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Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoprotein

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Rescue of synthetic RNAs into Thogoto and influenza A virus particles using core proteins purified from Thogoto virus

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Influenza virus matrix protein is the major driving force in virus budding

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Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins

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Influenza A virus NEP (NS2 protein) downregulates RNA synthesis of model template RNAs

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Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover

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Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin

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Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT) - Mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity

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Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I - Mutational analysis of a malonyl-CoA affinity domain

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Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT

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Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT

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ESF Programme on 'Integrated Approaches for Functional Genomics' Workshop on 'Modelling of Molecular Networks'.

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Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA

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Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition - Mutation of methionine 593 abolishes malonyl-CoA inhibition

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Structural (beta alpha)(8) TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase

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A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae

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Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection

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The substrate recognition mechanisms in chaperonins

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Sequence and structural alignments of eukaryotic and prokaryotic cytoskeletal proteins

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Bacterial morphogenes

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TRAF family proteins link PKR with NF-kappa B activation

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Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal

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Redesign of carnitine acetyltransferase specificity by protein engineering

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Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)(8) TIM Barrel model of HL

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Scoring docking models with evolutionary information

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Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients

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Computational approaches to model ligand selectivity in drug design

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A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase

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Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation

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Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase

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Mutational Spectrum of Maple Syrup Urine Disease in Spain

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The role of the S1 domain in exoribonucleolytic activity: Substrate specificity and multimerization

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Ca2+ activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin - Role in the heart malate-aspartate NADH shuttle

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Quasi-atomic model of bacteriophage T7 procapsid shell: Insights into the structure and evolution of a basic fold

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Control of the respiratory metabolism of Thermus thermophilus by the nitrate respiration conjugative element NCE

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Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A

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C-terminal end and aminoacid Lys(48) in HMG-CoA lyase are involved in substrate binding and enzyme activity

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Molecular genetics of HMG-CoA lyase deficiency

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An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions - Relevance for Gaucher disease

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Residues in human respiratory syncytial virus P protein that are essential for its activity on RNA viral synthesis

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New insights into the mechanism of RNA degradation by ribonuclease II - Identification of the residue responsible for setting the RNase II end product

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The structure of CCT-Hsc70(NBD) suggests a mechanism for Hsp70 delivery of substrates to the chaperonin

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Structural properties of the human respiratory syncytial virus P protein: Evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors

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Ten Novel HMGCL Mutations in 24 Patients of Different Origin with 3-Hydroxy-3-Methyl-Glutaric Aciduria

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C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

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Structural and Functional Model for Ionic (K+/Na+) and pH Dependence of GTPase Activity and Polymerization of FtsZ, the Prokaryotic Ortholog of Tubulin

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Determination of Key Residues for Catalysis and RNA Cleavage Specificity ONE MUTATION TURNS RNase II INTO A "SUPER-ENZYME"

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Mutations and Variants in the Cohesion Factor Genes NIPBL, SMC1A, and SMC3 in a Cohort of 30 Unrelated Patients With Cornelia de Lange Syndrome

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CDKN1C (p57(Kip2)) Analysis in Beckwith-Wiedemann Syndrome (BWS) Patients: Genotype-Phenotype Correlations, Novel Mutations, and Polymorphisms

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Strong FtsZ is with the force: mechanisms to constrict bacteria

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Neutralization of Human Respiratory Syncytial Virus Infectivity by Antibodies and Low-Molecular-Weight Compounds Targeted against the Fusion Glycoprotein

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Technical phosphoproteomic and bioinformatic tools useful in cancer research.

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Nanomechanics of the Cadherin Ectodomain "CANALIZATION" BYCa2 BINDING RESULTS IN A NEW MECHANICAL ELEMENT

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Swapping the domains of exoribonucleases RNase II and RNase R: Conferring upon RNase II the ability to degrade ds RNA

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The Role of GIn(61) in HRas GTP Hydrolysis: A Quantum Mechanics/Molecular Mechanics Study

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Molecular dynamics analysis of conformational change of paramyxovirus F protein during the initial steps of membrane fusion

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The role of Gln(61) in HRas GTP hydrolysis: a quantum mechanics/molecular mechanics study (vol 102, pg 152, 2012 )

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Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ

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Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway

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Surface-Enhanced Raman Scattering-Based Detection of the Interactions between the Essential Cell Division FtsZ Protein and Bacterial Membrane Elements

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The only exoribonuclease present in Haloferax volcanii has an unique response to temperature changes

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Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity

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Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol

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Genome Sequence of OXA-48 Carbapenemase-Producing Klebsiella pneumoniae KpO3210

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Simulation of Catalytic Water Activation in Mitochondrial F-1-ATPase Using a Hybrid Quantum Mechanics/Molecular Mechanics Approach: An Alternative Role for beta-Glu 188

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Ddi1-like protein from Leishmania major is an active aspartyl proteinase

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Analysis of aberrant splicing and nonsense-mediated decay of the stop codon mutations c.109G > T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency

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New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations

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Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN

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Torsion and curvature of FtsZ filaments

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FIREBALL/AMBER: An Efficient Local-Orbital DFT QM/MM Method for Biomolecular Systems

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Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients

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Severe ipsilateral musculoskeletal involvement in a Cornelia de Lange patient with a novel NIPBL mutation

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Design of clone-specific probes from genome sequences for rapid PCR-typing of outbreak pathogens

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Somatic mosaicism in a Cornelia de Lange syndrome patient with NIPBL mutation identified by different next generation sequencing approaches

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Comparing Molecular Dynamics Force Fields in the Essential Subspace

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A Practical Quantum Mechanics Molecular Mechanics Method for the Dynamical Study of Reactions in Biomolecules

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De Novo Heterozygous Mutations in SMC3 Cause a Range of Cornelia de Lange Syndrome-Overlapping Phenotypes

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ANISERP: a new serpin from the parasite Anisakis simplex

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The Cell Division Protein FtsZ from Streptococcus pneumoniae Exhibits a GTPase Activity Delay

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MEPSA: minimum energy pathway analysis for energy landscapes

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Quantum Mechanics/Molecular Mechanics Free Energy Maps and Nonadiabatic Simulations for a Photochemical Reaction in DNA: Cyclobutane Thymine Dimer

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Special Cases in Cornelia de Lange Syndrome: The Spanish Experience

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In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa

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mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de Lange Syndrome

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Two-step ATP-driven opening of cohesin head

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A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases

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Population structure of OXA-48-producing Klebsiella pneumoniae ST405 isolates during a hospital outbreak characterised by genomic typing.

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Human Mitochondrial HMG-CoA Synthase Deficiency: Role of Enzyme Dimerization Surface and Characterization of Three New Patients

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Identification of temperature-sensitive mutations and characterization of thermolabile RNase II variants

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More Than One HMG-CoA Lyase: The Classical Mitochondrial Enzyme Plus the Peroxisomal and the Cytosolic Ones

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Evaluating Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes

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Delineation of phenotypes and genotypes related to cohesin structural protein RAD21

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VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy

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Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome

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Things are not always what they seem: From Cornelia de Lange to KBG phenotype in a girl with genetic variants in NIPBL and ANKRD11

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DLG4-related synaptopathy: a new rare brain disorder

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Clinical relevance of postzygotic mosaicism in Cornelia de Lange syndrome and purifying selection of NIPBL variants in blood

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Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia

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Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome

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Computational Biology and Bioinformatics (BCB)

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