orcid publication

Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains

orcid publication

Structural and energy determinants in protein-RNA docking

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Modeling binding affinity of pathological mutations for computational protein design

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IRaPPA: Information retrieval based integration of biophysical models for protein assembly selection

orcid publication

Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations

orcid publication

A systematic analysis of scoring functions in rigid-body protein docking: The delicate balance between the predictive rate improvement and the risk of overtraining

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Structural Prediction of Protein–Protein Interactions by Docking: Application to Biomedical Problems

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LightDock: A new multi-scale approach to protein-protein docking

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Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases

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Hot-spot analysis for drug discovery targeting protein-protein interactions

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Structural and computational characterization of disease-related mutations involved in protein-protein interfaces

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SKEMPI 2.0: An updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation

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L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

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Structural Characterization of Protein–Protein Interactions with pyDockSAXS

orcid publication

PyDockEneRes: Per-residue decomposition of protein-protein docking energy

orcid publication

Modelling the evolution of COVID-19 in high-incidence European countries and regions: Estimated number of infections and impact of past and future intervention measures

orcid publication

Docking-based identification of small-molecule binding sites at protein-protein interfaces

orcid publication

Docking approaches for modeling multi-molecular assemblies

orcid publication

UEP: an open-source and fast classifier for predicting the impact of mutations in protein-protein complexes

orcid publication

Structural basis for the dominant or recessive character of GLIALCAM mutations found in leukodystrophies

orcid publication

Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitution

orcid publication

PirePred: An Accurate Online Consensus Tool to Interpret Newborn Screening–Related Genetic Variants in Structural Context

orcid publication

Novel treatment strategy for NRAS-mutated melanoma through a selective inhibitor of CD147/VEGFR-2 interaction

orcid publication

Architecture of the ESCPE-1 membrane coat

orcid publication

Diverging co-translational protein complex assembly pathways are governed by interface energy distribution

research line

Single-cell and spatial omics

Single-cell and spatial omics encompass a set of advanced technologies and analytical approaches that profile...

research line

Cell type markers and single-cell data analysis

Cell type markers and single-cell data analysis focus on identifying genes, proteins, or molecular signatures...

research line

Protein interactions and network molecular biology

Protein interactions and network molecular biology focuses on understanding how proteins interact with each other...

research line

Cancer Genomics and Transcriptomics

Cancer Genomics and Transcriptomics is a multidisciplinary field that investigates both the DNA-level alterations and...

researcher

Jose-Jesus Fernandez

researcher

ajaskolowski

researcher

manolofernandez

researcher

Franciscoandujar

researcher

cgallego

orcid publication

PharaohFUN: phylogenomic analysis for plant protein history and function elucidation

service unit

Bioinformatics unit at ibs.GRANADA

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Emerging human health concerns from chronic exposure to pesticide mixtures

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Distribution of y chromosomal STRs loci in Mayan and Mestizo populations from Guatemala

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Modulation of the endogenous antioxidants paraoxonase-1 and urate by pesticide exposure and genetic variants of xenobiotic-metabolizing enzymes

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Activity and determinants of cholinesterases and paraoxonase-1 in blood of workers exposed to non-cholinesterase inhibiting pesticides

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Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

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A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

orcid publication

Evaluation of Polyphenol Intake in Pregnant Women from South-Eastern Spain and the Effect on Anthropometric Measures at Birth and Gestational Age

orcid publication

Transcriptomic profiling unveils novel therapeutic options for drug-resistant temporal lobe epilepsy

researcher

Antonio Gómez Martín

orcid publication

Enrichment of Artemia nauplii in essential fatty acids with different types of liposomes and their use in the rearing of gilthead sea bream (Sparus aurata) larvae

orcid publication

Differential metabolic and gene expression profile of juvenile common dentex (Dentex dentex L.) and gilthead sea bream (Sparus aurata L.) in relation to redox homeostasis

orcid publication

Bacteria associated with winter mortalities in laboratory-reared common dentex (Dentex dentex L.)

orcid publication

Differential tissue expression of uncoupling proteins in gilthead sea bream (Sparus aurata L): Lessons from UCP1 and UCP3 in fish

orcid publication

Confinement exposure induces glucose regulated protein 75 (GRP75/mortalin/mtHsp70/PBP74/HSPA9B) in the hepatic tissue of gilthead sea bream (Sparus aurata L.)

orcid publication

The time course of fish oil wash-out follows a simple dilution model in gilthead sea bream (Sparus aurata L.) fed graded levels of vegetable oils

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Gene expression survey of mitochondrial uncoupling proteins (UCP1/UCP3) in gilthead sea bream (Sparus aurata L.)

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Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors

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Modelling the predictable effects of dietary lipid sources on the fillet fatty acid composition of one-year-old gilthead sea bream (Sparus aurata L.)

orcid publication

Feed restriction up-regulates uncoupling protein 3 (UCP3) gene expression in heart and red muscle tissues of gilthead sea bream (Sparus aurata L.) New insights in substrate oxidation and energy expenditure

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Dietary oils mediate cortisol kinetics and the hepatic mRNA expression profile of stress-responsive genes in gilthead sea bream (Sparus aurata) exposed to crowding stress. Implications on energy homeostasis and stress susceptibility

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Deep sequencing for de novo construction of a marine fish (Sparus aurata) transcriptome database with a large coverage of protein-coding transcripts

orcid publication

Tissue-specific gene expression and functional regulation of uncoupling protein 2 (UCP2) by hypoxia and nutrient availability in gilthead sea bream (Sparus aurata): implications on the physiological significance of UCP1-3 variants

orcid publication

Metabolic and transcriptional responses of gilthead sea bream (Sparus aurata L.) to environmental stress: New insights in fish mitochondrial phenotyping

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Effects of a silver nanomaterial on cellular organelles and time course of oxidative stress in a fish cell line (PLHC-1)

orcid publication

Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata)

orcid publication

Negligible cytotoxicity induced by different titanium dioxide nanoparticles in fish cell lines

orcid publication

Induction of EROD and BFCOD activities in tissues of barbel (Barbus callensis) from a water reservoir in Algeria

orcid publication

Fish cell lines as a tool for the ecotoxicity assessment and ranking of engineered nanomaterials

orcid publication

Gene expression profiling of whole blood cells supports a more efficient mitochondrial respiration in hypoxia-challenged gilthead sea bream (Sparus aurata)

orcid publication

Acute hazard of biocides for the aquatic environmental compartment from a life-cycle perspective

orcid publication

Preparation of feed with metal oxide nanoparticles for nanomaterial dietary exposure to fish and use in OECD TG 305

orcid publication

VKORC1 single nucleotide polymorphisms in rodents in Spain

orcid publication

New Genes Involved in Osmotic Stress Tolerance in Saccharomyces cerevisiae

orcid publication

Targeted exome sequencing of Krebs cycle genes reveals candidate cancer predisposing mutations in pheochromocytomas and paragangliomas

orcid publication

Gain-of-function mutations in DNMT3A in patients with paraganglioma

orcid publication

The Major Origin of Seedless Grapes Is Associated with a Missense Mutation in the MADS-Box Gene VviAGL11

orcid publication

passport-data-sylv.txt

orcid publication

genotypes_sylvestris.fam

orcid publication

genotypes_SYLV_OUT.ped

orcid publication

genotypes_SYLV_OUT.map

orcid publication

README.txt

orcid publication

A dataset of 9.896 single nuclear polymorphisms for 112 wild grapes, obtained with the GrapeReSeq 18K Vitis chip

orcid publication

WeReview: CRISPR Tools—Live Repository of Computational Tools for Assisting CRISPR/Cas Experiments

orcid publication

Hsa‐miR‐139‐5p is a prognostic thyroid cancer marker involved in HNRNPF‐mediated alternative splicing

orcid publication

VviUCC1 Nucleotide Diversity, Linkage Disequilibrium and Association with Rachis Architecture Traits in Grapevine

orcid publication

MYB transcription factors drive evolutionary innovations in Arabidopsis fruit trichome patterning

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Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution

orcid publication

Spatial control of potato tuberization by the TCP transcription factor BRANCHED1b

orcid publication

Variation and plasticity in life-history traits and fitness of wild Arabidopsis thaliana populations are not related to their genotypic and ecological diversity

orcid publication

The trichome pattern diversity of Cardamine shares genetic mechanisms with Arabidopsis but differs in environmental drivers

orcid publication

Genome resequencing and custom genotyping elucidates the origin and dissemination history of an emblematic grapevine cultivar, ‘Tempranillo Tinto’

service unit

Bioinformatics Service at CBM

The CBMSO Bioinformatics Service originated from the Bioinformatics Unit established by Angel Ramirez Ortiz around...

service unit

Cellular, Molecular and Bioinformatics Service at ICVV

We provide flexible, end-to-end bioinformatics support across genomics, transcriptomics (RNA-seq, scRNA-seq), metataxonomics, and structural bioinform...

research line

Ecology and Biodiversity of fungi

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Evaluation of secondary structure of proteins from uv circular dichroism spectra using an unsupervised learning neural network

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A resolution of the chemotactic wave paradox

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Spatial dynamics of a model for prebiotic evolution

orcid publication

Preface

orcid publication

Compartimentation in replicator models

orcid publication

Tubulin secondary structure analysis, limited proteolysis sites, and homology to FtsZ

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A prediction of DDP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma

orcid publication

Changes in microtubule protofilament number induced by taxol binding to an easily accessible site: Internal microtubule dynamics

orcid publication

Using Situs for the registration of protein structures with low-resolution bead models from x-ray solution scattering

orcid publication

Modeling tricks and fitting techniques for multiresolution structures