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Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1

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Normal mode analysis in structural biology

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Imods: Fast Exploration of Macromolecular Collective Motions

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IMODS: Internal coordinates normal mode analysis server

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FRODRUG: A virtual screening GPU accelerated approach for drug discovery

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DrugScore^PPI knowledge-based potentials used as scoring and objective function in protein-protein docking

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Structural modeling from electron microscopy data

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Molecular Dynamics and Assembly Switch of FtsZ Filaments

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Integrative Modeling Approaches to Interpret High-Resolution cryo-EM Reconstructions

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Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action

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Structure of promoter-bound TFIID and model of human pre-initiation complex assembly

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RCD plus : Fast loop modeling server

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New generation of elastic network models

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Near-atomic cryo-EM structure of PRC1 bound to the microtubule

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FRODOCK 2.0: fast protein-protein docking server.

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A fast band-Krylov eigensolver for macromolecular functional motion simulation on multicore architectures and graphics processors

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The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

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The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

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KORP: Knowledge-based 6D potential for fast protein and loop modeling

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The Structure of Human Tyrosine Hydroxylase Reveals the Mechanism for Feedback Inhibition by Dopamine

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Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures

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Atomic-level evolutionary information improves protein-protein interface scoring

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Current approaches to flexible loop modeling

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KORP-PL: a coarse-grained knowledge-based scoring function for protein–ligand interactions

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InterEvDock3: a combined template-based and free docking server with increased performance through explicit modeling of complex homologs and integration of covariation-based contact maps

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PIFOLD: TOWARD EFFECTIVE AND EFFICIENT PROTEIN INVERSE FOLDING

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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

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Learning rotations

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Local Normal Mode Analysis for Fast Loop Conformational Sampling

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Using a Graph Transformer Network to Predict 3D Coordinates of Proteins via Geometric Algebra Modelling

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Predicting protein stability changes upon mutation using a simple orientational potential

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Geometric Algebra Models of Proteins for Three-Dimensional Structure Prediction: A Detailed Analysis

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Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage ϕ29

research group

AgriFood Systems Integrative Biology Lab

AgriFood Systems Integrative Biology Lab Research Topics:Amplicon Sequencing, Analysis packages (R, Python, PERL, etc.), Annotation...

researcher

Maria Salud Garcia

research line

Transcriptomics

research line

Metabolomics

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Antiviral therapies

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Neuroinflammation

research line

Virology

research group

Advanced Computing

research line

Outreach for bioinformatics reserach

We develop actions and materials to bring the bioinformatics discipline to children, schools, and the...

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The 5' end generated in the in vitro self-cleavage reaction of avocado sunblotch viroid RNAs is present in naturally occurring linear viroid molecules

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Replication of avocado sunblotch viroid: Evidence for a symmetric pathway with two rolling circles and hammerhead ribozyme processing

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In vitro characterization of a cassette to accumulate multiple proteins through synthesis of a self-processing polypeptide

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Inhibition of a plant virus infection by analogs of melittin

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The complete nucleotide sequence of yam mosaic virus (Ivory Coast isolate) genomic RNA

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Studies on the diagnosis of hop stunt viroid in fruit trees: Identification of new hosts and application of a nucleic acid extraction procedure based on non-organic solvents

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Transgenic accumulation of two plant virus coat proteins on a single self processing polypeptide

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Hop stunt viroid (HSVd) sequence variants from Prunes species: Evidence for recombination between HSVd isolates

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Studies on the incidence of hop stunt viroid in apricot trees (Prunus armeniaca) by using an easy and short extraction method to analyze a large number of samples

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Simultaneous accumulation of multiple viral coat proteins from a TEV-NIa based expression vector

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Carmovirus isolation and RNA extraction.

