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Temporal dynamics of direct reciprocal and indirect effects in a host-parasite network

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Habitat loss and the disassembly of mutalistic networks

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Evolving Digital Ecological Networks

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Assessing the robustness of networks of spatial genetic variation

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Host–parasite network structure is associated with community-level immunogenetic diversity

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Community-level demographic consequences of urbanization: an ecological network approach

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Does removal of invasives restore ecological networks? An experimental approach

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Diversification and biodiversity dynamics of hot and cold spots

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Seasonal species interactions minimize the impact of species turnover on the likelihood of community persistence

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How does the functional diversity of frugivorous birds shape the spatial pattern of seed dispersal? A case study in a relict plant species

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Genetic specificity of a plant–insect food web: Implications for linking genetic variation to network complexity

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The genotype-phenotype map of an evolving digital organism

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Non-adaptive origins of evolutionary innovations increase network complexity in interacting digital organisms

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Analysis of spatial genetic variation reveals genetic divergence among populations of Primula veris associated to contrasting habitats

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Ecological succession drives the structural change of seed-rodent interaction networks in fragmented forests

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Deciphering the Interdependence between Ecological and Evolutionary Networks

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Plant interactions shape pollination networks via nonadditive effects

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Indigenous knowledge networks in the face of global change

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Coevolutionary dynamics shape the structure of bacteria‐phage infection networks

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Partner Fidelity and Asymmetric Specialization in Ecological Networks

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Mycoheterotrophic plants preferentially target arbuscular mycorrhizal fungi that are highly connected to autotrophic plants

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The phenotypic plasticity of an evolving digital organism

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Editorial: Digital evolution: Insights for biologists

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Ontology for the Avida digital evolution platform

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avidaR: an R library to perform complex queries on an ontology-based database of digital organisms

researcher

María Santos Romero

researcher

Rafael Laso Pérez

research line

Crop Genomics and Breeding Methods

project

Combining Genomic Approaches to Study Host–Pathogen Relationships in Wheat and Septoria CNS2024-154812

project

New Drought- and Heat-Tolerant Blueberry Varieties through Advanced Genomic Selection

project

Genomic Assisted breeding for SUStainable agriculture: A benchmark approach

tool

GEmetrics

An R package to calculate BLUP of the Genotype by environment metrics.

tool

TrainSel

R package for optimization of training populations in breeding programs.

orcid publication

The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance

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SAGA–CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity

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The promiscuity of the SAGA complex subunits: Multifunctional or moonlighting proteins?

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Transcriptional memory dampens heat shock responses in yeast: functional role of Mip6 and its interaction with Rpd3

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An exon three-way junction structure modulates splicing and degradation of the SUS1 yeast pre-mRNA

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A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export

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Sharing Marks: H3K4 Methylation and H2B Ubiquitination as Features of Meiotic Recombination and Transcription

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Decoding Transcriptional Memory in Yeast Heat Shock and the Functional Implication of the RNA Binding Protein Mip6

orcid publication

Unraveling gene expression: a beginner’s guide from chromatin modifications to mRNA export in Saccharomyces cerevisiae

tool

Avida: a digital evolution software platform for studying evolution

Avida is the most widely used Artificial Life software platform for studying evolutionary processes, in...

project

The Coevolving Web of Life

Understanding the mechanisms driving the ongoing (co)evolution of the Web of Life is a major...

project

Harnessing evolution by engineering ecological interactions to fight human disesases

Our society faces major biomedical challenges such as cancer, antibiotic resistance, and imbalanced microbiomes. While...

project

Evolving phages by engineering ecological interactions to treat antibiotic-resistant bacterial infections

The rate at which pathogenic bacteria evolve resistance to antibiotics exceeds the pace at which...

research line

Digital evolution

Studying evolution in the lab provides valuable insights but is often constrained by long timescales...

research line

Development of efficient methods for calculating paths of minimum or maximum parameter values (e.g., minimum energy paths) through surfaces of any number of dimensions.

