orcid publication

Numerical spatio-temporal characterization of Listeria monocytogenes biofilms

orcid publication

Quantitative image analysis to characterize the dynamics of Listeria monocytogenes biofilms

orcid publication

Numerical methods for a nonlinear reaction–diffusion system modelling a batch culture of biofilm

orcid publication

Modeling reveals the role of aging and glucose uptake impairment in L1A1 Listeria monocytogenes biofilm life cycle

research line

Mathematical methods and software tools for systems biology

orcid publication

Saccharomyces cerevisiae and S. kudriavzevii synthetic wine fermentation performance dissected by predictive modeling

orcid publication

Optimally designed vs intuition-driven inputs: The study case of promoter activity modelling

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On-line optimal input design increases the efficiency and accuracy of the modelling of an inducible synthetic promoter

orcid publication

Information content analysis reveals desirable aspects of in vivo experiments of a synthetic circuit

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Bayesian model selection in synthetic biology: Factor levels and observation functions

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Temperature Shapes Ecological Dynamics in Mixed Culture Fermentations Driven by Two Species of the Saccharomyces Genus

research line

Modeling intereactions in biological systems

orcid publication

Optimally designed model selection for synthetic biology

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Mixed growth curve data do not suffice to fully characterize the dynamics of mixed cultures

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Model-Based Real Time Operation of the Freeze-Drying Process

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A two-dimensional multi-species model for different Listeria monocytogenes biofilm structures and its numerical simulation

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The Monod Model Is Insufficient To Explain Biomass Growth in Nitrogen-Limited Yeast Fermentation

research line

Modeling microbial systems at multiple scales

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Optimal Experimental Design for Systems and Synthetic Biology Using AMIGO2

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A multiphase multiobjective dynamic genome-scale model shows different redox balancing among yeast species of the saccharomyces genus in fermentation

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A Cyber-Physical Platform for Model Calibration

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Modelling the physiological status of yeast during wine fermentation enables the prediction of secondary metabolism

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A Dynamic Genome-Scale Model Identifies Metabolic Pathways Associated with Cold Tolerance in Saccharomyces kudriavzevii

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Dynamic genome‐scale modeling of Saccharomyces cerevisiae unravels mechanisms for ester formation during alcoholic fermentation

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Combined Isotopic Tracer and Modelling Approach Reveals Differences in Nitrogen Metabolism in S. cerevisiae, S. uvarum and S. kudriavzevii Species

orcid publication

Temperature-Dependent Kinetic Modeling of Nitrogen-Limited Batch Fermentation by Yeast Species

research line

Development of Genomic tools for Population Analysis of Variability

Statistical Studies to develop methods to better understand the genetic variability. Development of Software and...

orcid publication

Insights into mammalian morphogen dynamics from embryonic stem cell systems

orcid publication

Quantifying cell transitions in C. elegans with data-fitted landscape models

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A quantitative landscape of cell fate transitions identifies principles of cellular decision-making

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Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions

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Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

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Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

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Combinatorial interpretation of BMP and WNT controls the decision between primitive streak and extraembryonic fates

researcher

fmpercan

researcher

frapercan

researcher

lbotigue

research line

omics analysis of male reproductive traits in swine

Applying different omics approaches (GWAS, WGS, RNA-Seq, MNase-Seq, single cell multiome – RNA + ATAC)...

project

BoarTeSC (PID21115)

project

Molecular analysis of semen quality at the cell level in swine (MoSeC;PID2021-123725OB-I00)

project

Genomics applied to the development of DNA markers for boar reproduction traits

(AGL2017-86946-R)

project

PigQSem: Genomic approaches for the assessment of boar semen quality (AGL2013-44978-R)

orcid publication

Test for positional candidate genes for body composition on pig chromosome 6

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QTL mapping for growth and carcass traits in an Iberian by Landrace pig intercross: additive, dominant and epistatic effects

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Detection of QTL affecting fatty acid composition in the pig

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Estimating the frequency of Asian cytochrome B haplotypes in standard European and local Spanish pig breeds

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Proteomic analysis of ovine muscle hypertrophy

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A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

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Differential expression of sarcoplasmic proteins in four heterogeneous ovine skeletal muscles

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Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep

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Integrating Y-Chromosome, Mitochondrial, and Autosomal Data to Analyze the Origin of Pig Breeds

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Short communication: Genetic variability in the predicted microRNA target sites of caprine casein genes

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Identification of positively selected sites in the goat kappa casein (CSN3) gene

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A Systems Model for Immune Cell Interactions Unravels the Mechanism of Inflammation in Human Skin

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Characterization of OAR1 and OAR18 QTL associated with muscle depth in British commercial terminal sire sheep