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Molecular characterization of an almond isolate of hop stunt viroid (HSVd) and conditions for eliminating spurious hybridization in its diagnosis in almond samples

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Characterization and in vitro translation analysis of pelargonium flower break virus

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Identification and characterization of a hexapeptide with activity against phytopathogenic fungi that cause postharvest decay in fruits

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Molecular variability of twenty-one geographically distinct isolates of Carnation mottle virus (CarMV) and phylogenetic relationships within the Tombusviridae family

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Identification of a peptide with specific activity against fungi that cause postharvest decay in fruits

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Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library

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Complexation of imazalil with β-cyclodextrin, residue uptake, persistence, and activity against Penicillium decay in citrus fruit following postharvest dip treatments

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Characterization of Pinalate, a novel Citrus sinensis mutant with a fruit-specific alteration that results in yellow pigmentation and decreased ABA content

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Biochemical and molecular analysis of carotenoid biosynthesis in flavedo of orange (Citrus sinensis L.) during fruit development and maturation

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Understanding the basis of chilling injury in citrus fruit

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Transient structural ordering of the RNA-binding domain of carnation mottle virus p7 movement protein modulates nucleic acid binding

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Involvement of ethylene biosynthesis and perception in the susceptibility of citrus fruits to Penicillium digitatum infection and the accumulation of defence-related mRNAs

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Studies on the mode of action of the antifungal hexapeptide PAF26

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Lactoferricin-related peptides with inhibitory effects on ACE-dependent vasoconstriction

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Activity and mode of action against fungal phytopathogens of bovine lactoferricin-derived peptides

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High-throughput approaches to the identification of citrus genes involved in fruit response to penicillium digitatum infection

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Comparative study of antimicrobial peptides to control citrus postharvest decay caused by Penicillium digitatum

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Identification and rational design of novel antimicrobial peptides for plant protection

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Antimicrobial peptides: To membranes and beyond

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β-Glucanases as a tool for the control of wine spoilage yeasts

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Antihypertensive properties of lactoferricin B-derived peptides

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A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection

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A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides

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Antimicrobial Peptides

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Concentration-dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26

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Antifungal peptides: Exploiting non-lytic mechanisms and cell penetration properties

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Two Functional Motifs Define the Interaction, Internalization and Toxicity of the Cell-Penetrating Antifungal Peptide PAF26 on Fungal Cells

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FLO11 gene is involved in the interaction of flor strains of saccharomyces cerevisiae with a biofilm-promoting synthetic hexapeptide

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The Penicillium digitatum protein O-mannosyltransferase Pmt2 is required for cell wall integrity, conidiogenesis, virulence and sensitivity to the antifungal peptide PAF26

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Concatemerization increases the inhibitory activity of short, cell-penetrating, cationic and tryptophan-rich antifungal peptides

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Occurrence and function of fungal antifungal proteins: a case study of the citrus postharvest pathogen Penicillium digitatum

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Nitric oxide synthesis by nitrate reductase is regulated during development in Aspergillus

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Nitric oxide in fungi: is there NO light at the end of the tunnel?

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A Penicillium chrysogenum-based expression system for the production of small, cysteine-rich antifungal proteins for structural and functional analyses

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Mapping and identification of antifungal peptides in the putative antifungal protein AfpB from the filamentous fungus Penicillium digitatum

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Efficient production and characterization of the novel and highly active antifungal protein AfpB from Penicillium digitatum

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Effect of Trichoderma-enriched organic charcoal in the integrated wood protection strategy

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Tryptophan-containing dual neuroprotective peptides: Prolyl endopeptidase inhibition and caenorhabditis elegans protection from β-amyloid peptide toxicity

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Three antifungal proteins from penicillium expansum: Different patterns of production and antifungal activity

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Rational design and biotechnological production of novel afpb-paf26 chimeric antifungal proteins

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The myosin motor domain-containing chitin synthases are involved in cell wall integrity and sensitivity to antifungal proteins in penicillium digitatum

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Rice seeds as biofactories of rationally designed and cell-penetrating antifungal PAF peptides

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Efficient production of antifungal proteins in plants using a new transient expression vector derived from tobacco mosaic virus

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Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies

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The antifungal protein afpb induces regulated cell death in its parental fungus penicillium digitatum

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Multigene Engineering by GoldenBraid Cloning: From Plants to Filamentous Fungi and Beyond

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Calcium homeostasis plays important roles in the internalization and activities of the small synthetic antifungal peptide PAF26