• Research Topics

Found 4596 Results
Page 6 of 46

orcid publication

Correction of GSK3β in DM1 reduces the mutant RNA and improves postnatal survival of DMSXL mice

orcid publication

CHAPTER 8. Protein Kinase Inhibitors for the Treatment of Multiple Sclerosis

orcid publication

A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

orcid publication

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation

orcid publication

Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases

orcid publication

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

orcid publication

A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential

orcid publication

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

orcid publication

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson’s Disease

orcid publication

TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis

orcid publication

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

orcid publication

Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases

orcid publication

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)

orcid publication

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

orcid publication

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

orcid publication

Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases

orcid publication

Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment

orcid publication

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

orcid publication

Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease

orcid publication

Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease

orcid publication

COVID-19: Drug Targets and Potential Treatments

orcid publication

Cognitive enhancement, TAU phosphorylation reduction, and neuronal protection by the treatment of an LRRK2 inhibitor in a tauopathy mouse model

orcid publication

Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis

orcid publication

Mitophagy Modulation, a New Player in the Race against ALS

orcid publication

Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles

orcid publication

Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP‐43‐related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)

orcid publication

Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses

orcid publication

Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β

orcid publication

Dynamics of Central Remyelination and Treatment Evolution in a Model of Multiple Sclerosis with Optic Coherence Tomography

orcid publication

Protein kinase inhibitors for amyotrophic lateral sclerosis therapy

orcid publication

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

orcid publication

Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles

orcid publication

Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems

orcid publication

Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods

orcid publication

Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related

orcid publication

Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?

orcid publication

Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis

orcid publication

From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein‐Templated Synthesis

orcid publication

Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target

orcid publication

Small molecule inhibitors of mammalian GSK-3β promote in vitro plant cell reprogramming and somatic embryogenesis in crop and forest species

orcid publication

Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson’s Disease

orcid publication

GSK3 Inhibitor-Induced Dentinogenesis Using a Hydrogel

orcid publication

TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy

orcid publication

Kinase Inhibitors as Underexplored Antiviral Agents

orcid publication

Glycogen Synthase Kinase-3 Maleimide Inhibitors As Potential PET-Tracers for Imaging Alzheimer’s Disease: 11C-Synthesis and In Vivo Proof of Concept

orcid publication

TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer’s Disease Patients

orcid publication

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

orcid publication

Targeting autophagy in disease: established and new strategies

orcid publication

Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from Talaromyces amestolkiae: Potential Antiproliferative and Neuroprotective Effect of These Molecules

orcid publication

Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19

orcid publication

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

orcid publication

The mechanism of macroautophagy: The movie

orcid publication

Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations

orcid publication

The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes

orcid publication

The Dual PDE7-GSK3β Inhibitor, VP3.15, as Neuroprotective Disease-Modifying Treatment in a Model of Primary Progressive Multiple Sclerosis

orcid publication

Efficacy of Bromhexine versus Standard of Care in Reducing Viral Load in Patients with Mild-to-Moderate COVID-19 Disease Attended in Primary Care: A Randomized Open-Label Trial

orcid publication

Emerging clinical investigational drugs for the treatment of amyotrophic lateral sclerosis

orcid publication

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts

orcid publication

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

orcid publication

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

orcid publication

N'-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile

orcid publication

The emerging role of mixed lineage kinase 3 (MLK3) and its potential as a target for neurodegenerative diseases therapies

orcid publication

Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents

orcid publication

Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis

orcid publication

Discovery of Thiophene Derivatives as Potent, Orally Bioavailable, and Blood–Brain Barrier-Permeable Ebola Virus Entry Inhibitors

orcid publication

Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation

orcid publication

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

orcid publication

TDP-43 Modulation for the Treatment of Neurodegenerative Diseases: Rationale and Assay Methodologies

orcid publication

RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection

orcid publication

11C-Labeling of a Flavanone Extracted from a South American Native Species for Evaluation of Its Interaction with GSK-3β

orcid publication

Discovery of Sphingosine-1-Phosphate Receptor Modulators as Potential CHI3L1 Inhibitors by Ligand-Based Virtual Screening and Molecular Dynamics Simulations

orcid publication

Discovery of a brain penetrant SGK1 inhibitor using a ligand- and structure-based virtual screening methodology

orcid publication

IgT and IgD dominance in the teleost central nervous system

orcid publication

Determination of thermal conductivity, specific heat and thermal diffusivity of albacore (Thunnus alalunga)

orcid publication

DEGRADATION KINETICS OF PROTEIN DIGESTIBILITY AND AVAILABLE LYSINE DURING THERMAL-PROCESSING OF TUNA

orcid publication

MATHEMATICAL-MODELING AND SIMULATION OF THE THERMAL-PROCESSING OF ANISOTROPIC AND NONHOMOGENEOUS CONDUCTION-HEATED CANNED FOODS - APPLICATION TO CANNED TUNA

orcid publication

Kinetics of thermal degradation of thiamine and surface colour in canned tuna

orcid publication

Optimal control of heat and mass transfer in food and bioproducts processing

orcid publication

OPTIMIZATION OF AIR-DRYING OF FOODS

orcid publication

ICRS/DS: A computer package for the optimization of batch processes and its applications in food processing

orcid publication

Different strategies for controlling pressure during the cooling stage in batch retorts

orcid publication

Computer aided design and optimization of sterilization of canned tuna

orcid publication

Time-temperature effects on microbial, chemical and sensory changes during cooling and aging of cheddar cheese

orcid publication

Global optimization of chemical processes using stochastic algorithms

orcid publication

Dynamic optimization of batch reactors using adaptive stochastic algorithms. (vol 36, pg 2256, 1997)

orcid publication

A complete dynamic model for the thermal processing of bioproducts in batch units and its application to controller design

orcid publication

Stochastic optimization for optimal and model-predictive control

orcid publication

Rebuttal to the comments of Rein Luus on "Dynamic optimization of batch reactors using adaptive stochastic algorithms"

orcid publication

Modeling and adaptive control for batch sterilization

orcid publication

Design of a class of stabilizing nonlinear state feedback controllers with bounded inputs

orcid publication

A hybrid method for the optimal control of chemical processes

orcid publication

Second-order sensitivities of general dynamic systems with application to optimal control problems

orcid publication

Temperature control in microwave combination ovens

orcid publication

Passive control design for distributed process systems: Theory and applications

orcid publication

Optimization of hybrid discrete/continuous dynamic systems

orcid publication

Numerical strategies for optimal experimental design for parameter identification of non-linear dynamic (Bio-)chemical processes

orcid publication

Efficient optimal control of bioprocesses using second-order information

orcid publication

Optimal control of distributed processes using reduced order models

orcid publication

On the optimal control of contact-cooking processes

orcid publication

Integrated process design and control via global optimization: A wastewater treatment plant case study

Page 6 of 46
Computational Biology and Bioinformatics (BCB)

CONTACT | LEGAL NOTICE | COOKIES POLICY | DATA PROTECTION

© CSIC - Consejo Superior de Investigaciones Científicas. 2025 - All rights reserved. Powered by Scienseed
Go to Top