MEPSAnd: Minimum Energy Path Surface Analysis over n-dimensional surfaces [http://bioweb.cbm.uam.es/software/MEPSAnd/] MEPSA: Minimum Energy Pathway A...

research line

Analysis by computational simulation of enzymatic reactions catalyzed by enzymes of biomedical interest. Design of specific inhibitors.

project

New drugs to inhibit Carbapenemases. Discovery of compounds by structural design (DrugCarbapenem)

orcid publication

The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens

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Modulating the RNA Processing and Decay by the Exosome: Altering Rrp44/Dis3 Activity and End-Product (vol 8, e76504, 2013)

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A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 – Review of the literature

orcid publication

MEPSAnd: minimum energy path surface analysis over n-dimensional surfaces

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An engineered miniACE2 protein secreted by mesenchymal stromal cells effectively neutralizes multiple SARS-CoV- 2 variants in vitro

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Biallelic loss-of-function variants in ZNF142 are associated with a robust DNA methylation signature affecting a limited number of genomic loci

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Postzygotic mosaicism in SMC1A and the first reported case of a female with Cornelia de Lange syndrome

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CONDITIONS RESTRICTING DEPOLARIZATION-DEPENDENT CALCIUM INFLUX IN SYNAPTOSOMES REVEAL A GRADED RESPONSE OF P96-DEPHOSPHORYLATION AND A TRANSIENT DEPHOSPHORYLATION OF P65

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PYRUVATE-DEHYDROGENASE DEPHOSPHORYLATION IN RAT-BRAIN SYNAPTOSOMES AND MITOCHONDRIA - EVIDENCE FOR A CALCIUM-MEDIATED EFFECT IN RESPONSE TO DEPOLARIZATION, AND VARIATIONS DUE TO AGING

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AGE-RELATED-CHANGES IN CALCIUM HOMEOSTATIC MECHANISMS IN SYNAPTOSOMES IN RELATION WITH WORKING-MEMORY DEFICIENCY

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THE ACTIVITY OF SYNAPTOSOMAL CALCIUM CHANNELS IS INVERSELY CORRELATED WITH WORKING-MEMORY PERFORMANCE IN MEMORY-IMPAIRED, AGED RATS

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IMPROVEMENT OF AFRICAN SWINE-FEVER VIRUS NEUTRALIZATION ASSAY USING RECOMBINANT VIRUSES EXPRESSING CHROMOGENIC MARKER GENES

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Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization

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The structural protein p54 is essential for African swine fever virus viability

orcid publication

Neutralization susceptibility of African swine fever virus is dependent on the phospholipid composition of viral particles

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High level expression of the major antigenic African swine fever virus proteins p54 and p30 in baculovirus and their potential use as diagnostic reagents

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Blocking antibodies inhibit complete African swine fever virus neutralization

orcid publication

Efficient formation of influenza virus-like particles: Dependence on the expression levels of viral proteins

orcid publication

In vitro inhibition of the replication of haemorrhagic septicaemia virus (VHSV) and African swine fever virus (ASFV) by extracts from marine microalgae

orcid publication

Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoprotein

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Rescue of synthetic RNAs into Thogoto and influenza A virus particles using core proteins purified from Thogoto virus

orcid publication

Influenza virus matrix protein is the major driving force in virus budding

orcid publication

Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins

orcid publication

Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs

orcid publication

Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover

orcid publication

Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin

orcid publication

Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT) - Mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity

orcid publication

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I - Mutational analysis of a malonyl-CoA affinity domain

orcid publication

Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT

orcid publication

Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT

orcid publication

ESF Programme on 'Integrated Approaches for Functional Genomics' Workshop on 'Modelling of Molecular Networks'.

orcid publication

Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA

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Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition - Mutation of methionine 593 abolishes malonyl-CoA inhibition

orcid publication

Structural (beta alpha)(8) TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase

orcid publication

A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae

orcid publication

Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection

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The substrate recognition mechanisms in chaperonins

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Sequence and structural alignments of eukaryotic and prokaryotic cytoskeletal proteins

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Bacterial morphogenes

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TRAF family proteins link PKR with NF-kappa B activation

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Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal

orcid publication

Redesign of carnitine acetyltransferase specificity by protein engineering

orcid publication

Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)(8) TIM Barrel model of HL

orcid publication

Scoring docking models with evolutionary information

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Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients

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Computational approaches to model ligand selectivity in drug design

orcid publication

A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase

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Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation

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Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase

orcid publication

Mutational Spectrum of Maple Syrup Urine Disease in Spain