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Copy number variation in the genomes of domestic animals

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Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

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Allele-Specific Cytokine Responses at the HLA-C Locus: Implications for Psoriasis

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A Genome-Wide Association Study of Female Sexual Dysfunction

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An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element

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Characterisation of sperm piRNAs and their correlation with semen quality traits in swine

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Identification of genetic variation in the swine toll-like receptors and development of a porcine TLR genotyping array

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A genome-wide association analysis for carcass traits in a commercial Duroc pig population

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Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

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A targeted genotyping approach enhances identification of variants in taste receptor and appetite/reward genes of potential functional importance for obesity-related porcine traits

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A technical assessment of the porcine ejaculated spermatozoa for a sperm-specific RNA-seq analysis

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A RNA-Seq Analysis to Describe the Boar Sperm Transcriptome and Its Seasonal Changes

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An integrative systems biology approach to identify the molecular basis of sperm quality in swine

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Identification of circular RNAs in porcine sperm and evaluation of their relation to sperm motility

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A pilot RNA-seq study in 40 pietrain ejaculates to characterize the porcine sperm microbiome

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Whole genome sequencing identifies Allelic Ratio Distortion in sperm involving genes related to spermatogenesis in a swine model

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A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine

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Characterization of the Impact of Density Gradient Centrifugation on the Profile of the Pig Sperm Transcriptome by RNA-Seq

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Assessing the levels of intraspecific admixture and interspecific hybridization in Iberian wild goats ( Capra pyrenaica )

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Exploring the ovine sperm transcriptome by RNAseq techniques. I Effect of seasonal conditions on transcripts abundance

orcid publication

Genomic, transcriptomic and epigenomic analysis towards the understanding of porcine semen quality traits. Past, current and future trends

tool

avidaR

Digital evolution is a branch of artificial life in which self-replicating computer programs—digital organisms—mutate and...

tool

OntoAvida

The Ontology for Avida (OntoAvida) aims to develop an integrated vocabulary for the description of Avida, the most...

service unit

Bioinformatics for Genomics and Proteomics (CNB)

Assistance on experimental design for deep sequencing and DNA microarrays experiments Biostatistical support for extracting...

researcher

José Luis Ruiz Rodriguez

researcher

Oscar Diaz Sanzo

research line

Productive efficiency and resilience of Spanish chicken breeds to global warming

This project proposes the sequencing of up to 600 hens of Spanish breeds. With this...

orcid publication

Histone H3 Dynamics Reveal Domains with Distinct Proliferation Potential in the Arabidopsis Root

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Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat

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Oxford nanopore sequencing as an alternative to reduced representation bisulphite sequencing for the identification of CpGs of interest in livestock populations

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MEG8 as an antagonistic pleiotropic mechanism in breast cancer

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Functional Annotation of Proteomes Using Protein Language Models: A High-Throughput Implementation of the ProtTrans Model

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FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life

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11C-Labeling of a Flavone Extracted from a South American Native Species for Evaluation of Its Interaction with Gsk-3β

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SYNTHESIS AND INTRAMOLECULAR CYCLIZATION OF BISTHIADIAZINYLMETHANE DERIVATIVES

orcid publication

N-GLUCOSYL-5-AMINO-4-CARBAMOYLIMIDAZOLES AND 4-ETHOXYCARBONYLIMIDAZOLES AS POTENTIAL PRECURSORS OF 4-OXOIMIDAZO[4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES

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SYNTHESIS OF 2S-DIOXO ISOSTERES OF PURINE AND PYRIMIDINE NUCLEOSIDES .4. SELECTIVE GLYCOSYLATION OF 4-AMINO-5H-IMIDAZO [4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDE

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Synthesis and spectroscopic properties of N -azolylpropanamides

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Synthesis and cytostatic screening of an SO2 analogue of doridosine

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Reaction of 4-hydrazinoquinolines with β-diketones. Synthesis and spectroscopy ( ¹ h, ¹³ c nmr, ms) of some pyrazolylquinolines

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ON THE TAUTOMERISM OF 2-PHENACYL-4-PYRIMIDINONES AND RELATED-COMPOUNDS

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Synthesis of a Valuable Precursor for the Preparation of Novel Quinolone Glycosides

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STRUCTURE OF 1,2,6-THIADIAZINE 1,1-DIOXIDES

orcid publication

ROTATIONAL-ISOMERISM IN 6-BETA-D-GLUCOPYRANOSIDES OF METHYL-1,2,6-THIADIAZIN-3(2H)-ONE 1,1-DIOXIDES

orcid publication

GLYCOSIDES OF PYRIDO[2,3-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES