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Estimating the frequency of Asian cytochrome B haplotypes in standard European and local Spanish pig breeds

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Proteomic analysis of ovine muscle hypertrophy

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A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

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Differential expression of sarcoplasmic proteins in four heterogeneous ovine skeletal muscles

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Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep

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Integrating Y-Chromosome, Mitochondrial, and Autosomal Data to Analyze the Origin of Pig Breeds

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Short communication: Genetic variability in the predicted microRNA target sites of caprine casein genes

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Identification of positively selected sites in the goat kappa casein (CSN3) gene

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A Systems Model for Immune Cell Interactions Unravels the Mechanism of Inflammation in Human Skin

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Characterization of OAR1 and OAR18 QTL associated with muscle depth in British commercial terminal sire sheep

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Copy number variation in the genomes of domestic animals

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Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

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Allele-Specific Cytokine Responses at the HLA-C Locus: Implications for Psoriasis

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A Genome-Wide Association Study of Female Sexual Dysfunction

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An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element

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Characterisation of sperm piRNAs and their correlation with semen quality traits in swine

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Identification of genetic variation in the swine toll-like receptors and development of a porcine TLR genotyping array

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A genome-wide association analysis for carcass traits in a commercial Duroc pig population

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Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

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A targeted genotyping approach enhances identification of variants in taste receptor and appetite/reward genes of potential functional importance for obesity-related porcine traits

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A technical assessment of the porcine ejaculated spermatozoa for a sperm-specific RNA-seq analysis

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A RNA-Seq Analysis to Describe the Boar Sperm Transcriptome and Its Seasonal Changes

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An integrative systems biology approach to identify the molecular basis of sperm quality in swine

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Identification of circular RNAs in porcine sperm and evaluation of their relation to sperm motility

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A pilot RNA-seq study in 40 pietrain ejaculates to characterize the porcine sperm microbiome

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Whole genome sequencing identifies Allelic Ratio Distortion in sperm involving genes related to spermatogenesis in a swine model

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A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine

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Characterization of the Impact of Density Gradient Centrifugation on the Profile of the Pig Sperm Transcriptome by RNA-Seq

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Assessing the levels of intraspecific admixture and interspecific hybridization in Iberian wild goats ( Capra pyrenaica )

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Exploring the ovine sperm transcriptome by RNAseq techniques. I Effect of seasonal conditions on transcripts abundance

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Genomic, transcriptomic and epigenomic analysis towards the understanding of porcine semen quality traits. Past, current and future trends

tool

avidaR

Digital evolution is a branch of artificial life in which self-replicating computer programs—digital organisms—mutate and...

tool

OntoAvida

The Ontology for Avida (OntoAvida) aims to develop an integrated vocabulary for the description of Avida, the most...

service unit

Bioinformatics for Genomics and Proteomics (CNB)

Assistance on experimental design for deep sequencing and DNA microarrays experiments Biostatistical support for extracting...

researcher

José Luis Ruiz Rodriguez

researcher

Oscar Diaz Sanzo

research line

Productive efficiency and resilience of Spanish chicken breeds to global warming

This project proposes the sequencing of up to 600 hens of Spanish breeds. With this...

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Histone H3 Dynamics Reveal Domains with Distinct Proliferation Potential in the Arabidopsis Root

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Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat

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Oxford nanopore sequencing as an alternative to reduced representation bisulphite sequencing for the identification of CpGs of interest in livestock populations

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MEG8 as an antagonistic pleiotropic mechanism in breast cancer

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Functional Annotation of Proteomes Using Protein Language Models: A High-Throughput Implementation of the ProtTrans Model

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FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life

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11C-Labeling of a Flavone Extracted from a South American Native Species for Evaluation of Its Interaction with Gsk-3β

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SYNTHESIS AND INTRAMOLECULAR CYCLIZATION OF BISTHIADIAZINYLMETHANE DERIVATIVES

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N-GLUCOSYL-5-AMINO-4-CARBAMOYLIMIDAZOLES AND 4-ETHOXYCARBONYLIMIDAZOLES AS POTENTIAL PRECURSORS OF 4-OXOIMIDAZO[4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES

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SYNTHESIS OF 2S-DIOXO ISOSTERES OF PURINE AND PYRIMIDINE NUCLEOSIDES .4. SELECTIVE GLYCOSYLATION OF 4-AMINO-5H-IMIDAZO [4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDE

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Synthesis and spectroscopic properties of N -azolylpropanamides

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Synthesis and cytostatic screening of an SO2 analogue of doridosine

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Reaction of 4-hydrazinoquinolines with β-diketones. Synthesis and spectroscopy ( ¹ h, ¹³ c nmr, ms) of some pyrazolylquinolines

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ON THE TAUTOMERISM OF 2-PHENACYL-4-PYRIMIDINONES AND RELATED-COMPOUNDS

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Synthesis of a Valuable Precursor for the Preparation of Novel Quinolone Glycosides

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STRUCTURE OF 1,2,6-THIADIAZINE 1,1-DIOXIDES

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ROTATIONAL-ISOMERISM IN 6-BETA-D-GLUCOPYRANOSIDES OF METHYL-1,2,6-THIADIAZIN-3(2H)-ONE 1,1-DIOXIDES

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GLYCOSIDES OF PYRIDO[2,3-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES

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A ¹ H and ¹³ c Nmr study of the structure and tautomerism of 4-pyrazolylpyrazolinones

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Synthesis and NMR spectroscopy ( ¹ H ¹³ C) of 1-(2′-benzothiazolyl)-3(5),4-polymethylenepyrazoles and related compounds

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SYNTHESIS OF PSI-[CH(CN)NH] PSEUDOPEPTIDES - A NEW PEPTIDE-BOND SURROGATE

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LIPASE-MEDIATED ACYLATION OF ACYCLONUCLEOSIDES - APPLICATION TO NOVEL FLUOROQUINOLONE DERIVATIVES

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TAUTOMERISM AND ACIDITY IN 4-QUINOLONE-3-CARBOXYLIC ACID-DERIVATIVES

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(E)-1-ALKYL-[2-(1H-AZOL-2-YL)VINYL]PYRIDINIUM SALTS - THEORETICAL-ANALYSIS, SYNTHESIS AND EVALUATION OF THEIR INTERACTION WITH CHOLINE-ACETYLTRANSFERASE

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THE PROBLEM OF THE EXISTENCE OF C(AR)-H...N INTRAMOLECULAR HYDROGEN-BONDS IN A FAMILY OF 9-AZAPHENYL-9H-CARBAZOLES

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THE MOLECULAR-STRUCTURE OF 3(5)-METHYL-4,5(3)-TRIMETHYLENEPYRAZOLE HYDROCHLORIDE AND ITS C-13 AND N-15 NMR-SPECTROSCOPY

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SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-QUINOLONE RIBOSIDES

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SO2 EXTRUSION IN 1,2,6-THIADIAZINE 1,1-DIOXIDES - A NOVEL SYNTHESIS OF PYRAZOLES

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TAUTOMERISM OF BENZOPENTA AND CYCLOPENTA-[1,2,6]THIADIAZINE S,S-DIOXIDES

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REGIOSELECTIVE LIPASE-MEDIATED ACYLATION-DEACYLATION IN THIADIAZINE DIACYCLONUCLEOSIDES

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The structure of the compounds resulting from the reaction of arylhydrazines with dehydroacetic acid: an NMR and crystallographic study

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The Regio- and Stereocontrolled Ring Opening of Heteroarylglycidates with Nitrogen Nucleophiles

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Semiempirical (AM1, PM3 and SAM1) calculations of the protonation enthalpies of proton sponges related to 1,8-diaminonaphthalene. Estimation of the aqueous basicity of new designed superbases

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Regioselective Mucor miehei lipase catalyzed synthesis of podands containing a 1,3-bis(1H-Pyrazol-1-yl)propane unit

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New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation

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Dioxides of bicyclic thiadiazines: a new family of smooth muscle relaxants

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New Synthetic Route to of 1,2,4-Thiadiazolines and 1,3-Thiazolines via Thiadiazolopyridinium Salts

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Conformation and ortho steric effects in a series of 2-(pyrazol-1-yl)quinolines

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Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides

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Selective carriers of norepinephrine and ammonium ions: ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit

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Regioselective lipase-catalyzed synthesis of l-glutamic α-monoamide derivatives. Effect of the N-blocking group

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Regioselective lipase catalyzed synthesis of diester crowns. New asymmetric macrocycles containing a 1,3-bis(1H-pyrazol-1-yl)propane unit

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Molecular modeling of (E)-1-Alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase

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Comparative molecular field analysis (CoMFA) on [6]+[6] fused pyrazines with nematocide properties

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Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infections

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Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers

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Applications of a statistical model to the analysis of the kinetic parameters in isothermal and non-isothermal crystallization of polymer blends based on PVDF

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Base promoted transformation on thiadiazolopyridinium chlorides

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Towards lipophilic derivatives of S-adenosyl-L-methionine

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Synthesis of nonsymmetrically 3,4-disubstituted 1,2,5-thiadiazole dioxides

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Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol by lipase mediated enantioselective alcoholysis, hydrolysis and acylation

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Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

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Lipase catalysed amidation of diethyl glutamate derivatives: peculiarities of ethyl S- and R-pyroglutamate

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Enzymatic alcoholysis of SO2-uracil analog diacyclonucleosides. Long-distance effect of the substituents on the regioselectivity

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Selective dopamine receptors: Synthesis, complexing properties, and molecular modelling studies of new podands derived from 4-hydroxy-1H-pyrazole

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On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds

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Novel potential agents for human cytomegalovirus infection: Synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

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Intramolecular oxidative cyclizations in heteroarylthioureas: A versatile pathway to bridgehead heterocyclic systems

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Imidazothiadiazine dioxides: Synthesis and antiviral activity

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Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors

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Candida antarctica lipase B catalysed amidation of pyroglutamic acid derivatives. A reaction survey

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Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity

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Regioselective lipase-catalysed gamma-monoamidation of D-glutamic acid diesters: effect of the N-protecting group