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Protein Kinases CK1 and CK2 as New Targets for Neurodegenerative Diseases

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Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

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PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

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Glycogen synthase kinase-3.

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Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.

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GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS.

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Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities

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An application of two MIFs-based tools (Volsurf plus and Pentacle) to binary QSAR: The case of a palinurin-related data set of non-ATP competitive Glycogen Synthase Kinase 3 beta (GSK-3 beta) inhibitors

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The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

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Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice

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Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo

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Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds

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Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals

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A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

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5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3 beta (GSK-3 beta) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood-brain barrier penetration and binding to human serum albumin

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5-Imino-1,2,4-thiadiazoles: First small molecules As substrate competitive inhibitors of glycogen synthase kinase 3

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beta-N-methylamino-L-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS

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Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

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Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

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Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

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Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease

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Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

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Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease.

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Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin

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Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

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Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis

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CHAPTER 12. Phosphodiesterase Inhibitors as a New Therapeutic Approach for the Treatment of Parkinson’s Disease

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A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

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cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases.

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Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis

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Phosphodiesterase 10 inhibitors: New disease modifying drugs for Parkinson's disease?

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Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors

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Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice

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Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders

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CB1 Blockade Potentiates Down-Regulation of Lipogenic Gene Expression in Perirenal Adipose Tissue in High Carbohydrate Diet-Induced Obesity

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Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

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Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats

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PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

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Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors

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Morphometric and neurochemical alterations found in L-BMAA treated rats

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Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3

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From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease

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Chapter 9. Heterocycles Containing Nitrogen and Sulfur as Potent Biologically Active Scaffolds

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Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

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Analysis of β-N-methylamino-l-alanine (L-BMAA) neurotoxicity in rat cerebellum

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3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3 beta Fragment Hits against Alzheimer's Disease

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Therapeutic approaches for the future treatment of Fragile X

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Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3 beta Inhibitors

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Tideglusib, a chemical inhibitor of GSK3beta, attenuates hypoxic-ischemic brain injury in neonatal mice.

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The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis.

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Targeting TDP-43 phosphorylation by Casein Kinase-1 delta inhibitors: a novel strategy for the treatment of frontotemporal dementia

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Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

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Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

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Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.

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Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders

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Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

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Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa

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Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.

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Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

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Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

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Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents.

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Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

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Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

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Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?

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GSK-3 inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice

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From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease

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Drugs in clinical development for the treatment of amyotrophic lateral sclerosis

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Chapter 8. Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs

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A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice.

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Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

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Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson’s Disease

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Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

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Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits

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TNFalpha disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.

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Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

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Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

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Amyloid beta-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.

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Identification of new allosteric sites and modulators of AChE through computational and experimental tools

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1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

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Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

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The adiponectin promoter activator NP-1 induces high levels of circulating TNF alpha and weight loss in obese (fa/fa) Zucker rats

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Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients.

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Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

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Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors

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High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses

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QSAR modelling for drug discovery: Predicting the activity of LRRK2 inhibitors for Parkinson’s disease using cheminformatics approaches

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Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3 beta, beta-secretase, and casein kinase 1 delta

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Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease

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GSK-3 Inhibitors: From the Brain to the Retina and Back Again

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Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

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Correction of GSK3β in DM1 reduces the mutant RNA and improves postnatal survival of DMSXL mice

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CHAPTER 8. Protein Kinase Inhibitors for the Treatment of Multiple Sclerosis

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A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

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1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation

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Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases

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Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

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A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential

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Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

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QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson’s Disease

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Computational Biology and Bioinformatics (BCB)

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