of Lipogenic Gene Expression in Perirenal Adipose Tissue in High Carbohydrate Diet-Induced Obesity

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Computational Biology and Bioinformatics (BCB)

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